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Information on EC 3.1.4.46 - glycerophosphodiester phosphodiesterase and Organism(s) Treponema pallidum and UniProt Accession O30405

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     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.46 glycerophosphodiester phosphodiesterase
IUBMB Comments
Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed.
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Treponema pallidum
UNIPROT: O30405
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The taxonomic range for the selected organisms is: Treponema pallidum
The enzyme appears in selected viruses and cellular organisms
Synonyms
glycerophosphodiester phosphodiesterase, lipoprotein d, glpq2, igd-binding protein, glpq1, gpd protein, outer membrane protein d, pfgdpd, gpcpd1, ttgdpd, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycerophosphodiester phosphodiesterase
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gene hpd protein
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-
-
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GlpQ
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-
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glycerophosphodiester phosphodiesterase
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-
-
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glycerophosphoryl diester phosphodiesterase
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-
-
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GPX-PDE
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-
-
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IGD-binding protein
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-
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IgD-binding protein D
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immunoglobulin D-binding protein
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phosphodiesterase, glycerophosphodiester
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-
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phosphohydrolase GpdQ
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic diester
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-
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
glycerophosphodiester glycerophosphohydrolase
Broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol and bis(glycerophospho)-glycerol are hydrolysed.
CAS REGISTRY NUMBER
COMMENTARY hide
86280-59-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
the enzyme is a hydrophilic lipoprotein that is also assumed to be anchored by N-terminal lipids to the periplasmic leaflet(s) of the peptidoglycan cytoplasmic membrane, and not to be exposed on the outer membrane of the pathogen
Manually annotated by BRENDA team
the enzyme resides on the outer leaflet of the outer membrane
Manually annotated by BRENDA team
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associated with spirochete´s peptidoglycan-cytoplasmic membrane complex
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
phylogenetic analysis, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lipoprotein
the enzyme is a hydrophilic lipoprotein that is also assumed to be anchored by N-terminal lipids to the periplasmic leaflet(s) of the peptidoglycan cytoplasmic membrane
lipoprotein
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
the enzyme has immunogenic potential as a vaccine. Improvement of the GlpQ-based vaccine formulation, a DNA-based vaccine constructed by fusing Treponema pallidum GlpQ with interleukin-2, using chitosan nanoparticles as the vector, effectively attenuated the development of syphilitic lesions
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shevchenko, D.V.; Sellati, T.J.; Cox, D.L.; Shevchenko, O.V.; Robinson, E.J.; Radolf, J.D.
Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog
Infect. Immun.
67
2266-2276
1999
Treponema pallidum
Manually annotated by BRENDA team
Corda, D.; Mosca, M.; Ohshima, N.; Grauso, L.; Yanaka, N.; Mariggio, S.
The emerging physiological roles of the glycerophosphodiesterase family
FEBS J.
281
998-1016
2014
Agrobacterium tumefaciens, Arabidopsis thaliana, Bacillus pumilus, Bacillus pumilus DSM 27, Bacillus subtilis (P54527), Borrelia hermsii (Q45201), Caldanaerobacter subterraneus subsp. tengcongensis, Escherichia coli (P09394), Escherichia coli (P10908), Haemophilus influenzae (Q06282), Haemophilus influenzae DSM 11121 (Q06282), Homo sapiens (Q8WTR4), Homo sapiens (Q9NPB8), Klebsiella aerogenes, Lupinus albus, Mus musculus, Musca domestica, Mycoplasma hyorhinis (E0TL71), Mycoplasma pneumoniae (P75367), Pasteurella multocida (Q79LP3), Plasmodium falciparum, Rattus norvegicus, Saccharomyces cerevisiae, Saccharomyces cerevisiae (Q02979), Staphylococcus aureus (Q99387), Streptomyces coelicolor, Thermotoga maritima, Treponema pallidum (O30405)
Manually annotated by BRENDA team