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Information on EC 3.1.4.17 - 3',5'-cyclic-nucleotide phosphodiesterase and Organism(s) Mus musculus and UniProt Accession Q01065
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3.1.4.17 3',5'-cyclic-nucleotide phosphodiesteraseIUBMB Comments
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
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Word Map
- 3.1.4.17
- cyclase
- adenylate
- rolipram
- cardiac
- artery
- pka
- guanosine
- agonist
-
camp-dependent
- forskolin
- ibmx
-
contractile
-
adenylyl
- theophylline
- milrinone
- cilostazol
- platelet
- isoproterenol
- prostaglandin
- striatal
-
schizophrenia
- 3-isobutyl-1-methylxanthine
-
vasodilator
- zaprinast
- papaverine
-
inotropic
- dipyridamole
-
spiny
-
camp-mediated
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beta-adrenergic
-
guanylyl
- sildenafil
- 3',5'-monophosphate
-
prkar1a
-
cardiotonic
- phosphodiesterase-4
- amrinone
- isobutylmethylxanthine
- trifluoperazine
- isoprenaline
-
bronchodilator
- methylxanthines
-
low-km
-
antilipolytic
- ehna
- aminophylline
- roflumilast
- molecular biology
- vardenafil
- medicine
- tadalafil
-
camp-elevating
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
pde4d, cyclic nucleotide phosphodiesterase, pde10a, camp phosphodiesterase, pde3a, pde3b, pde2a, camp-pde, phosphodiesterase 3, pde11a, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3',5'-cyclic nucleoside monophosphate phosphodiesterase
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-
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3',5'-cyclonucleotide phosphodiesterase
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-
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3',5'-nucleotide phosphodiesterase
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3':5'-CNP
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3':5'-cyclic nucleotide 5'-nucleotidohydrolase
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61 kDa Cam-PDE
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-
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63 kDa Cam-PDE
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Cam-PDE 1A
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-
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Cam-PDE 1B
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-
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Cam-PDE 1C
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-
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CGB-PDE
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-
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CGIP1
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-
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CGIPDE1
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cGMP-binding cGMP-specific phosphodiesterase
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-
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CGS-PDE
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cGSPDE
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-
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cyclic 3',5'-mononucleotide phosphodiesterase
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cyclic 3',5'-nucleotide phosphodiesterase
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cyclic 3',5'-phosphodiesterase
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cyclic 3',5-nucleotide monophosphate phosphodiesterase
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Cyclic GMP stimulated phosphodiesterase
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cyclic nucleotide phosphodiesterase
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DPDE1
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DPDE2
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DPDE3
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DPDE4
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Dunce protein
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-
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GMP-PDE alpha
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GMP-PDE beta
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GMP-PDE delta
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GMP-PDE gamma
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HCP1
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High-affinity cAMP phosphodiesterase
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Learning/ memory process protein
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Low-affinity cAMP phosphodiesterase
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MMPDE8
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nucleoside 3',5'-cyclic phosphate diesterase
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nucleoside-3',5-monophosphate phosphodiesterase
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p17 protein
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P2A
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PDE V-B1
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PDE V-C1
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PDE21
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PDE32
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PDE43
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PDE46
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PDEase
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PDEase regA
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phosphodiesterase, cyclic 3',5'-nucleotide
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TM22
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
CAS REGISTRY NUMBER
COMMENTARY
9040-59-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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isoform PDE2 regulates the basal cGMP concentration in thalamic neuron
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?
additional information
?
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PDE1 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response
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?
additional information
?
-
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function
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?
additional information
?
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-
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
isoform PDE2 regulates the basal cGMP concentration in thalamic neuron
-
-
?
additional information
?
-
-
PDE1 in Pukinje neurons may play a role in limiting the cGMP-mediated long-term depression response
-
-
?
additional information
?
-
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function
-
-
?
additional information
?
