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Information on EC 3.1.3.51 - dolichyl-phosphatase
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3.1.3.51 dolichyl-phosphataseSpecify your search results
Word Map
- 3.1.3.51
- dolichols
-
phosphatidic
- pyrophosphate
- oligosaccharide
- triton
-
polyisoprenoids
- polyprenols
-
n-glycosylation
-
calf
-
thermolability
- isoprene
-
phosphorylation-dephosphorylation
- pyriformis
-
alpha-isoprene
-
32pphosphate
-
dolichol-linked
-
ctp-dependent
- tetrahymena
-
unesterified
- bacitracin
The enzyme appears in viruses and cellular organisms
Synonyms
dol-p phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, dolichol monophosphatase, dolichol phosphate phosphatase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dol-P phosphatase
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dolichol monophosphatase
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dolichol phosphatase
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dolichol phosphate phosphatase
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dolichyl monophosphate phosphatase
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dolichyl phosphate phosphatase
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phosphatase, dolichol
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-
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polyisoprenyl phosphate phosphatase
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polyprenylphosphate phosphatase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dolichyl phosphate + H2O = dolichol + phosphate
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
dolichyl-phosphate phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
72994-50-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
alpha-trans-polyprenyl 19-phosphate + H2O
alpha-trans-polyprenol + phosphate
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-
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?
dolichyl phosphate + H2O
dolichol + phosphate
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?
dolichyl phosphate + H2O
dolichol + phosphate
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C95-dolichyl phosphate, C100-dolichyl phosphate, C90-dolichyl phosphate, C55-dolichyl phosphate
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-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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-
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-
?
additional information
?
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the enzyme regulates the dolichyl phosphate levels together with the dolichol kinase by interconversion of dolichyl phosphate and dolichol
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?
additional information
?
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enzyme of the dolichol pathway, involved in the biosynthesis of glycoproteins of the asparagine type
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?
additional information
?
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the enzyme is required for the regulation of the level of dolichyl phosphate and thus the rate of glycoprotein synthesis
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?
additional information
?
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the enzyme is required for the regulation of the level of dolichyl phosphate and thus the rate of glycoprotein synthesis
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the enzyme regulates the dolichyl phosphate levels together with the dolichol kinase by interconversion of dolichyl phosphate and dolichol
-
-
?
additional information
?
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enzyme of the dolichol pathway, involved in the biosynthesis of glycoproteins of the asparagine type
-
-
?
additional information
?
-
-
the enzyme is required for the regulation of the level of dolichyl phosphate and thus the rate of glycoprotein synthesis
-
-
?
additional information
?
-
-
the enzyme is required for the regulation of the level of dolichyl phosphate and thus the rate of glycoprotein synthesis
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ethoxy formic anhydride
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10 mM, 67% inhibition of dolichyl phosphate hydrolysis, no inhibition of p-nitrophenyl phosphate cleavage
Tartrate
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inhibits hydrolysis of p-nitrophenyl phosphate, no inhibition of the hydrolysis of dolichyl phosphate
vanadium oxide
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inhibits hydrolysis of p-nitrophenyl phosphate and dolichyl phosphate
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas.
Neoplasms
Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 10
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pH 5: about 35% of maximal activity, pH 10.0: about 85% of maximal activity
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5 - 9
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
embryonic brain cells, the enzyme is present at relatively low levels for the first 9 days in culture, but it increases steadily between days 9 and 30
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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loosely bound to mitochondrial membranes
brenda
additional information
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enzyme in the exponential growth phase contains more of this enzymic activity than cells in stationary or lag phase
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brenda
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highest activity in Golgi vesicles. Activity in smooth endoplasmic reticulum is 42% of that in Golgi membranes, activity in the rough endoplasmic reticulum is 11% of that in the Golgi membranes
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brenda
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
60
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ravi, K.; Rip, J.W.; Carroll, K.K.
Submicrosomal distribution of dolichol kinase and dolichyl phosphate phosphatase in the microsomes of germinating soybeans
Biochim. Biophys. Acta
884
497-501
1986
Glycine max
-
brenda
Adrian, G.S.; Keenan, R.W.
