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Synonyms
pon-1, serum paraoxonase, phosphotriesterase, organophosphorus hydrolase, dfpase, serum paraoxonase 1, pon 1, methyl parathion hydrolase, organophosphate hydrolase, hupon1,
more
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ethanol
-
ethanol consumption causes a significant decrease in liver paraoxonase activity. Gallic acid treatment partly restores this decreased paraoxonase activity. A gallic acid dose of 100 mg/kg shows highest restoring effect for paraoxonase activity. The activity of arylesterase is decreased in the ethanol group, but this decrease is not significant. Gallic acid treatment restores the loss of this activity due to ethanol exposure
Ba2+
-
-
Ba2+
-
plasma enzyme more resistant than liver enzyme
Co2+
-
-
Co2+
-
plasma enzyme more resistant than liver enzyme
Co2+
-
plasma enzyme more sensitive than liver enzyme
Cu2+
-
-
Cu2+
-
plasma enzyme more resistant than liver enzyme
EDTA
-
-
EDTA
-
plasma enzyme more resistant than liver enzyme
EDTA
-
activity restored by addition of Ca2+
Hg2+
-
-
Hg2+
-
plasma enzyme more resistant than liver enzyme
La3+
-
-
La3+
-
plasma enzyme more resistant than liver enzyme
Mg2+
-
-
Mg2+
-
plasma enzyme more resistant than liver enzyme
Mn2+
-
-
Mn2+
-
plasma enzyme more resistant than liver enzyme
Mn2+
-
plasma enzyme more sensitive than liver enzyme
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
plasma enzyme more resistant than liver enzyme
Zn2+
-
-
Zn2+
-
plasma enzyme more resistant than liver enzyme
additional information
infection with the intestinal nematode Nippostrongylus brasiliensis leads to decreased PON1 serum activity
-
additional information
-
infection with the intestinal nematode Nippostrongylus brasiliensis leads to decreased PON1 serum activity
-
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0.08
Co3+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M2
0.28
Co3+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M1
0.6
Cu2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M2
1.5
Cu2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M1
0.002
Hg2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M2
0.014
Hg2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M1
2.3
Mg2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M2
5
Mg2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M1
0.09
Mn2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M2
0.2
Mn2+
Rattus norvegicus
-
pH 8.5, 37°C, enzyme form M1
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Gil, F.; Pla, A.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.
Rat liver paraoxonase: subcellular distribution and characterization
Chem. Biol. Interact.
87
149-154
1993
Rattus norvegicus
brenda
Pond, A.L.; Chambers, H.W.; Coyne, C.P.; Chamers, J.E.
Purification of two rat hepatic proteins with A-esterase activity toward chlorpyrifos-oxon and paraoxon
J. Pharmacol. Exp. Ther.
286
1404-1411
1998
Rattus norvegicus
brenda
Mackness, M.I.; Thompson, H.M.; Hardy, A.R.; Walker, C.H.
Distinction between A-esterases and arylesterases. Implications for esterase classification
Biochem. J.
245
293-296
1987
Bos taurus, Felis catus, Homo sapiens, Hydrochoerus hydrochaeris, Meles taxus, Mus musculus, no activity in aves, Rattus norvegicus, Sus scrofa
brenda
Gil, F.; Gonzalvo, M.C.; Hernandez, A.F.; Villanueva, E.; Antonio, P.
Differences in the kinetic properties, effect of calcium and sensitivity to inhibitors of paraoxon hydrolase activity in rat plasma and microsomal fraction from rat liver
Biochem. Pharmacol.
48
1559-1568
1994
Rattus norvegicus
brenda
Gil, F.; Pla, A.; Gonzalco, M.C.; Hernandez, A.F.; Villanueva, E.
Partial purification of paraoxonase from rat liver
Chem. Biol. Interact.
87
69-75
1993
Rattus norvegicus
brenda
Pellin, M.C.; Moretto, A.; Lotti, M.; Vilanova, E.
Distribution and some biochemical properties of rat paraoxonase activity
Neurotoxicol. Teratol.
12
611-614
1990
Homo sapiens, Rattus norvegicus
brenda
Little, J.S.; Broomfield, C.A.; Fox-Talbot, M.K.; Boucher, L.J.; MacIver, B.; Lenz, D.E.
Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP)
Biochem. Pharmacol.
38
23-29
1989
Rattus norvegicus
brenda
Efremenko, E.N.; Sergeeva, V.S.
Organophosphate hydrolase - an enzyme catalyzing degradation of phosphorus-containing toxins and pesticides
Russ. Chem. Bull. (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya)
50
1826-1832
2001
Brevundimonas diminuta, Flavobacterium sp., Rattus norvegicus
-
brenda
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Marina, A.; Vazquez, J.; Pla, A.
Purification and characterization of paraoxon hydrolase from rat liver
Biochem. J.
321
595-601
1997
Rattus norvegicus
brenda
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Pla, A.
Identification of two rat liver proteins with paraoxonase activity: biochemical evidence for the identity of paraoxonase and arylesterase
Chem. Biol. Interact.
119-120
263-275
1999
Rattus norvegicus
brenda
Rodrigo, L.; Gil, F.; Hernandez, A.F.; Lopez, O.; Pla, A.
Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties
Biochem. J.
376
261-268
2003
Rattus norvegicus (Q68FP2)
brenda
Thomas-Moya, E.; Gianotti, M.; Llado, I.; Proenza, A.M.
Effects of caloric restriction and gender on rat serum paraoxonase 1 activity
J. Nutr. Biochem.
17
197-203
2006
Rattus norvegicus
brenda
Farid, A.S.; Nakahara, K.; Murakami, N.; Hayashi, T.; Horii, Y.
Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats
Am. J. Trop. Med. Hyg.
78
770-776
2008
Rattus norvegicus (P55159), Rattus norvegicus
brenda
Harisa, G.
L-arginine ameliorates arylesterase/paraoxonase activity of paraoxonase-1 in hypercholesterolemic rats
Asian J. Biochem.
6
263-272
2011
Rattus norvegicus
-
brenda
Kartkaya, K.; Oglakci, A.; sentuerk, H.; Bayramoglu, G.; Canbek, M.; Kanbak, G.
Investigation of the possible protective role of gallic acid on paraoxanase and arylesterase activities in livers of rats with acute alcohol intoxication
Cell Biochem. Funct.
31
208-213
2013
Rattus norvegicus
brenda