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bis(glycerophospho)glycerol + H2O
?
low activity
-
-
?
cardiolipin + H2O
?
low activity
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
sn-glycero-3-phospho-L-serine
L-serine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
?
bis(glycerophospho)glycerol + H2O
?
low activity
-
-
?
bis(glycerophospho)glycerol + H2O
sn-gycerol 3-phosphate + ?
-
-
-
?
cardiolipin + H2O
?
low activity
-
-
?
cyclic sn-2,3-phosphoglycerol + H2O
?
-
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
sn-glycero-3-phospho-L-serine
L-serine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoethanolamine + H2O
ethanolamine + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoglycerol + H2O
glycerol + sn-glycerol 3-phosphate
-
-
-
?
sn-glycero-3-phosphoinositol + H2O
inositol + sn-glycerol 3-phosphate
-
-
-
?
additional information
?
-
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
-
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
UgpQ accumulates under conditions of phosphate starvation suggesting a role in the utilization of phosphate from glycerophosphodiesters
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
additional information
?
-
-
not: bis(4-nitrophenyl)phosphate
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
additional information
?
-
the enzyme has a broad substrate specificity. It hydrolyzes glycerophosphodiester bonds through its recognition of the glycerophospho moiety, but it does not hydrolyze other types of bonds, such as that of bis(p-nitrophenyl)phosphate. No activity towards phosphatidyl-DL-glycerol or lysophosphatidyl-DL-glycerol
-
-
?
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glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
glycerophosphoglycerol + H2O
sn-glycerol 3-phosphate + glycerol
-
-
-
?
glycerophosphoinositol + H2O
sn-glycerol 3-phosphate + inositol
-
-
-
?
glycerophosphoserine + H2O
sn-glycerol 3-phosphate + serine
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
-
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
-
-
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
reaction provides choline which is an essential growth factor in bacteria
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
important for sn-glycerol-3-phosphate uptake, which serves as carbon and phosphate source
-
-
?
glycerophosphodiester + H2O
sn-glycerol 3-phosphate + alcohol
UgpQ accumulates under conditions of phosphate starvation suggesting a role in the utilization of phosphate from glycerophosphodiesters
sn-glycerol-3-phosphate supply is essential for the de novo synthesis of glycerophospholipids
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
-
-
?
glycerophosphoethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
reaction provides ethanolamine which is an essential growth factor in bacteria
-
-
?
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Ca2+
required
Ca2+
required for activity
additional information
Mg2+, Mn2+, Co2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
Mg2+, Mn2+, Co2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
-
Mg2+, Mn2+, Co2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
Ca2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
Ca2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
-
Ca2+, Cu2+, Ni2+, Cd2+, Zn2+, and Fe2+ are ineffective
additional information
the enzyme requires divalent cations for activity
additional information
the enzyme requires divalent cations for activity
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Larson, T.J.; Ehrmann, M.; Boos, W.
Periplasmic glycerophosphodiester phosphodiesterase of Escherichia coli, a new enzyme of the glp regulon
J. Biol. Chem.
258
5428-5432
1983
Escherichia coli
brenda
Kasahara, M.; Makino, K.; Amemura, M.; Nakata, A.
Nucleotide sequence of the ugpQ gene encoding glycerophosphoryl diester phosphodiesterase of Escherichia coli K-12
Nucleic Acids Res.
17
2854
1989
Escherichia coli
brenda
Brzoska, P.; Boos, W.
Characteristics of a ugp-encoded and phoB-dependent glycerophosphoryl diester phosphodiesterase which is physically dependent on the ugp transport system of Escherichia coli
J. Bacteriol.
170
4125-4135
1988
Escherichia coli
brenda
Tommassen, J.; Eiglmeier, K.; Cole, S.T.; Overduin, P.; Larson, T.J.; Boos, W.
Characterization of two genes, glpQ and ugpQ, encoding glycerophosphoryl diester phosphodiesterases of Escherichia coli
Mol. Gen. Genet.
226
321-327
1991
Escherichia coli
brenda
Brzoskia, P.; Boos, W.
The ugp-encoded glycerophosphoryldiester phosphodiesterase, a transport-related enzyme of Escherichia coli
FEMS Microbiol. Rev.
63
115-124
1989
Escherichia coli
-
brenda
Yanaka, N.
Mammalian glycerophosphodiester phosphodiesterases
Biosci. Biotechnol. Biochem.
71
1811-1818
2007
Haemophilus influenzae, Escherichia coli (P09394), Escherichia coli (P10908)
brenda
Ohshima, N.; Yamashita, S.; Takahashi, N.; Kuroishi, C.; Shiro, Y.; Takio, K.
Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity
J. Bacteriol.
190
1219-1223
2008
Escherichia coli K-12, Escherichia coli (P09394), Escherichia coli (P10908), Escherichia coli
brenda
Corda, D.; Mosca, M.; Ohshima, N.; Grauso, L.; Yanaka, N.; Mariggio, S.
The emerging physiological roles of the glycerophosphodiesterase family
FEBS J.
281
998-1016
2014
Agrobacterium tumefaciens, Arabidopsis thaliana, Bacillus pumilus, Bacillus pumilus DSM 27, Bacillus subtilis (P54527), Borrelia hermsii (Q45201), Caldanaerobacter subterraneus subsp. tengcongensis, Escherichia coli (P09394), Escherichia coli (P10908), Haemophilus influenzae (Q06282), Haemophilus influenzae DSM 11121 (Q06282), Homo sapiens (Q8WTR4), Homo sapiens (Q9NPB8), Klebsiella aerogenes, Lupinus albus, Mus musculus, Musca domestica, Mycoplasma hyorhinis (E0TL71), Mycoplasma pneumoniae (P75367), Pasteurella multocida (Q79LP3), Plasmodium falciparum, Rattus norvegicus, Saccharomyces cerevisiae, Saccharomyces cerevisiae (Q02979), Staphylococcus aureus (Q99387), Streptomyces coelicolor, Thermotoga maritima, Treponema pallidum (O30405)
brenda