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Information on EC 3.2.1.130 - glycoprotein endo-alpha-1,2-mannosidase

for references in articles please use BRENDA:EC3.2.1.130
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IUBMB Comments
The enzyme catalyses the hydrolysis of the terminal alpha-D-glucosyl-(1->3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of N-glucosylated proteins during their processing in the Golgi apparatus. The name for the isomer is based on a nomenclature proposed by Prien et al .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
alpha-1,2-endomannosidase, alpha-endomannosidase, BtGH99, endo-alpha-1,2-mannanase, endo-alpha-1,2-mannosidase, endo-alpha-1->2-mannanase, endo-alpha-D-mannosidase, endo-alpha-mannosidase, endomannosidase, GH99, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GlcMan9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,2) + alpha-D-glucosyl-(1->3)-alpha-D-mannopyranose
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involved in the synthesis of glycoproteins
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