Information on EC 3.1.3.55 - caldesmon-phosphatase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.3.55
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RECOMMENDED NAME
GeneOntology No.
caldesmon-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
caldesmon phosphate + H2O = caldesmon + phosphate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
caldesmon-phosphate phosphohydrolase
Dephosphorylation activates the calmodulin- and actin-binding ability of the protein caldesmon.
CAS REGISTRY NUMBER
COMMENTARY hide
93229-71-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
caldesmon phosphate + H2O
caldesmon + phosphate
show the reaction diagram
phosphorylated calponin + H2O
calponin + phosphate
show the reaction diagram
phosphorylated myosin LC20 + H2O
myosin LC20 + phosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
caldesmon phosphate + H2O
caldesmon + phosphate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0019 - 0.0032
caldesmon
0.0143
calponin
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pH 7.5, 30°C, calponin phosphorylated by PKC
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
smooth muscle neoplasm
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
38000
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x * 38000 catalytic subunit + x * 55000 + x * 60000, SDS-PAGE
55000
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x * 38000 catalytic subunit + x * 55000 + x * 60000, SDS-PAGE
60000
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x * 38000 catalytic subunit + x * 55000 + x * 60000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 38000 catalytic subunit + x * 55000 + x * 60000, SDS-PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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as an immunomarker for smooth muscle neoplasms, caldesmon has a sensitivity of 100% (31 out of 31 smooth muscle neoplasms show positivity) and a specificity of 80% (89 out of 111 non-smooth muscle neoplasms do not show positivity)