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Information on EC 3.2.1.183 - UDP-N-acetylglucosamine 2-epimerase (hydrolysing)

for references in articles please use BRENDA:EC3.2.1.183
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IUBMB Comments
The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus. It catalyses the first step of sialic acid (N-acetylneuraminic acid) biosynthesis. The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers . The mammalian enzyme is bifunctional and also catalyses EC 2.7.1.60, N-acetylmannosamine kinase. cf. EC 5.1.3.14, UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing).
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
bifunctional udp-n-acetylglucosamine 2-epimerase/n-acetylmannosamine kinase, bifunctional udp-glcnac 2-epimerase/mannac kinase, uridine diphosphate-n-acetylglucosamine-2-epimerase, uridine diphosphate-n-acetylglucosamine 2-epimerase/n-acetylmannosamine kinase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-D-mannosamine + UDP
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