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Information on EC 3.1.4.2 - glycerophosphocholine phosphodiesterase
for references in articles please use BRENDA:EC3.1.4.2
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.2 glycerophosphocholine phosphodiesterase
IUBMB Comments
Also acts on sn-glycero-3-phosphoethanolamine.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
- 3.1.4.2
- surfactant
- pulmonary
- influenza
- haemophilus
- pneumonia
- alveolar
- pneumococcal
- lectin
-
collectins
-
lavage
- children
- airway
-
bronchoalveolar
-
c-type
-
phid-cv
- otitis
-
interstitial
- infant
-
serotypes
- collagen
-
10-valent
-
non-typeable
- bal
-
agglutination
- nasopharyngeal
-
booster
-
mannose-binding
-
protein-d
-
conglutinin
-
clara
-
distress
-
surfactant-associated
- diagnostics
-
pneumolysin
-
mannan-binding
- toxoid
-
reactogenicity
- medicine
-
airspace
-
serotype-specific
-
spirometry
- emphysema
-
collagen-like
-
non-vaccine
-
dodecamers
-
lung-specific
-
glaxosmithkline
-
choline-binding
- proteinosis
-
opsonophagocytic
- biotechnology
-
lungen-6
-
srage
- drug development
Synonyms
protein d, gdpd5, glycerophosphodiesterase, gdpase, enpp6, glycerophosphocholine phosphodiesterase, gpx-pde, gdpd6, gpc diesterase, gpc:choline phosphodiesterase, more
top
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
GDE5
glycerolphosphorylcholine phosphodiesterase
-
-
-
-
glycerophosphinicocholine diesterase
-
-
-
-
glycerophosphocholinehydrolase
-
-
-
-
glycerophosphodiester phosphodiesterase
glycerophosphodiesterase
glycerylphosphorylcholinediesterase
-
-
-
-
GP-PDE
GPC diesterase
GPC:choline phosphodiesterase
GroPChoPDE
sn-glycero 3-phosphorylcholine diesterase
-
-
-
-
additional information
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
sn-glycero-3-phosphocholine + H2O = choline + sn-glycerol 3-phosphate
also acts on sn-glycero 3-phosphoethanolamine
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
hydrolysis of phosphoric ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
phosphatidylcholine resynthesis via glycerophosphocholine, phospholipid remodeling (phosphatidylethanolamine, yeast)
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SYSTEMATIC NAME
IUBMB Comments
sn-glycero-3-phosphocholine glycerophosphohydrolase
Also acts on sn-glycero-3-phosphoethanolamine.
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CAS REGISTRY NUMBER
COMMENTARY
9025-85-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2,2-trimethylpropyl methylphosphonate + H2O
3,3-dimethylbutan-2-ol + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
4-nitrophenyl ethylphosphonate + H2O
4-nitrophenyl + ethylphosphonate
-
Substrates: -
Products: -
Products: -
ir
4-nitrophenyl methylphosphonate + H2O
4-nitrophenyl + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
4-nitrophenyl phenyl phosphate + H2O
4-nitrophenol + phenyl phosphate
-
Substrates: -
Products: -
Products: -
ir
4-nitrophenyl phenyl phosphonate + H2O
4-nitrophenol + phenyl phosphonate
-
Substrates: -
Products: -
Products: -
ir
4-nitrophenylphosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
ir
bis(4-nitrophenyl) phosphate + H2O
4-nitrophenol + phosphate
-
Substrates: -
Products: -
Products: -
ir
choline lysoplasmalogen + H2O
choline + 1-(1-alkenyl)-sn-glycero-3-phosphate
Substrates: preferred substrate, i.e. 1-O-1'-(Z)-octadecenyl-2-hydroxy-sn-glycero-3-phosphocholine
Products: -
Products: -
?
diethyl phosphate + H2O
ethanol + ethyl phosphate
-
Substrates: -
Products: -
Products: -
ir
dimethyl phosphate + H2O
methanol + methyl phosphate
-
Substrates: -
Products: -
Products: -
ir
ethanolamine lysoplasmalogen + H2O
ethanolamine + 1-(1-alkenyl)-sn-glycero-3-phosphate
Substrates: modest activity, i.e. 1-O-1'-(Z)-octadecenyl-2-hydroxy-sn-glycero-3-phosphoethanolamine
Products: -
Products: -
?
ethyl 4-nitrophenyl phosphate + H2O
4-nitrophenol + ethyl phosphate
-
Substrates: -
Products: -
Products: -
ir
ethyl methyl 4-nitrophenyl phosphate + H2O
?
