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EC Tree
IUBMB CommentsActs on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
The taxonomic range for the selected organisms is: Escherichia coli
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
pde4d, cyclic nucleotide phosphodiesterase, pde10a, camp phosphodiesterase, pde3a, pde3b, pde2a, camp-pde, phosphodiesterase 3, pde11a,
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3',5'-cyclic nucleoside monophosphate phosphodiesterase
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3',5'-cyclonucleotide phosphodiesterase
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3',5'-nucleotide phosphodiesterase
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3':5'-cyclic nucleotide 5'-nucleotidohydrolase
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cGMP-binding cGMP-specific phosphodiesterase
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cyclic 3',5'-mononucleotide phosphodiesterase
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cyclic 3',5'-nucleotide phosphodiesterase
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cyclic 3',5'-phosphodiesterase
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cyclic 3',5-nucleotide monophosphate phosphodiesterase
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Cyclic GMP stimulated phosphodiesterase
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cyclic nucleotide phosphodiesterase
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High-affinity cAMP phosphodiesterase
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Learning/ memory process protein
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Low-affinity cAMP phosphodiesterase
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nucleoside 3',5'-cyclic phosphate diesterase
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nucleoside-3',5-monophosphate phosphodiesterase
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phosphodiesterase, cyclic 3',5'-nucleotide
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nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate
mechanism
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hydrolysis of phosphoric ester
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3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
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additional information
requires a divalent metal ion
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dithiothreitol
or other reductant, required
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computational analysis
SwissProt
brenda
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Richter, W.
3',5'-Cyclic nucleotide phosphodiesterases class III: members, structure, and catalytic mechanism
Proteins Struct. Funct. Genet.
46
278-286
2002
Escherichia coli (P0A8Z7)
brenda
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
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