Information on EC 3.1.4.59 - cyclic-di-AMP phosphodiesterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.59 cyclic-di-AMP phosphodiesterase
IUBMB Comments
The enzyme, described from Gram-positive bacteria, degrades the second messenger cyclic di-3',5'-adenylate. It is a membrane-bound protein that contains a cytoplasmic facing Per-Arnt-Sim (PAS) domain, a modified GGDEF domain, and a DHH/DHHA1 domain, which confers the phosphodiesterase activity. Activity requires Mn2+ and is inhibited by pApA.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
BB0619, CdnD, Dhhp, gdpP, llmg_1816, Lmo0052, MSMEG_2630, NrnA, PDE, PDE1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine
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