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Information on EC 3.1.3.57 - inositol-1,4-bisphosphate 1-phosphatase and Organism(s) Mus musculus and UniProt Accession P49442

for references in articles please use BRENDA:EC3.1.3.57
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase
IUBMB Comments
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
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This record set is specific for:
Mus musculus
UNIPROT: P49442
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
inositol polyphosphate 1-phosphatase, inositol polyphosphate-1-phosphatase, rnpip, inositol-1,4-bisphosphate 1-phosphatase, inositol-polyphosphate 1-phosphatase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
inositol-1,4-bisphosphate 1-phosphatase
-
inositol-polyphosphate 1-phosphatase
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inositol-polyphosphate 1-phosphatase
-
-
-
-
INPP
-
-
-
-
IPP
-
-
-
-
IPPase
-
-
-
-
phosphatase, inositol 1,4-bisphosphate 1-
-
-
-
-
RnPIP
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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hydrolysis of phosphoric ester
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
111070-17-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1D-myo-inositol 1,4-bisphosphate + H2O
1D-myo-inositol 4-phosphate + phosphate
show the reaction diagram
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
INPP_MOUSE
396
0
43346
Swiss-Prot
other Location (Reliability: 4)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
molecular biology
contains no D-domain and no FXFP motif as mitogen-activated protein kinase docking site
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Caldwell, K.K.; Sosa, M.; Buckley, C.T.
Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates
Cell Commun. Signal.
4
2-18
2006
Homo sapiens (P49441), Homo sapiens, Mus musculus (P49442), Mus musculus
Manually annotated by BRENDA team