Information on EC 3.1.3.50 - sorbitol-6-phosphatase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.3.50
-
RECOMMENDED NAME
GeneOntology No.
sorbitol-6-phosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
sorbitol 6-phosphate + H2O = sorbitol + phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sorbitol biosynthesis I
-
-
SYSTEMATIC NAME
IUBMB Comments
sorbitol-6-phosphate phosphohydrolase
Acts, very slowly, on hexose 6-phosphates.
CAS REGISTRY NUMBER
COMMENTARY hide
80449-21-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-sorbitol 6-phosphate + H2O
D-sorbitol + phosphate
show the reaction diagram
-
highly specific
-
?
sorbitol 6-phosphate + H2O
sorbitol + phosphate
show the reaction diagram
additional information
?
-
-
no substrate: other phosphate esters than sorbitol-6-phosphate
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sorbitol 6-phosphate + H2O
sorbitol + phosphate
show the reaction diagram
-
-
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
fluoride
-
-
molybdate
-
-
phosphate
-
-
sorbitol
-
competitive
vanadate
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20-hydroxyecdysone
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.85
D-sorbitol-6-phosphate
-
pH 6.8, 30°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
109
D-sorbitol
-
pH 6.8, 30°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
89.8
-
pH 6.8, 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low activity during feeding period, abrupt increase in activity during wandering, and decrease to low level after gut purge
Manually annotated by BRENDA team
-
of larva
Manually annotated by BRENDA team
-
hemolymph from larva
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
association with
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
61000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 61000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE