Information on EC 3.1.3.91 - 7-methylguanosine nucleotidase

for references in articles please use BRENDA:EC3.1.3.91
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
3.1.3.91
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RECOMMENDED NAME
GeneOntology No.
7-methylguanosine nucleotidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CMP + H2O = cytidine + phosphate
show the reaction diagram
(2)
-
-
-
N7-methyl-GMP + H2O = N7-methyl-guanosine + phosphate
show the reaction diagram
(1)
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
UTP and CTP dephosphorylation I
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-
pyrimidine metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
N7-methyl-GMP phosphohydrolase
The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N7-methyl-GDP + H2O
N7-methyl-guanosine + 2 phosphate
show the reaction diagram
N7-methyl-GMP + H2O
N7-methyl-guanosine + phosphate
show the reaction diagram
additional information
?
-
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
potassium acetate
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potassium phosphate
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
phosphate
stimulation
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0078 - 0.013
N7-methyl-GMP
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.24 - 6.3
N7-methyl-GMP
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3 - 460
N7-methyl-GMP
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2
AMP
Drosophila melanogaster;
Q9W197
pH 7.5, 25°C
0.52
KCl
Drosophila melanogaster;
Q9W197
pH 7.5, 25°C
0.65
potassium acetate
Drosophila melanogaster;
Q9W197
pH 7.5, 25°C
0.06
potassium phosphate
Drosophila melanogaster;
Q9W197
pH 7.5, 25°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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PDB
SCOP
CATH
UNIPROT
ORGANISM
Drosophila melanogaster;
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
34000
analytical ultracentrifugation
34400
34400, calculated
36300
1 * 40000, SDS-PAGE, 1 * 36300, calculated
40000
gel filtration
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
expression in S2 cell
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LINKS TO OTHER DATABASES (specific for EC-Number 3.1.3.91)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)