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Information on EC - linear primary-alkylsulfatase

for references in articles please use BRENDA:EC3.1.6.21
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
       linear primary-alkylsulfatase
IUBMB Comments
Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. It is active against linear primary-alkyl sulfate esters, such as dodecyl sulfate, decyl sulfate, octyl sulfate, and hexyl sulfate. The enzyme from Pseudomonas aeruginosa is secreted out of the cell. The catalytic mechanism begins with activation of a water molecule by the binuclear Zn2+ cluster, resulting in a nucleophilic attack on the carbon atom. cf. EC, branched primary-alkylsulfatase, and EC, (R)-specific secondary-alkylsulfatase (type III).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a primary alkyl sulfate ester
sdsa1, sdsap, primary alkylsulfatase, type iii alkylsulfatase, more
a primary alkyl sulfate ester + H2O = an alcohol + sulfate
show the reaction diagram
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