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Information on EC 3.2.1.183 - UDP-N-acetylglucosamine 2-epimerase (hydrolysing)

for references in articles please use BRENDA:EC3.2.1.183
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IUBMB Comments
The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus. It catalyses the first step of sialic acid (N-acetylneuraminic acid) biosynthesis. The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers . The mammalian enzyme is bifunctional and also catalyses EC 2.7.1.60, N-acetylmannosamine kinase. cf. EC 5.1.3.14, UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing).
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
bifunctional enzyme UDP-Nacetylglucosamine 2-epimerase/N-acetylmannosamine kinase, bifunctional UDP-GlcNAc 2-epimerase/ManNAc kinase, bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, GNE, hydrolyzing epimerase, hydrolyzing UDP-GlcNAc 2-epimerase, More, neuC, SeMet UDP-GlcNAc 2-epimerase, siaA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-D-mannosamine + UDP
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