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Information on EC 3.1.3.5 - 5'-nucleotidase and Organism(s) Homo sapiens and UniProt Accession Q9BXI3

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     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.5 5'-nucleotidase
IUBMB Comments
Wide specificity for 5'-nucleotides.
Specify your search results
Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: Q9BXI3
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
5'-adenylic phosphatase, 5'-AMP nucleotidase, 5'-AMPase, 5'-ectonucleotidase, 5'-mononucleotidase, 5'-NT, 5'-NT-1, 5'-NT-2, 5'-NT-3, 5'-NT-4, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-adenylic phosphatase
-
-
-
-
5'-AMP nucleotidase
-
-
-
-
5'-AMPase
-
-
-
-
5'-ectonucleotidase
247
-
5'-mononucleotidase
-
-
-
-
5'-nucleotidase
301889
-
5'-nucleotidase I
274801
-
5'-nucleotidase II
247
-
5'nucleotidase
-
-
-
-
adenosine 5'-monophosphatase
-
-
-
-
adenosine 5'-phosphatase
-
-
-
-
adenosine monophosphatase
-
-
-
-
AMP phosphatase
-
-
-
-
AMP phosphohydrolase
-
-
-
-
AMP-selective 5'-nucleotidase
247
-
AMPase
-
-
-
-
CD73 antigen
-
-
-
-
cN-II
cN-III
247
-
cNI
247
-
cNIIIB nucleotidase
247
-
cytoplasmic 5'-nucleotidase II
247
-
cytoplasmic 5'-nucleotidase II (IMP-selective or GMP/IMP-selective)
247
-
cytoplasmic 5'-nucleotidase III
247
-
cytoplasmic 5'-nucleotidase-I (AMP-selective)
247
-
cytosolic 5'-nucleotidase
247
-
cytosolic 5'-nucleotidase II
E-5'-Nu
247
-
e5'-NT
247
-
e5'NT
ecto 5'-NT
247
-
ecto 5'-nucleotidase
247
-
ecto-5'-NT
ecto-5'-NT/CD73
247
-
ecto-5'-nucleotidase
ecto-5'-nucleotidase/CD73
247
-
ecto-5-NT
247
-
ecto-5-nucleotidase
247
-
ecto-nucleotidase
301889
-
ectonucleotidase
247
-
ectonucleotidase CD73
247
-
eN
247
-
eNs
247
-
high Km 5'-nucleotidase
247
-
high-Km 5'-NT
247
-
IMP 5'-nucleotidase
-
-
-
-
IMP-GMP specific nucleotidase
247
-
IMP-specific, high Km 5'-nucleotidase
247
-
IMP/GMP selective 5'-NT
247
-
membrane-bound 5'-nucleotidase
247
-
NT5C3A
247
-
NT5E
301889
-
P5'N-1
247
-
Phm8
247
-
Pho5
247
-
PN-1
247
-
PN-I
247
-
purine 5'-NT
247
-
purine 5'-nucleotidase
247
-
pyrimidine 5'-nucleotidase
247
-
Sdt1
247
-
snake venom 5'-nucleotidase
-
-
-
-
thymidine monophosphate nucleotidase
-
-
-
-
type II cytosolic 5'-nucleotidase
278615
-
UMPase
-
-
-
-
UMPH-1
247
-
uridine 5'-nucleotidase
-
-
-
-
uridine monophosphate hydrolase-1
247
-
UshA
247
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
5'-ribonucleotide phosphohydrolase
Wide specificity for 5'-nucleotides.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-73-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-chloro-2'-deoxyadenosine monophosphate + H2O
2-chloro-2'-deoxyadenosine + phosphate
show the reaction diagram
39% of the activity with 5'-AMP
-
?
5'-AMP + H2O
adenosine + phosphate
show the reaction diagram
-
-
?
5'-CMP + H2O
cytidine + phosphate
show the reaction diagram
85% of the activity with 5'-AMP
-
?
5'-dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
61% of the activity with 5'-AMP
-
?
