Reference on EC 3.1.3.67 - phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kabuyama, Y.; Nakatsu, N.; Homma, Y.; Fukui, Y.
Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus
Eur. J. Biochem.
238
350-356
1996
Bos taurus
Moritake, H.; Horii, Y.; Kuroda, H.; Sugimoto, T.
Analysis of PTEN/MMAC1 alteration in neuroblastoma
Cancer Genet. Cytogenet.
125
151-155
2001
Homo sapiens
Maier, D.; Jones, G.; Li, X.; Schonthal, A.H.; Gratzl, O.; Van Meir, E.G.; Merlo, A.
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells
Cancer Res.
59
5479-5482
1999
Homo sapiens
Zhang, P.; Steinberg, B.M.
Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas
Cancer Res.
60
1457-1462
2000
Homo sapiens
Han, S.Y.; Kato, H.; Kato, S.; Suzuki, T.; Shibata, H.; Ishii, S.; Shiiba, K.I.; Matsuno, S.; Kanamaru, R.; Ishioka, C.
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay
Cancer Res.
60
3147-3151
2000
Homo sapiens
Haas-Kogan, D.; Shalev, N.; Wong, M.; Mills, G.; Yount, G.; Stokoe, D.
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
Curr. Biol.
8
1195-1198
1998
Homo sapiens
Hlobilkova, A.; Guldberg, P.; Thullberg, M.; Zeuthen, J.; Lukas, J.; Bartek, J.
Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity
Exp. Cell Res.
256
571-577
2000
Homo sapiens
Goberdhan, D.C.I.; Wilson, C.
PTEN: Tumour suppressor, multifunctional growth regulator and more
Hum. Mol. Genet.
12
R239-R248
2003
Homo sapiens
-
Maehama, T.; Dixon, J.E.
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
J. Biol. Chem.
273
13375-13378
1998
Homo sapiens
Vazquez, F.; Ramaswamy, S.; Nakamura, N.; Sellers, W.R.
Phosphorylation of the PTEN tail regulates protein stability and function
Mol. Cell. Biol.
20
5010-5018
2000
Homo sapiens
Paramio, J.M.; Navarro, M.; Segrelles, C.; Gomez-Casero, E.; Jorcano, J.L.
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
Oncogene
18
7462-7468
1999
Homo sapiens
Georgescu, M.M.; Kirsch, K.H.; Akagi, T.; Shishido, T.; Hanafusa, H.
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
Proc. Natl. Acad. Sci. USA
96
10182-10187
1999
Homo sapiens
Ramaswamy, S.; Nakamura, N.; Vazquez, F.; Batt, D.B.; Perera, S.; Roberts, T.M.; Sellers, W.R.
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
Proc. Natl. Acad. Sci. USA
96
2110-2115
1999
Homo sapiens
Sun, H.; Lesche, R.; Li, D.M.; Liliental, J.; Zhang, H.; Gao, J.; Gavrilova, N.; Mueller, B.; Liu, X.; Wu, H.
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-trisphosphate and Akt/protein kinase B signaling pathway
Proc. Natl. Acad. Sci. USA
96
6199-6204
1999
Mus musculus
Vinciguerra, M.; Foti, M.
PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling
Arch. Physiol. Biochem.
112
89-104
2006
Homo sapiens, Mus musculus
Hoshino, Y.; Nishimura, K.; Sumpio, B.E.
Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain
J. Cell. Biochem.
100
515-526
2007
Bos taurus
Wang, Y.; Cheng, A.; Mattson, M.P.
The PTEN phosphatase is essential for long-term depression of hippocampal synapses
Neuromolecular Med.
8
329-336
2006
Mus musculus
Gajewski, J.E.; Bird, M.J.; Crowhurst, M.O.; Sio-Seng Lio, D.; Liu, J.; Wettenhall, R.E.; Zhu, H.J.; Cheng, H.C.
Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase
Protein Expr. Purif.
55
334-342
2007
Rattus norvegicus (O54857)
Rankin, S.L.; Guy, C.S.; Mearow, K.M.
PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1
Biochem. Biophys. Res. Commun.
