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Information on EC 3.2.1.14 - chitinase
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3.2.1.14 chitinaseIUBMB Comments
The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo-chitodextrinases can act. Activity is greatly stimulated in the presence of EC 1.14.99.53, lytic chitin monoxygenase, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. cf. EC 3.2.1.202, endo-chitodextrinase.
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Word Map
- 3.2.1.14
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biocontrol
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colloidal
- trichoderma
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chitin-binding
- fusarium
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pathogenesis-related
- serratia
- n-acetylglucosamine
- marcescens
- chitosan
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3-like
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chi3l1
- solani
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freezing
- gaucher
- glcnac
- beta-1,3-glucanase
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phytopathogenic
- cellulase
- rhizoctonia
- oxysporum
- cinerea
- botrytis
- glucanase
- harzianum
- mycelial
- cuticle
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defense-related
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hysteresis
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rhizosphere
- colletotrichum
- chitooligosaccharides
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molt
- n-acetyl-d-glucosamine
- alternaria
- flounder
- circulans
- chitosanase
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entomopathogenic
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recrystallization
- sclerotiorum
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transglycosylation
- viride
- beauveria
- bassiana
- pythium
- nucleopolyhedrovirus
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anthracnose
- glucocerebrosidase
- gloeosporioides
- environmental protection
- molecular biology
- analysis
- synthesis
- pharmacology
- industry
- degradation
- medicine
- biotechnology
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
chitinase, chitotriosidase, endochitinase, antifreeze protein, chit1, amcase, chitinase a, exochitinase, acidic mammalian chitinase, class i chitinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,4-beta-poly-N-acetylglucosaminidase
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beta-1,4-poly-N-acetyl glucosamidinase
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CF-AG
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CF-antigen
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CHI-26
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CHIT 1A
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CHIT 1B
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chitodextrinase-N-
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Complement-fixation antigen
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endochitinase
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MF1 antigen
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poly-beta-glucosaminidase
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UDA
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
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SYSTEMATIC NAME
IUBMB Comments
(1->4)-2-acetamido-2-deoxy-beta-D-glucan glycanohydrolase
The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo-chitodextrinases can act. Activity is greatly stimulated in the presence of EC 1.14.99.53, lytic chitin monoxygenase, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. cf. EC 3.2.1.202, endo-chitodextrinase.
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CAS REGISTRY NUMBER
COMMENTARY
9001-06-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl beta-N,N'-diacetylchitobioside + H2O
4-nitrophenol + N,N'-diacetylchitobiose
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Assay for Assessing Mucin Binding to Bacteria and Bacterial Proteins.
Acquired Immunodeficiency Syndrome
Crystallization and preliminary X-ray analysis of a chitinase from the fungal pathogen Coccidioides immitis.
Acute Kidney Injury
Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study.
Acute Kidney Injury
Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort.
Acute Kidney Injury
Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients.
Acute Kidney Injury
Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients.
Adenocarcinoma
Effect of antifreeze proteins on frozen primary prostatic adenocarcinoma cells.
Adenocarcinoma
SI-CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages.
Adenoma
Molecular pathology of murine ureteritis causing obstructive uropathy with hydronephrosis.
Airway Obstruction
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
Airway Obstruction
The activity and expression of chitinase in the equine lung and its activity in normal horses and animals with recurrent airway obstruction.
Alagille Syndrome
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Albuminuria
Changes in glycosylation of human blood plasma chitotriosidase in patients with type 2 diabetes.
Alzheimer Disease
Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.
Alzheimer Disease
Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility.
Alzheimer Disease
Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.
Alzheimer Disease
Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.
Alzheimer Disease
Chitinase expression in Alzheimer's disease and non-demented brains regions.
Alzheimer Disease
Chitinase1 contributed to a potential protection via microglia polarization and A? oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments.
Alzheimer Disease
Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia.
Alzheimer Disease
Chitotriosidase attenuates brain inflammation via HDAC3/NF-?B pathway in D-galactose and aluminum-induced rat model with cognitive impairments.
Alzheimer Disease
Extreme Stability of Chitotriosidase in Cerebrospinal Flulid makes it a Suitable Marker for Microglial Activation in Clinical Trials.
Alzheimer Disease
Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease.
Alzheimer Disease
Functional Properties of Mouse Chitotriosidase Expressed in the Periplasmic Space of Escherichia coli.
Alzheimer Disease
Increased Levels of Chitotriosidase and YKL-40 in Cerebrospinal Fluid from Patients with Alzheimer's Disease.
Alzheimer Disease
Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease.
Amebiasis
Chitinase-gene-based analysis of the genetic variability among the clinical isolates of
Amyloidosis
A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency.
Amyotrophic Lateral Sclerosis
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Amyotrophic Lateral Sclerosis
Chitotriosidase - a putative biomarker for sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Chitotriosidase and lysosomal enzymes as potential biomarkers of disease progression in amyotrophic lateral sclerosis: a survey clinic-based study.
Amyotrophic Lateral Sclerosis
Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study.
Amyotrophic Lateral Sclerosis
Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation.
Amyotrophic Lateral Sclerosis
Chitotriosidase: shucking the role of microglia in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes.
Amyotrophic Lateral Sclerosis
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Amyotrophic Lateral Sclerosis
CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia.
Amyotrophic Lateral Sclerosis
Evaluation of Chitotriosidase and CC-Chemokine Ligand 18 as Biomarkers of Microglia Activation in Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy.
Amyotrophic Lateral Sclerosis
Monocyte-Derived Macrophages Contribute to Chitinase Dysregulation in Amyotrophic Lateral Sclerosis: A Pilot Study.
Anemia
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene.
Anemia
Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.
Anemia
Generation of osteoclasts from type 1 Gaucher patients and correlation with clinical and genetic features of disease.
Anemia
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Anemia, Hypochromic
Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI).
Anemia, Sickle Cell
Plasma chitotriosidase and carotid intima-media thickness in children with sickle cell disease.
Arthritis
Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients.
Arthritis
Human secreted protein SI-CLP aggravates the inflammation of rheumatoid arthritis and is a potential macrophage inflammatory regulator.
Arthritis
[Some data concerning the incidence of infectious, nonspecific polyarthritis in 1 of the districs of Chita]
Arthritis, Juvenile
Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients.
Arthritis, Rheumatoid
Chitinase 3-Like 1 Contributes to Food Allergy via M2 Macrophage Polarization.
Arthritis, Rheumatoid
Human secreted protein SI-CLP aggravates the inflammation of rheumatoid arthritis and is a potential macrophage inflammatory regulator.
Arthritis, Rheumatoid
Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects.
Aspartylglucosaminuria
Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and their correction by enzyme replacement therapy.
Aspergillosis
Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival.
Aspergillosis
Induction of chitinase in response to Aspergillus infection in sorghum (Sorghum bicolor (L) Moench).
Asthma
A chitinase-like protein in the lung and circulation of patients with severe asthma.
Asthma
A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts.
Asthma
Acidic Chitinase-Chitin Complex Is Dissociated in a Competitive Manner by Acetic Acid: Purification of Natural Enzyme for Supplementation Purposes.
Asthma
Acidic Mammalian chitinase and the eye: implications for ocular inflammatory diseases.
Asthma
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.
Asthma
Acidic Mammalian Chitinase Negatively Affects Immune Responses during Acute and Chronic Aspergillus fumigatus Exposure.
Asthma
Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Asthma
Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.
Asthma
Association of 24 bp Duplication of Human CHIT1 Gene with Asthma in a Heterozygous Population of North India: A Case-Control Study.
Asthma
Association of IL13R alpha 1 +1398A/G polymorphism in a North Indian population with asthma: A case-control study.
Asthma
Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase.
Asthma
Chitinase 3-like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population.
Asthma
Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammation.
Asthma
Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
Asthma
Chitinases and Chitinase-Like Proteins in Obstructive Lung Diseases - Current Concepts and Potential Applications.
Asthma
Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.
Asthma
Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-? expression and Foxp3
Asthma
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.
Asthma
Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
Asthma
Comparison of serum biomarkers between patients with asthma and with chronic obstructive pulmonary disease.
Asthma
Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.
Asthma
Differential allergy responses to Metarhizium anisopliae fungal component extracts in BALB/c mice.
Asthma
Differential enzymatic activity of common haplotypic versions of the human acidic mammalian chitinase protein.
Asthma
Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Asthma
Effect of Onchocerca volvulus chitinase on MUC5B expression in human airway epithelial cells.
Asthma
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Asthma
Evolutionary and biochemical differences between human and monkey acidic mammalian chitinases.
Asthma
Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps.
Asthma
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.
Asthma
Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.
Asthma
Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels.
Asthma
Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma.
Asthma
Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.
Asthma
Graphene oxide attenuates Th2-type immune responses, but augments airway remodeling and hyperresponsiveness in a murine model of asthma.
Asthma
Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening.
Asthma
Human chitinases and chitinase-like proteins as indicators for inflammation and cancer.
Asthma
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
Asthma
Improved fluorescent labeling of chitin oligomers: Chitinolytic properties of acidic mammalian chitinase under somatic tissue pH conditions.
Asthma
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
Asthma
Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis.
Asthma
Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps.
Asthma
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
Asthma
Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses OVA-sensitized Allergic Asthma.
Asthma
Joint influences of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like receptor-10 with Interleukin-13 in the genetics of asthma.
Asthma
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.
Asthma
Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease.
Asthma
Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma.
Asthma
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Asthma
Protein A-mouse acidic mammalian chitinase-V5-His expressed in periplasmic space of Escherichia coli possesses chitinase functions comparable to CHO-expressed protein.
Asthma
Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma.
Asthma
Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin.
Asthma
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
Asthma
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.
Asthma
The composition of house dust mite is critical for mucosal barrier dysfunction and allergic sensitisation.
Asthma
The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma.
Asthma
The effects of an insertion in the 5'UTR of the AMCase on gene expression and pulmonary functions.
Asthma
YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E.
Astrocytoma
The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis.
Atherosclerosis
Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients.
Atherosclerosis
Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children.
Atherosclerosis
Chitotriosidase enzyme activity: is this a possible chronic inflammation marker in children with common variable immunodeficiency and early atherosclerosis?
Atherosclerosis
Chitotriosidase genotype and serum activity in subjects with combined hyperlipidemia: effect of the lipid-lowering agents, atorvastatin and bezafibrate.
Atherosclerosis
Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice.
Atherosclerosis
Increased Expression of Chitinase 3-Like 1 in Aorta of Patients with Atherosclerosis and Suppression of Atherosclerosis in Apolipoprotein E-Knockout Mice by Chitinase 3-Like 1 Gene Silencing.
Atherosclerosis
Plasma Chitotriosidase Activity and Arteriogenic Erectile Dysfunction: Association with the Presence, Severity, and Duration.
Atherosclerosis
Plasma chitotriosidase and carotid intima-media thickness in children with sickle cell disease.
Atherosclerosis
Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events.
Atherosclerosis
Role of changes in serum chitotriosidase activity in mice under conditions of hyperlipidemia and lipid-lowering effect of carboxymethylated (1-3)-?-D-glycan.
Atherosclerosis
Serum chitotriosidase activity is increased in subjects with atherosclerosis disease.
Atherosclerosis
Serum cystatin C and chitotriosidase in acute P-407 induced dyslipidemia: Can they serve as potential early biomarkers for atherosclerosis?
Atherosclerosis
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.
Atherosclerosis
The effect of nonsurgical periodontal treatment on serum and saliva chitotriosidase activities in patients with periodontitis and coronary artery disease.
Atherosclerosis
[Chitotriosidase of human macrophages and mammalian chitinases: biological functions and abnormalities in pathology]
Atherosclerosis
[Effect of statins on activity of matrix metalloproteases and serum concentration of cystatin C in patients with various risk of development of ischemic heart disease and in patients after coronary artery bypass surgery].
Bacterial Infections
Characterization and expression analysis of chitinase genes (CHIT1, CHIT2 and CHIT3) in turbot (Scophthalmus maximus L.) following bacterial challenge.
Bacterial Infections
CHI3L1 alleviate acute liver injury by inhibiting Th1 cells differentiation through STAT3 signaling pathway.
Bacterial Infections
Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.
Bacterial Infections
Genetic engineering strategies for biotic and abiotic stress tolerance and quality enhancement in horticultural crops: a comprehensive review.
Bacterial Infections
Promoter activation of pepper class II basic chitinase gene, CAChi2, and enhanced bacterial disease resistance and osmotic stress tolerance in the CAChi2-overexpressing Arabidopsis.
Bacterial Infections
The Listeria monocytogenes ChiA Chitinase Enhances Virulence through Suppression of Host Innate Immunity.
beta-Thalassemia
Plasma chitotriosidase activity in beta-thalassemia major: a comparative study between Sicilian and Sardinian patients.
beta-Thalassemia
Plasma chitotriosidase activity in patients with beta-thalassemia.
beta-Thalassemia
Plasma chitotriosidase activity is a marker of recovery in transplanted patients affected by beta-thalassemia major.
beta-Thalassemia
Serum YKL-40 levels and chitotriosidase activity in patients with beta-thalassemia major.
Blister
Association of a Novel Pinus monticola Chitinase Gene (PmCh4B) with Quantitative Resistance to Cronartium ribicola
Blister
Association of a novel Pinus monticola chitinase gene (PmCh4B) with quantitative resistance to Cronartium ribicola.
Blister
Certain factors associated with blister blight resistance in Camellia sinensis (L.) O. Kuntze.
