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Information on EC 3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase and Organism(s) Mus musculus and UniProt Accession Q01063
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3.1.4.53 3',5'-cyclic-AMP phosphodiesteraseIUBMB Comments
Requires Mg2+ or Mn2+ for activity . This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation .
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- 3.1.4.53
- rolipram
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- phosphodiesterases
- roflumilast
- asthma
- airway
- cyclase
- pka
- psoriasis
- agonist
- apremilast
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inhale
- tnf
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camp-dependent
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atopic
- dermatitis
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corticosteroid
- cgmp
- forskolin
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bronchodilator
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adenylyl
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eosinophil
-
nausea
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bronchoalveolar
- emesis
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long-acting
- theophylline
- camp-pde
- salbutamol
-
ointment
- ibmx
- pruritus
- cilostamide
-
moderate-to-severe
- milrinone
-
bronchoconstriction
-
camp-mediated
- zaprinast
- medicine
- salmeterol
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pcreb
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beta2ars
-
beta2-adrenoceptors
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labas
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camp-elevating
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beta2-agonists
- pde10a
-
cgmp-specific
- molecular biology
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akaps
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tofacitinib
-
ustekinumab
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
pde4b, phosphodiesterase 4, phosphodiesterase-4, camp-phosphodiesterase, camp-specific phosphodiesterase, pde4d3, pde4d5, phosphodiesterase type 4, pde7b, pde7a, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PDE4B
PDE4B5
-
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6
PDE7B
PATHWAY SOURCE
PATHWAYS
KEGG
SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-AMP 5'-nucleotidohydrolase
Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].
CAS REGISTRY NUMBER
COMMENTARY
9036-21-9
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
cAMP + H2O
5'-AMP
-
isoform PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
-
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
no activity with cGMP
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
PDE8 is specific for the hydrolysis of cAMP
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
the enzyme is specific for cAMP
-
-
?
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
both PDE8A and 8B hydrolyze cAMP with a very high affinity
-
-
?
additional information
?
-
-
PDE4 is a component of signaling pathways involved in the mediation of antidepressant activity
-
-
?
additional information
?
-
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase
-
-
?
additional information
?
-
-
PDE4 regulates adenosine A2A receptor signaling in striatopallidal neurons
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine 3',5'-cyclic phosphate + H2O
adenosine 5'-phosphate
-
both PDE8A and 8B hydrolyze cAMP with a very high affinity
-
-
?
3',5'-cAMP + H2O
5'-AMP
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of C subunit of cAMP-dependent protein kinase
-
-
?
additional information
?
-
-
PDE4 is a component of signaling pathways involved in the mediation of antidepressant activity
-
-
?
additional information
?
-
-
PDE7A1 possesses a non-catalytic activity that can contribute to the termination of cAMP signals via direct inhibition of the C subunit of the cAMP-dependent kinase
-
-
?
additional information
?
-
-
PDE4 regulates adenosine A2A receptor signaling in striatopallidal neurons
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
-
PDE4 inhibitor, potent inhibitor of isoform PDE4D3
4-(3,4-dimethoxyphenyl)-2-{5-[(2-{5-[2-(2-fluoro-5-methoxyphenyl)ethyl]tetrahydrofuran-2-yl}ethyl)amino]pentyl}-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
-
the dual PDE4 inhibitor/selective serotonin reuptake inhibitor shows potent and selective serotonin reuptake inhibition
ayanin
-
i.e. quercetin-3,7,4'-O-trimethylether, non-selective phosphodiesterase 1-4 inhibitor
imperatorin
-
potent PFE4 inhibitor, imperatorin is significantly more active against PDE4B than PDE4A
rolipram
-
isozyme PDE4A is only partially inhibited by 0.02 mM rolipram, whereas PDE4B is completely inhibited at this concentration
additional information
-
the oxidant t-butylhydroperoxide signifcantly increases the cytosolic calcium concentration. Inhibition of both isoforms PDE1 and PDE4 completely prevent the t-butylhydroperoxide stimulated TNF-alpha release
-
additional information
zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B
-
additional information
-
zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B
-
additional information
-
unlike other cAMP-specific PDEs, PDE8s are insensitive to a common nonselective PDE inhibitor, 3-isobutyl-1-methylxanthine (IBMX), but ca be inhibited by a high concentration of dipyridamole
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000002