-
Substrates: -
Products: -
Products: -
ir
ethyl methylphosphonate + H2O
ethanol + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
glycerophosphocholine + H2O
glycerol 1,2-cyclic phosphate + choline
-
Substrates: -
Products: -
Products: -
?
glycerophosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
glycerophosphoglycerol + H2O
glycerol + glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
glycerophosphoserine + H2O
L-serine + glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
glycerophosphoserine + H2O
serine + glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
isobutyl methylphosphonate + H2O
isobutanol + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
isopropyl 4-nitrophenyl phosphate + H2O
4-nitrophenol + isopropyl phosphate
-
Substrates: -
Products: -
Products: -
ir
isopropyl methylphosphonate + H2O
isopropanol + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
methyl 4-nitrophenyl phosphate + H2O
4-nitrophenol + methyl phosphate
-
Substrates: -
Products: -
Products: -
ir
O-ethyl S-[2-(ethylsulfanyl)ethyl] hydrogen thiophosphate + H2O
?
-
Substrates: -
Products: -
Products: -
ir
p-nitrophenylphosphocholine + H2O
p-nitrophenol + phosphocholine
-
Substrates: -
Products: single enzyme utilizing both glycerophosphocholine and p-nitrophenylphosphocholine as substrates
Products: single enzyme utilizing both glycerophosphocholine and p-nitrophenylphosphocholine as substrates
?
paraoxon + H2O
4-nitrophenol + diethyl phosphate
-
Substrates: -
Products: -
Products: -
ir
phenyl methylphosphonate + H2O
phenol + methylphosphonate
-
Substrates: -
Products: -
Products: -
ir
polyglycerophosphate + H2O
glycerol + sn-glycerol 3-phosphate
-
Substrates: exhibits a structural requirement for phosphodiester bonds between adjacent glycerol units
Products: -
Products: -
?
S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl thiophosphate + H2O
?
-
Substrates: -
Products: -
Products: -
ir
S-[2-(ethylsulfanyl)ethyl] O-methyl hydrogen thiophosphate + H2O
?
-
Substrates: -
Products: -
Products: -
ir
S-[2-[bis(1-methylethyl)amino]ethyl] O-ethyl hydrogen thiophosphate + H2O
?
-
Substrates: -
Products: -
Products: -
ir
sn-glycero-3-phosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphoethanolamine + H2O
sn-glycerol-3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphoinositol + H2O
sn-glycerol-3-phosphate + inositol
-
Substrates: -
Products: -
Products: -
?
glycero-3-phosphoethanolamine + H2O
sn-glycerol-3-phosphate + ethanolamine
-
Substrates: hydrolysis of the 3'-5' phosphodiester bond
Products: -
Products: -
?
glycero-3-phosphoethanolamine + H2O
sn-glycerol-3-phosphate + ethanolamine
-
Substrates: also active on phosphomonoester, phosphodiester, phosphotriester and phosphorothiolate substrates
Products: -
Products: -
?
glycerophosphoethanolamine + H2O
glycerol 1,2-cyclic phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
glycerophosphoethanolamine + H2O
glycerol 1,2-cyclic phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
glycerophosphoinositol + H2O
inositol + glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
glycerophosphoinositol + H2O
inositol + glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
glycerophosphoinositol + H2O
inositol + glycerol 3-phosphate
-
Substrates: preferred substrate of inositol-starved yeast
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: produces glycolysable substrates that may shift the metabolic activity to the glycolytic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: maintenance to intracellular osmotic balance
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: enzyme amount decreases in dietary choline deficiency
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: only found in autopsied tissue
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: exclusive substrates
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
sn-glycerol 3-phosphate + ethanolamine
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
Substrates: specific substrate
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: glycerophosphodiester phosphodiesterase hydrolyzes glycerophosphodiesters into sn-glycerol-3-phosphate and the corresponding alcohols. AtGDPD1 and AtGDPDL1 hydrolyze glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine
Products: -
Products: -
?
additional information
?