Blister
Enhanced resistance to blister blight in transgenic tea (Camellia sinensis [L.] O. Kuntze) by overexpression of class I chitinase gene from potato (Solanum tuberosum).
Bone Resorption
Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells.
Brain Injuries, Traumatic
Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1.
Brain Injuries, Traumatic
Role for mammalian chitinase 3-like protein 1 in traumatic brain injury.
Brain Ischemia
Prognostic value of plasma chitotriosidase activity in acute stroke patients.
Brain Neoplasms
Transcriptional Effects of Dietary Exposure of Oil-Contaminated Calanus finmarchicus in Atlantic Herring (Clupea harengus).
Breast Neoplasms
Chitinase induces lysis of MCF-7 cells in culture and of human breast cancer xenograft B11-2 in SCID mice.
Breast Neoplasms
Chitotriosidase, a marker of innate immunity, is elevated in patients with primary breast cancer.
Breast Neoplasms
Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1.
Breast Neoplasms
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
Breast Neoplasms
SI-CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages.
Bronchial Hyperreactivity
Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma.
Bronchial Hyperreactivity
Polymorphisms and haplotypes of acid mammalian chitinase are associated with bronchial asthma.
Bronchiectasis
Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis.
Bronchiectasis
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
Brucellosis
Evaluating the validity of serum neopterin and chitotriosidase levels in follow-up brucellosis patients.
Candidiasis
Chitotriosidase Activity Is Counterproductive in a Mouse Model of Systemic Candidiasis.
Candidiasis, Oral
Fluorescence staining vs. routine KOH smear for rapid diagnosis of oral candidiasis-A diagnostic test.
Candidiasis, Vulvovaginal
Chitooligosaccharides and Thermostable Chitinase Against Vulvovaginal Candidiasis and Saprophyte Fungi: LC Mass Studies of Shrimp Shell Fermentation by Bacillus altitudinis.
Carcinogenesis
Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis.
Carcinogenesis
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.
Carcinoma
Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival.
Carcinoma
High expression of Chitinase 3-like-1 is an unfavorable prognostic factor in urothelial carcinoma of upper urinary tract and urinary bladder.
Carcinoma
Increased expression and possible role of chitinase 3-like-1 in a colitis-associated carcinoma model.
Carcinoma
Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma.
Carcinoma
M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma.
Carcinoma
Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.
Carcinoma, Hepatocellular
Chitinase 3-like-1, Tolloid-like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct-acting antivirals.
Carcinoma, Hepatocellular
Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan.
Carcinoma, Hepatocellular
The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.
Carcinoma, Non-Small-Cell Lung
Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis.
Carcinoma, Ovarian Epithelial
Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer.
Carcinoma, Renal Cell
Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma.
Cardiovascular Diseases
[Primary disability in cardiovascular diseases in Chita during the years 1967-1971]
Carotid Stenosis
Serum chitotriosidase activity is increased in subjects with atherosclerosis disease.
Celiac Disease
Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease.
chitinase deficiency
A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency.
chitinase deficiency
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
chitinase deficiency
Acidic Mammalian Chitinase Negatively Affects Immune Responses during Acute and Chronic Aspergillus fumigatus Exposure.
chitinase deficiency
CCL18 as an alternative marker in Gaucher and Niemann-Pick disease with chitotriosidase deficiency.
chitinase deficiency
Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
chitinase deficiency
Chitotriosidase deficiency in Brazil: evaluation of enzyme activity and genotypes.
chitinase deficiency
Chitotriosidase deficiency in the Cypriot population: Identification of a novel deletion in the CHIT1 gene.
chitinase deficiency
Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.
chitinase deficiency
Chitotriosidase Deficiency: A Mutation Update in an African Population.
chitinase deficiency
Clinical evaluation of chitotriosidase enzyme activity in Gaucher and Niemann Pick A/B diseases: A retrospective study from India.
chitinase deficiency
High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites.
chitinase deficiency
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
chitinase deficiency
Plasma chitotriosidase activity in acute Plasmodium falciparum malaria.
chitinase deficiency
Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae.
chitinase deficiency
[Application of plasma glucosylsphingosine detection in the follow-up of patients with Gaucher disease].
Cholera
Proteomic analysis of the vibrio cholerae type II secretome reveals new proteins including three related serine proteases.
Cholera
The extracellular transport signal of the Vibrio cholerae endochitinase (ChiA) is a structural motif located between amino acids 75 and 555.
Cholera
[Cholera vibrios lectins as main pathogenicity and persistence factors (biotechnological aspects of use)].
Cholestasis
Oxysterol/chitotriosidase based selective screening for Niemann-Pick type C in infantile cholestasis syndrome patients.
Cholesterol Ester Storage Disease
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Chromoblastomycosis
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease.
Chronic Limb-Threatening Ischemia
Evaluation of Chitotriosidase as a Marker of Inflammatory Status in Critical Limb Ischemia.
Chronic Periodontitis
The effect of nonsurgical periodontal treatment on serum and saliva chitotriosidase activities in patients with periodontitis and coronary artery disease.
Coccidioidomycosis
Disruption of the gene which encodes a serodiagnostic antigen and chitinase of the human fungal pathogen Coccidioides immitis.
Colitis
Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis.
Colitis
Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells.
Colitis, Ulcerative
Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease.
Colitis-Associated Neoplasms
Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.
Colitis-Associated Neoplasms
Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer.
Colorectal Neoplasms
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer.
Colorectal Neoplasms
Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
Colorectal Neoplasms
Mobilization of epithelial mesenchymal transition genes distinguishes active from inactive lesional tissue in patients with ulcerative colitis.
Colorectal Neoplasms
Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection.
Colorectal Neoplasms
Serum chitinase activity prognosticates metastasis of colorectal cancer.
Common Variable Immunodeficiency
Chitotriosidase enzyme activity: is this a possible chronic inflammation marker in children with common variable immunodeficiency and early atherosclerosis?
Communicable Diseases
Elevated plasma chitotriosidase activity in various lysosomal storage disorders.
Communicable Diseases
Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.
Communicable Diseases
The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE).
Confusion
Plasma methylumbelliferyl-tetra-N-acetyl-chitotetraoside hydrolase: further study of its characteristics as a chitinase and comparison with its activity on Remazol Brilliant Violet carboxymethyl chitin.
Conjunctivitis, Allergic
Acidic Mammalian chitinase and the eye: implications for ocular inflammatory diseases.
Conjunctivitis, Allergic
Effect of chitinase inhibitors on endotoxin-induced uveitis (EIU) in rabbits.
Coronary Artery Disease
24 bp duplication of CHIT1 gene is not correlated with coronary artery disease in Corsica Island (France).
Coronary Artery Disease
Chitotriosidase: A New Inflammatory Marker in Diabetic Complications.
Coronary Artery Disease
Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.
Coronary Artery Disease
Increased Expression of Chitinase 3-Like 1 in Aorta of Patients with Atherosclerosis and Suppression of Atherosclerosis in Apolipoprotein E-Knockout Mice by Chitinase 3-Like 1 Gene Silencing.
Coronary Artery Disease
Serum chitotriosidase activity in patients with coronary artery disease.
Coronary Artery Disease
The effect of nonsurgical periodontal treatment on serum and saliva chitotriosidase activities in patients with periodontitis and coronary artery disease.
Coronary Disease
Chitinase 3-like 1 gene-329G/A polymorphism, plasma concentration and risk of coronary heart disease in a Chinese population.
Coronary Disease
Serum Chitotriosidase Activity, a Marker of Activated Macrophages, Predicts New Cardiovascular Events Independently of C-Reactive Protein.
COVID-19
Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19.
COVID-19
Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID-19 patients.
Creutzfeldt-Jakob Syndrome
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Crohn Disease
Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease.
Cryptococcosis
Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection.
Cystic Fibrosis
Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
Cystic Fibrosis
Functional Properties of Mouse Chitotriosidase Expressed in the Periplasmic Space of Escherichia coli.
Cystinosis
Chitotriosidase as a Novel Biomarker for Therapeutic Monitoring of Nephropathic Cystinosis.
Cysts
Biology of Giardia lamblia. Detection of N-acetyl-D-glucosamine as the only surface saccharide moiety and identification of two distinct subsets of trophozoites by lectin binding.
Cysts
Different structure and mRNA expression of Entamoeba invadens chitinases in the encystation and excystation.
Cysts
Identification and partial characterization of three chitinase forms in Entamoeba invadens with emphasis on their inhibition by allosamidin.
Cysts
The Jacob2 lectin of the Entamoeba histolytica cyst wall binds chitin and is polymorphic.
Cysts
The most abundant glycoprotein of amebic cyst walls (Jacob) is a lectin with five Cys-rich, chitin-binding domains.
Cysts
The parasitic and lethal effects of Trichoderma longibrachiatum against Heterodera avenae
Cysts
Unique posttranslational modifications of chitin-binding lectins of Entamoeba invadens cyst walls.
Cysts
[Parasitic and lethal action of Trichoderma longibrachiatum against Heterodera avenae].
Dehydration
Antifreeze protein complements cryoprotective dehydration in the freeze-avoiding springtail Megaphorura arctica.
Dehydration
Cloning of a cDNA for a chitinase homologue which lacks chitin-binding sites and is down-regulated by water stress and wounding.
Dehydration
Induced expression of the class II chitinase gene during cold acclimation and dehydration of bermudagrass (Cynodon sp.). [Erratum: Dec 2001, v. 103 (8), p. 1312].
Dehydration
Isolation of an osmotic stress- and abscisic acid-induced gene encoding an acidic endochitinase from Lycopersicon chilense.
Dehydration
[Intercellular 27 kD protein is a chitinase induced by water stress or Pseudoperonospora cubensis in cucumber leaves]
Dementia
Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia.
Dementia
Serum markers of monocyte/macrophage activation in patients with Alzheimer's disease and other types of dementia.
Demyelinating Diseases
Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes.
Dermatitis
Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice.
Dermatitis, Contact
Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice.
Dermatitis, Contact
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
Dermatomycoses
Utilization of chitinase in treatment of dermatomycosis. I. Influence of Bacilli chitinovori on the culture of dermatophytes.
Dermatomycoses
Utilization of chitinase in treatment of dermatomycosis. II. Influence of crude chitinase fluid on the culture of fungi.
Diabetes Complications
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications.
Diabetes Complications
Chitotriosidase: A New Inflammatory Marker in Diabetic Complications.
Diabetes Mellitus
Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus.
Diabetes Mellitus
Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus.
Diabetes Mellitus
Serum chitotriosidase enzyme activity is closely related to HbA1c levels and the complications in patients with diabetes mellitus type 2.
Diabetes Mellitus, Type 1
Chitinase expression in parotid glands of non-obese diabetic mice.
Diabetes Mellitus, Type 1
Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Association of chitotriosidase enzyme activity and genotype with the risk of nephropathy in type 2 diabetes.
Diabetes Mellitus, Type 2
Changes in glycosylation of human blood plasma chitotriosidase in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Increased chitotriosidase activity in plasma of patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Neutrophils as a Source of Chitinases and Chitinase-Like Proteins in Type 2 Diabetes.
Diabetic Angiopathies
Increased chitotriosidase activity in plasma of patients with type 2 diabetes.
Diabetic Nephropathies
Association of chitotriosidase enzyme activity and genotype with the risk of nephropathy in type 2 diabetes.
Diabetic Neuropathies
Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus.
Diabetic Retinopathy
C-reactive protein and chitinase 3-like protein 1 as biomarkers of spatial redistribution of retinal blood vessels on digital retinal photography in patients with diabetic retinopathy.
Diabetic Retinopathy
The changing features of serum adropin, copeptin, neprilysin and chitotriosidase which are associated with vascular endothelial function in type 2 diabetic retinopathy patients.
Disorders of Excessive Somnolence
Cerebrospinal fluid biomarkers of neurodegeneration are decreased or normal in narcolepsy.
Disorders of Excessive Somnolence
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.
Drug Hypersensitivity
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
Dry Eye Syndromes
Acidic Mammalian chitinase and the eye: implications for ocular inflammatory diseases.
Dyslipidemias
Serum cystatin C and chitotriosidase in acute P-407 induced dyslipidemia: Can they serve as potential early biomarkers for atherosclerosis?
Elephantiasis
Differential recognition of microfilarial chitinase, a transmission-blocking vaccine candidate antigen, by sera from patients with Brugian and Bancroftian filariasis.
Elephantiasis, Filarial
Differential recognition of microfilarial chitinase, a transmission-blocking vaccine candidate antigen, by sera from patients with Brugian and Bancroftian filariasis.
Elephantiasis, Filarial
Evaluation of recombinant chitinase antigen in serological diagnosis and surveillance of lymphatic filariasis.
Elephantiasis, Filarial
The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai?Myanmar Border.
Elephantiasis, Filarial
Transmission-blocking antibodies recognize microfilarial chitinase in brugian lymphatic filariasis.
Encephalitis
Chitotriosidase attenuates brain inflammation via HDAC3/NF-?B pathway in D-galactose and aluminum-induced rat model with cognitive impairments.
Encephalitis
The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE).
Encephalomyelitis
An attempt to produce a complement-fixation antigen for the avian encephalomyelitis virus from infected chick embryo brains.
Endometrial Neoplasms
YKL-40 Protein Levels and Clinical Outcome of Human Endometrial Cancer.
Eosinophilia
Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Eosinophilia
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-?B.
Eosinophilia
Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.
Eosinophilia
The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma.
Eosinophilic Esophagitis
Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis.
Erectile Dysfunction
Plasma Chitotriosidase Activity and Arteriogenic Erectile Dysfunction: Association with the Presence, Severity, and Duration.
