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1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
arachidonoylphosphatidylinositol + H2O
myo-inositol 1-phosphate + 1,2-diarachidonoylglycerol
-
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + glycerophosphoinositol + phosphate + ?
-
-
ratio between products decreased with increasing pH, 1D-myo-inositol 1,2-cyclic phosphate is also formed
-
?
phosphatidylinositol + H2O
?
phosphatidylinositol + H2O
diacylglycerol + 1D-myo-inositol 1-phosphate
-
enzyme is specific for phosphatidylinositol
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
?
-
enzyme activities for phosphatidylinositol 4,5-bisphosphate are strongly dependent on the relative levels of calcium and pH in the assay buffer
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
phosphatidylinositol 4-phosphate
?
phosphatidylinositol 4-phosphate + H2O
1D-myo-inositol 4,5-bisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4-phosphate + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
additional information
?
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
domain structures of PLCbeta, -gamma and -delta isoenzymes
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-delta1, structure of the catalytic domain, His-311 and His-356 act as general acid-base catalysts
4- and 5-phosphoryl groups of inositol 1,4,5-trisphosphate interact with the side chains of Lys-32 and Lys-57 and with those of Lys-30, Arg-40 and Lys-57 of PLC-delta1, respectively
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
key enzyme in signal transduction generating the intracellular second messengers DAG and IP3
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
amino acids Pro500 and His503 are critical for binding of PLC-gamma1 to one of its substrates, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate in the membrane
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC beta1b
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-delta1
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC-gamma1
-
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
interaction analysis, modeling and binding kinetics of substrate and enzyme PH-PLCdelta1, overview. PH-PLCdelta1 binds specifically to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, breaking up clusters and expelling nonspecifically associated peptide from the surface
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
1D-myo-inositol 1,2-cyclic-phosphate is also formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in vitro also 1D-myo-inositol 1,2-cyclic phosphate formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
-
in vitro also inositol cyclic monophosphate formed
-
?
phosphatidylinositol + H2O
1D-myo-inositol 1-phosphate + diacylglycerol
-
enzyme hydrolyses both membrane-bound and extracted phosphatidylinositol
in vitro myo-inositol 1,2-cyclic phosphate, myo-inositol 1-phosphate, and glycerophosphoinositol in the molar proportions approx. 2:1:1
-
?
phosphatidylinositol + H2O
?
-
-
-
-
?
phosphatidylinositol + H2O
?
-
-
-
?
phosphatidylinositol + H2O
?
-
phosphatidylinositol 4,5-bisphosphate is a better substrate
-
-
?
phosphatidylinositol + H2O
?
-
PLC-delta1, structure of the catalytic domain
-
?
phosphatidylinositol + H2O
?
-
low molecular weight PLC hydrolyzes both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate, high molecular PLC shows much greater activity against phosphatidylinositol than phosphatidylinositol 4,5-bisphosphate
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
isoenzyme PLC beta1 produces 21% inositol 1:2,4,5 cyclic trisphosphate at pH 5.5 and 7.5% at pH 7.0
?
phosphatidylinositol 4,5-bisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
phosphatidylinositol 4-phosphate
?
-
-
-
-
?
phosphatidylinositol 4-phosphate
?
-
enzyme attacks phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-phosphate with equal facility
-
-
?
additional information
?
-
PLCepsilon contains a GTP exchange factor and two C-terminal Ras-binding domains
-
?
additional information
?
-
-
regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and betagamma subunits is dependent of enzyme subtype and concentration of Mg2+
-
-
?
additional information
?
-
-
the inositol lipid breakdown is controlled by different phosphoinositidase C isoenzymes in various cell compartments
-
-
?
additional information
?
-
-
the activation of the enzyme by m3-mascarinic acid receptor stimulation is mediated via alpha-subunit of the Gq/11 family of G-proteins
-
-
?
additional information
?
-
-
perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown
-
-
?
additional information
?
