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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase
IUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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UNIPROT: P96830
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70Z-SHP
-
-
-
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Brain-derived phosphatase
-
-
-
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BVP
-
-
-
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CD148 antigen
-
-
-
-
CD45
-
-
-
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CD45 antigen
-
-
-
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Cdc25-like protein
-
-
-
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CDK2-associated dual specificity phosphatase
-
-
-
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Ch-1PTPase
-
-
-
-
CPTP1
-
-
-
-
DLAR
-
-
-
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Dual specificity phosphatase Cdc25A
-
-
-
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Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
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ES cell phosphatase
-
-
-
-
HCP
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
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Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
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Hematopoietic protein-tyrosine phosphatase
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-
-
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HEPTP
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-
-
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HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
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hPTPE1
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-
-
-
ICAAR
-
-
-
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Islet cell autoantigen related protein
-
-
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kinase associated phosphatase
-
-
-
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L-CA
-
-
-
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Late protein H1
-
-
-
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LCA
-
-
-
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LCA-related phosphatase
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-
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Leukocyte antigen related
-
-
-
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Low molecular weight cytosolic acid phosphatase
-
-
-
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
LyP
-
-
-
-
M1851
-
-
-
-
MAP-kinase phosphatase CPG21
-
-
-
-
MEG
-
-
-
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Mitosis initiation protein
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-
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Mitosis initiation protein MIH1
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-
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Mitotic inducer homolog
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-
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MKP-1 like protein tyrosine phosphatase
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-
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MPTP
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-
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MPTP-PEST
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-
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NC-PTPCOM1
-
-
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Neural-specific protein-tyrosine phosphatase
-
-
-
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ORF5
-
-
-
-
OST-PTP
-
-
-
-
P19-PTP
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-
-
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P80
-
-
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-
PC12-PTP1
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-
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Phogrin
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Phosphacan
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phosphatase, phosphoprotein (phosphotyrosine)
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phosphatase, phosphotyrosine
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phosphoprotein phosphatase (phosphotyrosine)
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phosphotyrosine histone phosphatase
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phosphotyrosine phosphatase
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-
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Phosphotyrosine phosphatase 13
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phosphotyrosine protein phosphatase
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phosphotyrosylprotein phosphatase
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-
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protein phosphotyrosine phosphatase
-
-
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Protein tyrosine phosphatase-NP
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-
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Protein-protein-tyrosine phosphatase HA2
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-
-
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Protein-tyrosine phosphatase 1B
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-
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Protein-tyrosine phosphatase 1C
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-
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-
Protein-tyrosine phosphatase 1E
-
-
-
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Protein-tyrosine phosphatase 2C
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-
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Protein-tyrosine phosphatase 2E
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-
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Protein-tyrosine phosphatase 3CH134
-
-
-
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Protein-tyrosine phosphatase CL100
-
-
-
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Protein-tyrosine phosphatase D1
-
-
-
-
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
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Protein-tyrosine phosphatase MEG1
-
-
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-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
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Protein-tyrosine phosphatase PCPTP1
-
-
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Protein-tyrosine phosphatase pez
-
-
-
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Protein-tyrosine phosphatase PTP-RL10
-
-
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Protein-tyrosine phosphatase PTP36
-
-
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Protein-tyrosine phosphatase PTPL1
-
-
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Protein-tyrosine phosphatase striatum-enriched
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-
-
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Protein-tyrosine phosphatase SYP
-
-
-
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Protein-tyrosine-phosphatase SL
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-
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Protein-tyrosine-phosphate phosphohydrolase
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-
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PTP IA-2beta
-
-
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PTP-1B
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-
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PTP-1C
-
-
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PTP-1D
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PTP-2C
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PTP-BAS
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PTP-E1
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PTP-H1
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PTP-HA2
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-
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PTP-NP
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-
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PTP-SH2beta
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-
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PTP1C
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-
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PTP1D
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PTP2C
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PTPase YVH1
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-
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PTPase-MEG1
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-
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PTPase-MEG2
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PTPG1
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PTPN6
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PTPNE6
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PY protein phosphatase
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R-PTP-alpha
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-
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R-PTP-beta
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R-PTP-delta
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-
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R-PTP-epsilon
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R-PTP-eta
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R-PTP-gamma
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R-PTP-kappa
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R-PTP-mu
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R-PTP-zeta
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Receptor-linked protein-tyrosine phosphatase 10D
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Receptor-linked protein-tyrosine phosphatase 99A
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RNA/RNP complex-intereracting phosphatase
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ROL B protein
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RPTPalpha
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SH-PTP1
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SH-PTP2
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SH-PTP3
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SHP
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Small tyrosine phosphatase
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Small, acidic phosphotyrosine protein phosphatase
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STEP
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-
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String protein
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Syp
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T-cell protein-tyrosine phosphatase
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T-DSP11
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T200
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-
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TCPTP
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Testis-and skeletal-muscle-specific DSP
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tyrosine O-phosphate phosphatase
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Tyrosine phosphatase CBPTP
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-
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tyrosylprotein phosphatase
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[phosphotyrosine]protein phosphatase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-tyrosine-phosphate phosphohydrolase
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
CAS REGISTRY NUMBER
COMMENTARY hide
79747-53-8
-
97162-86-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
P96830_MYCTO
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
276
0
30154
TrEMBL
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with phosphate
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grundner, C.; Ng, H.L.; Alber, T.
Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure reveals a diverged fold and a buried active site
Structure
13
1625-1634
2005
Mycobacterium tuberculosis (P96830), Mycobacterium tuberculosis
Manually annotated by BRENDA team