5'-GMP + H2O
guanosine + phosphate
show the reaction diagram
57% of the activity with 5'-AMP
-
?
5'-TMP + H2O
thymidine + phosphate
show the reaction diagram
13% of the activity with 5'-AMP
-
?
5'-UMP + H2O
uridine + phosphate
show the reaction diagram
78% of the activity with 5'-AMP
-
?
dAMP + H2O
deoxyadenosine + phosphate
show the reaction diagram
91% of the activity with 5'-AMP
-
?
dCMP + H2O
deoxycytidine + phosphate
show the reaction diagram
10% of the activity with 5'-AMP
-
?
dGMP + H2O
deoxyguanosine + phosphate
show the reaction diagram
75% of the activity with 5'-AMP
-
?
dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
84% of the activity with 5'-AMP
-
?
dUMP + H2O
deoxyuridine + phosphate
show the reaction diagram
7% of the activity with 5'-AMP
-
?
2'-chloro-2'-deoxyAMP + H2O
2'-chloro-2'-deoxyadenosine + phosphate
show the reaction diagram
-
cNII
-
-
?
3'-azido-3'deoxy-dTMP + H2O
3'-azido-3'-deoxythymidine + phosphate
show the reaction diagram
-
cNII
-
-
?
5'-AMP + H2O
adenosine + phosphate
show the reaction diagram
5'-CMP + H2O
cytidine + phosphate
show the reaction diagram
5'-dAMP + H2O
deoxyadenosine + phosphate
show the reaction diagram
5'-dCMP + H2O
2'-deoxycytidine + phosphate
show the reaction diagram
5'-dCMP + H2O
deoxycytidine + phosphate
show the reaction diagram
5'-dGMP + H2O
deoxyguanosine + phosphate
show the reaction diagram
5'-dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
5'-dTMP + H2O
deoxythymidine + phosphate
show the reaction diagram
5'-dUMP + H2O
deoxyuridine + phosphate
show the reaction diagram
5'-dUMP + H2O
deoxyuridne + phosphate
show the reaction diagram
-
i.e. 2'-deoxyuridine 5'-phosphate
-
?
5'-GMP + H2O
guanosine + phosphate
show the reaction diagram
5'-IMP + H2O
inosine + phosphate
show the reaction diagram
5'-TMP + H2O
thymidine + phosphate
show the reaction diagram
-
-
-
?
5'-UMP + H2O
uridine + phosphate
show the reaction diagram
5'-XMP + H2O
xanthosine + phosphate
show the reaction diagram
5-fluoro-dUMP + H2O
5-fluoro-uridine + phosphate
show the reaction diagram
-
cNII
-
-
?
7-methylguanosine diphosphate + H2O
7-methylguanosine monophosphate + phosphate
show the reaction diagram
-
preferred substrate
-
-
?
7-methylguanosine monophosphate + H2O
7-methylguanosine + phosphate
show the reaction diagram
-
preferred substrate
-
-
?
9-beta-D-arabinosyl-2-fluoroadenine monophosphate + H2O
9-beta-D-arabinosyl-2-fluoroadenine + phosphate
show the reaction diagram
-
-
-
-
?
a 5'-ribonucleotide + H2O
a ribonucleoside + phosphate
show the reaction diagram
-
-
-
-
?
AMP + H2O
adenosine + phosphate
show the reaction diagram
-
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
microsomal enzyme
-
-
?
IMP + H2O
inosine + phosphate
show the reaction diagram
-
-
-
-
?
inosine + 5'-IMP
5'-IMP + inosine
show the reaction diagram
-
-
-
?
inosine + phosphate
5'-IMP + H2O
show the reaction diagram
-
-
-
-
r
methylthio-IMP + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
-
-
-
-
?
ribavirin + 5'-IMP
?
show the reaction diagram
better substrate than viramidine
-
-
?
thio-GMP + H2o
6-thioguanosine + phosphate
show the reaction diagram
-
-
-
-
?
thio-IMP + H2O
6-thioinosine + phosphate
show the reaction diagram
-
-
-
-
?
viramidine + 5'-IMP
?
show the reaction diagram
worse substrate than ribavirin
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5'-AMP + H2O
adenosine + phosphate
show the reaction diagram
5'-CMP + H2O
cytidine + phosphate
show the reaction diagram
-
-
-
-
?