Escherichia coli Infections
Immunomodulation of Host Chitinase 3-Like 1 During a Mammary Pathogenic Escherichia coli Infection.
Esophageal Squamous Cell Carcinoma
Chitinase 3-like 1 secreted by peritumoral macrophages in esophageal squamous cell carcinoma is a favorable prognostic factor for survival.
Eye Diseases
High-level expression of a tobacco chitinase gene in Nicotiana sylvestris. Susceptibility of transgenic plants to Cercospora nicotianae infection.
Fabry Disease
Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and their correction by enzyme replacement therapy.
Familial Mediterranean Fever
Decreased Chitotriosidase Activity and Levels in Familial Mediterranean Fever.
Familial Mediterranean Fever
S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever.
Fatty Liver
Adiponectin and the steatosis marker Chi3L1 decrease following switch to raltegravir compared to continued PI/NNRTI-based antiretroviral therapy.
Fatty Liver
Association of chitotriosidase genotype with the development of non-alcoholic fatty liver disease.
Fatty Liver
Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease.
Fatty Liver
Potential role of chitotriosidase gene in nonalcoholic Fatty liver disease evolution.
Filariasis
Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.
Filariasis
Evaluation of recombinant chitinase and SXP1 antigens as antimicrofilarial vaccines.
Filariasis
Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Filariasis
[Evaluation of DNA recombinant chitinase fusion protein antigens in serological diagnosis for filariasis]
Food Hypersensitivity
Chitinase 3-Like 1 Contributes to Food Allergy via M2 Macrophage Polarization.
Food Hypersensitivity
Maize food allergy: lipid-transfer proteins, endochitinases, and alpha-zein precursor are relevant maize allergens in double-blind placebo-controlled maize-challenge-positive patients.
Foot Rot
Differential induction of chitinase in Piper colubrinum in response to inoculation with Phytophthora capsici, the cause of foot rot in black pepper.
Frontotemporal Dementia
Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.
Frontotemporal Lobar Degeneration
Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype.
Frontotemporal Lobar Degeneration
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Frontotemporal Lobar Degeneration
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Fucosidosis
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Fusariosis
Immunolocalization of a class III chitinase in two muskmelon cultivars reacting differently to Fusarium oxysporum f. sp. melonis.
Gangliosidoses
Dual Diagnosis of Dihydropyrimidine Dehydrogenase Deficiency and GM(1) Gangliosidosis.
Gastritis
CHIT1 and AMCase expression in human gastric mucosa: correlation with inflammation and Helicobacter pylori infection.
Gastroenteritis
A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis.
Gaucher Disease
A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency.
Gaucher Disease
A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV.
Gaucher Disease
Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher disease.
Gaucher Disease
Accuracy of chitotriosidase activity and CCL18 concentration in assessing type I Gaucher disease severity. A systematic review with meta-analysis of individual participant data.
Gaucher Disease
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene.
Gaucher Disease
Allele frequency of a 24?bp duplication in exon 10 of the CHIT1 gene in the general Korean population and in Korean patients with Gaucher disease.
Gaucher Disease
Allelic frequency determination of the 24-bp chitotriosidase duplication in the Portuguese population by real-time PCR.
Gaucher Disease
Biochemical and molecular characterization of adult patients with type I Gaucher disease and carrier frequency analysis of Leu444Pro - a common Gaucher disease mutation in India.
Gaucher Disease
Biochemical and Molecular Chitotriosidase Profiles in Patients with Gaucher Disease Type 1 in Minas Gerais, Brazil: New Mutation in CHIT1 Gene.
Gaucher Disease
Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.
Gaucher Disease
Biochemical study on beta-glucosidase in individuals with Gaucher's disease and normal subjects.
Gaucher Disease
Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease.
Gaucher Disease
Changes in serum chitotriosidase activity with cessation of replacement enzyme (cerebrosidase) administration in Gaucher disease.
Gaucher Disease
Chitotriosidase Activity and Gene Polymorphism in Iranian Patients with Gaucher Disease and Sibling Carriers.
Gaucher Disease
Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases.
Gaucher Disease
Chitotriosidase determination in plasma and in dried blood spots: a comparison using two different substrates in a microplate assay.
Gaucher Disease
Chitotriosidase genotype and plasma activity in patients type 1 Gaucher's disease and their relatives (carriers and non carriers).
Gaucher Disease
Chitotriosidase on treatment-naïve patients with Gaucher disease: A genotype vs phenotype study.
Gaucher Disease
Chitotriosidase variants in patients with Gaucher disease. Implications for diagnosis and therapeutic monitoring.
Gaucher Disease
Clinical evaluation of chitotriosidase enzyme activity in Gaucher and Niemann Pick A/B diseases: A retrospective study from India.
Gaucher Disease
Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages.
Gaucher Disease
Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.
Gaucher Disease
Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
Gaucher Disease
Comparison between the biochemical properties of plasma chitotriosidase from normal individuals and from patients with Gaucher disease, GM1-gangliosidosis, Krabbe disease and heterozygotes for Gaucher disease.
Gaucher Disease
Correlation of surrogate markers of Gaucher disease. Implications for long-term follow up of enzyme replacement therapy.
Gaucher Disease
Could GSD type I expand the spectrum of disorders with elevated plasma chitotriosidase activity?
Gaucher Disease
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
Gaucher Disease
Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.
Gaucher Disease
Elevated plasma chitotriosidase activity in various lysosomal storage disorders.
Gaucher Disease
Functional Properties of Mouse Chitotriosidase Expressed in the Periplasmic Space of Escherichia coli.
Gaucher Disease
Gaucher disease: single gene molecular characterization of one-hundred Indian patients reveals novel variants and the most prevalent mutation.
Gaucher Disease
High levels of human chitotriosidase hinder the formation of peritrophic membrane in anopheline vectors.
Gaucher Disease
Human chitinases and chitinase-like proteins as indicators for inflammation and cancer.
Gaucher Disease
Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases.
Gaucher Disease
Identification of chitotriosidase isoforms in plasma of Gaucher disease patients by two dimensional gel electrophoresis.
Gaucher Disease
Improvement In Symptoms Of Gaucher's Disease By Enzyme Replacement Therapy.
Gaucher Disease
Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease.
Gaucher Disease
Marked differences in tissue-specific expression of chitinases in mouse and man.
Gaucher Disease
Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.
Gaucher Disease
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention.
Gaucher Disease
Modelling long-term evolution of chitotriosidase in non-neuronopathic Gaucher disease.
Gaucher Disease
New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Gaucher Disease
Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.
Gaucher Disease
Plasma chitotriosidase activity in beta-thalassemia major: a comparative study between Sicilian and Sardinian patients.
Gaucher Disease
Plasma chitotriosidase activity in Gaucher disease patients who have been treated either by bone marrow transplantation or by enzyme replacement therapy with alglucerase.
Gaucher Disease
Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data.
Gaucher Disease
Plasma chitotriosidase activity versus plasma glucosylsphingosine in wide spectrum of Gaucher disease phenotypes - A statistical insight.
Gaucher Disease
Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Gaucher Disease
Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and their correction by enzyme replacement therapy.
Gaucher Disease
Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.
Gaucher Disease
Rapid screening for lipid storage disorders using biochemical markers. Expert center data and review of the literature.
Gaucher Disease
Reduction in imiglucerase dosage causes immediate rise of chitotriosidase activity in patients with Gaucher disease.
Gaucher Disease
Serum chitotriosidase enzyme activity is closely related to HbA1c levels and the complications in patients with diabetes mellitus type 2.
Gaucher Disease
Serum Chitotriosidase, a Putative Marker of Chronically Activated Macrophages, Increases With Normal Aging.
Gaucher Disease
Splenomegaly, cardiomegaly, and osteoporosis in a child with Gaucher disease.
Gaucher Disease
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.
Gaucher Disease
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.
Gaucher Disease
Superior effects of high-dose enzyme replacement therapy in type 1 Gaucher disease on bone marrow involvement and chitotriosidase levels: a 2-center retrospective analysis.
Gaucher Disease
Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease.
Gaucher Disease
TNF-alpha levels and TNF-alpha gene polymorphism in type I Gaucher disease.
Gaucher Disease
Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.
Gaucher Disease
Twenty- five years of biochemical diagnosis of Gaucher disease: the Egyptian experience.
Gaucher Disease
Type 1 Gaucher disease: null and hypomorphic novel chitotriosidase mutations-implications for diagnosis and therapeutic monitoring.
Gaucher Disease
Type I Gaucher disease with severe skeletal destruction, extraosseous extension, and monoclonal gammopathy.
Gaucher Disease
Validating glycoprotein non-metastatic melanoma B (gpNMB, osteoactivin), a new biomarker of Gaucher disease.
Gaucher Disease
Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.
Gaucher Disease
[Application of plasma glucosylsphingosine detection in the follow-up of patients with Gaucher disease].
Gaucher Disease
[Biochemical and genetic diagnosis of Gaucher disease and its phenotypical heterogeneity]
Gaucher Disease
[Chitotriosidase of human macrophages and mammalian chitinases: biological functions and abnormalities in pathology]
Gaucher Disease
[Comparison and clinical application of two methods for determination of plasma chitotriosidase activity].
Gaucher Disease
[Effect of enzyme replacement therapy on lipid profile in patients with Gaucher's disease]
Gaucher Disease
[Plasma chitotriosidase activity in Argentinian patients with Gaucher disease, various lysosomal diseases and other inherited metabolic disorders]
Gaucher Disease
[The possibility of increasing the precision of biochemical diagnostics of Gaucher disease]
Gingivitis
Chitinase in whole and glandular human salivas and in whole saliva of patients with periodontal inflammation.
Gingivitis
Salivary Total Protease Activity Based on a Broad-Spectrum Fluorescence Resonance Energy Transfer Approach to Monitor Induction and Resolution of Gingival Inflammation.
Glioblastoma
Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma.
Glioblastoma
Chitinase 3-like protein 2 (CHI3L2, YKL-39) activates phosphorylation of extracellular signal-regulated kinases ERK1/ERK2 in human embryonic kidney (HEK293) and human glioblastoma (U87 MG) cells.
Glucose Intolerance
Inflammatory marker levels in obese adolescents with glucose intolerance: Increased chitotriosidase activity.
glucosylceramidase deficiency
A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency.
Glycogen Storage Disease
A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV.
Glycogen Storage Disease
Could GSD type I expand the spectrum of disorders with elevated plasma chitotriosidase activity?
Glycogen Storage Disease
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Glycogen Storage Disease Type I
Could GSD type I expand the spectrum of disorders with elevated plasma chitotriosidase activity?
Glycogen Storage Disease Type IV
A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV.
Glycogen Storage Disease Type IV
Distinctly Elevated Chitotriosidase Activity in a Child with Congenital Andersen Disease (Glycogen Storage Disease Type IV).
Glycogen Storage Disease Type IV
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Graft vs Host Disease
Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.
Graft vs Host Disease
Chitinase 3-Like-1-Deficient Splenocytes Deteriorated the Pathogenesis of Acute Graft-Versus-Host Disease via Regulating Differentiation of Tfh Cells.
Granulomatosis with Polyangiitis
Serum chitotriosidase activity and Wegener's granulomatosis.
Heart Failure
Clinical significance of chitotriosidase in outpatients with advanced heart failure.
Hemorrhagic Fever, Crimean
Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever.
Hemorrhoids
[Detection and analysis of the characteristic expression of microRNAs of anal fistula patients].
Hepatitis
Chitinase 3-like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice.
Hepatitis
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Hepatitis
The clinical significance of serum chitinase 3-like 1 in hepatitis B-related chronic liver diseases.
Hepatitis B
Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus-related compensated chronic liver disease.
Hepatitis B
The clinical significance of serum chitinase 3-like 1 in hepatitis B-related chronic liver diseases.
Hepatitis B, Chronic
Changes of serum Chitinase 3-like 1 levels correlate with changes of liver fibrosis measured by the two established quantitative methods in chronic hepatitis B patients following antiviral therapy.
Hepatitis C
Chitinase 3-like-1, Tolloid-like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct-acting antivirals.
Hepatomegaly
Elevated plasma chitotriosidase activity in various lysosomal storage disorders.
Hepatomegaly
Outcome of enzyme replacement therapy in patients with Gaucher disease type I. The Romanian experience.
Hepatomegaly
Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease.
Herpes Zoster
An uncommon cause of early infantile liver disease and raised chitotriosidase.
Herpes Zoster
Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease.
Hookworm Infections
Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.
Hydrocephalus
Cerebrospinal fluid and serum chitotriosidase levels in patients with aneurysmal subarachnoid haemorrhage: preliminary results.
Hydrocephalus
Increased plasma levels of chitinase 3-like 1 (CHI3L1) protein in patients with idiopathic normal-pressure hydrocephalus.
Hydrops Fetalis
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Hyperlipidemias
Chitotriosidase genotype and serum activity in subjects with combined hyperlipidemia: effect of the lipid-lowering agents, atorvastatin and bezafibrate.
Hyperlipidemias
Effect of atorvastatin on activities of matrix metalloproteinases and chitotriosidase in male and female mice with experimental hyperlipidemia.
Hyperlipidemias
Hypolipidemic Effect of Mannan in Mice with Acute Lipemia Induced by Poloxamer 407.
Hyperlipidemias
Role of changes in serum chitotriosidase activity in mice under conditions of hyperlipidemia and lipid-lowering effect of carboxymethylated (1-3)-?-D-glycan.
