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Aberrant Crypt Foci
Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats.
Abortion, Spontaneous
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Acalculous Cholecystitis
Gallbladder epithelial acid hydrolases in human cholecystitis.
Achondroplasia
Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes.
Acidosis
Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.
Acidosis
Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells.
Acne Vulgaris
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome: is PTPN22 involved?
Acne Vulgaris
The systemic autoinflammatory diseases: inborn errors of the innate immune system.
Acquired Immunodeficiency Syndrome
A126: Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity.
Acquired Immunodeficiency Syndrome
Role of the F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases.
Acquired Immunodeficiency Syndrome
[Common genetic factors in autoimmunity].
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Coronary Syndrome
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease.
Acute Coronary Syndrome
Increased PTPN22 expression and defective CREB activation impair regulatory T-cell differentiation in non-ST-segment elevation acute coronary syndromes.
Acute Coronary Syndrome
Protein tyrosine phosphatase receptor-type O expression as a prognostic marker in patients with acute coronary syndrome undergoing percutaneous coronary intervention: A prospective study.
Acute Kidney Injury
Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc.
Acute Kidney Injury
Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-?B (NF-?B) pathways.
Acute Kidney Injury
p66shc and Gender-specific Dimorphism in Acute Renal Injury.
Acute Kidney Injury
SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1.
Acute Lung Injury
MAP Kinase Phosphatase 5 Protects Against Sepsis-induced Acute Lung Injury.
Acute Lung Injury
Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.
Acute Lung Injury
Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury.
Addison Disease
Association of Autoimmune Addison's Disease with Alleles of STAT4 and GATA3 in European Cohorts.
Addison Disease
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Addison Disease
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Addison Disease
Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease.
Addison Disease
Novel homozygous AIRE mutation in a German patient with severe APECED.
Addison Disease
Pathogenesis of primary adrenal insufficiency.
Addison Disease
Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.
Addison Disease
Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population.
Addison Disease
The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.
Addison Disease
The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22 gene) predisposes to autoimmune Addison's disease.
Adenocarcinoma
Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C.
Adenocarcinoma
Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1.
Adenocarcinoma
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades.
Adenocarcinoma
Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system.
Adenocarcinoma
Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family.
Adenocarcinoma
Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.
Adenocarcinoma
Dual-specificity phosphatase 6 (Dusp6), a negative regulator of FGF2/ERK1/2 signaling, enhances 17?-estrodial-induced cell growth in endometrial adenocarcinoma cell.
Adenocarcinoma
Dual-specificity phosphatase 6 predicts the sensitivity of progestin therapy for atypical endometrial hyperplasia.
Adenocarcinoma
Expression and functional significance of CDC25B in human pancreatic ductal adenocarcinoma.
Adenocarcinoma
Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73.
Adenocarcinoma
Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis.
Adenocarcinoma
Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases.
Adenocarcinoma
Genome Wide Methylome Alterations in Lung Cancer.
Adenocarcinoma
Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.
Adenocarcinoma
Helicobacter Pylori CagA and Gastric Carcinogenesis.
Adenocarcinoma
High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma.
Adenocarcinoma
High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.
Adenocarcinoma
High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study.
Adenocarcinoma
High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues.
Adenocarcinoma
Immunohistochemical expression of dual-specificity protein phosphatase 4 in patients with colorectal adenocarcinoma.
Adenocarcinoma
Immunological detection of metastases from prostatic adenocarcinoma.
Adenocarcinoma
Increase in receptor-like protein tyrosine phosphatase activity and expression level on density-dependent growth arrest of endothelial cells.
Adenocarcinoma
Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma.
Adenocarcinoma
Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer.
Adenocarcinoma
Inhibitory Effect of Artesunate on Growth and Apoptosis of Gastric Cancer Cells.
Adenocarcinoma
Involvement of beta3A subunit of adaptor protein-3 in intracellular trafficking of receptor-like protein tyrosine phosphatase PCP-2.
Adenocarcinoma
Label-free biosensor: a novel phage-modified Light Addressable Potentiometric Sensor system for cancer cell monitoring.
Adenocarcinoma
MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B.
Adenocarcinoma
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Adenocarcinoma
Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.
Adenocarcinoma
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.
Adenocarcinoma
NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases.
Adenocarcinoma
Nuclear binding of androgens and acid phosphatase activity in prostatic tumors of Nb rats.
Adenocarcinoma
Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells.
Adenocarcinoma
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Adenocarcinoma
Phosphatase of Regenerating Liver-3 Induces Angiogenesis by Increasing Extracellular Signal-Regulated Kinase Phosphorylation in Endometrial Adenocarcinoma.
Adenocarcinoma
Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin.
Adenocarcinoma
Prospective comparison between serum monoclonal prostate specific antigen and acid phosphatase measurements in metastatic prostatic cancer.
Adenocarcinoma
PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.
Adenocarcinoma
PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma.
Adenocarcinoma
PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma.
Adenocarcinoma
R3327 prostate adenocarcinoma clonogenic cells: epithelial properties and hormone response.
