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Information on EC 3.1.4.4 - phospholipase D and Organism(s) Danio rerio and UniProt Accession A2BG86

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.4 phospholipase D
IUBMB Comments
Also acts on other phosphatidyl esters.
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This record set is specific for:
Danio rerio
UNIPROT: A2BG86
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
pld, phospholipase d, nape-pld, phospholipase d1, dermonecrotic toxin, phospholipase d2, pc-pld, pldalpha, rpld1, spo14, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AtPLDalpha1
-
-
-
-
AtPLDalpha2
-
-
-
-
AtPLDbeta1
-
-
-
-
AtPLDbeta2
-
-
-
-
AtPLDdelta
-
-
-
-
AtPLDepsilon
-
-
-
-
AtPLDgamma1
-
-
-
-
AtPLDgamma2
-
-
-
-
AtPLDgamma3
-
-
-
-
AtPLDp1
-
-
-
-
AtPLDp2
-
-
-
-
AtPLDzeta
-
-
-
-
choline phosphatase
-
-
-
-
hPLD1
-
-
-
-
hPLD2
-
-
-
-
lecithinase D
-
-
-
-
lipophosphodiesterase II
-
-
-
-
Meiosis-specific sporulation protein SPO14
-
-
-
-
mPLD1
-
-
-
-
mPLD2
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D1
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D2
-
-
-
-
Phospholipase D1 PHOX and PX containing domain
-
-
-
-
Phospholipase D2 PHOX and PX containing domain
-
-
-
-
PLD delta
-
-
-
-
PLD epsilon
-
-
-
-
PLD zeta
-
-
-
-
PLD1
-
-
PLD1C
-
-
-
-
PLDalpha
-
-
-
-
PLDalpha3
-
-
-
-
PLDbeta
-
-
-
-
PLDdelta1
-
-
-
-
PLDzeta1
-
-
-
-
PLDzeta2
-
-
-
-
rPLD1
-
-
-
-
rPLD2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine phosphatidohydrolase
Also acts on other phosphatidyl esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-87-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
choline + phosphatidic acid
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
-
-
-
?
phosphatidylcholine + H2O
choline + phosphatidic acid
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-butanol
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PLD2; isozyme PLD2 encoded by gene pld2
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
dynamic expression pattern of pld1 during early zebrafish development, overview
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
inhibition of Pld1 function, by siRNA-mediated downregulation or 1-butanol, does not strongly impair the dorsal-ventral guidance of primary/secondary motor axons
physiological function
-
activity of Pld1 in the developing notochord is essential for vascular development in vertebrates. Pld1 may regulate the ISV development through a parallel pathway controlling angiogenesis or play a role downstream of these angiogenic pathways, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A2BG86_DANRE
927
0
106867
TrEMBL
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
generation of mosaic pld1 deficient embryos, that show partial suppression of intersegmental vessel defects in the segments containing transplanted wild-type somitic and notochord cells, or notochord cells alone. 1-Butanol treatment phenocopies the ISV defects of pld1 morphants, overview. The early chordamesoderm marker shh is normally downregulated in pld1 morphants or 1-butanol treated embryos, ths notochord differentiation is not affected when Pld1 function is disrupted. No changes in VEGF and semaphorins 3a1 expressions
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene pld2, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, expression analysis and regulation
gene pld1, in vitro transcription and translation
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Raghu, P.; Manifava, M.; Coadwell, J.; Ktistakis, N.T.
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors)
Biochim. Biophys. Acta
1791
889-897
2009
Saccharomyces cerevisiae, Caenorhabditis elegans, Danio rerio (A2BG86), Danio rerio, Homo sapiens (O14939), Homo sapiens (Q13393), Dictyostelium discoideum (Q54UK0), Dictyostelium discoideum (Q54WR4), Dictyostelium discoideum (Q54Z25), Drosophila melanogaster (Q7KML4)
Manually annotated by BRENDA team
Zeng, X.X.; Zheng, X.; Xiang, Y.; Cho, H.P.; Jessen, J.R.; Zhong, T.P.; Solnica-Krezel, L.; Brown, H.A.
Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish
Dev. Biol.
328
363-376
2009
Danio rerio
Manually annotated by BRENDA team