Hyperlipidemias
Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice.
Hyperlipidemias
[The role of changes in matrix metalloproteases and chitotriosidase in the mechanism of protective effect of atorvastatin in experimental murine lipemia]
Hypersensitivity
Association of 24 bp Duplication of Human CHIT1 Gene with Asthma in a Heterozygous Population of North India: A Case-Control Study.
Hypersensitivity
Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.
Hypersensitivity
Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers.
Hypersensitivity
Class I chitinases as potential panallergens involved in the latex-fruit syndrome.
Hypersensitivity
Class I endochitinase containing a hevein domain is the causative allergen in latex-associated avocado allergy.
Hypersensitivity
Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps.
Hypersensitivity
Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana.
Hypersensitivity
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
Hypersensitivity
Inflammation during Schistosoma haematobium infection and anti-allergy in pre-school-aged children living in a rural endemic area in Zimbabwe.
Hypersensitivity
Maize food allergy: lipid-transfer proteins, endochitinases, and alpha-zein precursor are relevant maize allergens in double-blind placebo-controlled maize-challenge-positive patients.
Hypersensitivity
Safety evaluation of the food enzyme chitinase from Streptomyces violaceoruber (strain pChi).
Hypersensitivity
Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome.
Hypersensitivity
Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy.
Hypersensitivity
[Expression of AMCase mRNA in nasal mucosa of allergic rhinitis in SD rats].
Hypertension
Association of chitotriosidase enzyme activity and genotype with the risk of nephropathy in type 2 diabetes.
Hypertension, Pulmonary
Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.
Hypothyroidism
Increased serum chitotriosidase activity following restoration of euthyroidism in patients with subclinical hypothyroidism.
Hypothyroidism
[Fatty acid composition of the blood serum and erythrocyte membrane lipids in patients with hypothyroidism and left ventricular diastolic dysfunction]
Idiopathic Hypersomnia
Cerebrospinal fluid biomarkers of neurodegeneration are decreased or normal in narcolepsy.
Idiopathic Hypersomnia
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.
Idiopathic Pulmonary Fibrosis
Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3.
Idiopathic Pulmonary Fibrosis
Chitotriosidase activity in patients with interstitial lung diseases.
Idiopathic Pulmonary Fibrosis
Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Idiopathic Pulmonary Fibrosis
Two sides of a coin: the dual roles of chitinase 3-like 1 in idiopathic pulmonary fibrosis.
Immune System Diseases
Serum YKL-40 and IL 17 in Psoriasis: Reliability as prognostic markers for disease severity and responsiveness to treatment.
Infections
A Class IV Chitinase Is Up-Regulated by Fungal Infection and Abiotic Stresses and Associated with Slow-Canker-Growth Resistance to Cronartium ribicola in Western White Pine (Pinus monticola).
Infections
A class IV chitinase is up-regulated by fungal infection and abiotic stresses and associated with slow-canker-growth resistance to Cronartium ribicola in western white pine (Pinus monticola).
Infections
A Listeria monocytogenes ST2 clone lacking chitinase ChiB from an outbreak of non-invasive gastroenteritis.
Infections
A noncoding plant pathogen provokes both transcriptional and posttranscriptional alterations in tomato.
Infections
A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut.
Infections
A plant chitinase controls cortical infection thread progression and nitrogen-fixing symbiosis.
Infections
Accumulation of defense related transcripts in sunflower hypocotyls (Helianthus annuus L.) infected with Plasmopara halstedii.
Infections
Acidic and basic class III chitinase mRNA accumulation in response to TMV infection of tobacco.
Infections
Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients.
Infections
Activation of autophagic programmed cell death and innate immune gene expression reveals immuno-competence of integumental epithelium in Bombyx mori infected by a dipteran parasitoid.
Infections
Activity, stability and folding analysis of the chitinase from Entamoeba histolytica.
Infections
An acidic class III chitinase in sugar beet: induction by Cercospora beticola, characterization, and expression in transgenic tobacco plants.
Infections
An agglutinating chitinase with two chitin-binding domains confers fungal protection in transgenic potato.
Infections
Analysis of variation in virulence of Beauveria bassiana against insect pests of pigeonpea using qPCR.
Infections
Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.
Infections
Assessment of relations between clinical outcome of ischemic stroke and activity of inflammatory processes in the acute phase based on examination of selected parameters.
Infections
Association of the hydrolytic enzyme chitinase against Rhizoctonia solani in rhizobacteria-treated rice plants.
Infections
Biological control of the root-knot nematode Meloidogyne javanica by Trichoderma harzianum
Infections
BjMYB1, a transcription factor implicated in plant defence through activating BjCHI1 chitinase expression by binding to a W-box-like element.
Infections
Changes in gene expression profiles as they relate to the adult plant leaf rust resistance in the wheat cv. Toropi.
Infections
Characterisation and antifungal activity of extracellular chitinase from a biocontrol fungus, Trichoderma asperellum PQ34.
Infections
Characterization and expression analysis of a chitinase gene (PmChi-4) from black tiger shrimp (Penaeus monodon) under pathogen infection and ambient ammonia nitrogen stress.
Infections
Characterization and expression analysis of a chitinase gene (PmChi-5) from black tiger shrimp (Penaeus monodon) under pathogens infection and ambient ammonia-N stress.
Infections
Characterization and Ultrastructural Localization of Chitinases from Metarhizium anisopliae, M. flavoviride, and Beauveria bassiana during Fungal Invasion of Host (Manduca sexta) Cuticle.
Infections
Characterization of root-associated bacteria from paddy and its growth-promotion efficacy.
Infections
Characterization of the Maize Chitinase Genes and Their Effect on Aspergillus flavus and Aflatoxin Accumulation Resistance.
Infections
Chikungunya virus titration, detection and diagnosis using N-Acetylglucosamine (GlcNAc) specific lectin based virus capture assay.
Infections
CHIT1 and AMCase expression in human gastric mucosa: correlation with inflammation and Helicobacter pylori infection.
Infections
Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection.
Infections
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1? and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.
Infections
Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children.
Infections
Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells.
Infections
Chitinase cDNA Cloning and mRNA Induction by Fungal Elicitor, Wounding, and Infection.
Infections
Chitinase Gene Positively Regulates Hypersensitive and Defense Responses of Pepper to Colletotrichum acutatum Infection.
Infections
Chitinase levels in guinea pig blood are increased after systemic infection with Aspergillus fumigatus.
Infections
Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.
Infections
Cloning of the gene Lecanicillium psalliotae chitinase Lpchi1 and identification of its potential role in the biocontrol of root-knot nematode Meloidogyne incognita.
Infections
Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia.
Infections
Comparative analysis of shrimp (Penaeus vannamei) miRNAs expression profiles during WSSV infection under experimental conditions and in pond culture.
Infections
Comparative proteomic analysis of the sweetpotato provides insights into response mechanisms to Fusarium oxysporum f. sp. batatas.
Infections
Comparison of protein profiles and enzymes in non-mycorrhizal and mycorrhizal roots of Pennisetum pedicellatum.
Infections
Conferred resistance to Botrytis cinerea in Lilium by overexpression of the RCH10 chitinase gene.
Infections
Coordinated expression of defense-related genes by TMV infection or salicylic acid treatment in tobacco.
Infections
Crystallization and preliminary crystallographic analysis of a chitinase from Clonostachys rosea.
Infections
Dataset on recombinant expression of an ancient chitinase gene from different species of Leishmania parasites in bacteria and in Spodoptera frugiperda cells using baculovirus.
Infections
Defense Responses in Infected and Elicited Cucumber (Cucumis sativus L.) Hypocotyl Segments Exhibiting Acquired Resistance.
Infections
Deletion of the Autographa californica nucleopolyhedrovirus chitinase KDEL motif and in vitro and in vivo analysis of the modified virus.
Infections
Development of a high-efficiency gene knockout system for Pochonia chlamydosporia.
Infections
Developmental and Pathogen-Induced Activation of the Arabidopsis Acidic Chitinase Promoter.
Infections
Differential expression of eight chitinase genes in Medicago truncatula roots during mycorrhiza formation, nodulation, and pathogen infection.
Infections
Differential induction and accumulation of beta-1,3-glucanase and chitinase isoforms in soybean hypocotyls and leaves after compatible and incompatible infection with Phytophthora megasperma f.sp. glycinea.
Infections
Disruption of the gene which encodes a serodiagnostic antigen and chitinase of the human fungal pathogen Coccidioides immitis.
Infections
Distribution of chitinase in guinea pig tissues and increases in levels of this enzyme after systemic infection with Aspergillus fumigatus.
Infections
DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice.
Infections
Effect of chitinase antisense RNA expression on disease susceptibility of Arabidopsis plants.
Infections
Effect of geminivirus infection and Bemisia infestation on accumulation of pathogenesis-related proteins in tomato.
Infections
Effect of Introducing Chitinase Gene on the Resistance of Tuber Mustard against White Mold.
Infections
Effects of enhanced UV-B radiation on the interaction between rice and Magnaporthe oryzae in Yuanyang terrace.
Infections
Effects of Listeria monocytogenes EGD-e and Salmonella enterica ser. Typhimurium LT2 chitinases on intracellular survival in Dictyostelium discoideum and mammalian cell lines.
Infections
Effects of Rhizoctonia infection and drought on peroxidase and chitinase activity in Norway spruce (Picea abies).
Infections
Endochitinase CHI2 of the biocontrol fungus Metarhizium anisopliae affects its virulence toward the cotton stainer bug Dysdercus peruvianus.
Infections
Ethylene: Symptom, Not Signal for the Induction of Chitinase and beta-1,3-Glucanase in Pea Pods by Pathogens and Elicitors.
Infections
Evaluation of recombinant chitinase and SXP1 antigens as antimicrofilarial vaccines.
Infections
Evidence of alternative splicing of the chi2 chitinase gene from Metarhizium anisopliae.
Infections
Expression of a chitinase gene and lysis of the host cell wall during Chlorella virus CVK2 infection.
Infections
Expression of heterologous lycopene ?-cyclase gene in flax can cause silencing of its endogenous counterpart by changes in gene-body methylation and in ABA homeostasis mechanism.
Infections
Functional and Promoter Analysis of ChiIV3, a Chitinase of Pepper Plant, in Response to Phytophthora capsici Infection.
Infections
Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model.
Infections
Gene expression analysis of the biocontrol fungus Trichoderma harzianum in the presence of tomato plants, chitin, or glucose using a high-density oligonucleotide microarray.
Infections
Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India.
Infections
Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk.
Infections
Genome-wide survey for baculoviral host homologs using the Bombyx genome sequence.
Infections
Greenhouse and field testing of transgenic wheat plants stably expressing genes for thaumatin-like protein, chitinase and glucanase against Fusarium graminearum.
Infections
High-level expression of a tobacco chitinase gene in Nicotiana sylvestris. Susceptibility of transgenic plants to Cercospora nicotianae infection.
Infections
Hydrogen peroxide regulates elicitor PB90-induced cell death and defense in non-heading Chinese cabbage.
Infections
Identification and characterization of a new soybean promoter induced by Phakopsora pachyrhizi, the causal agent of Asian soybean rust.
Infections
Identification and preliminary characterization of a chitinase gene in the Autographa californica nuclear polyhedrosis virus genome.
Infections
Identification of chitinase as the immunodominant filarial antigen recognized by sera of vaccinated rodents.
Infections
Identification of Critical Host Mitochondrion-Associated Genes during Ehrlichia chaffeensis Infections.
Infections
Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazeki strain E. IV. Persistence of immunity and a note as to differing complement-fixation antigen requirements in post-infection and post-vaccination sera.
Infections
Immunolocalization of a class III chitinase in two muskmelon cultivars reacting differently to Fusarium oxysporum f. sp. melonis.
Infections
Immunomodulation of Host Chitinase 3-Like 1 During a Mammary Pathogenic Escherichia coli Infection.
Infections
Improved Carica papaya tolerance to carmine spider mite by the expression of Manduca sexta chitinase transgene.
Infections
Increased chitotriosidase activity in serum of leprosy patients: Association with bacillary leprosy.
Infections
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
Infections
Induced resistance in Yali pear (Pyrus bretschneideri Rehd.) fruit against infection of Penicillium expansum by postharvest infiltration of acibenzolar-S-methyl.
Infections
Induction and purification of chitinase in Brassica napus L. ssp. oleifera infected with Phoma lingam.
Infections
Induction by pathogen, salt and drought of a basic class II chitinase mRNA and its in situ localization in pepper (Capsicum annuum).
Infections
Induction of chitinase in response to Aspergillus infection in sorghum (Sorghum bicolor (L) Moench).
Infections
Induction of Defense Responses in Cucumber Plants by Using the Cell-free Filtrate of the Plant Growth-Promoting Fungus Penicillium simplicissimum GP17-2.
Infections
Induction of different chitinase and beta-1,3-glucanase isoenzymes in sunflower (Helianthus annuus L.) seedlings in response to infection by Plasmopara halstedii.
Infections
Induction of Direct or Priming Resistance against Botrytis cinerea in Strawberries by ?-Aminobutyric Acid and Their Effects on Sucrose Metabolism.
Infections
Induction of resistance in host against the infection of leaf blight pathogen (Alternaria palandui) in onion (Allium cepa var aggregatum).
Infections
Inflammation during Schistosoma haematobium infection and anti-allergy in pre-school-aged children living in a rural endemic area in Zimbabwe.
Infections
Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination.
Infections
Involvement of ethylene biosynthesis and perception in the susceptibility of citrus fruits to Penicillium digitatum infection and the accumulation of defence-related mRNAs.
Infections
Isoform patterns of chitinase and beta-1,3-glucanase in maturing corn kernels (Zea mays L.) associated with Aspergillus flavus milk stage infection.
Infections
LeCTR2, a CTR1-like protein kinase from tomato, plays a role in ethylene signalling, development and defence.
Infections
Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung.
Infections
Melatonin Mitigates the Infection of Colletotrichum gloeosporioides via Modulation of the Chitinase Gene and Antioxidant Activity in Capsicum annuum L.
Infections
Metarhizium anisopliae chitinase CHIT30 is involved in heat-shock stress and contributes to virulence against Dysdercus peruvianus.
Infections
Molecular and immunohistochemical characterization of the chitinase gene from Pieris rapae granulovirus.
Infections
Molecular characterization of plantain class i chitinase gene and its expression in response to infection by Gloeosporium musarum Cke and Massee and other abiotic stimuli.
Infections
Molecular mechanism of BjCHI1-mediated plant defense against Botrytis cinerea infection.
Infections
Molecular size and net charge of pathogenesis-related enzymes from barley (Hordeum vulgare L., v. Karat) infected with Drechslera teres f. teres (Sacch.) Shoem.
Infections
Multitrophic interactions of the silverleaf whitefly, host plants, competing herbivores, and phytopathogens.
Infections
N-linked glycans located in the pro-region of Bombyx mori nucleopolyhedrovirus V-CATH are essential for the proper folding of V-CATH and V-CHIA.
Infections
Nematocidal activity of extracellular enzymes produced by the nematophagous fungus Duddingtonia flagrans on cyathostomin infective larvae.
Infections
Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat.
Infections
Pepper gene encoding a basic class II chitinase is inducible by pathogen and ethephon.
Infections
Peptidoglycan from fermentation by-product triggers defense responses in grapevine.
Infections
Phyllosticta musarum Infection-Induced Defences Suppress Anthracnose Disease Caused by Colletotrichum musae in Banana Fruits cv 'Embul'.
Infections
Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Infections
Primary structure and expression of mRNAs encoding basic chitinase and 1,3-beta-glucanase in potato.
Infections
Production and regulation of extracellular chitinase from the entomopathogenic fungus Isaria fumosorosea.
Infections
Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages.
Infections
Proteomic analysis of tobacco mosaic virus-infected tomato (Lycopersicon esculentum M.) fruits and detection of viral coat protein.
Infections
Protocol: transient expression system for functional genomics in the tropical tree Theobroma cacao L.
Infections
Quantitative changes in serum concentration of bovine gut chitinase in Theileria infection.
Infections
Rapid detection of phylloplane bacterium Enterobacter cloacae based on chitinase gene transformation and lytic infection by specific bacteriophages.
Infections
Real-time quantitative RT-PCR assay of gene expression in plant roots during fungal pathogenesis.
Infections
Refractoriness of Sergentomyia schwetzi to Leishmania spp is mediated by the peritrophic matrix.
Infections
Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae.
Infections
Regulation of Chitinase in Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae) During Infection by Heliothis virescens ascovirus 3h (HvAV-3h).
Infections
Reprogramming the chiA expression profile of Autographa californica multiple nucleopolyhedrovirus.
Infections
Rickettsia-like organisms and chitinase production in relation to transmission of trypanosomes by tsetse flies.
Infections
Sequential Expression of Bacterial Virulence and Plant Defense Genes During Infection of Tomato with Clavibacter michiganensis subsp. michiganensis
Infections
Sequential expression of bacterial virulence and plant defense genes during infection of tomato with Clavibacter michiganensis subsp. michiganensis.
Infections
Serum chitotriosidase levels in cancer patients undergoing high dose chemotherapy and stem cell transplantation.
Infections
Signal transduction by Tga3, a novel G protein alpha subunit of Trichoderma atroviride.
Infections
Studies on the Cloning and Expression of Bbchit1 Gene of Beauveria bassiana NCIM 1216.
Infections
Surface ?-1,3-Glucan Facilitates Fungal Stealth Infection by Interfering with Innate Immunity in Plants.
Infections
The effect of chitosan and Bion on resistance to pink snow mould in perennial ryegrass and winter wheat.
Infections
The Listeria monocytogenes ChiA Chitinase Enhances Virulence through Suppression of Host Innate Immunity.
Infections
The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants.
Infections
The microbial environment and intestinal nematode infections of Heligmosomoides polygyrus in laboratory mice.
Infections
The promoter of the potato chitinase C gene directs expression to epidermal cells.
Infections
The role of chitosan in protection of soybean from sudden death syndrome caused by Fusarium solani f. sp. glycines.
Infections
The role of the peritrophic matrix and red blood cell concentration in Plasmodium vivax infection of Anopheles aquasalis.
Infections
The symptoms of infection by Bacillus thuringiensis + Chitinase formulation in larvae of Choristoneura fumiferana.
Infections
Tobacco-expressed Brassica juncea chitinase BjCHI1 shows antifungal activity in vitro.
Infections
Toxicological and biochemical basis of synergism between the entomopathogenic fungus Lecanicillium muscarium and the insecticide matrine against Bemisia tabaci (Gennadius).
Infections
Transcriptomic profiling of susceptible and resistant flax seedlings after Fusarium oxysporum lini infection.
Infections
Transgenic wheat expressing a barley class II chitinase gene has enhanced resistance against Fusarium graminearum.
Infections
Ultrastructural observation of Botrytis cinerea and physical changes in resistant and susceptible grapevines.
Infections
Virulence Vs. Immunomodulation: Roles of the Paracoccin Chitinase and Carbohydrate-Binding Sites in Paracoccidioides brasiliensis Infection.
Infections
[Cloning and expression of the chitinase gene Chit1 from entomopathogenic fungus Nomuraea rileyi CQ]
Infections
[Effect of multi-generation culture on virulence of Lecanicilliurn lecanii in different media]
Infections
[Intercellular 27 kD protein is a chitinase induced by water stress or Pseudoperonospora cubensis in cucumber leaves]
Infections
[Studies on recombinant chitinase and SXP-1 antigens as antimicrofilarial vaccines]
Infections
[Survival of helminth eggs in the wastewater mud in the sludge beds of Chita waterworks]
Infections
[The relationship between activities of chitinase and beta-1,3-glucanase and resistance to rhizomania in sugar beet]
Infections
[Tuberculosis infection rate among adult population of the Chernyshevsk district of the Chita region]
Inflammatory Bowel Diseases
Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis.
Inflammatory Bowel Diseases
Faecal chitinase 3-like 1 is a reliable marker as accurate as faecal calprotectin in detecting endoscopic activity in adult patients with inflammatory bowel diseases.
Inflammatory Bowel Diseases
Faecal chitinase 3-like-1: a novel biomarker of disease activity in paediatric inflammatory bowel disease.
Inflammatory Bowel Diseases
Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease.
Inflammatory Bowel Diseases
Potential association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer.
Inflammatory Bowel Diseases
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Inflammatory Bowel Diseases
Serum concentrations of fibrosis markers in children with inflammatory bowel disease.
Influenza, Human
[Clinical aspects of influenza in 1965 (based on data of the Chita Hospital and military unit hospitals]
Insulin Resistance
Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Insulin Resistance
Women with polycystic ovary syndrome have increased plasma chitotriosidase activity: a pathophysiological link between inflammation and impaired insulin sensitivity?
Insulinoma
Antifreeze Protein Prolongs the Life-Time of Insulinoma Cells during Hypothermic Preservation.
Intestinal Volvulus
A computational analysis of the binding mode of closantel as inhibitor of the Onchocerca volvulus chitinase: insights on macrofilaricidal drug design.
Intestinal Volvulus
Chitinase genes expressed by infective larvae of the filarial nematodes, Acanthocheilonema viteae and Onchocerca volvulus.
Intestinal Volvulus
Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi.
Intestinal Volvulus
Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.
Intestinal Volvulus
DNA immunisation with Onchocerca volvulus chitinase induces partial protection against challenge infection with L3 larvae in mice.
Intestinal Volvulus
Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.
Intestinal Volvulus
Effect of Onchocerca volvulus chitinase on MUC5B expression in human airway epithelial cells.
Intestinal Volvulus
Expression and secretion of a larval-specific chitinase (family 18 glycosyl hydrolase) by the infective stages of the parasitic nematode, Onchocerca volvulus.
Intestinal Volvulus
Human immune responses to infective stage larval-specific chitinase of filarial parasite, Onchocerca volvulus, Ov-CHI-1.
Intestinal Volvulus
Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode Onchocerca volvulus.
Intestinal Volvulus
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis.
Iron Overload
Plasma chitotriosidase activity in beta-thalassemia major: a comparative study between Sicilian and Sardinian patients.
Ischemic Stroke
24 bp duplication of CHIT1 gene is not correlated with coronary artery disease in Corsica Island (France).
Ischemic Stroke
Serum Chitotriosidase Activity, a Marker of Activated Macrophages, Predicts New Cardiovascular Events Independently of C-Reactive Protein.
Latex Hypersensitivity
Latex-allergic patients sensitized to the major allergen hevein and hevein-like domains of class I chitinases show no increased frequency of latex-associated plant food allergy.
Legionnaires' Disease
Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation.
Leishmaniasis
Dataset on recombinant expression of an ancient chitinase gene from different species of Leishmania parasites in bacteria and in Spodoptera frugiperda cells using baculovirus.
Leishmaniasis
Molecular characterization of Llchit1, a midgut chitinase cDNA from the leishmaniasis vector Lutzomyia longipalpis.
Leishmaniasis, Visceral
Alternative splicing originates different domain structure organization of Lutzomyia longipalpis chitinases.
Leprosy
Increased chitotriosidase activity in serum of leprosy patients: Association with bacillary leprosy.
Leukemia, Myeloid, Acute
Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia.
Leukodystrophy, Globoid Cell
Comparison between the biochemical properties of plasma chitotriosidase from normal individuals and from patients with Gaucher disease, GM1-gangliosidosis, Krabbe disease and heterozygotes for Gaucher disease.
Lipidoses
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Liver Abscess
Chitinase-gene-based analysis of the genetic variability among the clinical isolates of
Liver Abscess
Two different chitinase genotypes in a patient with an amebic liver abscess: a case report.
Liver Abscess, Amebic
Two different chitinase genotypes in a patient with an amebic liver abscess: a case report.
Liver Cirrhosis
A noninvasive diagnostic model for significant liver fibrosis in patients with chronic hepatitis B based on CHI3L1 and routine clinical indicators.
Liver Cirrhosis
Changes of serum Chitinase 3-like 1 levels correlate with changes of liver fibrosis measured by the two established quantitative methods in chronic hepatitis B patients following antiviral therapy.
Liver Cirrhosis
Chitinase 3-like 1 deficiency ameliorates liver fibrosis by promoting hepatic macrophage apoptosis.
Liver Cirrhosis
Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis.
Liver Cirrhosis
Decrease in Chitinase 3-Like Protein 1 Levels Reflects Improvement in Liver Fibrosis after HCV Eradication.
Liver Cirrhosis
The clinical significance of serum chitinase 3-like 1 in hepatitis B-related chronic liver diseases.
Liver Diseases
A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV.
Liver Diseases
Adiponectin and the steatosis marker Chi3L1 decrease following switch to raltegravir compared to continued PI/NNRTI-based antiretroviral therapy.
Liver Diseases
An uncommon cause of early infantile liver disease and raised chitotriosidase.
Liver Diseases
Association of chitotriosidase genotype with the development of non-alcoholic fatty liver disease.
Liver Diseases
Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease.
Liver Diseases
Evaluation of Chitinase 3-like 1 (CHI3L1) as a noninvasive biomarker of hepatic fibrosis in patients with Hepatitis B virus-related compensated chronic liver disease.
Liver Diseases
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Liver Diseases
Potential role of chitotriosidase gene in nonalcoholic Fatty liver disease evolution.
Liver Diseases
Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Liver Diseases
Serum YKL-40 levels and chitotriosidase activity in patients with beta-thalassemia major.
Liver Diseases
The clinical significance of serum chitinase 3-like 1 in hepatitis B-related chronic liver diseases.
Liver Neoplasms
Mortality from liver disease among Italian vinyl chloride monomer/polyvinyl chloride manufacturers.
Lung Diseases
Chitinase 3-like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population.
Lung Diseases
Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.
Lung Diseases
Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
Lung Diseases
Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Lung Diseases
Duplication in CHIT1 gene and the risk for Aspergillus lung disease in CF patients.
Lung Diseases
Marked differences in tissue-specific expression of chitinases in mouse and man.
Lung Diseases
Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.
Lung Diseases, Fungal
Association of 24 bp Duplication of Human CHIT1 Gene with Asthma in a Heterozygous Population of North India: A Case-Control Study.
Lung Diseases, Fungal
Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection.
Lung Diseases, Interstitial
Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF-?1 Signaling.
Lung Diseases, Interstitial
Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3.
Lung Diseases, Interstitial
Chitotriosidase activity in patients with interstitial lung diseases.
Lung Diseases, Interstitial
Chitotriosidase in the Pathogenesis of Inflammation, Interstitial Lung Diseases and COPD.
Lung Diseases, Interstitial
Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease.
Lung Diseases, Interstitial
Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Lung Injury
Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters.
Lung Injury
Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.
Lung Neoplasms
Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients.
Lung Neoplasms
Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis.
Lung Neoplasms
Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans.
Lung Neoplasms
The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma.
