Information on EC 3.1.3.58 - sugar-terminal-phosphatase

for references in articles please use BRENDA:EC3.1.3.58
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The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY hide
3.1.3.58
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RECOMMENDED NAME
GeneOntology No.
sugar-terminal-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glucose 6-phosphate + H2O = D-glucose + phosphate
show the reaction diagram
acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
gluconeogenesis III
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SYSTEMATIC NAME
IUBMB Comments
sugar-omega-phosphate phosphohydrolase
Acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
99283-70-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Cl-16
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
show the reaction diagram
3-phosphoglycerate + H2O
glycerate + phosphate
show the reaction diagram
6-phosphogluconate + H2O
gluconate + phosphate
show the reaction diagram
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relative activity 69%
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-
?
alpha-glycerophosphate + H2O
glycerol + phosphate
show the reaction diagram
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relative activity 50%
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-
?
beta-D-glucose-1,6-diphosphate + H2O
beta-D-glucose + phosphate
show the reaction diagram
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relative activity 56%
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-
?
D-erythrose-4-phosphate + H2O
D-erythrose + phosphate
show the reaction diagram
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relative activity 69%
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-
?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
show the reaction diagram
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D-fructose-1,6-diphosphate + H2O
D-fructose + phosphate
show the reaction diagram
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relative activity 16%
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?
D-fructose-1-phosphate + H2O
D-fructose + phosphate
show the reaction diagram
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relative activity 8%
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?
D-fructose-6-phosphate + H2O
D-fructose + phosphate
show the reaction diagram
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relative activity 47%
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?
D-galactose-1-phosphate + H2O
D-galactose + phosphate
show the reaction diagram
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relative activity 8%
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?
D-galactose-6-phosphate + H2O
D-galactose + phosphate
show the reaction diagram
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relative activity 11%
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?
D-glucosamine-6-phosphate + H2O
D-glucosamine + phosphate
show the reaction diagram
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relative activity 28%
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
D-glucose-1-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
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relative activity 3%
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?
D-mannose 6-phosphate + H2O
D-mannose + phosphate
show the reaction diagram
D-ribitol-5-phosphate + H2O
D-ribitol + phosphate
show the reaction diagram
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relative activity 15%
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?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
show the reaction diagram
D-sedoheptulose-7-phosphate + H2O
sedoheptulose + phosphate
show the reaction diagram
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relative activity 34%
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?
D-sorbitol-6-phosphate + H2O
D-sorbitol + phosphate
show the reaction diagram
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relative activity 33%
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?
D-xylitol-5-phosphate + H2O
D-xylitol + phosphate
show the reaction diagram
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relative activity 34%
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?
D-xylose-1-phosphate + H2O
D-xylose + phosphate
show the reaction diagram
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relative activity 3%
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?
erythrose 4-phosphate + H2O
erythrose + phosphate
show the reaction diagram
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mannitol-1-phosphate + H2O
D-mannitol + phosphate
show the reaction diagram
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relative activity 16%
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?
o-nitrophenyl-galactose-6-phosphate + H2O
o-nitrophenyl-galactose + phosphate
show the reaction diagram
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relative activity 6%
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?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
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additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucose 6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
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key component of the futile xylitol cycle
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?
D-xylitol-5-phosphate + H2O
D-xylitol + phosphate
show the reaction diagram
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relative activity 34%
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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Mn2+ and Ni2+ have no effect on enzyme activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1526
erythrose 4-phosphate
+/- 0.055
0.2
fructose 6-phosphate
+/- 0.02
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.154
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2-deoxyglucose 6-phosphate as substrate
2.63
+/- 0.56, erythrose 4-phosphate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32000
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2 * 32000, SDS-PAGE
62000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 5% glycerol, 0.5 M NaCl, pH 7.5, no loss in activity after several months
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE