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Information on EC 3.1.4.3 - phospholipase C and Organism(s) Burkholderia pseudomallei and UniProt Accession Q9RGS8

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.3 phospholipase C
IUBMB Comments
The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
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This record set is specific for:
Burkholderia pseudomallei
UNIPROT: Q9RGS8
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Word Map
The taxonomic range for the selected organisms is: Burkholderia pseudomallei
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
phospholipase c, plc, hemolysin, pc-plc, lecithinase, phosphatidylcholine-specific phospholipase c, plcbeta, plcg2, beta toxin, plcg1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphatidylcholine-hydrolyzing phospholipase C
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alpha-toxin
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-
-
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Beta toxin
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-
-
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Beta-hemolysin
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-
-
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Beta-toxin
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-
-
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Cbp
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-
-
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Clostridium oedematiens beta- and gamma-toxins
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-
-
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Clostridium welchii alpha-toxin
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-
-
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Gamma-toxin
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-
-
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Heat labile-hemolysin
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-
-
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heat-labile hemolysin
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-
-
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Hemolysin
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-
-
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Lecithinase
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-
-
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lecithinase C
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-
-
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lipophosphodiesterase C
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-
-
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lipophosphodiesterase I
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-
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MTP40 antigen
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-
-
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PC-PLC
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-
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phosphatidase C
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Phosphatidylcholine cholinephosphohydrolase
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-
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PLC
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-
-
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SMase
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-
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sphingomyelinase
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine cholinephosphohydrolase
The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-86-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
show the reaction diagram
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
77000
x * 77000, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 77000, calculated
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
proteolytic modification
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
more |
isoform Plc-2 inactivation mutant shows decreased extracellular enzyme activity. Plc-2 is involved in plaque formationand has a significant role in host cell cytotoxicity
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Korbsrisate, S.; Suwanasai, N.; Leelaporn, A.; Ezaki, T.; Kawamura, Y.; Sarasombath, S.
Cloning and characterization of a nonhemolytic phospholipase C gene from Burkholderia pseudomallei
J. Clin. Microbiol.
37
3742-3745
1999
Burkholderia pseudomallei (Q9RGS8), Burkholderia pseudomallei
Manually annotated by BRENDA team
Korbsrisate, S.; Tomaras, A.P.; Damnin, S.; Ckumdee, J.; Srinon, V.; Lengwehasatit, I.; Vasil, M.L.; Suparak, S.
Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei
Microbiology
153
1907-1915
2007
Burkholderia pseudomallei (Q9RGS8), Burkholderia pseudomallei
Manually annotated by BRENDA team