Lung Neoplasms
[Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report)]
Lymphatic Metastasis
Serum chitinase activity prognosticates metastasis of colorectal cancer.
Lymphedema
Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis.
Lymphocytic Choriomeningitis
[Complement-fixation antigen in lymphocytic choriomeningitis prepared by bentonine purification.]
Lymphoma
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells.
Lymphoma
Potential Diagnostic Value of the Peripheral Blood Mononuclear Cell Transcriptome From Cattle With Bovine Tuberculosis.
Lymphoma, B-Cell
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells.
Lymphoma, B-Cell
Potential Diagnostic Value of the Peripheral Blood Mononuclear Cell Transcriptome From Cattle With Bovine Tuberculosis.
Lymphoma, Large B-Cell, Diffuse
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells.
Lymphoma, Non-Hodgkin
Chitotriosidase as a new marker of macrophage stimulation in a tumor model treated with cyclophosphamide and Ukrain.
Lysosomal Storage Diseases
A Rare Cause of Elevated Chitotriosidase Activity: Glycogen Storage Disease Type IV.
Lysosomal Storage Diseases
Allelic Frequency of a 24-bp Duplication in Exon 10 of the CHIT1 Gene in the General Iranian Population.
Lysosomal Storage Diseases
Biochemical and Molecular Chitotriosidase Profiles in Patients with Gaucher Disease Type 1 in Minas Gerais, Brazil: New Mutation in CHIT1 Gene.
Lysosomal Storage Diseases
Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases.
Lysosomal Storage Diseases
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Lysosomal Storage Diseases
Human chitotriosidase: a potential new marker of sarcoidosis severity.
Lysosomal Storage Diseases
Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases.
Lysosomal Storage Diseases
[Chitotriosidase of human macrophages and mammalian chitinases: biological functions and abnormalities in pathology]
Malaria
A fine functional homology between chitinases from host and parasite is relevant for malaria transmissibility.
Malaria
An anti-Chitinase malaria transmission-blocking single-chain antibody as an effector molecule for creating a Plasmodium falciparum-refractory mosquito.
Malaria
Bioconversion of Chitin to Bioactive Chitooligosaccharides: Amelioration and Coastal Pollution Reduction by Microbial Resources.
Malaria
Characterization of a novel gut-specific chitinase gene from the human malaria vector Anopheles gambiae.
Malaria
Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.
Malaria
Chitinases of the avian malaria parasite Plasmodium gallinaceum, a class of enzymes necessary for parasite invasion of the mosquito midgut.
Malaria
Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.
Malaria
Comparative genomic analysis of chitinase and chitinase-like genes in the African malaria mosquito (Anopheles gambiae).
Malaria
Different effects of modulation of mosquito (Diptera:Culicidae) trypsin activity on the infectivity of two human malaria (Hemosporidia:Plasmodidae) parasites.
Malaria
Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.
Malaria
Enzymatic characterization of the Plasmodium vivax chitinase, a potential malaria transmission-blocking target.
Malaria
High levels of human chitotriosidase hinder the formation of peritrophic membrane in anopheline vectors.
Malaria
Identification of an eosinophil chemotactic factor from anopheline mosquitoes as a chitinase family protein.
Malaria
Knockout of the rodent malaria parasite chitinase pbCHT1 reduces infectivity to mosquitoes.
Malaria
Monoclonal antibody against the Plasmodium falciparum chitinase, PfCHT1, recognizes a malaria transmission-blocking epitope in Plasmodium gallinaceum ookinetes unrelated to the chitinase PgCHT1.
Malaria
Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix.
Malaria
Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission.
Malaria
Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages.
Malaria
Synthetic propeptide inhibits mosquito midgut chitinase and blocks sporogonic development of malaria parasite.
Malaria
The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences.
Malaria
Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease.
Malaria, Avian
An anti-Chitinase malaria transmission-blocking single-chain antibody as an effector molecule for creating a Plasmodium falciparum-refractory mosquito.
Malaria, Avian
Chitinases of the avian malaria parasite Plasmodium gallinaceum, a class of enzymes necessary for parasite invasion of the mosquito midgut.
Malaria, Avian
Disruption of Plasmodium falciparum chitinase markedly impairs parasite invasion of mosquito midgut.
Malaria, Avian
Knockout of the rodent malaria parasite chitinase pbCHT1 reduces infectivity to mosquitoes.
Malaria, Avian
The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences.
Malaria, Cerebral
Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.
Malaria, Falciparum
Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children.
Malaria, Falciparum
Plasma chitotriosidase activity in acute Plasmodium falciparum malaria.
Malaria, Falciparum
Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages.
Measles
The measles specificity of the lymphocyte stimulation test with measles complement-fixation antigen.
Melanoma
Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease.
Melanoma
Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment.
Motor Neuron Disease
Cerebrospinal fluid phosphorylated neurofilament heavy chain and chitotriosidase in primary lateral sclerosis.
Mucolipidoses
Type II sialidosis: review of the clinical spectrum and identification of a new splicing defect with chitotriosidase assessment in two patients.
Multiple Myeloma
Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.
Multiple Sclerosis
Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.
Multiple Sclerosis
Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis.
Multiple Sclerosis
Cerebrospinal fluid chitinase-3-like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis.
Multiple Sclerosis
Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis.
Multiple Sclerosis
CHIT1 at Diagnosis Reflects Long-Term Multiple Sclerosis Disease Activity.
Multiple Sclerosis
Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis.
Multiple Sclerosis
Chitinase 3-like 1 is not a target antigen in patients with multiple sclerosis.
Multiple Sclerosis
Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.
Multiple Sclerosis
Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes.
Multiple Sclerosis
Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis.
Multiple Sclerosis
Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.
Multiple Sclerosis
Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain.
Multiple Sclerosis
CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis.
Multiple Sclerosis
Determination of chitinase 3-like 1 in cerebrospinal fluid in multiple sclerosis and other neurological diseases.
Multiple Sclerosis
Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1.
Multiple Sclerosis
Extreme Stability of Chitotriosidase in Cerebrospinal Flulid makes it a Suitable Marker for Microglial Activation in Clinical Trials.
Multiple Sclerosis
Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosis.
Multiple Sclerosis
Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome.
Multiple Sclerosis
Protein-Based Classifier to Predict Conversion from Clinically Isolated Syndrome to Multiple Sclerosis.
Muscle Cramp
Proteins induced by telomere dysfunction are associated with human IgA nephropathy.
Muscular Atrophy, Spinal
Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy.
Mycetoma
A Polymorphism in the Chitotriosidase Gene Associated with Risk of Mycetoma Due to Madurella mycetomatis Mycetoma--A Retrospective Study.
Mycoses
(123)I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in mice.
Mycoses
A Class IV Chitinase Is Up-Regulated by Fungal Infection and Abiotic Stresses and Associated with Slow-Canker-Growth Resistance to Cronartium ribicola in Western White Pine (Pinus monticola).
Mycoses
A class IV chitinase is up-regulated by fungal infection and abiotic stresses and associated with slow-canker-growth resistance to Cronartium ribicola in western white pine (Pinus monticola).
Mycoses
A study of some biochemical and histopathological responses of wet-stored recalcitrant seeds of Avicennia marina infected by Fusarium moniliforme.
Mycoses
Activation of a Bean Chitinase Promoter in Transgenic Tobacco Plants by Phytopathogenic Fungi.
Mycoses
Antifungal genes expressed in transgenic pea (Pisum sativum L.) do not affect root colonization of arbuscular mycorrhizae fungi.
Mycoses
BjMYB1, a transcription factor implicated in plant defence through activating BjCHI1 chitinase expression by binding to a W-box-like element.
Mycoses
Chitin nanofibers trigger membrane bound defense signaling and induce elicitor activity in plants.
Mycoses
Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection.
Mycoses
Chitinolytic assay of indigenous Trichoderma isolates collected from different geographical locations of Chhattisgarh in Central India.
Mycoses
Co-expression of chimeric chitinase and a polygalacturonase-inhibiting protein in transgenic canola (Brassica napus) confers enhanced resistance to Sclerotinia sclerotiorum.
Mycoses
Cuticle-induced endo/exoacting chitinase CHIT30 from Metarhizium anisopliae is encoded by an ortholog of the chi3 gene.
Mycoses
Defence-related gene expression in transgenic lemon plants producing an antimicrobial Trichoderma harzianum endochitinase during fungal infection.
Mycoses
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease.
Mycoses
Differential physiological and biochemical responses of Quercus infectoria and Q. libani to drought and charcoal disease.
Mycoses
Electrical Stimulation Enhances Plant Defense Response in Grapevine through Salicylic Acid-Dependent Defense Pathway.
Mycoses
Endochitinase CHI2 of the biocontrol fungus Metarhizium anisopliae affects its virulence toward the cotton stainer bug Dysdercus peruvianus.
Mycoses
Enhanced resistance to Sclerotinia sclerotiorum in Brassica napus by co-expression of defensin and chimeric chitinase genes.
Mycoses
Ethylene: Symptom, Not Signal for the Induction of Chitinase and beta-1,3-Glucanase in Pea Pods by Pathogens and Elicitors.
Mycoses
Expression analysis of chitinase upon challenge inoculation to Alternaria wounding and defense inducers in Brassica juncea.
Mycoses
Expression of a fungal endochitinase gene in transgenic tomato and tobacco results in enhanced tolerance to fungal pathogens.
Mycoses
Family 19 chitinase of Streptomyces griseus HUT6037 increases plant resistance to the fungal disease.
Mycoses
Field performance of chitinase transgenic silver birches (Betula pendula): resistance to fungal diseases.
Mycoses
Heterologous expression of genes mediating enhanced fungal resistance in transgenic wheat.
Mycoses
Identification of fungus-responsive cis-acting element in the promoter of Brassica juncea chitinase gene, BjCHI1.
Mycoses
Isolation and characterization of two chitinase-encoding genes (cts1, cts2) from the fungus Coccidioides immitis.
Mycoses
Molecular cloning and characterization of a pea chitinase gene expressed in response to wounding, fungal infection and the elicitor chitosan.
Mycoses
Molecular cloning and characterization of the promoter for the multiple stress-inducible gene BjCHI1 from Brassica juncea.
Mycoses
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.
Mycoses
Proteome responses to individual pathogens and abiotic conditions in rice seedlings.
Mycoses
Radiolabeled white blood cells and direct targeting of micro-organisms for infection imaging.
Mycoses
Spatial distribution of chitinases and beta-1,3-glucanase transcripts in bean arbuscular mycorrhizal roots under low and high soil phosphate conditions.
Mycoses
The chitinase gene (Bbchit1) from Beauveria bassiana enhances resistance to Cytospora chrysosperma in Populus tomentosa Carr.
Mycoses
The Lupinus albus class-III chitinase gene, IF3, is constitutively expressed in vegetative organs and developing seeds.
Mycoses
Transformants of Metarhizium anisopliae sf. anisopliae overexpressing chitinase from Metarhizium anisopliae sf. acridum show early induction of native chitinase but are not altered in pathogenicity to Manduca sexta.
Mycoses
Transformation of blackgram (Vigna mungo (L.) Hepper) by barley chitinase and ribosome-inactivating protein genes towards improving resistance to Corynespora leaf spot fungal disease.
Mycoses
[Lytic enzymes of Trichoderma and their role in protecting plants from fungal diseases]
Myocardial Infarction
Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events.
Myocardial Infarction
Serum Chitotriosidase Activity, a Marker of Activated Macrophages, Predicts New Cardiovascular Events Independently of C-Reactive Protein.
Myocardial Ischemia
24 bp duplication of CHIT1 gene is not correlated with coronary artery disease in Corsica Island (France).
Myocardial Ischemia
Serum chitotriosidase activity is increased in subjects with atherosclerosis disease.
Myocardial Ischemia
[Effect of statins on activity of matrix metalloproteases and serum concentration of cystatin C in patients with various risk of development of ischemic heart disease and in patients after coronary artery bypass surgery].
Narcolepsy
Cerebrospinal fluid biomarkers of neurodegeneration are decreased or normal in narcolepsy.
Narcolepsy
Cerebrospinal Fluid Biomarkers of Neurodegeneration Are Decreased or Normal in Narcolepsy.
Nasal Polyps
Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps.
Nasal Polyps
Increased expression of acidic mammalian chitinase in chronic rhinosinusitis with nasal polyps.
Nematode Infections
Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells.
Nematode Infections
Chitotriosidase deficiency is not associated with human hookworm infection in a Papua New Guinean population.
Neoplasm Metastasis
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through ?-catenin/Erk/Akt signaling in gastric cancer.
Neoplasm Metastasis
Chitotriosidase, a marker of innate immunity, is elevated in patients with primary breast cancer.
Neoplasm Metastasis
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Neoplasm Metastasis
Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma.
Neoplasm Metastasis
Key biomarkers within the colorectal cancer related inflammatory microenvironment.
Neoplasm Metastasis
M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma.
Neoplasm Metastasis
Mobilization of epithelial mesenchymal transition genes distinguishes active from inactive lesional tissue in patients with ulcerative colitis.
Neoplasm Metastasis
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.
Neoplasm Metastasis
Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis.
Neoplasm Metastasis
Serum chitinase activity prognosticates metastasis of colorectal cancer.
Neoplasm Metastasis
SI-CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages.
Neoplasm Metastasis
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
Neoplasms
?Np63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer.
Neoplasms
Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma.
Neoplasms
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
Neoplasms
CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells.
Neoplasms
CHI3L1 alleviate acute liver injury by inhibiting Th1 cells differentiation through STAT3 signaling pathway.
