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Information on EC 3.1.7.6 - farnesyl diphosphatase for references in articles please use BRENDA:EC3.1.7.6
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IUBMB Comments The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids .
The enzyme appears in viruses and cellular organisms
Synonyms
farnesyl diphosphatase, farnesyl pyrophosphatase, FPPase, Pho8DELTA62, pNPP/FPP phosphatase,
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farnesyl diphosphatase
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Pho8DELTA62
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the purified phosphatase is a truncated Pho8 lacking 62 amino acids at the N-terminus and is designated Pho8DELTA62N
farnesyl pyrophosphatase
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farnesyl pyrophosphatase
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FPPase
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(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate
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(2E,6E)-farnesyl-diphosphate diphosphohydrolase
The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids [1].
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(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate not determined
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate not determined
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate not determined
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate is not determined
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate not determined
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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biosynthesis of acyclic sesquiterpenoids
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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diphosphate is the major product, traces of phosphate. The amount of release of diphosphate is approximately equal to the amount of release of farnesol
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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biosynthesis of acyclic sesquiterpenoids
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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the enzyme also hydrolyzes geranyl diphosphate and geranylgeranyl diphosphate to the corresponding alcohols
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?
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(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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biosynthesis of acyclic sesquiterpenoids
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?
(2E,6E)-farnesyl diphosphate + H2O
(2E,6E)-farnesol + diphosphate
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biosynthesis of acyclic sesquiterpenoids
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?
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Ca2+
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2 mM, 2.2fold activation
Zn2+
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2 mM, 1.4fold activation
Mg2+
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slight stimulation
Mg2+
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activity is dependent on
additional information
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Mg2+-independent enzyme
additional information
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Mg2+-independent enzyme
additional information
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the activity is metal ion independent
additional information
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2 mM CuSO4 shows no effect
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(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienoic acid
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(2E,6E)-farnesyl diphosphate
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competitive
farnesyl diphosphate
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0.25 mM, 80% inhibition
geranylgeranyl diphosphate
isopentenyl diphosphate
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competitive
Mg2+
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2 mM, 92% inhibition. 0.06 mM, no inhibition
Mn2+
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2 mM, 93% inhibition
NaF
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100 mM, about 70% inhibition
phosphate
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2 mM, 85% inhibition
zaragozic acid B
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i.e. L694,581, mixed type inhibition at 0.04 mM. No inhibition by zaragozic acid A up to 0.1 mM
farnesyl monophosphate
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0.07 mM, 35% inhibition
farnesyl monophosphate
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geranyl diphosphate
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16% inhibition of soluble enzyme at 0.1 mM. 26% inhibition of microsomal enzyme at 0.05 mM
geranylgeranyl diphosphate
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0.05 mM, 60% inhibition
geranylgeranyl diphosphate
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0.05 mM, 16% inhibition of soluble enzyme, 38% inhibition of microsomal enzyme
geranylgeranyl diphosphate
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geranylgeranyl diphosphate
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potent noncompetitive inhibitor
additional information
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no inhibition by 1 mM p-mercuribenzoate
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additional information
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2 mM CuSO4 shows no effect
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isopentenyl diphosphate
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20% stimulation of soluble enzyme at 0.1 mM, 20% stimulation of microsomal enzyme at 0.02 mM
p-nitrophenyl phosphate
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0.05, 10% stimulation
Triton X-100
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0.05 g/l, stimulates
ATP
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0.05, 8% stimulation
ATP
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0.93 mM, stimulates
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0.007 - 1.2
(2E,6E)-farnesyl diphosphate
additional information
additional information
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the KM-value for (2E,6E)-farnesyl diphosphate increases with an increase in pH
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0.007
