Reference on EC 3.2.1.113 - mannosyl-oligosaccharide 1,2-alpha-mannosidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Porwoll, S.; Fuchs, H.; Tauber, R.
Characterization of a soluble class I alpha-mannosidase in human serum
FEBS Lett.
449
175-178
1999
Homo sapiens
Vallee, F.; Lal, A.; Moremen, K.W.; Howell, P.L.
Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a class I alpha-mannosidase involved in Asn-linked oligosaccharide maturation
Acta Crystallogr. Sect. D
55
571-573
1999
Mus musculus
Shigematsu, Y.; Tsukahara, K.; Tanaka, T.; Takeuchi, M.; Ichishima, E.
Molecular and enzymic properties of 1,2-alpha-D-mannosidase from Aspergillus saitoi
Curr. Microbiol.
13
43-46
1986
Aspergillus phoenicis
-
Szumilo, T.; Kaushal, G.P.; Hori, H.; Elbein, A.D.
Purification and properties of a glycoprotein processing alpha-mannosidase from mung bean seedlings
Plant Physiol.
81
383-389
1986
Vigna radiata var. radiata
Tulsiani, D.R.P.; Hubbard, S.C.; Robbins, P.W.; Touster, O.
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates
J. Biol. Chem.
257
3660-3668
1982
Rattus norvegicus, Rattus norvegicus Wistar
Tabas, I.; Kornfeld, S.
Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides
J. Biol. Chem.
254
11655-11663
1979
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Forsee, W.T.; Springfield, J.D.; Schutzbach, J.S.
Effect of phospholipids on alpha-1,2-mannosidase activity
J. Biol. Chem.
257
9963-9967
1982
Oryctolagus cuniculus
Chandrasekaran, E.V.; Savila, M.; Nixon, D.; Mendicino, J.
Purification and properties of alpha-D-mannose:beta-1,2-N-acetylglucosaminyl-transferases and alpha-D-mannosidases from human adenocarcinoma
Cancer Res.
44
4059-4068
1984
Homo sapiens
Palamarczyk, G.; Mitchell, M.; Smith, P.W.; Fleet, G.W.; Elbein, A.D.
1,4-Dideoxy-1,4-imino-D-mannitol inhibits glycoprotein processing and mannosidase
Arch. Biochem. Biophys.
243
35-45
1985
Rattus norvegicus
Schweden, J.; Legler, G.; Bause, E.
Purification and characterization of a neutral processing mannosidase from calf liver acting on (Man)9(GlcNAc)2 oligosaccharides
Eur. J. Biochem.
157
563-570
1986
Bos taurus
Kobata, A.; Amano, J.
alpha-Mannosidases I and II from Aspergillus saitoi
Methods Enzymol.
138
779-785
1987
Aspergillus phoenicis
Kaushal, G.P.; Elbein, A.D.
Glycoprotein processing enzymes of plants
Methods Enzymol.
179
452-475
1989
Vigna radiata var. radiata
Schweden, J.; Bause, E.
Characterization of trimming Man9-mannosidase from pig liver. Purification of a catalytically active fragment and evidence for the transmembrane nature of the intact 65 kDa enzyme
Biochem. J.
264
347-355
1989
Sus scrofa
Tulsiani, D.R.P.; Touster, O.
Mannosidase IA from rat liver Golgi membranes
Methods Enzymol.
179
446-451
1989
Rattus norvegicus
Kimura, Y.; Yamaguchi, O.; Suehisa, H.; Tagaki, S.
In vitro hydrolysis of oligomannose-type sugar chains by an alpha-1,2-mannosidase from microsomes of developing castor bean cotyledons
Biochim. Biophys. Acta
1075
6-11
1991
Ricinus communis
Elbein, A.D.
Glycosidase inhibitors: inhibitors of N-linked oligosaccharide processing
FASEB J.
5
3055-3063
1991
Embryophyta, Rattus norvegicus
Bause, E.; Breuer, W.; Schweden, J.; Roeser, R.; Geyer, R.
Effect of substrate structure on the activity of Man9-mannosidase from pig liver involved in N-linked oligosaccharide processing
Eur. J. Biochem.
208
451-457
1992
Sus scrofa
Ren, J.; Bretthauer, R.K.; Castellino, F.J.
Purification and properties of a Golgi-derived (alpha 1,2)-mannosidase-I from baculovirus-infected lepidopteran insect cells (IPLB-SF21AE) with preferential activity toward mannose6-N-acetylglucosamine2
Biochemistry
34
2489-2495
1995
Spodoptera frugiperda
Maruyama, Y.; Nakajima, T.; Ichishima, E.
