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Information on EC 3.1.3.66 - phosphatidylinositol-3,4-bisphosphate 4-phosphatase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9C5G5

for references in articles please use BRENDA:EC3.1.3.66
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EC Tree
IUBMB Comments
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9C5G5
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
inpp4b, inpp4a, inositol polyphosphate 4-phosphatase type ii, inositol polyphosphate 4-phosphatase, inositol polyphosphate 4-phosphatase type i, pi-4-phosphatase ii, 4-ptase-1, phosphoinositide 4-phosphatase, inositol polyphosphate 4-phosphatase ii, sac1p-like phosphoinositide phosphatase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphatidylinositol-4-phosphate phosphatase
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Sac1p-like phosphoinositide phosphatase
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D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
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-
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inositol polyphosphate 4-phosphatase
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-
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inositol polyphosphate 4-phosphatase type II
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-
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inositol-3,4-bisphosphate 4-phosphatase
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phosphatase, inositol 3,4-bisphosphate 4-
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-
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phosphoinositide 4-phosphatase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.
CAS REGISTRY NUMBER
COMMENTARY hide
122653-78-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylinositol-4-phosphate + H2O
?
show the reaction diagram
prefered substrate
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
RHD4 is selectively recruited to RabA4-blabeled membranes that are involved in polarized expansion of root hair cells. In conjunction with the phosphoinositide kinase PI-4Kb1, RHD4 regulates the accumulation of phosphatidylinositol-4-phosphate on membrane compartments at the tips of growing root hairs
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SAC7_ARATH
597
0
68237
Swiss-Prot
Mitochondrion (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G449S
rhd4-2 mutant containing a mutation in motif VII of the SAC phosphatase domain, reduces the phosphatidylinositol-4-phosphate phosphatase activity to residual levels
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
by gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
wild-type RHD4 and the mutant rhd4-2 N-terminal catalytic domains expressed from Escherichia coli Rosetta cells or BL21 cells as GST fusion proteins. EYFP-wild-type fusion protein transformed into Arabidopsis under control of the native RHD4 promoter
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Thole, J.M.; Vermeer, J.E.; Zhang, Y.; Gadella, T.W.; Nielsen, E.
Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana
Plant Cell
20
381-395
2008
Arabidopsis thaliana (Q9C5G5), Arabidopsis thaliana
Manually annotated by BRENDA team