(2E,6E)-farnesyl diphosphate
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pH 5.5, 37°C
0.015
(2E,6E)-farnesyl diphosphate
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pH 5.5, 37°C
0.7 - 1.2
(2E,6E)-farnesyl diphosphate
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pH 8.8, 37°C
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0.37
(2E,6E)-farnesyl diphosphate
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pH 5.5, 37°C
0.1
geranyl diphosphate
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0.005
geranylgeranyl diphosphate
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5.2
isopentenyl diphosphate
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pH 8.8, 37°C
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0.07
farnesyl monophosphate
Rattus norvegicus
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pH 5.5, 37°C
0.005
geranylgeranyl diphosphate
Rattus norvegicus
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pH 5.5, 37°C
0.02
zaragozic acid B
Rattus norvegicus
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5.5
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assay at
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4.5 - 6.8
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pH 4.5: about 55% of maximal activity, pH 6.8: about 60% of maximal activit, soluble enzyme
5 - 6.8
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pH 5.0: about 60% of maximal activity, pH 6.8: about 65% of maximal activit, microsomal enzyme
5 - 6.2
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pH 5.0: about 45% of maximal activity, pH 6.2: about 75% of maximal activity
6.3 - 7
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pH 6.3: about 80% of maximal activity, pH 7.0: about about 70% of maximal activity
7
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maximal activity at pH 7.0, less than 1% of maximal activity at pH 6.0, less than 10% of maximal activity at pH 8.5
8.5 - 9.1
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pH 8.5: about 40% of maximal activity, pH 9.1: about 65% of maximal activity
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brenda
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brenda
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brenda
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brenda
cv. Nakdong
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brenda
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brenda
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brenda
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brenda
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brenda
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soluble farnesyl diphosphatase is highest in fruit and flower followed by root and leaf
brenda
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soluble farnesyl diphosphatase is highest in fruit and flower followed by root and leaf
brenda
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soluble farnesyl diphosphatase is highest in fruit and flower followed by root and leaf
brenda
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brenda
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soluble farnesyl diphosphatase is highest in fruit and flower followed by root and leaf. Root has the highest level of microsomal enzyme
brenda
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brenda
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brenda
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constitutively expressed at a high level in the soluble and the microsomal fraction
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brenda
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constitutively expressed at a high level in the soluble and the microsomal fraction
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brenda
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brenda
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brenda
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PPB_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
566
1
63004
Swiss-Prot
ACSS_MAIZE
590
0
67328
Swiss-Prot
A0A084FZX7_9PEZI
197
0
20386
TrEMBL
A0A0H4P3T2_9BACI
526
0
58160
TrEMBL
A0A0C5KH39_9POAL
546
0
63085
TrEMBL
A0A0C5KR55_9POAL
541
0
62290
TrEMBL
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60000
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x * 60000, SDS-PAGE
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up
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enzyme activity increases under conditions of increased metabolic flow through the isoprenoid pathway
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constitutively expressed at a high level in the soluble and the microsomal fraction
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maximally induced 36 h after UV-C irradiation and decreased until 60 h
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the flux of farnesyl diphosphate to farnesol is two times lower in cells elicited with pectin treatment than in control cells
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Tsai, S.C.; Gaylor, J.L.
Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophophohydrolase
J. Biol. Chem.
241
4043-4050
1966
Rattus norvegicus
brenda
Ha, S.B.; Lee, D.E.; Lee, H.J.; Song, S.J.; Back, K.
Activities of soluble and microsomal farnesyl diphosphatases in Datura stramonium
Biol. Plant.
47
477-479
2003
Datura stramonium
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brenda
Nah, J.; Song, S.J.; Back, K.
Partial characterization of farnesyl and geranylgeranyl diphosphatases induced in rice seedlings by UV-C irradiation
Plant Cell Physiol.
42
864-867
2001
Oryza sativa
brenda
Hornby, J.M.; Kebaara, B.W.; Nickerson, K.W.
Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B
Antimicrob. Agents Chemother.
47
2366-2369
2003
Candida albicans, Candida albicans A72
brenda
Song, L.
A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol
Appl. Biochem. Biotechnol.
128
149-158
2006
Saccharomyces cerevisiae
brenda
Bansal, V.S.; Vaidya, S.
Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes
Arch. Biochem. Biophys.
315
393-399
1994
Rattus norvegicus
brenda
Meigs, T.E.; Simoni, R.D.
Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase
Arch. Biochem. Biophys.
345
1-9
1997
Cricetulus griseus
brenda
Flores-Sanchez, I.J.; Ortega-Lopez, J.M.; del Carmen Montes-Horcasitas, M.; Ramos-Valdivia, A.C.
Biosynthesis of sterols and triterpenes in cell suspension cultures of Uncaria tomentosa
Plant Cell Physiol.
43
1502-1509
2002
Uncaria tomentosa
brenda
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