-
-
transformation-linked and progression-linked signal transduction enzyme
-
-
?
additional information
?
-
-
hepatocyte growth factor can activate phosphoinositidase C in rat hepatocytes
-
-
?
additional information
?
-
-
cellular signaling
-
?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
-
?
additional information
?
-
-
activation of phospholipase C is a vital step in the neuronal protective adenosine-induced signal transduction pathway, conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
-
-
?
additional information
?
-
-
Galpha12712- and Rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors
-
-
?
additional information
?
-
-
interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
-
-
?
additional information
?
-
-
PLC activity is under tight dynamic control of the Ca2+ concentration. In insulin-secreting beta-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion
-
-
?
additional information
?
-
-
reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders
-
-
?
additional information
?
-
-
inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
-
-
?
additional information
?
-
overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
-
PLC activity in vascular smooth muscle cells can be divided into two types based on their calcium and pH requirements, substrate preferences, and molecular weights
-
-
?
additional information
?
-
-
several different assay conditions for both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate are tested on samples of crude supernatant for their ability to support PLC activity
-
-
?
additional information
?
-
-
the injection fraction shows no activity against phosphatidylcholine
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
additional information
?
-
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
-
products are two second messengers
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
key enzyme in signal transduction generating the intracellular second messengers DAG and IP3
second messengers
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes
second messengers
?
additional information
?
-
-
regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and betagamma subunits is dependent of enzyme subtype and concentration of Mg2+
-
-
?
additional information
?
-
-
the inositol lipid breakdown is controlled by different phosphoinositidase C isoenzymes in various cell compartments
-
-
?
additional information
?
-
-
the activation of the enzyme by m3-mascarinic acid receptor stimulation is mediated via alpha-subunit of the Gq/11 family of G-proteins
-
-
?
additional information
?
-
-
perturbation in a membrane in vivo equivalent to a non-bilayer configuration is sufficient to induce phosphodiesterase-catalyzed phosphatidylinositol 4,5-diphosphate breakdown
-
-
?
additional information
?
-
-
transformation-linked and progression-linked signal transduction enzyme
-
-
?
additional information
?
-
-
hepatocyte growth factor can activate phosphoinositidase C in rat hepatocytes
-
-
?
additional information
?
-
-
cellular signaling
-
?
additional information
?
-
PLCepsilon is a Ras effector, directly regulated by Ras and links two critical signaling pathways
-
?
additional information
?
-
-
activation of phospholipase C is a vital step in the neuronal protective adenosine-induced signal transduction pathway, conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
-
-
?
additional information
?
-
-
Galpha12712- and Rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors
-
-
?
additional information
?
-
-
interaction of phospholipase C-beta1 with cell polarity Par proteins may serve as a nexus to transduce extracellular signals to transcriptional reguation through G-protein-mediated signaling pathway in cell polarity and cell asymmetric division
-
-
?
additional information
?
-
-
PLC activity is under tight dynamic control of the Ca2+ concentration. In insulin-secreting beta-cells, this mechanism provides a link between Ca2+ influx and release from intracellular stores that may be important in the regulation of insulin secretion
-
-
?
additional information
?
-
-
reduction in phospholipase C may be critical in the pathophysiology of depression and other stress-related disorders
-
-
?
additional information
?
-
-
inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
-
-
?
additional information
?
-
overview: role of nuclear PI-PLCbeta1 in cell proliferation and differentiation
-
-
?
additional information
?
-
-
PLC eta enzyme influences intracellular Ca 2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of G-protein-coupled receptor regulation likely mediates G-protein-coupled receptor signalling pathways
-
-
?
additional information
?
-
-
PLC activity in vascular smooth muscle cells can be divided into two types based on their calcium and pH requirements, substrate preferences, and molecular weights
-
-
?
additional information
?
-
-
several different assay conditions for both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate are tested on samples of crude supernatant for their ability to support PLC activity
-
-
?
additional information
?