5'-dCMP + H2O
2'-deoxycytidine + phosphate
show the reaction diagram
-
-
-
-
?
5'-dGMP + H2O
deoxyguanosine + phosphate
show the reaction diagram
-
-
-
-
?
5'-dIMP + H2O
deoxyinosine + phosphate
show the reaction diagram
-
-
-
-
?
5'-dTMP + H2O
deoxythymidine + phosphate
show the reaction diagram
-
-
-
-
?
5'-dUMP + H2O
deoxyuridine + phosphate
show the reaction diagram
-
-
-
-
?
5'-GMP + H2O
guanosine + phosphate
show the reaction diagram
5'-IMP + H2O
inosine + phosphate
show the reaction diagram
5'-UMP + H2O
uridine + phosphate
show the reaction diagram
-
-
-
-
?
5'-XMP + H2O
xanthosine + phosphate
show the reaction diagram
-
-
-
-
?
a 5'-ribonucleotide + H2O
a ribonucleoside + phosphate
show the reaction diagram
-
-
-
-
?
AMP + H2O
adenosine + phosphate
show the reaction diagram
-
-
-
-
?
IMP + H2O
inosine + phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
1 mM used in assay conditions
Mn2+
-
-
Zn2+
60% recovery of initial activity with EDTA-treated enzyme
additional information
divalent metal ion is required; no effect: Mg2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-fluoroadenine-9-beta-D-arabinofuranoside
1 mM, 70% inhibition with 5 mM 5'-AMP as substrate
araCMP
1 mM, 25% inhibition with 5 mM 5'-AMP as substrate
(2E)-5-(5-methylfuran-2-yl)-N-(2-methylphenyl)-3-oxo-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxamide
-
67% inhibition at 0.005 mM
(2Z)-2-[[3-(3-fluoro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene]-6-[(4-methylphenyl)methyl]-7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione
-
61% inhibition at 0.005 mM
1-(6-deoxy-6-phosphono-beta-D-allofuranosyl)-5-(2-(E)-phenylvinyl)-cytosine
-
-
1-(6-deoxy-6-phosphono-beta-D-allofuranosyl)-5-phenyl-cytosine
-
-
1-(6-deoxy-6-phosphono-beta-D-allofuranosyl)-cytosine
-
-
1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
-
-
1-pentyl-1H-benzofuro[3,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile
-
-
1-tert-butyl-1H-benzofuro[3,2-b]pyrrolo[3,2-e]pyridine-3-carbonitrile
-
-
1-tert-butyl-5-chloro-6-(2-hydroxy-5-methylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
-
-
1-tert-butyl-5-chloro-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
-
-
2,2'-(2-(2-((2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-carboxamido)ethylamino)-2-oxoethylazanediyl) diacetic acid
-
nucleotide-derived inhibitor
2,3,5-tri-O-benzyl-1-O-(4-nitrobenzoyl)-D-arabinofuranose
-
68% inhibition at 0.005 mM
2-((4'-cyano-4,4''-dimethoxy-[1,1':3',1''-terphenyl]-5'-yl)thio)-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)acetamide
-
73% inhibition at 0.005 mM
2-(3,4-dihydroisoquinolin-2(1H)-yl)-N-[4-[1-(4-methylbenzoyl)-2,3-dihydro-1H-indol-5-yl]-5-sulfanyl-1,3-thiazol-2-yl]acetamide
-
74% inhibition at 0.005 mM
2-(3-methyl-1,5-diphenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
-
-
2-(5-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
-
-
2-(5-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-5-methoxyphenol
-
-
2-(5-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
-
-
2-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
-
-
2-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
-
-
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-methylphenol
-
-
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)-5-methoxyphenol
-
-
2-(5-chloro-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol
-
-
2-chloro-N-(pyridin-4-yl)benzamide