-
-
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
BAY60-7550
inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons
erythro-9-(2-hydroxy-3-nonyl)adenine
inhibition of isoform PDE2, results in increase in basal cGMP levels after application to thalamic neurons
ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid
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soluble but not particulate form
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
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soluble but not particulate form
additional information
-
the oxidant t-butylhydroperoxide signifcantly increases the cytosolic calcium concentration, which is prevented by inhibition of enzyme isoform PDE1. Inhibition of both isoforms PDE1 and PDE4 completely prevent the t-butylhydroperoxide stimulated TNF-alpha release
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
biphasic behaviour with 3',5'-cAMP as substrate
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0003
5-(2-propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10
living thalamic neurons, expression of enzyme isoforms PDE1, PDE2, PDE9, and PDE10
PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm
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isoforms PDE1B, PDE1C, PDE2A, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B does not change with age. Age-related increases in PDE11A4, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents, as are age-related increases in PDE8A3 protein expression in the striatum
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age-related increases in isoforms PDE11A4, and PDE1C1 protein expression are confirmed in hippocampus of old versus young rodents
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
PDE9A localizes to the membrane in all organs except the bladder
additional information
-
spatial and temporal expression profiles of PDE1A, PDE1B, PDE1C and their physiological roles
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
blockade of isoform PDE2 promotes cGMP signaling to offset the pathogenesis of experimental heart failure (induced by pressure overload or sympathetic hyperactivation), reversing the development of left ventricular hypertrophy, compromised contractility, and cardiac fibrosis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PDE1B_MOUSE
535
0
61226
Swiss-Prot
other Location (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme mRNA expression/localization dramatically changes across neurodevelopment
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isoforms PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A does not change with age
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
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reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryan, J.A.; Toscano, W.A.
Multiple forms of cyclic nucleotide phosphodiesterase in a murine adrenal cortex cell line (Y-1)
Arch. Biochem. Biophys.
241
403-412
1985
Mus musculus
Giorgi, M.; Caniglia, C.; Scarsella, G.; Augusti-Tocco, G.
Characterization of 3':5' cyclic nucleotide phosphodiesterase activities of mouse neuroblastoma N18TG2 cells
FEBS Lett.
324
76-80
1993
Mus musculus
Yan, C.; Zhao, A.Z.; Sonnenburg, W.K.; Beavo, J.A.
Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis
Biol. Reprod.
64
1746-1754
2001
Mus musculus
Vasta, V.; Sonnenburg, W.K.; Yan, C.; Soderling, S.H.; Shimizu-Albergine, M.; Beavo, J.A.
Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm
Biol. Reprod.
73
598-609
2005
Mus musculus (Q61481), Mus musculus
Bender, A.T.; Beavo, J.A.
Specific localized expression of cGMP PDEs in Purkinje neurons and macrophages
Neurochem. Int.
45
853-857
2004
Mus musculus
Hepp, R.; Tricoire, L.; Hu, E.; Gervasi, N.; Paupardin-Tritsch, D.; Lambolez, B.; Vincent, P.
Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons
J. Neurochem.
102
1875-1886
2007
Mus musculus (Q01065)
Brown, D.M.; Hutchison, L.; Donaldson, K.; MacKenzie, S.J.; Dick, C.A.; Stone, V.
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
Toxicol. Lett.
168
1-6
2007
Homo sapiens, Mus musculus
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
Patel, N.S.; Klett, J.; Pilarzyk, K.; Lee, D.I.; Kass, D.; Menniti, F.S.; Kelly, M.P.
Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span
Neurobiol. Aging
65
217-234
2018
Homo sapiens, Mus musculus
Baliga, R.S.; Preedy, M.E.J.; Dukinfield, M.S.; Chu, S.M.; Aubdool, A.A.; Bubb, K.J.; Moyes, A.J.; Tones, M.A.; Hobbs, A.J.
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure
Proc. Natl. Acad. Sci. USA
115
E7428-E7437
2018
Mus musculus (Q922S4), Mus musculus
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