-
-
the injection fraction shows no activity against phosphatidylcholine
-
-
?
additional information
?
-
-
PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine
-
histamine-induced elevation of plasma noradrenaline and adrenaline is dose-dependently reduced by ET-18-OCH3
aggregated amyloid beta protein
-
full-length Abeta 1-40, aggregated form inhibits Ca2+-regulated phosphoinositide degradation by cytosolic and membrane-bound PLC by 30-40%, inhibitor may interact with the Ca2+-binding site of enzyme, no inhibition by nonaggregated soluble full-length amyloid beta protein
-
Blood lipoprotein
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
Blood plasma
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
Blood serum
-
enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins
-
choline plasmalogen
-
18.5% of choline plasmalogen is needed for 50% inhibition
lysocholine plasmalogen
-
8.5% of choline plasmalogen is needed for 50% inhibition
-
NaCl
-
inhibits phosphatidylinositol hydrolysis of low molecular weight PLC. Conversely, PIP2 hydrolysis is stimulated by increasing concentrations of NaCl
sphingomyelin
-
50% inhibition at low concentration, and 97% at high concentration
sphingosylphosphocholine
-
-
stearoyl sphingomyelin
-
-
lysophosphatidylcholine
-
C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length
lysophosphatidylcholine
-
50% inhibition is produced by 7% molar
phosphatidylcholine
-
the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate
phosphatidylcholine
-
little effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine
U-73122
-
U-73122
-
histamine-induced elevation of plasma noradrenaline and adrenaline is dose-dependently reduced by U-73122
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
-
regulation of the PLC delta isoenzymes, under hyperoxia conditions acrylonitrile decreases PLC delta1 level, PLC delta4 gene is down-regulated after spinal cord injury
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
increases in PLC beta1, beta3, gamma1, and delta1 activities and gene expression in response to norepinephrine are prevented by prazosin, an alpha1-adrenoceptor antagonist
-
additional information
-
mepacrine (PLA2 inhibitor) and D609 (phosphatidylcholine-specific PLC inhibitor) have no effect. Histamine-induced elevation of plasma noradrenaline and adrenaline is also dose-dependently reduced by RHC-80267 (diacylglycerol lipase inhibitor)
-
additional information
-
enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory
-
additional information
-
phosphatidic acid does not inhibit
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
albumin
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
-
Ca2+
-
requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+
cytochrome c
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
decanoylglycerophosphate
-
only little activating effect
decanoyllysophosphatidylcholine
-
C10 lysophosphatidylcholine activates the reaction
diacylglycerol
-
5-6fold stimulation of rat brain phosphatidylinositol phosphodiesterase. The addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol
dihexanoylglycerophosphocholine
-
-
Epidermal growth factor
stimulates PLCepsilon overexpressed in COS-7 cells
histone
-
maximal activation of hydrolysis of phosphatidylinositol 4,5-diphosphate at 0.0125 mg/ml
oleic acid
-
causes a marked stimulation of the enzyme activity when the membrane-bound substrate is used
oleoylglycerophosphate
-
activates the hydrolysis at a physiological pH
palmitoylglycerophosphate
-
activates the hydrolysis at a physiological pH
phosphatidic acid
-
activates the hydrolysis at a physiological pH
phosphatidylethanolamine
-
activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase
Q61L H-Ras
constitutively active Q61L H-Ras stimulates PLCepsilon co-expressed in COS-7 cells in parallel with Ras binding
-
RhoA
-
PLC-epsilon is a direct downstream efector for RhoA. RhA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase
soluble amyloid beta protein fragment 25-35
-
activates PI-PLC
-
deoxycholate
-
-
deoxycholate
-
required for activity with membrane-bound phosphatidylinositol, slight stimulation with isolated phosphatidylinositol
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
-
rat brain protein kinase C phosphorylates phosphoinositidase gamma but not phosphoinositidase beta1. Incubation with the kinase increases the activity of both enzymes however, possibly by phosphorylation of another protein in the preparations
-
additional information
-
regulation of the PLC delta isoenzymes, acrylonitrile causes a significant increase in PLC delta1 level in the heart and cytosol of cerebral cortex
-
additional information
study of PLCepsilon activation by several Ras mutants, recombinant purified PLCepsilon is not activated by Galpha-q, Gbetagamma or H-Ras in vitro
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
norepinephrine increases PLC beta1, beta3, gamma1, and delta1 isozyme gene expression
-
additional information
-
sodium lauryl sulfate, tetradecyl-trimethylammonium bromide, and Triton X-100 do not activate phosphatidylinositol phosphodiesterase in the presence of Ca2+
-
additional information
-
the enzyme is not stimulated by sodium deoxycholate
-
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Divecha, N.; Rhee, S.G.; Letcher, A.J.; Irvine, R.F.
Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinoeitidase C isoform beta1 is specifically, but not predominantly located in the nucleus
Biochem. J.
289
617-620
1993
Rattus norvegicus
-
brenda
Irvine, R.F.; Letcher, A.J.; Dawson, R.M.C.
Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms
Biochem. J.
218
177-185
1984
Rattus norvegicus
brenda
Yang, H.; Shen, F.; Herenyiova, M.; Weber, G.
Phospholipase C (EC 3.1.4.11): A malignancy linked signal transduction enzyme
Anticancer Res.
18
1399-1404
1998
Rattus norvegicus
brenda
Downes, C.P.; Michell, R.H.
The polyphosphoinositide phosphodiesterase of erythrocyte membranes
Biochem. J.
198
133-140
1981
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
brenda
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Rattus norvegicus
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Rattus norvegicus
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Rattus norvegicus
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Rattus norvegicus
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Rattus norvegicus
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Nature
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1996
Rattus norvegicus
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Homo sapiens, Rattus norvegicus
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Shute, J.K.; Smith, M.E.
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Mus musculus, Mus musculus C57BL, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
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Shute, J.K.; Smith, M.E.
Soluble phosphatidylinositol phosphodiesterase in normal and denervated fast and slow muscles of the rat
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Rattus norvegicus
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Schwertz, D.W.; Kreisberg, J.I.; Venkatachalam, M.A.
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Rattus norvegicus
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Hirasawa, K.; Irvine, R.F.; Dawson, R.M.C.
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Rattus norvegicus
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Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
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1980
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Quinn, P.J.; Barenholz, Y.
A comparison of the activity of phosphatidylinositol phosphodiesterase against substrate in dispersions and as monolayers at the air-water interface
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Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
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Homo sapiens, Mammalia, Rattus norvegicus, Rattus norvegicus PLC-delta1
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Rattus norvegicus (Q99P84), Rattus norvegicus PLCepsilon (Q99P84)
brenda
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Aggregated beta amyloid peptide 1-40 decreases Ca2+- and cholinergic receptor-mediated phosphoinositide degradation by alteration of membrane and cytosolic phospholipase C in brain cortex
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Arabidopsis thaliana, Saccharomyces cerevisiae, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae PLC1p
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Rattus norvegicus
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Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
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Kim, S.K.; Wee, S.M.; Chang, J.S.; Kwon, T.K.; Min do, S.; Lee, Y.H.; Suh, P.G.
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37
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Rattus norvegicus
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Rattus norvegicus
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G{alpha}12/13- and Rho-dependent activation of phospholipase C-{epsilon} by lysophosphatidic acid and thrombin receptors
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Rattus norvegicus
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Single and repeated stress-induced modulation of phospholipase C catalytic activity and expression: role in LH behavior
Neuropsychopharmacology
30
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2005
Rattus norvegicus
brenda
Rogel, A.; Bromberg, Y.; Sperling, O.; Zoref-Shani, E.
