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Disease on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
arylsulfatase (type i) deficiency
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Carcinoma, Ductal
Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma.
Carcinoma, Hepatocellular
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Carcinoma, Intraductal, Noninfiltrating
Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma.
Liver Neoplasms
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Lung Neoplasms
MicroRNA-527 inhibits TGF-?/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
Lymphatic Metastasis
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Lysosomal Storage Diseases
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidoses
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidosis III
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Molecular characterization of MPS IIIA, MPS IIIB and MPS IIIC in Tunisian patients.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Recombinant caprine 3H-[N-acetylglucosamine-6-sulfatase] and human 3H-[N-acetylgalactosamine-4-sulfatase]: plasma clearance, tissue distribution, and cellular uptake in the rat.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Sanfilippo syndrome, type D: a spectrophotometric assay with prenatal diagnostic potential.
Multiple Sulfatase Deficiency Disease
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Neoplasm Metastasis
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Neoplasms
Endo-sulfatase Sulf-1 protein expression is down-regulated in gastric cancer.
Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells.
Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses.
Over expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo.
SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15.
Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin.
Osteoarthritis
Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.
Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.
Osteoarthritis, Knee
Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.
Ovarian Neoplasms
Upregulation of sulfatase-1 decreases metastatic potential of SKOV3 human ovarian cancer cells in vitro and in vivo.
Pneumonia
Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses.
Stomach Neoplasms
Endo-sulfatase Sulf-1 protein expression is down-regulated in gastric cancer.