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Information on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase and Organism(s) Mus musculus and UniProt Accession Q571E4

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.4 N-acetylgalactosamine-6-sulfatase
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This record set is specific for:
Mus musculus
UNIPROT: Q571E4 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
galns, n-acetylgalactosamine-6-sulfate sulfatase, n-acetylgalactosamine-6-sulfatase, 6-sulfatase, chondroitin sulfatase, n-acetylgalactosamine 6-sulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, n-acetylgalactosamine 6-sulphate sulphatase, atsa2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N-acetylgalactosamine-6-sulfate sulfatase
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acetylgalactosamine 6-sulfatase
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-
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chondroitin sulfatase
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-
-
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chondroitinase
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-
-
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chondroitinsulfatase
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-
-
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galactose-6-sulfate sulfatase
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-
-
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GalNAc6S sulfatase
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-
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GALNS
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N-acetylgalactosamine 6-sulfatase
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-
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N-acetylgalactosamine 6-sulphate sulphatase
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N-acetylgalactosamine-6-sulfate sulfatase
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sulfatase, acetylgalactosamine 6-
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sulfatase, chondroitin
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric ester
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
59299-00-2
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9025-60-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
chondroitin sulfate + H2O
chondroitin + sulfate
show the reaction diagram
-
-
-
?
keratan sulfate + H2O
keratan + sulfate
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
precursor
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GALNS_MOUSE
520
0
57673
Swiss-Prot
Secretory Pathway (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C76S
active site mutation, results in inactive enzyme
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tomatsu, S.; Vogler, C.; Montano, A.M.; Gutierrez, M.; Oikawa, H.; Dung, V.C.; Orii, T.; Noguchi, A.; Sly, W.S.
Murine model (Galns(tm(C76S)slu)) of MPS IVA with missense mutation at the active site cysteine conserved among sulfatase proteins
Mol. Genet. Metab.
91
251-258
2007
Mus musculus (Q571E4), Mus musculus
Manually annotated by BRENDA team