Reference on EC 3.2.1.169 - protein O-GlcNAcase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ngoh, G.A.; Facundo, H.T.; Hamid, T.; Dillmann, W.; Zachara, N.E.; Jones, S.P.
Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury
Circ. Res.
104
41-49
2009
Rattus norvegicus
Dorfmueller, H.C.; Borodkin, V.S.; Schimpl, M.; van Aalten, D.M.F.
GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation
Biochem. J.
420
221-227
2009
Homo sapiens, Clostridium perfringens (Q0TR53)
Lee, T.N.; Alborn, W.E.; Knierman, M.D.; Konrad, R.J.
The diabetogenic antibiotic streptozotocin modifies the tryptic digest pattern for peptides of the enzyme O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase that contain amino acid residues essential for enzymatic activity
Biochem. Pharmacol.
72
710-718
2006
Homo sapiens
Cetinbas, N.; Macauley, M.S.; Stubbs, K.A.; Drapala, R.; Vocadlo, D.J.
Identification of Asp174 and Asp175 as the Key Catalytic Residues of Human O-GlcNAcase by Functional Analysis of Site-Directed Mutants
Biochemistry
45
3835-3844
2006
Homo sapiens
Toleman, C.; Paterson, A.J.; Kudlow, J.E.
Location and characterization of the O-GlcNAcase active site
Biochim. Biophys. Acta
1760
829-839
2006
Mus musculus (Q9EQQ9)
Macauley, M.S.; Vocadlo, D.J.
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase
Biochim. Biophys. Acta
1800
107-121
2010
Homo sapiens
Kim, E.J.; Kang, D.O.; Love, D.C.; Hanover, J.A.
Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate
Carbohydr. Res.
341
971-982
2006
Homo sapiens
Macauley, M.S.; Vocadlo, D.J.
Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase
Carbohydr. Res.
344
1079-1084
2009
Homo sapiens
He, Y.; Martinez-Fleites, C.; Bubb, A.; Gloster, T.M.; Davies, G.J.
Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase
Carbohydr. Res.
344
627-631
2009
Bacteroides thetaiotaomicron (Q89ZI2), Bacteroides thetaiotaomicron
Rao, F.V.; Dorfmueller, H.C.; Villa, F.; Allwood, M.; Eggleston, I.M.; van Aalten, D.M.
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis
EMBO J.
25
1569-1578
2006
Clostridium perfringens (Q0TR53)
Macauley, M.S.; Stubbs, K.A.; Vocadlo, D.J.
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis
J. Am. Chem. Soc.
127
17202-17203
2005
Homo sapiens
Greig, I.R.; Macauley, M.S.; Williams, I.H.; Vocadlo, D.J.
Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships
J. Am. Chem. Soc.
131
13415-13422
2009
Homo sapiens
He, Y.; Macauley, M.S.; Stubbs, K.A.; Vocadlo, D.J.; Davies, G.J.
Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase
J. Am. Chem. Soc.
132
1807-1809
2010
Bacteroides thetaiotaomicron (Q89ZI2)
Gao, Y.; Wells, L.; Comer, F.I.; Parker, G.J.; Hart, G.W.
Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain
J. Biol. Chem.
276
9838-9845
2001
Chlorocebus aethiops, Homo sapiens (P06865)
Wells, L.; Gao, Y.; Mahoney, J.A.; Vosseller, K.; Chen, C.; Rosen, A.; Hart, G.W.
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase
J. Biol. Chem.
277
1755-1761
2002
Chlorocebus aethiops, Bos taurus, Cricetulus griseus, Homo sapiens
Macauley, M.S.; Whitworth, G.E.; Debowski, A.W.; Chin, D.; Vocadlo, D.J.
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors
J. Biol. Chem.
280
25313-25322
2005
Homo sapiens
Dennis, R.J.; Taylor, E.J.; Macauley, M.S.; Stubbs, K.A.; Turkenburg, J.P.; Hart, S.J.; Black, G.N.; Vocadlo, D.J.; Davies, G.J.