4-(3,4-dimethoxyphenyl)-2-{5-[(2-{5-[2-(2-fluoro-5-methoxyphenyl)ethyl]tetrahydrofuran-2-yl}ethyl)amino]pentyl}-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one
-
isoform PDE4D3, pH and temperature not specified in the publication
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00159
carboxyamidotriazole
Mus musculus
-
enzyme from peritoneal macrophage, at pH 8.0 and 30°C
0.00562
carboxyamidotriazole
Mus musculus
-
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C
0.0000002
PF-04957325
Mus musculus
-
PDE8B, pH and temperature not specified in the publication
0.0000007
PF-04957325
Mus musculus
-
PDE8A, pH and temperature not specified in the publication
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
PDE4D11 expression levels increase in the cerebellum with progressive age
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
-
lowering cyclic adenosine-3',5'-monophosphate levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
-
PDE4B. Ablation of PDE4B partially protects mice from LPS-induced shock
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
in the brain, PDE4D11 expression levels increase in the cerebellum, but decrease in the hippocampus with progressive age
-
isoforms PDE4A, PDE4D, PDE7A, PDE8A, PDE8B show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE7A, PDE7B does not change with age. Age-related increases in PDE11A4, PDE8A3, PDE8A4/5, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
-
age-related increases in isoform PDE8A3 protein expression are confirmed in hippocampus of old versus young rodents
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
PDE4D11 expression levels decrease in the hippocampus with progressive age
-
age-related increases in isoforms PDE8A3, PDE8A4/5 and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order
highest expression in testis, followed by eye, liver, skeletal muscle, heart, 7-day embryo, kidney, ovary, and brain in decreasing order. In testis PDE8 is expressed in the seminiferous epithelium in a stage-specific manner
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region
-
colocalization of isoform PDE7A1 with protein kinase II in the golgi-centrosome region
-
PDE4B5 is distributed predominantly and unevenly within the cytosol
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
-
a transmembrane-adenylyl-cyclase-cAMP-protein kinase A cascade modulated by isoform PDE1C is critical in regulating platelet-derived growth factor -receptor-beta degradation
physiological function
malfunction
-
PDE8B KO mice have elevated levels of urinary corticosterone in both basal and stressed conditions compared with their littermate wild-type controls. PDE8B KO mice exhibit adrenal hypersensitivity toward adrenocorticotropin. PDE8B gene ablation increases mRNA expressions of StAR protein and MC2R
malfunction
-
in cultured smooth muscle cells, isoform PDE1C deficiency or PDE1 inhibition attenuates smooth muscle cell proliferation and migration
physiological function
-
importance of PDE8s in cAMP regulation of steroid production. PDE8A plays an important role in regulating a pool of cAMP that promotes testicular steroidogenesis. PDE8B regulates adrenocorticotropin-stimulated AZF steroidogenesis by both short- and long-term mechanisms
physiological function
-
isoform PDE4B is involved in beta-adrenergic signaling in the heart. Genetic ablation of PDE4B disrupts beta-adrenergic signaling-induced cAMP transients at the sarcolemma but not in the bulk cytosol of cardiomyocytes. PDE4B regulates beta1-adrenergic signaling-, but not beta2-adrenergic signaling- or PGE2-induced responses. PDE4B shows selective effects on protein kinase A-mediated phosphorylation patterns. PDE4B limits the proein kinase A-mediated phosphorylation of key players in excitation-contraction coupling that reside in the sarcolemmal compartment, including L-type Ca2+ channels and ryanodine receptors, but not phosphorylation of distal cytosolic proteins. beta1-Adrenergic signaling- but not beta2-adrenergic signaling-ligation induced protein kinase A-dependent activation of PDE4B and interruption of this negative feedback with protein kinase A inhibitors increase sarcolemmal cAMP
physiological function
-
cAMP-phosphodiesterase 1C plays a role in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PDE4D_MOUSE
747
0
84563
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
isoform PDE7A1 associates with the dissociated C subunit of cAMP dependent protein kinase, but does not bind tetrameric protein kinase holoenzyme. Binding of protein kinase C subunit inhibits kinase activity in vitro, the N-terminal repeat region f PDE7A1 is sufficient for inhibition
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
generation of PDE8B KO mice, that show elevated levels of urinary corticosterone in both basal and stressed conditions compared with their littermate wild-type controls
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
isoform PDE1C expression is low in contractile smooth muscle cells but drastically elevated in synthetic smooth muscle cells in vitro and in various mouse vascular injury models in vivo
-
isoforms PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A does not change with age
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
medicine
-
PDE4 may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram
medicine
-
reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
Dlaboga, D.; Hajjhussein, H.; O'Donnell J.M.
Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: Comparison with rolipram
Brain Res.
1096
104-112
2006
Mus musculus
Han, P.; Sonati, P.; Rubin, C.; Michaeli, T.
PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C
J. Biol. Chem.
281
15050-15057
2006
Mus musculus
Jin, S.L.; Lan, L.; Zoudilova, M.; Conti, M.
Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages
J. Immunol.
175
1523-1531
2005
Mus musculus
Cheung, Y.F.; Kan, Z.; Garrett-Engele, P.; Gall, I.; Murdoch, H.; Baillie, G.S.; Camargo, L.M.; Johnson, J.M.; Houslay, M.D.; Castle, J.C.
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)
J. Pharmacol. Exp. Ther.
322
600-609
2007
Mus musculus, Homo sapiens (Q07343), Homo sapiens
Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
Toxicol. Lett.
168
1-6
2007
Homo sapiens, Mus musculus
Gardner, C.; Robas, N.; Cawkill, D.; Fidock, M.
Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase
Biochem. Biophys. Res. Commun.
272
186-192
2000
Homo sapiens (Q9NP56), Homo sapiens, Mus musculus (Q9QXQ1), Mus musculus
Cherry, J.A.; Thompson, B.E.; Pho, V.
Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse
Biochim. Biophys. Acta
1518
27-35
2001
Mus musculus (O89084), Mus musculus (Q9QXI7), Mus musculus
Houslay, M.D.; Baillie, G.S.; Maurice, D.H.
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling
Circ. Res.
100
950-966
2007
Homo sapiens (P27815), Homo sapiens (Q07343), Homo sapiens (Q08499), Mus musculus (Q01063)
Horvath, A.; Giatzakis, C.; Tsang, K.; Greene, E.; Osorio, P.; Boikos, S.; Libe, R.; Patronas, Y.; Robinson-White, A.; Remmers, E.; Bertherat, J.; Nesterova, M.; Stratakis, C.A.
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex
Eur. J. Hum. Genet.
16
1245-1253
2008
Homo sapiens, Homo sapiens (O95263), Mus musculus
Yoshida, H.; Beltran-Parrazal, L.; Butler, P.; Conti, M.; Charles, A.C.; Weiner, R.I.
Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
Mol. Endocrinol.
17
1982-1990
2003
Mus musculus
Soderling, S.H.; Bayuga, S.J.; Beavo, J.A.
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
Proc. Natl. Acad. Sci. USA
95
8991-8996
1998
Mus musculus (O88502), Mus musculus
Hetman, J.M.; Soderling, S.H.; Glavas, N.A.; Beavo, J.A.
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase
Proc. Natl. Acad. Sci. USA
97
472-476
2000
Mus musculus (P70453), Mus musculus (Q9QXQ1)
Lynex, C.N.; Li, Z.; Chen, M.L.; Toh, K.Y.; Low, R.W.; Goh, D.L.; Tay, S.K.
Identification and molecular characterization of a novel PDE4D11 cAMP-specific phosphodiesterase isoform
Cell. Signal.
20
2247-2255
2008
Mus musculus (B1PSD9), Mus musculus
Ivey, F.D.; Demirbas, D.; Allain, C.; Hoffmann, C.S.
Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases
J. Biomol. Screen.
13
62-71
2008
Mus musculus
Nishi, A.; Kuroiwa, M.; Miller, D.B.; O'Callaghan, J.P.; Bateup, H.S.; Shuto, T.; Sotogaku, N.; Fukuda, T.; Heintz, N.; Greengard, P.; Snyder, G.L.
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
J. Neurosci.
28
10460-10471
2008
Mus musculus
De Arcangelis, V.; Soto, D.; Xiang, Y.
Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor
Mol. Pharmacol.
74
1453-1462
2008
Mus musculus
Lee, F.P.; Shih, C.M.; Shen, H.Y.; Chen, C.M.; Chen, C.M.; Ko, W.C.
Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia
Eur. J. Pharmacol.
635
198-203
2010
Mus musculus
Cashman, J.R.; Voelker, T.; Zhang, H.T.; ODonnell, J.M.
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake
J. Med. Chem.
52
1530-1539
2009
Mus musculus
Tsai, L.C.; Shimizu-Albergine, M.; Beavo, J.A.
The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland
Mol. Pharmacol.
79
639-648
2011
Mus musculus
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
Mika, D.; Richter, W.; Westenbroek, R.E.; Catterall, W.A.; Conti, M.
PDE4B mediates local feedback regulation of beta1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
J. Cell Sci.
127
1033-1042
2014
Mus musculus
Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia
Circ. Res.
116
1120-1132
2015
Homo sapiens, Mus musculus, Rattus norvegicus
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