Neoplasms
CHI3L1 promotes proliferation and improves sensitivity to cetuximab in colon cancer cells by down-regulating p53.
Neoplasms
Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis.
Neoplasms
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1? and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.
Neoplasms
Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer.
Neoplasms
Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics.
Neoplasms
Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.
Neoplasms
Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.
Neoplasms
Chitinase induces lysis of MCF-7 cells in culture and of human breast cancer xenograft B11-2 in SCID mice.
Neoplasms
Chitotriosidase as a new marker of macrophage stimulation in a tumor model treated with cyclophosphamide and Ukrain.
Neoplasms
Chitotriosidase, a marker of innate immunity, is elevated in patients with primary breast cancer.
Neoplasms
Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia.
Neoplasms
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Neoplasms
Comparison of the Adipose and Luminal Mammary Gland Compartment as Orthotopic Inoculation Sites in a 4T1-Based Immunocompetent Preclinical Model for Triple-Negative Breast Cancer.
Neoplasms
Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex.
Neoplasms
Detection of bacterial chitinase activity in transformed plant tumour cells using a specific exochitinase substrate.
Neoplasms
Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.
Neoplasms
Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages.
Neoplasms
Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients.
Neoplasms
Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cells.
Neoplasms
G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway.
Neoplasms
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Neoplasms
High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice.
Neoplasms
hYKL-40 cancer biomarker electroanalysis in serum samples and model cell lysates: capacitive immunosensing compared with enzyme label immunosorbent assays (ELISA).
Neoplasms
Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma.
Neoplasms
Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis.
Neoplasms
Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages.
Neoplasms
Key biomarkers within the colorectal cancer related inflammatory microenvironment.
Neoplasms
Linking molecular biomarkers with higher level condition indicators to identify effects of copper exposures on the endangered delta smelt (Hypomesus transpacificus).
Neoplasms
Melanoma Associated Chitinase 3-Like 1 Promoted Endothelial Cell Activation and Immune Cell Recruitment.
Neoplasms
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
Neoplasms
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Neoplasms
Occupational exposure to gasoline in gasoline station male attendants promotes M1 polarization in macrophages.
Neoplasms
Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer's disease.
Neoplasms
Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer.
Neoplasms
Profiling of a few immune responsive genes expressed in postlarvae of Fenneropenaeus indicus challenged with Vibrio harveyi D3.
Neoplasms
Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.
Neoplasms
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.
Neoplasms
Serum chitotriosidase levels in cancer patients undergoing high dose chemotherapy and stem cell transplantation.
Neoplasms
Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.
Neoplasms
SI-CLP inhibits the growth of mouse mammary adenocarcinoma by preventing recruitment of tumor-associated macrophages.
Neoplasms
Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans.
Neoplasms
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
Neoplasms
Systems Biology-Derived Biomarkers to Predict Progression of Renal Function Decline in Type 2 Diabetes.
Neoplasms
The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha.
Neoplasms
The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis.
Neoplasms
The expression of chitinase 3-like 1: a novel prognostic predictor for hepatocellular carcinoma.
Neoplasms
The mechanism of the anticancer function of M1 macrophages and their use in the clinic.
Neoplasms
The Role of CHI3L1 Expression in Angiogenesis in Invasive Ductal Breast Carcinoma.
Neoplasms
Tissue Indices of Telomere Length and p53 in Patients with Different Gastrointestinal Tumors: Correlation with Clinicopathological Status.
Neoplasms
Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation.
Neoplasms
[Adipose-derived stem cells promote the polarization from M1 macrophages to M2 macrophages].
Neoplasms
[Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report)]
Neurodegenerative Diseases
Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression.
Neurodegenerative Diseases
Increased chitotriosidase 1 concentration following nusinersen treatment in spinal muscular atrophy.
Neurodegenerative Diseases
Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases.
Neuroinflammatory Diseases
Chitotriosidase and lysosomal enzymes as potential biomarkers of disease progression in amyotrophic lateral sclerosis: a survey clinic-based study.
Neuroinflammatory Diseases
Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation.
Neuroinflammatory Diseases
Fungal infection in neural tissue of patients with amyotrophic lateral sclerosis.
Neuroinflammatory Diseases
Monocyte-Derived Macrophages Contribute to Chitinase Dysregulation in Amyotrophic Lateral Sclerosis: A Pilot Study.
Neuromyelitis Optica
Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.
Niemann-Pick Disease, Type B
Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Niemann-Pick Disease, Type C
Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study.
Niemann-Pick Diseases
Allelic Frequency of a 24-bp Duplication in Exon 10 of the CHIT1 Gene in the General Iranian Population.
Niemann-Pick Diseases
Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study.
Niemann-Pick Diseases
Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.
Niemann-Pick Diseases
CCL18 as an alternative marker in Gaucher and Niemann-Pick disease with chitotriosidase deficiency.
Niemann-Pick Diseases
Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases.
Niemann-Pick Diseases
Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C.
Niemann-Pick Diseases
Hematopoietic stem cell transplantation in Niemann-Pick disease type B monitored by chitotriosidase activity.
Niemann-Pick Diseases
Lysosomal Storage Disorders in Indian Children with Neuroregression Attending a Genetic Center.
Niemann-Pick Diseases
Neonatal chitotriosidase activity is not predictive for Niemann-Pick disease type A/B: implications for newborn screening for lysosomal storage disorders.
Niemann-Pick Diseases
Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Niemann-Pick Diseases
[Comparison and clinical application of two methods for determination of plasma chitotriosidase activity].
Non-alcoholic Fatty Liver Disease
Association of chitotriosidase genotype with the development of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Chitotriosidase: A New Inflammatory Marker in Diabetic Complications.
Non-alcoholic Fatty Liver Disease
Potential role of chitotriosidase gene in nonalcoholic Fatty liver disease evolution.
Non-alcoholic Fatty Liver Disease
Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Obesity
Evaluation of chitotriosidase as a biomarker for adipose tissue inflammation in overweight individuals and type 2 diabetic patients.
Obesity
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.
Obesity
Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study.
Obesity
The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity.
Obstetric Labor, Premature
Increased neopterin level and chitotriosidase activity in pregnant women with threatened preterm labor.
Oligospermia
Investigation of seminal plasma chitotriosidase-1 and leukocyte elastase as potential markers for 'silent' inflammation of the reproductive tract of the infertile male - a pilot study.
Onchocerciasis
Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.
Optic Neuritis
Cerebrospinal fluid chitinase-3-like 2 and chitotriosidase are potential prognostic biomarkers in early multiple sclerosis.
Optic Neuritis
Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis.
Osteoarthritis
Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles.
Osteoarthritis
Human cartilage chitinase 3-like protein 2: cloning, expression, and production of polyclonal and monoclonal antibodies for osteoarthritis detection and identification of potential binding partners.
Osteoarthritis
Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease.
Osteolysis
Adverse local tissue reaction (ALTR) associated with corrosion products in metal-on-metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma-mediated chemokine signaling.
Osteolysis
An Alternative Macrophage Activation Pathway Regulator, CHIT1, May Provide a Serum and Synovial Fluid Biomarker of Periprosthetic Osteolysis.
Osteomyelitis
CHI3L1 regulation of inflammation and the effects on osteogenesis in a Staphylococcus aureus-induced murine model of osteomyelitis.
Osteonecrosis
Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy.
Osteoporosis
Erratum to: Serum chitotriosidase in postmenopausal women with severe osteoporosis.
Ovarian Neoplasms
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Overweight
Evaluation of chitotriosidase as a biomarker for adipose tissue inflammation in overweight individuals and type 2 diabetic patients.
Pancreatic Neoplasms
Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine.
Pancreatic Neoplasms
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Pancreatic Neoplasms
Prognostic Value of Combined Detection of Serum IL6, YKL-40, and C-reactive Protein in Patients with Unresectable Pancreatic Cancer.
Pancreatic Neoplasms
[Detection of chitinase 3-like 1 combined with other biomarkers for diagnosis of pancreatic cancer].
Panniculitis, Peritoneal
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Paracoccidioidomycosis
Virulence Vs. Immunomodulation: Roles of the Paracoccin Chitinase and Carbohydrate-Binding Sites in Paracoccidioides brasiliensis Infection.
Paraproteinemias
Type I Gaucher disease with severe skeletal destruction, extraosseous extension, and monoclonal gammopathy.
Parasitic Diseases
A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions.
Parasitic Diseases
Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients.
Parkinson Disease
Value of plasma chitotriosidase to assess non-neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy.
Periodontitis
Chitinase in whole and glandular human salivas and in whole saliva of patients with periodontal inflammation.
Periodontitis
Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study.
Periodontitis
Effect of periodontal treatment on the activity of chitinase in whole saliva of periodontitis patients.
Periodontitis
Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.
Periodontitis
The effect of nonsurgical periodontal treatment on serum and saliva chitotriosidase activities in patients with periodontitis and coronary artery disease.
Phytoplasma Disease
A Trichoderma harzianum chitinase destroys the cell wall of the phytopathogen Crinipellis perniciosa, the causal agent of witches' broom disease of cocoa
Phytoplasma Disease
A trichoderma harzianum chitinase destroys the cell wall of the phytopathogen Crinipellis perniciosa, the causal agent of witches' broom disease of cocoa.
Phytoplasma Disease
Purification, characterization and structural determination of chitinases produced by Moniliophthora perniciosa.
Phytoplasma Disease
Use of response surface methodology to examine chitinase regulation in the basidiomycete Moniliophthora perniciosa.
Plague
A comparative study of molecular diagnostic methods designed to detect the crayfish plague pathogen, Aphanomyces astaci.
Plant Diseases
A chitinase with antifungal activity from naked oat (Avena chinensis) seeds.
Plant Diseases
Both extracellular chitinase and a new cyclic lipopeptide, chromobactomycin, contribute to the biocontrol activity of Chromobacterium sp. C61.
Plant Diseases
Cloning and characterization of a novel chitinase gene (chi46) from Chaetomium globosum and identification of its biological activity.
Plant Diseases
Control of plant diseases by chitinase expressed from cloned DNA in Escherichia coli.
Plant Diseases
Differential expression of maize chitinases in the presence or absence of Trichoderma harzianum strain T22 and indications of a novel exo- endo-heterodimeric chitinase activity.
Plant Diseases
Enhancing plant disease suppression by Burkholderia vietnamiensis through chromosomal integration of Bacillus subtilis chitinase gene chi113
Plant Diseases
Enhancing plant disease suppression by Burkholderia vietnamiensis through chromosomal integration of Bacillus subtilis chitinase gene chi113.
Plant Diseases
Gene expression profiling of papaya (Carica papaya L.) immune response induced by CTS-N after inoculating PLDMV.
Plant Diseases
Identification and characterization of a novel chitinase with antifungal activity from 'Baozhu' pear (Pyrus ussuriensis Maxim.).
Plant Diseases
Identification of an endo-chitinase from Corallococcus sp. EGB and evaluation of its antifungal properties.
Plant Diseases
The cell factory approach toward biotechnological production of high-value chitosan oligomers and their derivatives: an update.
Pneumococcal Infections
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1? and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.
Pneumonia
A novel chitinase having a unique mode of action from Aspergillus fumigatus YJ-407.
Pneumonia
An IL-4/IL-13 Dual Antagonist Reduces Lung Inflammation, Airway Hyperresponsiveness, and IgE Production in Mice.
Pneumonia
Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study.
Pneumonia
Chitinase 3-Like 1 (Chil1) Regulates Survival and Macrophage-Mediated Interleukin-1? and Tumor Necrosis Factor Alpha during Pseudomonas aeruginosa Pneumonia.
Pneumonia
Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage.
Pneumonia
Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.
Pneumonia
Microbial diversity in bioaerosol samples causing ODTS compared to reference bioaerosol samples as measured using Illumina sequencing and MALDI-TOF.
Pneumonia
Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation.
Polycystic Kidney Diseases
Catalytic efficiency of a multi-domain transglycosylating chitinase from Enterobacter cloacae subsp. cloacae (EcChi2) is influenced by polycystic kidney disease domains.
Polycystic Kidney Diseases
Characterization of an exochitinase from Epiphyas postvittana nucleopolyhedrovirus (family Baculoviridae).
Polycystic Kidney Diseases
Role of the N-terminal polycystic kidney disease domain in chitin degradation by chitinase A from a marine bacterium, Alteromonas sp. strain O-7.
Polycystic Ovary Syndrome
Women with polycystic ovary syndrome have increased plasma chitotriosidase activity: a pathophysiological link between inflammation and impaired insulin sensitivity?
Pre-Eclampsia
Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia.
Pre-Eclampsia
First-trimester maternal serum metastin, placental growth factor and chitotriosidase levels in pre-eclampsia.
Pre-Eclampsia
Umbilical artery serum chitotriosidase concentration in pregnancies complicated by preeclampsia and relationship between chitotriosidase levels and fetal blood flow velocity.
Premature Birth
Comparison of early pregnancy serum concentration of neopterin, neopterin/creatinine ratio, C-reactive protein, and chitotriosidase, in pregnant women with birth at term and spontaneous preterm birth.
Prion Diseases
CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Prostatic Hyperplasia
Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Elevated YKL40 is associated with advanced prostate cancer (PCa) and positively regulates invasion and migration of PCa cells.
Prostatic Neoplasms
Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.
Protozoan Infections
Quantitative changes in serum concentration of bovine gut chitinase in Theileria infection.
Psoriasis
A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase.
Pulmonary Disease, Chronic Obstructive
Chitinase 3-like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population.