-
-
2-methyl-N-(pyridin-4-yl)benzamide
-
-
2-nitro-N-(pyridin-4-yl)benzamide
-
-
2-phenyl-N-(pyridin-4-yl)acetamide
-
-
3,4,5-trimethoxy-N-(pyridin-4-yl)benzamide
-
-
3,5-dinitro-N-(pyridine-4-yl)benzamide
-
-
3,8-dimethyl-1-p-tolyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
-
-
3,8-dimethyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
-
-
3-(2-(3,4,5-trimethoxybenzylideneamino)thiazol-4-yl)-2Hchromen-2-one
-
-
3-(2-(3-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(3-methoxy-4-phenoxybenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(3-nitrobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(4-bromobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(4-chlorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(4-fluorobenzylideneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-(2-(furan-2-ylmethyleneamino)thiazol-4-yl)-2H-chromen-2-one
-
-
3-chloro-N-(pyridin-4-yl)benzamide
-
-
3-methyl-1-p-tolyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
-
-
3-methyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
-
-
3-methyl-N-(pyridin-4-yl)benzamide
-
-
3-nitro-N-(pyridin-4-yl)benzamide
-
-
3-[4,5-di([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]-1H-indole
-
93% inhibition at 0.005 mM
4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid
-
compound shows high cytotoxicity on H157 cells, with about 72% at 100 mM final concentration
4-(4-[1-[(3-chlorophenyl)methyl]-4-hydroxy-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl]piperidine-1-sulfonyl)-N-cycloheptylbenzene-1-sulfonamide
-
63% inhibition at 0.005 mM
4-(6-[[2-(4-aminophenyl)-1H-benzimidazol-5-yl]methyl]-1H-benzimidazol-2-yl)aniline
-
78% inhibition at 0.005 mM
4-chloro-N-(pyridin-4-yl)benzamide
-
-
4-methyl-N-(pyridin-4-yl)benzamide
-
-
4-nitro-N-(pyridin-4-yl)benzamide
-
-
5'-deoxy-5'-S-isobutylthioadenosine
-
-
5'-deoxy-7-methyl-5'-(4-phosphono-1H-pyrazol-1-yl)guanosine
-
moderately potent inhibitor
5-chloro-3-methyl-1-phenyl-6-(2-propoxyphenyl)-1H-pyrazolo[3,4-b]pyridine
-
-
5-chloro-6-(2-(heptyloxy)phenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
-
-
5-chloro-6-(2-hydroxy-5-methylphenyl)-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol
-
-
5-chloro-6-(2-hydroxyphenyl)-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol
-
-
5-chloro-6-(2-methoxyphenyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine
-
-
5-ethynyldideoxyuridine
-
selective inhibitor
6-(4-ethoxyphenyl)-3-(4-methylphenyl)-N-(2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
-
65% inhibition at 0.005 mM
6-amino-4-hydroxynaphthalene-2-sulfonic acid
-
most potent inhibitor of the screen
6-chloro-7-(2-hydroxy-5-methylphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
-
-
6-chloro-7-(2-hydroxyphenyl)-1-methylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
-
-
6-chloro-7-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
-
-
6-N,N-diethyl-D-beta-gamma-dibromomethylene adenosine triphosphate
Q53Z63
originally named FPL 67156 or ARL 67156, 28% inhibition at 0.1 mM
6-Thiopurine
-
-
7-methoxy-3-methyl-1-phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine
-
-
adenosine 5'-(alpha,beta-methylene)diphosphate
adenosine 5'-(alpha,beta-methylene)triphosphate
-
-
alpha,beta-methylene adenosine 5'-diphosphate
-
specific inhibitor
alpha,beta-methylene adenosine-5'-diphosphate
-
-
alpha,beta-methylene-ADP
