Reference on EC 3.1.4.41 - sphingomyelin phosphodiesterase D
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Soucek, A.; Michalec, C.; Souckova, A.
Identification and characterization of a new enzyme of the group "phospholipase D" isolated from Corynebacterium ovis
Biochim. Biophys. Acta
227
116-128
1971
Corynebacterium pseudotuberculosis, Corynebacterium pseudotuberculosis NCTC4655
Carne, H.R.; Onon, E.O.
Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels
Nature
271
246-248
1978
Corynebacterium pseudotuberculosis
Forrester, L.J.; Barrett, J.T.; Campbell, B.J.
Red blood cell lysis induced by the venom of brown recluse spider
Arch. Biochem. Biophys.
187
355-365
1978
Loxosceles reclusa
Onon, E.O.
Purification and partial characterization of the exotoxin of Corynebacterium ovis
Biochem. J.
177
181-186
1979
Corynebacterium pseudotuberculosis
Kurpiewski, G.; Forrester, L.J.; Barrett, J.T.; Campbell, B.J.
Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles rescula
Biochim. Biophys. Acta
678
467-476
1981
Loxosceles reclusa
Linder, R; Bernheimer, A.W.
Enzymatic oxidation of membrane cholesterol in relation to lysis of sheep erythrocytes by corynebacterial enzymes
Arch. Biochem. Biophys.
213
395-404
1982
Rhodococcus equi, Arcanobacterium haemolyticum, Corynebacterium pseudotuberculosis, Corynebacterium ulcerans, Rhodococcus equi C
Kreger, A.S.; Bernheimer, A.W.; Etkin, L.A.; Daniel, L.W.
Phospholipase D activity of Vibrioi damsela cytolysin and its interaction with sheep erythrocytes
Infect. Immun.
55
3209-3212
1987
Photobacterium damselae
Truett III, A.P.; King, L.E.
Sphingomyelinase D: A pathogenic agent produced by bacteria and arthropods
Adv. Lipid Res.
26
275-291
1993
Corynebacterium pseudotuberculosis, Corynebacterium ulcerans, Loxosceles reclusa, Photobacterium damselae
Songer, J.G.; Libby, S.J.; Iandolo, J.J.; Cuevas, W.A.
Cloning and expression of the phospholipase D gene from Corynebacterium pseudotuberculosis in Escherichia coli
Infect. Immun.
58
131-136
1990
Corynebacterium pseudotuberculosis
Gates, C.A.; Rees, R.S.
Serum amyloid P component: its role in platelet activation stimulated by sphingomyelinase D purified from the venom of the brown recluse spider (Loxosceles reclusa)
Toxicon
28
1303-1315
1990
Loxosceles reclusa
Merchant, M.L.; Hinton, J.F.; Geren, C.R.
Effect of hyperbaric oxygen on sphingomyelinase D activity of brown recluse spider (Loxosceles reclusa) venom as studied by 31P nuclear magnetic resonance spectroscopy
Am. J. Trop. Med. Hyg.
56
335-338
1997
Loxosceles reclusa
Binford, G.J.; Wells, M.A.
The phylogenetic distribution of sphingomyelinase D activity in venoms of Haplogyne spiders
Comp. Biochem. Physiol. B
135
25-33
2003
no activity in Ctenus captiosus, no activity in Scytodes perfecta, no activity in Leptoneta oasa, Loxosceles sp., Sicarius hahni, Sicarius testaceus, no activity in Drymusa capensis, no activity in Diguetia canites, no activity in Plectreurys tristis, no activity in Kukulcania arizonica
Van Meeteren, L.A.; Frederiks, F.; Giepmans, B.N.G.; Pedrosa, M.F.F.; Billington, S.J.; Jost, B.H.; Tambourgi, D.V.; Moolenaar, W.H.
Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine
J. Biol. Chem.
279
10833-10836
2004
Corynebacterium pseudotuberculosis, Loxosceles laeta
Subbaiah, P.V.; Billington, S.J.; Jost, B.H.; Songer, J.G.; Lange, Y.
Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts
J. Lipid Res.
44
1574-1580
2003
Corynebacterium pseudotuberculosis
Hassler, D.F.; Laethem, R.M.; Smith, G.K.