Phospholipase C is involved in the adenosine-activated signal transduction pathway conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures
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Rattus norvegicus
brenda
Cai, Y.; Stafford, L.J.; Bryan, B.A.; Mitchell, D.; Liu, M.
G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6
Oncogene
24
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2005
Homo sapiens, Rattus norvegicus
brenda
Cocco, L.; Faenza, I.; Fiume, R.; Billi, A.M.; Gilmour, R.S.; Manzoli, F.A.
Phosphoinositide-specific phospholipase C (PI-PLC) beta 1 and nuclear lipid-dependent signaling
Biochim. Biophys. Acta
1761
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2006
Rattus norvegicus (P10687), Mus musculus (Q9Z1B3)
brenda
Faenza, I.; Ramazzotti, G.; Bavelloni, A.; Fiume, R.; Gaboardi, G.C.; Follo, M.Y.; Gilmour, R.S.; Martelli, A.M.; Ravid, K.; Cocco, L.
Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter
Endocrinology
148
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2007
Rattus norvegicus
brenda
Shimizu, T.; Yamaguchi, N.; Okada, S.; Lu, L.; Sasaki, T.; Yokotani, K.
Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats
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2007
Rattus norvegicus
brenda
Lo Vasco, V.R.; Fabrizi, C.; Artico, M.; Cocco, L.; Billi, A.M.; Fumagalli, L.; Manzoli, F.A.
Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes
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Rattus norvegicus, Rattus norvegicus (P10686), Rattus norvegicus (P10687), Rattus norvegicus (P10688), Rattus norvegicus (Q62711), Rattus norvegicus (Q99JE6), Rattus norvegicus (Q99P84), Rattus norvegicus (Q9QW07)
brenda
Stewart, A.J.; Morgan, K.; Farquharson, C.; Millar, R.P.
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues
Neuroendocrinology
86
243-248
2007
Chlorocebus aethiops, Homo sapiens, Rattus norvegicus
brenda
Grubb, D.R.; Vasilevski, O.; Huynh, H.; Woodcock, E.A.
The extreme C-terminal region of phospholipase Cbeta1 determines subcellular localization and function; the b splice variant mediates alpha1-adrenergic receptor responses in cardiomyocytes
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2008
Rattus norvegicus (P10687)
brenda
Nelson, C.P.; Nahorski, S.R.; Challiss, R.A.
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons
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2008
Homo sapiens, Rattus norvegicus
brenda
Singal, T.; Dhalla, N.S.; Tappia, P.S.
Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes
Mol. Cell. Biochem.
327
229-239
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Rattus norvegicus (P10686), Rattus norvegicus (P10687), Rattus norvegicus (P10688), Rattus norvegicus (Q99JE6)
brenda
Baumann, M.K.; Swann, M.J.; Textor, M.; Reimhult, E.
Pleckstrin homology-phospholipase C-delta1 interaction with phosphatidylinositol 4,5-bisphosphate containing supported lipid bilayers monitored in situ with dual polarization interferometry
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6267-6274
2011
Rattus norvegicus
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Lo Vasco, V.R.; Fabrizi, C.; Panetta, B.; Fumagalli, L.; Cocco, L.
Expression pattern and sub-cellular distribution of phosphoinositide specific phospholipase C enzymes after treatment with U-73122 in rat astrocytoma cells
J. Cell. Biochem.
110
1005-1012
2010
Rattus norvegicus
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Fiume, R.; Teti, G.; Faenza, I.; Cocco, L.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus
Methods Mol. Biol.
645
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2010
Rattus norvegicus (P10687), Homo sapiens (Q9NQ66), Homo sapiens, Mus musculus (Q9Z1B3)
brenda
Fukami, K.; Inanobe, S.; Kanemaru, K.; Nakamura, Y.
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Prog. Lipid Res.
49
429-437
2010
Homo sapiens, Mus musculus, Rattus norvegicus
brenda