alpha-beta-methylene-ADP
-
-
alpha/beta-methylene-ADP
-
a specific CD73 inhibitor
beta-gamma-methylene-ATP
-
-
concanavalin A
-
Cu2+
further inhibition of the residual activity in EDTA-treated enzyme
dADP
-
-
dATP
-
-
dCTP
-
-
dGDP
-
-
dGTP
-
-
dITP
-
-
dUTP
-
-
ethyl 4-(2-((4'-cyano-4''-methoxy-4-methyl-[1,1':3',1''-terphenyl]-5'-yl)thio)acetamido)benzoate
-
80% inhibition at 0.005 mM
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
monastrol
ethyl 4-[4-(dimethylamino)phenyl]-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
-
LaSOM 63
Fe2+
further inhibition of the residual activity in EDTA-treated enzyme
Ly-294002
-
0.01 mM LY-294002 abolishes lipopolysaccharide-induced ecto-5'-nucleotidase activity
MEDI9447
-
non-competitive inhibitor
-
myricetin
-
-
N-(4-methylcyclohexyl)-1-(2-phenyl-1H-benzimidazole-5-sulfonyl)piperidine-3-carboxamide
-
17% inhibition at 0.005 mM
N-(pyridin-4-yl)furan-2-carboxamide
-
-
N-[4-[5-([2-[2-(4-methoxybenzoyl)hydrazinyl]-2-oxoethyl]sulfanyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]phenyl]-4-methylbenzene-1-sulfonamide
-
64% inhibition at 0.005 mM
NAD+
-
-
NADH
-
-
NADP+
-
-
NADPH
-
-
pentoxifillin
-
-
phosphate
-
-
quercetin
-
-
Reactive blue
-
-
-
Reactive blue 2
-
-
sodium 1-amino-4-(2-carboxy-4-fluoroanilino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
-
PSB-0952
sodium 1-amino-4-anilino-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
-
AB-25
sodium 1-amino-4-[(anthracen-2-yl)amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
-
PSB-0963
sulfamic acid
-
-
Sulfanilic acid
-
-
suramin
-
-
tenascin C
-
thio-IMP
-
substrate inhibition
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ADP
required for full activity, of the recombinant human enzyme, allosteric activator
ATP
activates
GTP
serves as activitor, not as strong as ADP
2,3-bisphosphoglycerate
2,3-diphosphoglycerate
-
activation
ammonium pyrrolidin dithiocarbamate
-
0.01 mM ammonium pyrrolidin dithiocarbamate increases the basal activity of ecto-5'-nucleotidase by 17% but has no effect on the lipopolysaccharide-induced increase in ecto-5'-nucleotidase activity
D-fructose
-
the activity of 5'-nucleotidase increases with increasing D-fructose concentrations (5-30 mM) in diabetic patients
D-glucose
-
the activity of 5'-nucleotidase increases with increasing D-glucose concentrations (5-30 mM) in diabetic patients
diadenosine 5',5'''-P1,P4-tetraphosphate
-
-
diadenosine polyphosphate
-
allosteric activation
-
Diadenosine tetraphosphate
-
activates cytosolic 5'-nucleotidase II by increase binding and dimer formation, interface binding structure modeling
GTP
-
; activates
indomethacin
-
0.1 mM, causes 62% increase of activity in vivo after 48 h
lipopolysaccharide
-
ecto-5'-nucleotidase activity increases after incubation with 10 ng/ml lipopolysaccharide for 24 h but is not changed after shorter incubation times
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0038 - 2.96
5'-AMP
0.002 - 0.0564
5'-CMP
0.035 - 0.114
5'-dAMP
0.023
5'-dCMP
-
-
0.044
5'-dGMP
-
-
0.057
5'-dIMP
-
-
0.017
5'-dUMP
-
-
0.0065 - 0.017
5'-GMP
0.0071 - 12.11
5'-IMP
0.008
5'-TMP
37°C, pH not specified in the publication
0.014 - 0.0316
5'-UMP
0.065
5'-XMP
-
-
10
9-beta-D-arabinosyl-2-fluoroadenine monophosphate
-
pH 8.3, 25°C
0.0091
AMP
-
at pH 8.5
0.012 - 0.193
dCMP
1.8 - 2.17
Inosine
0.024 - 0.095
ribavirin
additional information
additional information
-