A high throughput sphingomyelinase assay
Methods Enzymol.
311
176-184
2000
Rattus norvegicus
Murakami, M.T.; Fernandes-Pedrosa, M.F.; de Andrade, S.A.; Gabdoulkhakov, A.; Betzel, C.; Tambourgi, D.V.; Arni, R.K.
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
Biochem. Biophys. Res. Commun.
342
323-329
2006
Loxosceles laeta (Q8I914)
Murakami, M.T.; Fernandes-Pedrosa, M.F.; Tambourgi, D.V.; Arni, R.K.
Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D
J. Biol. Chem.
280
13658-13664
2005
Loxosceles laeta
Paixao-Cavalcante, D.; van den Berg, C.W.; de Freitas Fernandes-Pedrosa, M.; Goncalves de Andrade, R.M.; Tambourgi, D.V.
Role of matrix metalloproteinases in HaCaT keratinocytes apoptosis induced by loxosceles venom sphingomyelinase D
J. Invest. Dermatol.
126
61-68
2006
Loxosceles intermedia (P0CE83)
Tambourgi, D.V.; Pedrosa, M.F.; de Andrade, R.M.; Billington, S.J.; Griffiths, M.; van den Berg, C.W.
Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis
Mol. Immunol.
44
576-582
2007
Corynebacterium pseudotuberculosis, Loxosceles intermedia
Binford, G.J.; Cordes, M.H.; Wells, M.A.
Sphingomyelinase D from venoms of Loxosceles spiders: evolutionary insights from cDNA sequences and gene structure
Toxicon
45
547-560
2005
Loxosceles arizonica
Ramos-Cerrillo, B.; Olvera, A.; Odell, G.V.; Zamudio, F.; Paniagua-Solis, J.; Alagon, A.; Stock, R.P.
Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa. [Erratum to document cited in CA141:421209]
Toxicon
46
241
2005
Loxosceles reclusa, Loxosceles boneti
-
de Andrade, S.A.; Murakami, M.T.; Cavalcante, D.P.; Arni, R.K.; Tambourgi, D.V.
Kinetic and mechanistic characterization of the sphingomyelinases D from Loxosceles intermedia spider venom
Toxicon
47
380-386
2006
Loxosceles intermedia, Loxosceles intermedia (P0CE81)
Dragulev, B.; Bao, Y.; Ramos-Cerrillo, B.; Vazquez, H.; Olvera, A.; Stock, R.; Algaron, A.; Fox, J.W.
Upregulation of IL-6, IL-8, CXCL1, and CXCL2 Dominates Gene Expression in Human Fibroblast Cells Exposed to Loxosceles reclusa Sphingomyelinase D: Insights into Spider Venom Dermonecrosis
J. Invest. Dermatol.
127
1264-1266
2007
Loxosceles reclusa
van Meeteren, L.A.; Stortelers, C.; Moolenaar, W.H.
Upregulation of Cytokine Expression in Fibroblasts Exposed to Loxosceles Sphingomyelinase D: What is the Trigger?
J. Invest. Dermatol.
127
1266-1267
2007
Loxosceles sp.
Felicori, L.; Araujo, S.C.; de Avila, R.A.; Sanchez, E.F.; Granier, C.; Kalapothakis, E.; Chavez-Olortegui, C.
Functional characterization and epitope analysis of a recombinant dermonecrotic protein from Loxosceles intermedia spider
Toxicon
48
509-519
2006
Loxosceles intermedia (P0CE81), Loxosceles intermedia
Olvera, A.; Ramos-Cerrillo, B.; Estevez, J.; Clement, H.; de Roodt, A.; Paniagua-Solis, J.; Vazquez, H.; Zavaleta, A.; Arruz, M.S.; Stock, R.P.; Alagon, A.
North and South American Loxosceles spiders: development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens
Toxicon
48
64-74
2006
Loxosceles laeta (Q1KY80), Loxosceles laeta, Loxosceles reclusa (Q5YD75), Loxosceles reclusa, Loxosceles boneti (Q5YD76), Loxosceles boneti
de Almeida, D.M.; Fernandes-Pedrosa, M.d.e..F.; de Andrade, R.M.; Marcelino, J.R.; Gondo-Higashi, H.; de Azevedo, I.d.e..L.; Ho, P.L.; van den Berg, C.; Tambourgi, D.V.
