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The taxonomic range for the selected organisms is: Dictyostelium discoideum
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
phosphodiesterase type 5, phosphodiesterase-5, pde-5, phosphodiesterase 5, cgmp phosphodiesterase, pde5a, cyclic gmp phosphodiesterase, phosphodiesterase type-5, pde6b, cgmp-phosphodiesterase,
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3',5'-cyclic GMP phosphodiesterase
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cGMP phosphodiesterase
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cGMP-selective phosphodiesterase
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cyclic 3',5'-GMP phosphodiesterase
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cyclic GMP phosphodiesterase
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cyclic guanosine 3',5'-monophosphate phosphodiesterase
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cyclic guanosine 3',5'-phosphate phosphodiesterase
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guanosine cyclic 3',5'-phosphate phosphodiesterase
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phosphodiesterase cGMP
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phosphodiesterase, guanosine cyclic 3',5'-phosphate
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hydrolysis of phosphoric ester
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3',5'-cyclic-GMP 5'-nucleotidohydrolase
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guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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cGMP + H2O
5'-GMP
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degradation of intracellular cGMP
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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very low activity with cAMP
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?
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guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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?
guanosine 3',5'-cyclic phosphate + H2O
guanosine 5'-phosphate
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very low activity with cAMP
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?
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Mg2+
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required for activity, maximal activity at 3-10 mM MgCl2
Mn2+
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approx. 2.5fold higher activation than with Mg2+, maximal activity at 3-10 mM Mn2+
additional information
Zn+-binding motif
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3-isobutyl-1-methylxanthine
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0.06 mM, 50% inhibition
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additional information
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not activated by 8-bromo-cGMP
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0.00022
cGMP
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0.005
cGMP
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isoform PDE5, high affinity form, pH 7.0, 22°C
0.02
cGMP
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isoform PDE5, low affinity form, pH 7.0, 22°C
0.8
cGMP
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isoform PDE6, high affinity form, pH 7.0, 22°C
1.6
cGMP
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isoform PDE6, low affinity form, pH 7.0, 22°C
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strains NC4, XP55 and NP377
SwissProt
brenda
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PDE5_DICDI
867
0
97992
Swiss-Prot
other Location (Reliability: 5)
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expression of PdeD-YFP fusion protein in Escherichia coli and Dictyostelium
expression of DdPDE3 catalytic domain in Escherichia coli and Dictyostelium
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Kuwayama, H.; Snippe, H.; Derks, M.; Roelofs, J.; Van Haastert, P.J.
Identification and characterization of DdPDE3, a cGMP-selective phosphodiesterase from Dictyostelium
Biochem. J.
353
635-644
2001
Dictyostelium discoideum
brenda
Meima, M.E.; Biondi, R.M.; Schaap, P.
Identification of a novel type of cGMP phosphodiesterase that is defective in the chemotactic stmF mutants
Mol. Biol. Cell
13
3870-3877
2002
Dictyostelium discoideum (Q8MLZ3)
brenda
Bader, S.; Kortholt, A.; Van Haastert, P.J.
Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP
Biochem. J.
402
153-161
2007
Dictyostelium discoideum
brenda
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