A dolichyl phosphate-cleaving acid phosphatase from Tetrahymena pyriformis
Biochim. Biophys. Acta
575
431-438
1979
Tetrahymena pyriformis, Tetrahymena pyriformis WH14
brenda
Wedgwood, J.F.; Strominger, J.L.
Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate
J. Biol. Chem.
255
1120-1123
1980
Homo sapiens
brenda
Idoyaga-Vargas, V.; Belocopitow, E.; Mentaberry, A.; Carminatti, H.
A phosphatase acting on dolichyl phosphate in membranes from neuronal perikarya
FEBS Lett.
112
63-66
1980
Rattus norvegicus
brenda
Rip, J.W.; Rupar, C.A.; Chaudhary, N.; Carroll, K.K.
Localization of a dolichyl phosphate phosphatase in plasma membranes of rat liver
J. Biol. Chem.
256
1929-1934
1981
Rattus norvegicus
brenda
Keller, R.K.; Adair, W.L.; Cafmeyer, N.; Simion, F.A.; Fleischer, B.; Fleischer, S.
Characterization of polyisoprenyl phosphate phosphatase activity in rat liver
Arch. Biochem. Biophys.
249
207-214
1986
Rattus norvegicus
brenda
Scher, M.G.; Sumbilla, C.M.; Waechter, Ch.J.
Dolichyl phosphate metabolism in brain. Developmental increase in polyisoprenyl phosphate phosphatase activity
J. Biol. Chem.
260
13742-13746
1985
Sus scrofa
brenda
Sumbilla, C.; Waechter, C.J.
Dolichol kinase, phosphatase, and esterase activity in calf brain
Methods Enzymol.
111
471-482
1988
Bos taurus
brenda
Burton, W.A.; Scher, M.G.; Waechter, C.J.
Enzymatic dephosphorylation of endogenous and exogenous dolichyl monophosphate by calf brain membranes
Arch. Biochem. Biophys.
208
409-417
1981
Bos taurus
brenda
Boscoboinik, D.O.; Morera, S.; Belocopitow, E.
Dolichyl phosphate phosphatase in rat liver microsomes. Avoidance of the use of detergent in testing the effect of phospholipids on dolichyl phosphate phosphatase
Biochim. Biophys. Acta
794
41-48
1984
Rattus norvegicus
brenda
Rip, J.W.; Chaudhary, N.; Carroll, K.K.
The submicrosomal distribution of dolichyl phosphate and dolichyl phosphate phosphatase in rat liver
J. Biol. Chem.
258
14926-14930
1983
Rattus norvegicus
brenda
Belocopitow, E.; Boscoboinik, D.
Dolichyl-phosphate phosphatase and dolichyl-diphosphate phosphatase in rat-liver microsomes
Eur. J. Biochem.
125
167-173
1982
Rattus norvegicus
brenda
Rupar, C.A.; Rip, J.W.; Chaudhary, N.; Carroll, K.K.
The subcellular localization of enzymes of dolichol metabolism in rat liver
J. Biol. Chem.
257
3090-3094
1982
Rattus norvegicus
brenda
Adrian, G.S.; Keenan, R.W.
Dolichyl phosphate phosphatase from Tetrahymena pyriformis
Biochem. J.
197
233-238
1981
Tetrahymena pyriformis
brenda
Ravi, K.; Rip, J.W.; Carroll, K.K.
Characterization of dolichol and dolichyl phosphate phosphatase from soya beans (Glycine max)
Biochem. J.
213
513-518
1983
Glycine max
brenda
Bhat, N.R.; Frank, D.W.; Wolf, M.J.; Waechter, C.J.
Developmental changes in enzymes involved in dolichyl phosphate metabolism in cultured embryonic rat brain cells
J. Neurochem.
56
339-344
1991
Rattus norvegicus
brenda
Frank, D.W.; Waechter, C.J.
Purification and characterization of a polyisoprenyl phosphate phosphatase from pig brain
J. Biol. Chem.
273
11791-11798
1998
Bos taurus, Sus scrofa
brenda
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