A new anti-loxoscelic serum produced against recombinant sphingomyelinase D: results of preclinical trials
Am. J. Trop. Med. Hyg.
79
463-470
2008
Loxosceles gaucho, Loxosceles intermedia (P0CE81), Loxosceles intermedia (P0CE83), Loxosceles intermedia, Loxosceles laeta (Q8I914), Loxosceles laeta
Kusma, J.; Chaim, O.M.; Wille, A.C.; Ferrer, V.P.; Sade, Y.B.; Donatti, L.; Gremski, W.; Mangili, O.C.; Veiga, S.S.
Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity
Biochimie
90
1722-1736
2008
Loxosceles intermedia (P0CE81)
Binford, G.J.; Bodner, M.R.; Cordes, M.H.; Baldwin, K.L.; Rynerson, M.R.; Burns, S.N.; Zobel-Thropp, P.A.
Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms
Mol. Biol. Evol.
26
547-566
2009
Sicarius hahni, no activity in Drymusa capensis, no activity in Sicarius rupestris, no activity in Sicarius peruensis, no activity in Sicarius rugosus, Sicarius patagonicus, Loxosceles apachea, Loxosceles sabina, Loxosceles deserta, Loxosceles amazonica, Loxosceles rufescens, Loxosceles spadicea, Loxosceles hirsuta, Loxosceles vonwredei, Loxosceles spinulosa, Loxosceles speluncarum, Sicarius damarensis, Sicarius dolichocephalus, Sicarius albospinosus, no activity in Drymusa serrana, no activity in Drymusa dinora, no activity in Sicarius terrosus, Loxosceles reclusa (P0CE78), Loxosceles intermedia (P0CE81), Loxosceles intermedia (P0CE83), Loxosceles laeta (Q1KY79), Loxosceles laeta (Q1KY80), Ixodes scapularis (Q202J4), Loxosceles arizonica (Q7Z1Y7)
de Santi Ferrara, G.I.; Fernandes-Pedrosa, M.D.; Junqueira-de-Azevedo, I.D.; Goncalves-de-Andrade, R.M.; Portaro, F.C.; Manzoni-de-Almeida, D.; Murakami, M.T.; Arni, R.K.; van den Berg, C.W.; Ho, P.L.; Tambourgi, D.V.
SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: Molecular cloning, expression, function and structural analysis
Toxicon
53
743-753
2009
Loxosceles laeta (Q8I912), Loxosceles laeta (Q8I914), Loxosceles laeta
Zobel-Thropp, P.A.; Bodner, M.R.; Binford, G.J.
Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity
Toxicon
55
1274-1282
2010
Loxosceles arizonica, Sicarius cf. hahni GJB-2008, Sicarius damarensis, Sicarius rugosus
Ullah, A.; de Giuseppe, P.O.; Murakami, M.T.; Trevisan-Silva, D.; Wille, A.C.; Chaves-Moreira, D.; Gremski, L.H.; da Silveira, R.B.; Sennf-Ribeiro, A.; Chaim, O.M.; Veiga, S.S.; Arni, R.K.
Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom
Acta Crystallogr. Sect. F
67
234-236
2011
Loxosceles intermedia
de Giuseppe, P.O.; Ullah, A.; Silva, D.T.; Gremski, L.H.; Wille, A.C.; Chaves Moreira, D.; Ribeiro, A.S.; Chaim, O.M.; Murakami, M.T.; Veiga, S.S.; Arni, R.K.
Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge
Biochem. Biophys. Res. Commun.
409
622-627
2011
Loxosceles intermedia
Vargas-Villarreal, J.; Palacios-Corona, R.; Hernandez-Luna, C.; Mata-Cardenas, B.D.; Torres de la Cruz, V.M.; Cortes-Gutierrez, E.I.; Gonzalez-Salazar, F.; Garza-Gonzalez, J.N.; Escobedo-Guajardo, B.L.; Said-Fernandez, S.
Entamoeba histolytica: soluble and membrane-associated neutral sphingomyelinase-C and other unidentified esterase activity
Exp. Parasitol.
125
394-399
2010
Entamoeba histolytica, Entamoeba histolytica HM1
Catalan, A.; Cortes, W.; Sagua, H.; Gonzalez, J.; Araya, J.E.
Two new phospholipase D isoforms of Loxosceles laeta: Cloning, heterologous expression, functional characterization, and potential biotechnological application
J. Biochem. Mol. Toxicol.
25
393-403
2011
Loxosceles laeta
Gomes, M.T.; Guimaraes, G.; Frezard, F.; Kalapothakis, E.; Minozzo, J.C.; Chaim, O.M.; Veiga, S.S.; Oliveira, S.C.; Chavez-Olortegui, C.
Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase
Toxicon
57
574-579
2011
Loxosceles laeta, Loxosceles intermedia, Loxosceles gaucho, no activity in Micrurus frontalis, Loxosceles similis, no activity in Tityus serrulatus, no activity in Phoneutria nigriventer, no activity in Bothrops jararaca, no activity in Crotalus durissus, no activity in Lachesis muta
Ullah, A.; Magalhaes, G.S.; Masood, R.; Mariutti, R.B.; Coronado, M.A.; Murakami, M.T.; Barbaro, K.C.; Arni, R.K.
Crystallization and preliminary X-ray diffraction analysis of a novel sphingomyelinase D from Loxosceles gaucho venom
Acta Crystallogr. Sect. F
70
1418-1420
2014
Loxosceles gaucho (K9USW8), Loxosceles gaucho
van den Berg, C.W.; Goncalves-de-Andrade, R.M.; Okamoto, C.K.; Tambourgi, D.V.
C5a receptor is cleaved by metalloproteases induced by sphingomyelinase D from Loxosceles spider venom
Immunobiology
217
935-941
2012
Loxosceles sp.
Stock, R.P.; Brewer, J.; Wagner, K.; Ramos-Cerrillo, B.; Duelund, L.; Jernsh?j, K.D.; Olsen, L.F.; Bagatolli, L.A.
Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate
PLoS ONE
7
e36003
2012
Loxosceles laeta
Lajoie, D.M.; Zobel-Thropp, P.A.; Kumirov, V.K.; Bandarian, V.; Binford, G.J.; Cordes, M.H.
Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates
PLoS ONE
8
e72372
2013
Loxosceles arizonica (Q4ZFU2), Loxosceles laeta, Loxosceles reclusa
Zobel-Thropp, P.A.; Kerins, A.E.; Binford, G.J.
Sphingomyelinase D in sicariid spider venom is a potent insecticidal toxin
Toxicon
60
265-271
2012
Loxosceles arizonica
Catalan, A.; Cortes, W.; Munoz, C.; Araya, J.E.
Tryptophan and aspartic acid residues present in the glycerophosphoryl diester phosphodiesterase (GDPD) domain of the Loxosceles laeta phospholipase D are essential for substrate recognition
Toxicon
81
43-47
2014
Loxosceles laeta
Pedroso, A.; Matioli, S.R.; Murakami, M.T.; Pidde-Queiroz, G.; Tambourgi, D.V.
Adaptive evolution in the toxicity of a spiders venom enzymes
BMC Evol. Biol.
15
290
2015
Arcanobacterium haemolyticum, Corynebacterium pseudotuberculosis, Loxosceles reclusa, Loxosceles laeta, Loxosceles intermedia, Loxosceles boneti, Loxosceles arizonica, Loxosceles gaucho, Sicarius patagonicus, Loxosceles apachea, Loxosceles sabina, Loxosceles deserta, Loxosceles amazonica, Loxosceles rufescens, Loxosceles spadicea, Loxosceles hirsuta, Loxosceles spinulosa, Sicarius damarensis, Sicarius albospinosus, Ixodes scapularis, Loxosceles similis, Loxosceles variegata, Loxosceles sp. 4 GJB-2008, Loxosceles aff. spinulosa GJB-2008, Loxosceles adelaida, Rhipicephalus pulchellus, Loxosceles cf. spinulosa GJB-2008, Sicarius peruensis, Sicarius terrosus
Gellings, P.S.; McGee, D.J.
