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Information on EC 3.1.4.58 - RNA 2',3'-cyclic 3'-phosphodiesterase and Organism(s) Rattus norvegicus and UniProt Accession P13233

for references in articles please use BRENDA:EC3.1.4.58
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.58 RNA 2',3'-cyclic 3'-phosphodiesterase
IUBMB Comments
The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.
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This record set is specific for:
Rattus norvegicus
UNIPROT: P13233
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The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
cpdase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ligT
-
-
-
-
thpR
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(ribonucleotide)n-2',3'-cyclic phosphate 3'-nucleotidohydrolase
The enzyme hydrolyses RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. However, the ligase activity is unlikely to be relevant in vivo.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
CNP associates with poly(A)+ mRNAs in vivo and suppresses translation in vitro in a dose-dependent manner. The inhibitory effect of CNP on translation can be suppressed by RNA aptamers. CNP1 can bridge an association between tubulin and RNA
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CN37_RAT
420
0
47268
Swiss-Prot
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure of the catalytic domain by NMR studies
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gravel, M.; Robert, F.; Kottis, V.; Gallouzi, I.E.; Pelletier, J.; Braun, P.E.
2',3'-Cyclic nucleotide 3'-phosphodiesterase a novel RNA-binding protein that inhibits protein synthesis
J. Neurosci. Res.
87
1069-1079
2009
Rattus norvegicus (P13233)
Manually annotated by BRENDA team