Pulmonary Disease, Chronic Obstructive
Chitinases and Chitinase-Like Proteins in Obstructive Lung Diseases - Current Concepts and Potential Applications.
Pulmonary Disease, Chronic Obstructive
Chitotriosidase Activity in Plasma and COPD Exacerbations.
Pulmonary Disease, Chronic Obstructive
Chitotriosidase in the Pathogenesis of Inflammation, Interstitial Lung Diseases and COPD.
Pulmonary Disease, Chronic Obstructive
Chitotriosidase: a marker and modulator of lung disease.
Pulmonary Disease, Chronic Obstructive
Comparison of serum biomarkers between patients with asthma and with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Functional Properties of Mouse Chitotriosidase Expressed in the Periplasmic Space of Escherichia coli.
Pulmonary Disease, Chronic Obstructive
Genetic association between human chitinases and lung function in COPD.
Pulmonary Disease, Chronic Obstructive
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
Pulmonary Disease, Chronic Obstructive
Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.
Pulmonary Disease, Chronic Obstructive
Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.
Pulmonary Disease, Chronic Obstructive
Macrophage chitinase 1 stratifies chronic obstructive lung disease.
Pulmonary Disease, Chronic Obstructive
New immune pathways from chronic post-viral lung disease.
Pulmonary Disease, Chronic Obstructive
Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD.
Pulmonary Disease, Chronic Obstructive
Overexpression of chitotriosidase and YKL-40 in peripheral blood and sputum of healthy smokers and patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers.
Pulmonary Eosinophilia
A semisynthetic diterpenoid lactone inhibits NF-?B signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model.
Pulmonary Fibrosis
A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors.
Pulmonary Fibrosis
Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF-?1 Signaling.
Pulmonary Fibrosis
Chitinase 1 regulates pulmonary fibrosis by modulating TGF-?/SMAD7 pathway via TGFBRAP1 and FOXO3.
Pulmonary Fibrosis
Modifiers of TGF-?1 effector function as novel therapeutic targets of pulmonary fibrosis.
Pulmonary Fibrosis
Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
Rabies
[Results of a study of natural foci of rabies and evaluation of the risk of hydrophobia in new construction areas of Eastern Siberia and the Far East]
Renal Insufficiency
Clinical utility of chitotriosidase enzyme activity in nephropathic cystinosis.
Respiratory Hypersensitivity
Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A.
Respiratory Hypersensitivity
Kinetic characterization of recombinant human acidic Mammalian chitinase.
Rhinitis, Allergic
Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis.
Rhinitis, Allergic
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
Rhinitis, Allergic
Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis.
Rhinitis, Allergic
[Expression of AMCase mRNA in nasal mucosa of allergic rhinitis in SD rats].
Rhinitis, Allergic, Seasonal
NMR assignments and ligand-binding studies on a two-domain family GH19 chitinase allergen from Japanese cedar (Cryptomeria japonica) pollen.
Rhinitis, Allergic, Seasonal
Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes.
Sarcoidosis
A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker.
Sarcoidosis
Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis.
Sarcoidosis
Chitotriosidase analysis in bronchoalveolar lavage of patients with sarcoidosis.
Sarcoidosis
Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity.
Sarcoidosis
Chitotriosidase gene polymorphisms and mutations limit the determination of chitotriosidase expression in sarcoidosis.
Sarcoidosis
Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis.
Sarcoidosis
Combined application of angiotensin converting enzyme and chitotriosidase analysis improves the laboratory diagnosis of sarcoidosis.
Sarcoidosis
Common chitotriosidase duplication gene polymorphism and clinical outcome status in sarcoidosis.
Sarcoidosis
Correction to: Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis.
Sarcoidosis
Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
Sarcoidosis
Identification of Active Sarcoidosis Using Chitotriosidase and Angiotensin-Converting Enzyme.
Sarcoidosis
Plasma chitotriosidase and CCL18 as surrogate markers for granulomatous macrophages in sarcoidosis.
Sarcoidosis
Prognostic Biomarkers of Sarcoidosis: A Comparative Study of Serum Chitotriosidase, ACE, Lysozyme, and KL-6.
Sarcoidosis
Serial chitotriosidase measurements in sarcoidosis - Two to five year follow-up study.
Sarcoidosis
Serum levels of chitotriosidase as a marker of disease activity and clinical stage in sarcoidosis.
Sarcoidosis
The Role of Urinary Calcium and Chitotriosidase in a Cohort of Chronic Sarcoidosis Patients.
Sarcoidosis
Verifying Sarcoidosis Activity: Chitotriosidase versus ACE in Sarcoidosis - a Case-control Study.
Sarcoidosis, Pulmonary
Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis.
Sarcoidosis, Pulmonary
Chitotriosidase analysis in bronchoalveolar lavage of patients with sarcoidosis.
Sarcoma
Glycine rich segments adopt polyproline II helices: Implications for biomolecular condensate formation.
Schistosomiasis
Inflammation during Schistosoma haematobium infection and anti-allergy in pre-school-aged children living in a rural endemic area in Zimbabwe.
Scleroderma, Systemic
Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1.
Scleroderma, Systemic
Chitotriosidase activity in patients with interstitial lung diseases.
Sepsis
Sepsis in acute myeloid leukaemia patients receiving high-dose chemotherapy: No impact of chitotriosidase and mannose-binding lectin polymorphisms.
Sialic Acid Storage Disease
Novel biochemical abnormalities and genotype in Farber disease.
Siderosis
Serum YKL-40 levels and chitotriosidase activity in patients with beta-thalassemia major.
Silicosis
Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis.
Skin Ulcer
Virulence patterns of Aeromonas eucrenophila isolated from water and infected fish.
Sleep Apnea Syndromes
Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study.
Sleep Apnea, Obstructive
24 bp duplication of CHIT1 gene and determinants of human chitotriosidase activity among participants of EPISONO, a population-based cross-sectional study, São Paulo, Brazil.
Sleep Apnea, Obstructive
Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study.
Spondylitis, Ankylosing
Serum chitotriosidase and neopterin levels in patients with ankylosing spondylitis.
Sporotrichosis
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease.
Starvation
Autolysis and aging of Penicillium chrysogenum cultures under carbon starvation: Chitinase production and antifungal effect of allosamidin.
Starvation
Characterization and functional analyses of the chitinase-encoding genes in the nematode-trapping fungus Arthrobotrys oligospora.
Starvation
Characterization and heterologous expression of an age-dependent fungal/bacterial type chitinase of Aspergillus nidulans.
Starvation
Expression of the ech42 (endochitinase) gene of Trichoderma atroviride under carbon starvation is antagonized via a BrlA-like cis-acting element.
Starvation
Expression of two major chitinase genes of Trichoderma atroviride (T. harzianum P1) is triggered by different regulatory signals.
Starvation
Fusarium graminearum growth inhibition due to glucose starvation caused by osthol.
Starvation
Interaction of ammonium, glucose, and chitin regulates the expression of cell wall-degrading enzymes in Trichoderma atroviride strain P1.
Starvation
Primary structure and expression pattern of the 33-kDa chitinase gene from the mycoparasitic fungus Trichoderma harzianum.
Starvation
Transcriptional regulation of a chitinase gene by 20-hydroxyecdysone and starvation in the oriental fruit fly, Bactrocera dorsalis.
Starvation
Use of a promoterless lacZ gene insertion to investigate chitinase gene expression in the marine bacterium Pseudoalteromonas sp. strain S9.
Stomach Neoplasms
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through ?-catenin/Erk/Akt signaling in gastric cancer.
Stroke
Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events.
Stroke
Serum chitotriosidase activity is increased in subjects with atherosclerosis disease.
Stroke
[Stroke epidemiology and evaluation of risk factors significance for survival of patients during 28 poststroke days in the open population of Chita]
Subarachnoid Hemorrhage
Cerebrospinal fluid and serum chitotriosidase levels in patients with aneurysmal subarachnoid haemorrhage: preliminary results.
Superinfection
The Role of CHI3L1 (Chitinase-3-Like-1) in the Pathogenesis of Infections in Burns in a Mouse Model.
Thrombocythemia, Essential
Serum chitotriosidase: a circulating biomarker in polycythemia vera.
Thrombocytopenia
Acute Gaucher Disease-Like Condition in an Indian Infant with a Novel Biallelic Mutation in the Prosaposin Gene.
Trichomonas Infections
The chitinase system from Trichomonas vaginalis as a potential target for antimicrobial therapy of urogenital trichomoniasis.
Tuberculosis
Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis.
Tuberculosis
Efficacy of serum chitotriosidase activity in early treatment of patients with active tuberculosis and a negative sputum smear.
Tuberculosis
Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages.
Tuberculosis
Evidence for the expression of native Mycobacterium tuberculosis phospholipase C: recognition by immune sera and detection of promoter activity.
Tuberculosis
Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity.
Tuberculosis
Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination.
Tuberculosis
[Complex exzmination for tuberculosis of the inhabitants of the Tungokochensk region of the Chita district]
Tuberculosis
[Tuberculosis infection rate among adult population of the Chernyshevsk district of the Chita region]
Tuberculosis, Pulmonary
Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis.
Tuberculosis, Pulmonary
Serum chitotriosidase activity in pulmonary tuberculosis: response to treatment and correlations with clinical parameters.
Typhus, Epidemic Louse-Borne
Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazeki strain E. IV. Persistence of immunity and a note as to differing complement-fixation antigen requirements in post-infection and post-vaccination sera.
Urinary Bladder Neoplasms
Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus.
Uterine Cervical Neoplasms
Chitinase 3 like 1 (CHI3L1) promotes vasculogenic mimicry formation in cervical cancer.
Uterine Cervical Neoplasms
Chitinase 3 like 1 is associated with tumor angiogenesis in cervical cancer.
Uterine Cervical Neoplasms
Correlation of chitinase 3-like 1 single nucleotide polymorphisms and haplotypes with uterine cervical cancer in Taiwanese women.
Virus Diseases
Deletion of the Autographa californica nucleopolyhedrovirus chitinase KDEL motif and in vitro and in vivo analysis of the modified virus.
Virus Diseases
Differential expression of bean chitinase genes by virus infection, chemical treatment and UV irradiation.
Virus Diseases
Expression of the Cydia pomonella granulovirus matrix metalloprotease enhances Autographa californica multiple nucleopolyhedrovirus virulence and can partially substitute for viral cathepsin.
Virus Diseases
Partial redistribution of the Autographa californica nucleopolyhedrovirus chitinase in virus-infected cells accompanies mutation of the carboxy-terminal KDEL ER-retention motif.
Virus Diseases
Silencing of Mythimna separata chitinase genes via oral delivery of in planta-expressed RNAi effectors from a recombinant plant virus.
Virus Diseases
The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update.
Wound Infection
[Method of estimation of lysozyme activity in serum with chitin azure as substrate]
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.09
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D524A
0.12
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme E526Q
0.46
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, wild-type enzyme
0.54
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D522N
0.61
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D524N
0.74
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D522A
12.7
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme W664A
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.022
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D524A
0.022
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme W664A
0.045
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme E526Q
1.49
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D522A
2.36
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D522N
2.47
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, mutant enzyme D524N
6.7
4-nitrophenyl beta-N,N'-diacetylchitobioside
pH 4.8, 50°C, wild-type enzyme
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0017
4-nitrophenyl chitobioside
pH 4.8, 50°C, mutant enzyme W664A
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q8U1H5_PYRFU
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
717
0
78635
TrEMBL
other Location (Reliability: 4)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain of chitinase recombinantly expressed in Escherichia coli, hanging-drop vapour diffusion method, resolution of 1.50 A. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 90.0, b = 92.8, c = 107.2 A
hanging drop vapor diffusion method, crystallographic analyses of the catalytic domain of chitinase. Crystals of these mutant enzymes E526A and D524A in complex with chito-oligosaccharide substrate by means of cocrystallization and soaking methods, respectively, and determination of their tertiary structures. X-ray diffraction data are collected, resolutions of 1.80 A and 1.76 A
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
D522A
mutation causes a 7.3fold decrease in kcat/Km for 4-nitrophenyl chitobioside
D522N
mutation causes a 3.4fold decrease in kcat/Km for 4-nitrophenyl chitobioside
D524A
mutation causes a 58.4 fold decrease in kcat/Km for 4-nitrophenyl chitobioside
D524N
mutation causes a 3.6fold decrease in kcat/Km for 4-nitrophenyl chitobioside
E526Q
mutation causes a 38.4fold decrease in kcat/Km for 4-nitrophenyl chitobioside
W664A
mutation causes a 8588fold decrease in kcat/Km for 4-nitrophenyl chitobioside
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain of chitinase recombinantly expressed in Escherichia coli
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression of wild-type enzyme and mutant enzymes D522N, D522A, D524N, D524A, E526Q and E526A in Escherichia coli
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mine, S.; Nakamura, T.; Hirata, K.; Ishikawa, K.; Hagihara, Y.; Uegaki, K.
Crystallization and X-ray diffraction analysis of a catalytic domain of hyperthermophilic chitinase from Pyrococcus furiosus
Acta Crystallogr. Sect. F
62
791-793
2006
Pyrococcus furiosus (Q8U1H5), Pyrococcus furiosus
brenda
Tsuji, H.; Nishimura, S.; Inui, T.; Kado, Y.; Ishikawa, K.; Nakamura, T.; Uegaki, K.
Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus - the role of conserved residues in the active site
FEBS J.
277
2683-2695
2010
Pyrococcus furiosus (Q8U1H5), Pyrococcus furiosus
brenda
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Release 2023.1 (January 2023)
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