379
721-725
2009
Rattus norvegicus
Redfern, R.E.; Redfern, D.; Furgason, M.L.; Munson, M.; Ross, A.H.; Gericke, A.
PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes
Biochemistry
47
2162-2171
2008
Homo sapiens
Semba, S.; Satake, S.; Matsushita, M.; Yokozaki, H.
Phosphatase activity of nuclear PTEN is required for CDX2-mediated intestinal differentiation of gastric carcinoma
Cancer Lett.
274
143-150
2009
Homo sapiens
Dey, N.; Crosswell, H.E.; De, P.; Parsons, R.; Peng, Q.; Su, J.D.; Durden, D.L.
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration
Cancer Res.
68
1862-1871
2008
Mus musculus
Qiu, W.; Federico, L.; Naples, M.; Avramoglu, R.K.; Meshkani, R.; Zhang, J.; Tsai, J.; Hussain, M.; Dai, K.; Iqbal, J.; Kontos, C.D.; Horie, Y.; Suzuki, A.; Adeli, K.
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins
Hepatology
48
1799-1809
2008
Homo sapiens, Mus musculus
Feng, W.; Wu, H.; Chan, L.N.; Zhang, M.
Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment
J. Biol. Chem.
283
23440-23449
2008
Canis lupus
Knobbe, C.B.; Lapin, V.; Suzuki, A.; Mak, T.W.
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
Oncogene
27
5398-5415
2008
Mus musculus
Leslie, N.R.; Batty, I.H.; Maccario, H.; Davidson, L.; Downes, C.P.
Understanding PTEN regulation: PIP2, polarity and protein stability
Oncogene
27
5464-5476
2008
Homo sapiens
Rahdar, M.; Inoue, T.; Meyer, T.; Zhang, J.; Vazquez, F.; Devreotes, P.N.
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
Proc. Natl. Acad. Sci. USA
106
480-485
2009
Homo sapiens
Fan, C.; He, L.; Kapoor, A.; Rybak, A.P.; De Melo, J.; Cutz, J.C.; Tang, D.
PTEN inhibits BMI1 function independently of its phosphatase activity
Mol. Cancer
8
98
2009
Homo sapiens
Kini, V.; Chavez, A.; Mehta, D.
A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis
J. Biol. Chem.
285
33082-33091
2010
Homo sapiens
Langlois, M.J.; Bergeron, S.; Bernatchez, G.; Boudreau, F.; Saucier, C.; Perreault, N.; Carrier, J.C.; Rivard, N.
The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression
PLoS ONE
5
e15742
2010
Homo sapiens
Shearn, C.T.; Smathers, R.L.; Backos, D.S.; Reigan, P.; Orlicky, D.J.; Petersen, D.R.
Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis
Free Radic. Biol. Med.
65
680-692
2013
Mus musculus
Ijuin, T.; Takenawa, T.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP)
J. Biol. Chem.
287
6991-6999
2012
Mus musculus
Kurokawa, T.; Takasuga, S.; Sakata, S.; Yamaguchi, S.; Horie, S.; Homma, K.J.; Sasaki, T.; Okamura, Y.
3'Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP)
Proc. Natl. Acad. Sci. USA
109
10089-10094
2012
Ciona intestinalis, Homo sapiens
Hsu, F.; Zhu, W.; Brennan, L.; Tao, L.; Luo, Z.Q.; Mao, Y.
Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase
Proc. Natl. Acad. Sci. USA
109
13567-13572
2012
Legionella pneumophila (Q5ZSD5)
Zhou, H.M.; Sun, Q.X.; Cheng, Y.
Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor
Exp. Ther. Med.
14
3213-3220
2017
Homo sapiens (P60484)
Chen, Z.; Dempsey, D.R.; Thomas, S.N.; Hayward, D.; Bolduc, D.M.; Cole, P.A.
Molecular features of phosphatase and tensin homolog (PTEN) regulation by C-terminal phosphorylation
J. Biol. Chem.
291
14160-14169
2016
Homo sapiens (P60484)
Shenker, B.J.; Walker, L.P.; Zekavat, A.; Boesze-Battaglia, K.
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate
Mol. Oral Microbiol.
31
33-42
2016
Aggregatibacter actinomycetemcomitans (Q9S676)
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