Arcanobacterium haemolyticum utilizes both phospholipase D and arcanolysin to mediate its uptake into non-phagocytic cells
Infect. Immun.
87
e00832-18
2019
Arcanobacterium haemolyticum
Mariutti, R.B.; Chaves-Moreira, D.; Vuitika, L.; Caruso, I.P.; Coronado, M.A.; Azevedo, V.A.; Murakami, M.T.; Veiga, S.S.; Arni, R.K.
Bacterial and arachnid sphingomyelinases D comparison of biophysical and pathological activities
J. Cell. Biochem.
118
2053-2063
2017
Corynebacterium pseudotuberculosis, Loxosceles intermedia
Lopes, P.H.; Murakami, M.T.; Portaro, F.C.V.; Mesquita Pasqualoto, K.F.; van den Berg, C.; Tambourgi, D.V.
Targeting Loxosceles spider sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism
J. Enzyme Inhib. Med. Chem.
34
310-321
2019
Loxosceles laeta
Combs, D.J.; Lu, Z.
Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current
J. Gen. Physiol.
146
161-172
2015
Corynebacterium pseudotuberculosis
Manzoni-de-Almeida, D.; Squaiella-Baptistao, C.C.; Lopes, P.H.; van den Berg, C.W.; Tambourgi, D.V.
Loxosceles venom sphingomyelinase D activates human blood leukocytes Role of the complement system
Mol. Immunol.
94
45-53
2018
Loxosceles intermedia
Correa, M.A.; Okamoto, C.K.; Goncalves-de-Andrade, R.M.; van den Berg, C.W.; Tambourgi, D.V.
Sphingomyelinase D from Loxosceles laeta venom induces the expression of MMP7 in human keratinocytes contribution to dermonecrosis
PLoS ONE
11
e0153090
2016
Loxosceles laeta
Gellings, P.; McGee, D.
Arcanobacterium haemolyticum phospholipase D enzymatic activity promotes the hemolytic activity of the cholesterol-dependent cytolysin arcanolysin
Toxins
10
213
2018
Arcanobacterium haemolyticum (C7SZ47), Arcanobacterium haemolyticum, Arcanobacterium haemolyticum DSM 20595 (C7SZ47)
Gellings, P.S.; McGee, D.J.
Arcanobacterium haemolyticum phospholipase D enzymatic activity promotes the hemolytic activity of the cholesterol-dependent cytolysin arcanolysin
Toxins
10
E213
2018
Arcanobacterium haemolyticum (C7SZ47), Arcanobacterium haemolyticum, Arcanobacterium haemolyticum ATCC 9345 (C7SZ47)
Rivera, I.G.; Ordonez, M.; Presa, N.; Gomez-Larrauri, A.; Simon, J.; Trueba, M.; Gomez-Munoz, A.
Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation
Toxins
7
1457-1466
2015
Arcanobacterium haemolyticum, Corynebacterium pseudotuberculosis, Corynebacterium ulcerans, Loxosceles reclusa, Loxosceles laeta, Loxosceles intermedia, Loxosceles arizonica, Loxosceles gaucho, Loxosceles rufescens, Photobacterium damselae subsp. damselae
Torabi, E.; Behdani, M.; Chafi, M.H.; Moazzami, R.; Sabatier, J.M.; Khalaj, V.; Shahbazzadeh, D.; Bagheri, K.P.
Characteristics and lethality of a novel recombinant dermonecrotic venom phospholipase D from Hemiscorpius lepturus
Toxins
9
E102
2017
Hemiscorpius lepturus (A0A1L4BJ98)
Oliveira, C.F.; Vilela, A.; Coura, L.A.; Rodrigues, F.T.; Nagem, R.A.; Chavez-Olortegui, C.; Maioli, T.U.; Felicori, L.F.
Protective antibodies against a sphingomyelinase D from Loxosceles intermedia spider venom elicited in mice with different genetic background
Vaccine
34
3828-3834
2016
Loxosceles intermedia
html completed