Structure and mechanism of a bacterial beta -glucosaminidase having O-GlcNAcase activity
Nat. Struct. Mol. Biol.
13
365-371
2006
Bacteroides thetaiotaomicron (Q89ZI2)
Stubbs, K.A.; Zhang, N.; Vocadlo, D.J.
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase
Org. Biomol. Chem.
4
839-845
2006
Homo sapiens
Duran-Reyes, G.; Pascoe-Lira, D.; Garcia-Macedo, R.; Medina-Navarro, R.; Rosales-Torres, A.M.; Vergara-Onofre, M.; Foyo-Niembro, E.; Gutierrez-Rodriguez, M.E.; Garcia-Gutierrez, M.T.; Valladares-Salgado, A.; Kumate, J.; Cruz, M.
O-GlcNAc-selective-N-acetyl-beta-D-glucosaminidase activity and mRNA expression in muscle is related to glucosamine-induced insulin resistance
Pharmacology
85
121-130
2010
Rattus norvegicus
Dong, D.L.; Hart, G.W.
Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol
J. Biol. Chem.
269
19321-19330
1994
Rattus norvegicus
Borodkin, V.S.; Rafie, K.; Selvan, N.; Aristotelous, T.; Navratilova, I.; Ferenbach, A.T.; van Aalten, D.M.F.
O-GlcNAcase fragment discovery with fluorescence polarimetry
ACS Chem. Biol.
13
1353-1360
2018
Homo sapiens (O60502), Homo sapiens, Clostridium perfringens (Q0TR53), Clostridium perfringens
Mariappa, D.; Selvan, N.; Borodkin, V.; Alonso, J.; Ferenbach, A.T.; Shepherd, C.; Navratilova, I.H.; van Aalten, D.M.F.
A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development
Biochem. J.
470
255-262
2015
Clostridium perfringens
Chen, W.; Shen, S.; Dong, L.; Zhang, J.; Yang, Q.
Selective inhibition of beta-N-acetylhexosaminidases by thioglycosyl-naphthalimide hybrid molecules
Bioorg. Med. Chem.
26
394-400
2018
Homo sapiens (O60502)
Shadnezhad, A.; Naegeli, A.; Collin, M.
CP40 from Corynebacterium pseudotuberculosis is an endo-beta-N-acetylglucosaminidase
BMC Microbiol.
16
261
2016
Corynebacterium pseudotuberculosis, Corynebacterium pseudotuberculosis DSM-20689
Keembiyehetty, C.; Love, D.C.; Harwood, K.R.; Gavrilova, O.; Comly, M.E.; Hanover, J.A.
Conditional knock-out reveals a requirement for O-linked N-acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis
J. Biol. Chem.
290
7097-7113
2015
Mus musculus (Q9EQQ9), Mus musculus
Akan, I.; Love, D.C.; Harwood, K.R.; Bond, M.R.; Hanover, J.A.
Drosophila O-GlcNAcase deletion globally perturbs chromatin O-GlcNAcylation
J. Biol. Chem.
291
9906-9919
2016
Drosophila melanogaster
Elsen, N.L.; Patel, S.B.; Ford, R.E.; Hall, D.L.; Hess, F.; Kandula, H.; Kornienko, M.; Reid, J.; Selnick, H.; Shipman, J.M.; Sharma, S.; Lumb, K.J.; Soisson, S.M.; Klein, D.J.
Insights into activity and inhibition from the crystal structure of human O-GlcNAcase
Nat. Chem. Biol.
13
613-615
2017
Homo sapiens (O60502), Homo sapiens
Selvan, N.; Williamson, R.; Mariappa, D.; Campbell, D.G.; Gourlay, R.; Ferenbach, A.T.; Aristotelous, T.; Hopkins-Navratilova, I.; Trost, M.; van Aalten, D.M.F.
A mutant O-GlcNAcase enriches Drosophila developmental regulators
Nat. Chem. Biol.
13
882-887
2017
Drosophila melanogaster
html completed