A 1,2-alpha-D-mannosidase from a Bacillus sp.: purification, characterization, and mode of action
Carbohydr. Res.
251
89-98
1994
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) M-90
Mulakala, C.; Reilly, P.J.
Understanding protein structure-function relationships in family 47 a-1,2-mannosidases through computational docking of ligands
Proteins Struct. Funct. Genet.
49
125-134
2002
Saccharomyces cerevisiae
Schneikert, J.; Herscovics, A.
Two naturally occurring mouse alpha-1,2-mannosidase IB cDNA clones differ in three point mutations. Mutation of Phe592 to Ser592 is sufficient to abolish enzyme activity
J. Biol. Chem.
270
17736-17740
1995
Mus musculus
Shah, N.; Kuntz, D.A.; Rose, D.R.
Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms
Biochemistry
42
13812-13816
2003
Homo sapiens
Bonay, P.; Fresno, M.
Isolation and purification of a neutral alpha(1,2)-mannosidase from Trypanosoma cruzi
Glycobiology
9
423-433
1999
Trypanosoma cruzi
Bause E.;Bieberich E.;Rolfs A.;Volker C.;Schmidt B.
Molecular cloning and primary structure of Man9-mannosidase from human kidney
Eur. J. Biochem.
217
535-40
1993
Homo sapiens
Tatara, Y.; Yoshida, T.; Ichishima, E.
A single free cysteine residue and disulfide bond contribute to the thermostability of Aspergillus saitoi 1,2-alpha-mannosidase
Biosci. Biotechnol. Biochem.
69
2101-2108
2005
Aspergillus phoenicis
Akao, T.; Yamaguchi, M.; Yahara, A.; Yoshiuchi, K.; Fujita, H.; Yamada, O.; Akita, O.; Ohmachi, T.; Asada, Y.; Yoshida, T.
Cloning and expression of 1,2-alpha-mannosidase gene (fmanIB) from filamentous fungus Aspergillus oryzae: in vivo visualization of the FmanIBp-GFP fusion protein
Biosci. Biotechnol. Biochem.
70
471-479
2006
Aspergillus oryzae
Tempel, W.; Karaveg, K.; Liu, Z.J.; Rose, J.; Wang, B.C.; Moremen, K.W.
Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
J. Biol. Chem.
279
29774-29786
2004
Mus musculus (P45700)
Lobsanov, Y.D.; Yoshida, T.; Desmet, T.; Nerinckx, W.; Yip, P.; Claeyssens, M.; Herscovics, A.; Howell, P.L.
Modulation of activity by Arg407: structure of a fungal alpha-1,2-mannosidase in complex with a substrate analogue
Acta Crystallogr. Sect. D
64
227-236
2008
Penicillium citrinum, Penicillium citrinum (P31723)
Lunetta, J.M.; Simmons, K.A.; Johnson, S.M.; Pappagianis, D.
Molecular cloning and expression of a cDNA encoding a Coccidioides posadasii 1,2-alpha-mannosidase identified in the coccidioidal T27K vaccine by immunoproteomic methods
Ann. N. Y. Acad. Sci.
1111
164-180
2007
Coccidioides posadasii (Q3HYC1)
Lu, Y.; Xu, Y.Y.; Fan, K.Y.; Shen, Z.H.
1-Deoxymannojirimycin, the alpha1,2-mannosidase inhibitor, induced cellular endoplasmic reticulum stress in human hepatocarcinoma cell 7721
Biochem. Biophys. Res. Commun.
344
221-225
2006
Homo sapiens
Tremblay, L.O.; Nagy Kovacs, E.; Daniels, E.; Wong, N.K.; Sutton-Smith, M.; Morris, H.R.; Dell, A.; Marcinkiewicz, E.; Seidah, N.G.; McKerlie, C.; Herscovics, A.
Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation
J. Biol. Chem.
282
2558-2566
2007
Mus musculus, Mus musculus (P39098), Mus musculus (P45700)
Mast, S.W.; Moremen, K.W.
Family 47 alpha-mannosidases in N-glycan processing
Methods Enzymol.
415
31-46
2006
Mus musculus (P45700)
Saint-Jore-Dupas, C.; Nebenfuehr, A.; Boulaflous, A.; Follet-Gueye, M.L.; Plasson, C.; Hawes, C.; Driouich, A.; Faye, L.; Gomord, V.
Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway
Plant Cell
18
3182-3200
2006
Arabidopsis thaliana, Solanum lycopersicum, Nicotiana tabacum, Glycine max (Q9SEH8), Glycine max
Liu, Y.L.; Lu, W.C.; Brummel, T.J.; Yuh, C.H.; Lin, P.T.; Kao, T.Y.; Li, F.Y.; Liao, P.C.; Benzer, S.; Wang, H.D.
Reduced Expression of Alpha-1,2-mannosidase I Extends Lifespan in Drosophila melanogaster and Caenorhabditis elegans
Aging Cell
8
370-379
2009
Caenorhabditis elegans, Drosophila melanogaster, Caenorhabditis elegans N2 Bristol
Kajiura, H.; Koiwa, H.; Nakazawa, Y.; Okazawa, A.; Kobayashi, A.; Seki, T.; Fujiyama, K.
Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation
Glycobiology
20
235-247
2010
Arabidopsis thaliana
Chen, H.L.; Li, C.F.; Grigorian, A.; Tian, W.; Demetriou, M.
T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching
J. Biol. Chem.
284
32454-32461
2009
Homo sapiens
Long, E.T.; Baker, S.; Oliveira, V.; Sawitzki, B.; Wood, K.J.
Alpha-1,2-mannosidase and hence N-glycosylation are required for regulatory T cell migration and allograft tolerance in mice
PLoS ONE
5
e8894
2010
Mus musculus
Isoyama-Tanaka, J.; Dohi, K.; Misaki, R.; Fujiyama, K.
Improved expression and characterization of recombinant human Golgi alpha1,2-mannosidase I isoforms (IA2 and IC) by Escherichia coli
J. Biosci. Bioeng.
112
14-19
2011
Homo sapiens (O60476), Homo sapiens (Q9NR34)
Tu, H.C.; Hsiao, Y.C.; Yang, W.Y.; Tsai, S.L.; Lin, H.K.; Liao, C.Y.; Lu, J.W.; Chou, Y.T.; Wang, H.D.; Yuh, C.H.
Up-regulation of Golgi alpha-mannosidase IA and down-regulation of Golgi alpha-mannosidase IC activates unfolded protein response during hepatocarcinogenesis
Hepatol. Commun.
1
230-247
2017
Homo sapiens (P33908), Homo sapiens (Q9NR34)
Jin, Z.C.; Kitajima, T.; Dong, W.; Huang, Y.F.; Ren, W.W.; Guan, F.; Chiba, Y.; Gao, X.D.; Fujita, M.
Genetic disruption of multiple alpha1,2-mannosidases generates mammalian cells producing recombinant proteins with high-mannose-type N-glycans
J. Biol. Chem.
293
5572-5584
2018
Homo sapiens (O60476), Homo sapiens (P33908), Homo sapiens (Q9UKM7)
Li, H.; Wang, G.; Yu, Y.; Jian, W.; Zhang, D.; Wang, Y.; Wang, T.; Meng, Y.; Yuan, C.; Zhang, C.
alpha-1,2-Mannosidase MAN1C1 inhibits proliferation and invasion of clear cell renal cell carcinoma
J. Cancer
9
4618-4626
2018
Homo sapiens (Q9NR34), Homo sapiens
Liu, C.; Niu, G.; Zhang, H.; Sun, Y.; Sun, S.; Yu, F.; Lu, S.; Yang, Y.; Li, J.; Hong, Z.
Trimming of N-glycans by the Golgi-localized alpha-1,2-mannosidases, MNS1 and MNS2, is crucial for maintaining RSW2 protein abundance during salt stress in Arabidopsis
Mol. Plant
11
678-690
2018
Arabidopsis thaliana (Q8H116), Arabidopsis thaliana (Q9C512)
Liebminger, E.; Huettner, S.; Vavra, U.; Fischl, R.; Schoberer, J.; Grass, J.; Blaukopf, C.; Seifert, G.J.; Altmann, F.; Mach, L.; Strasser, R.
Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana
Plant Cell
21
3850-3867
2009
Arabidopsis thaliana (Q8H116), Arabidopsis thaliana (Q9C512)
Hu, S.; Jiang, L.B.; Zou, X.J.; Yi, W.; Tian, D.Y.
Hepatitis B virus upregulates host expression of alpha-1,2-mannosidases via the PPARalpha pathway
World J. Gastroenterol.
22
9534-9543
2016
Homo sapiens (O60476), Homo sapiens (P33908), Homo sapiens (Q9NR34), Homo sapiens (Q9UKM7), Homo sapiens
Mulakala, C.; Nerinckx, W.; Reilly, P.
