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Information on EC 3.1.3.57 - inositol-1,4-bisphosphate 1-phosphatase
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3.1.3.57 inositol-1,4-bisphosphate 1-phosphataseIUBMB Comments
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
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Word Map
- 3.1.3.57
- lithium
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bipolar
- 1,3,4-trisphosphate
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monophosphatase
- li+
- nucleotidase
- 3'-phosphoadenosine
- fiery1
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majerus
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3'2',5'-bisphosphate
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manic-depressive
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1,6-bisphosphatase
- phosphoinositols
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li+-sensitive
- molecular biology
- 3,4-bisphosphate
- manic
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lithium-sensitive
- medicine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
inositol polyphosphate 1-phosphatase, inositol polyphosphate-1-phosphatase, inositol-1,4-bisphosphate 1-phosphatase, inositol-polyphosphate 1-phosphatase, INPP, IPP, IPPase, phosphatase, inositol 1,4-bisphosphate 1-, RnPIP, 
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topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate
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1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate
mechanism
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate
the enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate, with similar vmax values for both substrates, but with a five-times higher affinity for the bisphosphate, does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate
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