-
-
Substrates: physiological role of enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: GPX-PDE1 shows catalytic activity with glycerophosphocholine while GPX-PDE2 shows highest activity with glycerophosphoinositol
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme shows no significant activity with glycerophosphoglycerol, GroPIns, and glycerophosphoserine as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: the enzyme shows no significant activity with glycerophosphoglycerol, GroPIns, and glycerophosphoserine as substrates
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycero-3-phosphoethanolamine + H2O
sn-glycerol-3-phosphate + ethanolamine
-
Substrates: hydrolysis of the 3'-5' phosphodiester bond
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
sn-glycerol 3-phosphate + choline
-
Substrates: -
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: produces glycolysable substrates that may shift the metabolic activity to the glycolytic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: maintenance to intracellular osmotic balance
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: enzyme amount decreases in dietary choline deficiency
Products: -
Products: -
?
sn-glycero 3-phosphorylcholine + H2O
?
-
Substrates: cellular phosphatidylcholine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero 3-phosphorylethanolamine + H2O
?
-
Substrates: cellular phosphatidyethanolamine catabolic pathway
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
Substrates: specific substrate
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
sn-glycero-3-phosphocholine + H2O
choline + sn-glycerol 3-phosphate
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: glycerophosphodiester phosphodiesterase hydrolyzes glycerophosphodiesters into sn-glycerol-3-phosphate and the corresponding alcohols. AtGDPD1 and AtGDPDL1 hydrolyze glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine
Products: -
Products: -
?
additional information
?
-
-
Substrates: physiological role of enzyme
Products: -
Products: -
?
additional information
?
-
-
Substrates: GPX-PDE1 shows catalytic activity with glycerophosphocholine while GPX-PDE2 shows highest activity with glycerophosphoinositol
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Co2+
Cu2+
Mg2+
Mn2+
Zn2+
Ca2+
-
stimulation of glycero 3-phosphocholine breakdown, but decrease of glycerol 1,2-cyclic phosphate production
Ca2+
-
6-fold activation at 5 mM, 2-fold activation at 0.1 mM with sigmoidal kinetic charactaristics
Ca2+
the enzyme is activated in the presence of 0.5-10 mM Ca2+
Co2+
-
the enzyme shows maximum activity at very low concentrations (less than 0.05 mM) of Co2+
Mg2+
-
preferred cofactor. The enzyme activity increases with increasing concentrations of Mg2+ (up to 3 mM)
Mg2+
-
stimulation of glycero 3-phosphocholine breakdown, but decrease of glycerol 1,2-cyclic phosphate production
Mn2+
-
specific acitivity towards bis(4-nitrophenyl) phosphate is enhanced 4fold in presence of MnCl2
Mn2+
-
the enzyme shows maximum activity at very low concentrations (less than 0.05 mM) of Mn2+
Zn2+
-
activity of enzyme with Zn2+ 30 fold less than with Co2+ with substrate bis(p-nitro-phenyl)phosphate
Zn2+
-
specific acitivity towards bis(4-nitrophenyl) phosphate is enhanced 2fold in presence of ZnCl2
Zn2+
-
stimulation of glycero 3-phosphocholine breakdown, but decrease of glycerol 1,2-cyclic phosphate production
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-stearoyl-2-hydroxy-sn-glycero-3-phosphate
89.8% residual activity at 4 mM
2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-(1-benzyl-2-oxo-2-thiazol-2-yl-ethyl)-acetamide
-
-