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Information on EC 3.1.6.19 - (R)-specific secondary-alkylsulfatase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.19 (R)-specific secondary-alkylsulfatase
IUBMB Comments
The enzyme from Rhodococcus ruber is involved in the biodegradation of alkyl sulfate esters used as detergents and released into the environment. The prefered substrates are linear secondary-alkyl sulfate esters, particularly octan-2-yl, octan-3-yl, and octan-4-yl sulfates . The enzyme from Pseudomonas sp. DSM6611 utilizes a range of secondary-alkyl sulfate esters bearing aromatic, olefinic and acetylenic moieties. Perfect enantioselectivities are obtained for substrates bearing groups of different size adjacent to the sulfate moiety . The enzymic hydrolysis proceeds through inversion of the configuration at the stereogenic carbon atom [1,4]. The enzyme contains a Zn2+ ion .
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Word Map
  • 3.1.6.19
  • scaling
  • ichthyosiform
  • lamellar
  • alox12b
  • enantioselective
  • 12r-lox
  • consanguineous
  • hepoxilin
  • erythroderma
  • erythema
  • epoxyalcohol
  • homochiral
  • sec-alcohols
  • elox-3
  • synthesis
  • non-bullous
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
(R)-specific sec-alkylsulfatase, S3 secondary alkylsulphohydrolase, sec-alkylsulfatase, sulfatase RS2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an (R)-secondary-alkyl sulfate + H2O = an (S)-secondary-alcohol + sulfate
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PATHWAY SOURCE
PATHWAYS
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