Information on EC 3.1.4.43 - glycerophosphoinositol inositolphosphodiesterase

for references in articles please use BRENDA:EC3.1.4.43
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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY hide
3.1.4.43
-
RECOMMENDED NAME
GeneOntology No.
glycerophosphoinositol inositolphosphodiesterase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase
This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P
CAS REGISTRY NUMBER
COMMENTARY hide
72414-13-2
not distinguished from EC 3.1.4.44
9076-91-9
formerly EC 3.1.4.43
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-myo-inositol 1,2-cyclic phosphate + H2O
1D-myo-inositol 1-phosphate + H+
show the reaction diagram
-
-
-
-
?
sn-glycero-3-phospho-1-inositol + H2O
?
show the reaction diagram
-
catabolism of phosphatidylinositol
-
-
-
sn-glycero-3-phospho-1-inositol + H2O
glycerol + inositol 1-phosphate
show the reaction diagram
-
-
-
?
sn-glycero-3-phospho-1-inositol + H2O
glycerol + inositol cyclic phosphate
show the reaction diagram
-
-
the enzyme can act as a cyclizing phosphotransferase
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sn-glycero-3-phospho-1-inositol + H2O
?
show the reaction diagram
-
catabolism of phosphatidylinositol
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
2-3 mM, stimulates
Mn2+
-
limited stimulation
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.2
sn-glycero-3-phospho-1-inositol
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8.6
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
outer cortex, brush border of proximal tubules
Manually annotated by BRENDA team