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Information on EC 3.1.3.81 - diacylglycerol diphosphate phosphatase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.81 diacylglycerol diphosphate phosphatase
IUBMB Comments
The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response . The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) .The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
DGPP phosphatase, DGPP phosphohydrolase, diacylglycerol pyrophosphate phosphatase, DPP1, DPP1-encoded DGPP phosphatase, DPP1-encoded diacylglycerol pyrophosphate phosphatase, DPP1-encoded PAP2, Dpp1p, DPPL1, DPPL2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate
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