The fate of beta-D-mannopyranose after its formation by endoplasmic reticulum alpha-(1->2)-mannosidase I catalysis
Carbohydr. Res.
342
163-169
2007
Saccharomyces cerevisiae
Cantu, D.; Nerinckx, W.; Reilly, P.
Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum alpha-(1->2)-mannosidase I
Carbohydr. Res.
343
2235-2242
2008
Homo sapiens (Q9UKM7)
Massaad, M.; Franzusoff, A.; Herscovics, A.
The processing alpha1,2-mannosidase of Saccharomyces cerevisiae depends on Rer1p for its localization in the endoplasmic reticulum
Eur. J. Cell Biol.
78
435-440
1999
Saccharomyces cerevisiae, Saccharomyces cerevisiae TH2-lOD
Mora-Montes, H.; Lopez-Romero, E.; Zinker, S.; Ponce-Noyola, P.; Flores-Carreon, A.
Purification of soluble alpha1,2-mannosidase from Candida albicans CAI-4
FEMS Microbiol. Lett.
256
50-56
2006
Candida albicans, Candida albicans CAI-4
Ziegler, F.; Trimble, R.
Glycoprotein biosynthesis in yeast Purification and characterization of the endoplasmic reticulum Man9 processing alpha-mannosidase
Glycobiology
1
605-612
1991
Saccharomyces cerevisiae
Lal, A.; Pang, P.; Kalelkar, S.; Romero, P.A.; Herscovics, A.; Moremen, K.W.
Substrate specificities of recombinant murine Golgi alpha-1,2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing alpha-1,2-mannosidases
Glycobiology
8
981-995
1998
Mus musculus (P39098), Mus musculus (P45700)
Yoshida, T.; Kato, Y.; Asada, Y.; Nakajima, T.
Filamentous fungus Aspergillus oryzae has two types of alpha-1,2-mannosidases, one of which is a microsomal enzyme that removes a single mannose residue from Man9GlcNAc2
Glycoconj. J.
17
745-748
2000
Aspergillus oryzae
Pan, Y.T.; Kaushal, G.P.; Papandreou, G.; Ganem, B.; Elbein, A.D.
D-Mannonolactam amidrazone. A new mannosidase inhibitor that also inhibits the endoplasmic reticulum or cytoplasmic alpha-mannosidase
J. Biol. Chem.
267
8313-8318
1992
Oryctolagus cuniculus, Vigna radiata var. radiata
Gonzalez, D.; Karaveg, K.; Vandersall-Nairn, A.; Lal, A.; Moremen, K.
Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis
J. Biol. Chem.
274
21375-21386
1999
Homo sapiens (Q9UKM7), Homo sapiens
Lobsanov, Y.D.; Vallee, F.; Imberty, A.; Yoshida, T.; Yip, P.; Herscovics, A.; Howell, P.L.
Structure of Penicillium citrinum alpha-1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and golgi class I enzymes
J. Biol. Chem.
277
5620-5630
2002
Penicillium citrinum, Penicillium citrinum (P31723)
Hosokawa, N.; Tremblay, L.; You, Z.; Herscovics, A.; Wada, I.; Nagata, K.
Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong alpha1-antitrypsin by human ER mannosidase I
J. Biol. Chem.
278
26287-26294
2003
Homo sapiens
Akao, T.; Yahara, A.; Sakamoto, K.; Yamada, O.; Akita, O.; Yoshida, T.
Lack of endoplasmic reticulum 1,2-alpha-mannosidase activity that trims N-glycan Man9GlcNAc2 to Man8GlcNAc2 isomer B in a manE gene disruptant of Aspergillus oryzae
J. Biosci. Bioeng.
113
438-441
2012
Aspergillus oryzae
Fujiyama, K.; Sakuradani, S.; Moran, D.G.; Yoshida, T.; Seki, T.
Effect of alpha-1,2-mannosidic linkage located in a alpha1,3-branch of Man6GlcNAc2 oligosaccharide on enzyme activity of recombinant human Man9-mannosidase produced in Escherichia coli
J. Biosci. Bioeng.
91
419-421
2001
Homo sapiens
Mora-Montes, H.; Lopez-Romero, E.; Zinker, S.; Ponce-Noyola, P.; Flores-Carreon, A.
Heterologous expression and biochemical characterization of an alpha1,2-mannosidase encoded by the Candida albicans MNS1 gene
Mem. Inst. Oswaldo Cruz
103
724-730
2008
Candida albicans (Q8J0Q0), Candida albicans ATCC 26555 (Q8J0Q0)
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