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Information on EC 3.2.1.106 - mannosyl-oligosaccharide glucosidase

for references in articles please use BRENDA:EC3.2.1.106

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IUBMB Comments

This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal α-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.

The enzyme appears in viruses and cellular organisms

Synonyms
acid alpha-glucosidase, rhgaa, glucosidase i, alpha-glucosidase i, cwh41, knopf, tggaa, processing alpha-glucosidase i, mannosyl-oligosaccharide glucosidase, cwh41p, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
protein N-glycosylation processing phase (endoplasmic reticulum, yeast), protein N-glycosylation processing phase (plants and animals)