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Information on EC 3.1.4.41 - sphingomyelin phosphodiesterase D and Organism(s) Hemiscorpius lepturus and UniProt Accession A0A1L4BJ98

for references in articles please use BRENDA:EC3.1.4.41
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.41 sphingomyelin phosphodiesterase D
IUBMB Comments
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
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This record set is specific for:
Hemiscorpius lepturus
UNIPROT: A0A1L4BJ98
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The taxonomic range for the selected organisms is: Hemiscorpius lepturus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
smase d, sphingomyelinase d, glycerophosphoryl diester phosphodiesterase, smased, damselysin, lgrec1, sphingomyelinase-d, phospholipase d 1, sphingomyelin-specific phospholipase d, smase-d, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
RecPLD1
recombinant isoform
damselysin
-
-
-
-
SMD
-
-
-
-
sphingomyelinase D
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
sphingomyelin ceramide-phosphohydrolase
Does not act on phosphatidylcholine, but hydrolyses 2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
CAS REGISTRY NUMBER
COMMENTARY hide
54992-31-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
sphingomyelin + H2O
ceramide phosphate + choline
show the reaction diagram
-
-
-
?
trinitrophenylaminolauric acid sphingomyelin + H2O
?
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sphingomyelin + H2O
ceramide phosphate + choline
show the reaction diagram
-
-
-
?
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8
recombinant isoform RecPLD1, calculated from amino acid sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DTPLD_HEMLE
324
0
36979
Swiss-Prot
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA agarose column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Torabi, E.; Behdani, M.; Chafi, M.H.; Moazzami, R.; Sabatier, J.M.; Khalaj, V.; Shahbazzadeh, D.; Bagheri, K.P.
Characteristics and lethality of a novel recombinant dermonecrotic venom phospholipase D from Hemiscorpius lepturus
Toxins
9
E102
2017
Hemiscorpius lepturus (A0A1L4BJ98)
Manually annotated by BRENDA team