Reference on EC 3.2.1.183 - UDP-N-acetylglucosamine 2-epimerase (hydrolysing)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stsche, R.; Hinderlich, S.; Weise, C.; Effertz, K.; Lucka, L.; Moormann, P.; Reutter, W.
A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase
J. Biol. Chem.
272
24319-24324
1997
Rattus norvegicus
Hinderlich, S.; Stsche, R.; Zeitler, R.; Reutter, W.
A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
J. Biol. Chem.
272
24313-24318
1997
Rattus norvegicus
Campbell, R.E.; Mosimann, S.C.; Tanner, M.E.; Strynadka, N.C.
The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases
Biochemistry
39
14993-15001
2000
Streptococcus pneumoniae (P27828)
Chou, W.K.; Hinderlich, S.; Reutter, W.; Tanner, M.E.
Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-N-acetylglucosamine 2-epimerase
J. Am. Chem. Soc.
125
2455-2461
2003
Rattus norvegicus
Vann, W.F.; Daines, D.A.; Murkin, A.S.; Tanner, M.E.; Chaffin, D.O.; Rubens, C.E.; Vionnet, J.; Silver, R.P.
The NeuC protein of Escherichia coli K1 is a UDP N-acetylglucosamine 2-epimerase
J. Bacteriol.
186
706-712
2004
Escherichia coli
Murkin, A.S.; Chou, W.K.; Wakarchuk, W.W.; Tanner, M.E.
Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase
Biochemistry
43
14290-14298
2004
Neisseria meningitidis, Neisseria meningitidis MC58 group B
Blume, A.; Ghaderi, D.; Liebich, V.; Hinderlich, S.; Donner, P.; Reutter, W.; Lucka, L.
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, functionally expressed in and purified from Escherichia coli, yeast, and insect cells
Protein Expr. Purif.
35
387-396
2004
Rattus norvegicus
Moeller, H.; Boehrsch, V.; Lucka, L.; Hackenberger, C.P.; Hinderlich, S.
Efficient metabolic oligosaccharide engineering of glycoproteins by UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) knock-down
Mol. Biosyst.
7
2245-2251
2011
Homo sapiens
Ringenberg, M.A.; Steenbergen, S.M.; Vimr, E.R.
The first committed step in the biosynthesis of sialic acid by Escherichia coli K1 does not involve a phosphorylated N-acetylmannosamine intermediate
Mol. Microbiol.
50
961-975
2003
Escherichia coli
Yardeni, T.; Choekyi, T.; Jacobs, K.; Ciccone, C.; Patzel, K.; Anikster, Y.; Gahl, W.A.; Kurochkina, N.; Huizing, M.
Identification, tissue distribution, and molecular modeling of novel human isoforms of the key enzyme in sialic acid synthesis, UDP-GlcNAc 2-epimerase/ManNAc kinase
Biochemistry
50
8914-8925
2011
Homo sapiens (Q9Y223)
Yardeni, T.; Jacobs, K.; Niethamer, T.K.; Ciccone, C.; Anikster, Y.; Kurochkina, N.; Gahl, W.A.; Huizing, M.
Murine isoforms of UDP-GlcNAc 2-epimerase/ManNAc kinase: secondary structures, expression profiles, and response to ManNAc therapy
Glycoconj. J.
30
609-618
2013
Mus musculus (Q3UW64), Mus musculus (Q91WG8), Mus musculus C57/BL6J (Q3UW64), Mus musculus C57/BL6J (Q91WG8)
Grover, S.; Arya, R.
Role of UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) in beta1-integrin-mediated cell adhesion
Mol. Neurobiol.
50
257-273
2014
Homo sapiens
Ko, T.P.; Lai, S.J.; Hsieh, T.J.; Yang, C.S.; Chen, Y.
The tetrameric structure of sialic-acid-synthesizing UDP-GlcNAc 2-epimerase from Acinetobacter baumannii a comparative study with human GNE
J. Biol. Chem.
293
10119-10127
2018
Homo sapiens (Q9Y223), Homo sapiens
Grover, S.; Arya, R.
Role of UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) in beta-integrin-mediated cell adhesion
Mol. Neurobiol.
50
257-273
2014
Homo sapiens (Q9Y223)
Harazi, A.; Becker-Cohen, M.; Zer, H.; Moshel, O.; Hinderlich, S.; Mitrani-Rosenbaum, S.
The interaction of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and alpha-actinin 2 is altered in GNE myopathy M743T mutant
Mol. Neurobiol.
54
2928-2938
2017
Homo sapiens (Q9Y223)
Liu, N.; Wang, Z.K.; Wang, H.X.; Li, Y.; Niu, Z.H.; Yu, X.F.
Muscle biopsy and UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene mutation analysis in two Chinese patients with distal myopathy with rimmed vacuoles
NeuroReport
26
598-601
2015
Homo sapiens (Q9Y223)
Chen, S.C.; Huang, C.H.; Lai, S.J.; Yang, C.S.; Hsiao, T.H.; Lin, C.H.; Fu, P.K.; Ko, T.P.; Chen, Y.
Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis
Sci. Rep.
6
23274
2016
Homo sapiens (Q9Y223)
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