Information on EC 3.1.6.19 - (R)-specific secondary-alkylsulfatase (type III)

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EC Tree
IUBMB Comments
Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors. This enzyme belongs to the type III sulfatase family. The enzyme from the bacterium Rhodococcus ruber prefers linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates . The enzyme from the bacterium Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties. Hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom, resulting in perfect enantioselectivity. cf. EC 3.1.6.1, arylsulfatase (type I), and EC 1.14.11.77, alkyl sulfatase (type II).
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Word Map
  • 3.1.6.19
  • enantioselective
  • sec-alcohols
  • r-enantiomer
  • sulfur
  • stereoselective
  • synthesis
  • homochiral
  • deracemization
  • furnish
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
(R)-specific sec-alkylsulfatase, Pisa1, S3 secondary alkylsulphohydrolase, sec-alkylsulfatase, sulfatase RS2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an (R)-secondary-alkyl sulfate + H2O = an (S)-secondary-alcohol + sulfate
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PATHWAY SOURCE
PATHWAYS
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