Adenocarcinoma
Rapid rise of serum acid phosphatase after irradiation of metastatic carcinoma of prostate.
Adenocarcinoma
Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells.
Adenocarcinoma
Reduced expression of PTPRD correlates with poor prognosis in gastric adenocarcinoma.
Adenocarcinoma
SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD-1-Resistant Model of Non-Small Cell Lung Cancer.
Adenocarcinoma
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Adenocarcinoma
Significance of PTPRZ1 and CIN85 expression in cervical carcinoma.
Adenocarcinoma
The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.
Adenocarcinoma
The Expression of p66Shc Protein in Benign, Premalignant, and Malignant Gastrointestinal Lesions.
Adenocarcinoma
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers.
Adenocarcinoma
The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
Adenocarcinoma
Transcriptional gene expression profiles of oesophageal adenocarcinoma and normal oesophageal tissues.
Adenocarcinoma
[Down regulation of mitogen activated protein kinase phosphatase-1 mediate acquired multidrug resistance in pancreatic adenocarcinoma cell line SW1990/Fu]
Adenocarcinoma
[The relationship between histological classification of lung cancer and protein tyrosine phosphatase.]
Adenocarcinoma of Lung
17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells.
Adenocarcinoma of Lung
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Adenocarcinoma of Lung
Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression.
Adenocarcinoma of Lung
Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.
Adenocarcinoma of Lung
Genomic data from NSCLC tumors reveals correlation between SHP-2 activity and PD-L1 expression and suggests synergy in combining SHP-2 and PD-1/PD-L1 inhibitors.
Adenocarcinoma of Lung
Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.
Adenocarcinoma of Lung
MicroRNA-183 promotes migration and invasion of CD133(+)/CD326(+) lung adenocarcinoma initiating cells via PTPN4 inhibition.
Adenocarcinoma of Lung
MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma.
Adenocarcinoma of Lung
MicroRNA-383-5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A.
Adenocarcinoma of Lung
miR-146b Reverses epithelial-mesenchymal transition via targeting PTP1B in cisplatin-resistance human lung adenocarcinoma cells.
Adenocarcinoma of Lung
miR-516a-3p promotes proliferation, migration, and invasion and inhibits apoptosis in lung adenocarcinoma by targeting PTPRD.
Adenocarcinoma of Lung
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity.
Adenocarcinoma of Lung
Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer.
Adenocarcinoma of Lung
Prognostic significance of CDC25C in lung adenocarcinoma: An analysis of TCGA data.
Adenocarcinoma of Lung
Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.
Adenocarcinoma of Lung
Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors.
Adenocarcinoma of Lung
SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.
Adenocarcinoma of Lung
Somatic mutations affect key pathways in lung adenocarcinoma.
Adenocarcinoma of Lung
The High Expression of PTPRH Is Associated with Poor Prognosis of Human Lung Adenocarcinoma.
Adenocarcinoma of Lung
YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma.
Adenocarcinoma of Lung
[LB100 reverses the acquired resistance to gefitinib in lung adenocarcinoma cells with EGFR mutation].
Adenoma
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.
Adenoma
Downregulation of PTPRH (Sap-1) in colorectal tumors.
Adenoma
Expression of cdc25A and cdc25B proteins in thyroid neoplasms.
Adenoma
Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases.
Adenoma
Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues.
Adenoma
Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells.
Adenoma
Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer.
Adenoma
LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.
Adenoma
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
Adenoma
miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model.
Adenoma
Mkp-1 is required for chemopreventive activity of butylated hydroxyanisole and resveratrol against colitis-associated colon tumorigenesis.
Adenoma
p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling.
Adenoma
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Adenoma
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro.
Adenoma
Systematic Investigation of Expression of G2/M Transition Genes Reveals CDC25 Alteration in Nonfunctioning Pituitary Adenomas.
Adenoma
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.
Adenoma
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.
Adenoma
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
Adenoma
USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status.
Adenoma
[Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma]
Adenoma
[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]
Adenoma
[Expression of the zinc finger transcriptional factor Snail in colorectal carcinoma and its significance]
Adenoma, Pleomorphic
Ultrastructural cytochemistry of phosphatases in the ductal component of pleomorphic adenoma of human parotid and submandibular salivary glands.
Adenomatous Polyposis Coli
Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: the effect of sulindac.
Adenomatous Polyposis Coli
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.
Adenomatous Polyposis Coli
ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.
Adenomatous Polyposis Coli
BI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells.
Adenomatous Polyposis Coli
Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.
Adenomatous Polyposis Coli
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
Adenomatous Polyposis Coli
Inhibition of Wnt signaling pathway by a novel axin-binding protein.
Adenomatous Polyposis Coli
The ?-catenin destruction complex.
Adenomatous Polyposis Coli
The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor.
Adenomatous Polyposis Coli
Wnt signalling in mammalian development and cancer.
Adenoviridae Infections
Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.
African Swine Fever
Evidence for an acid phosphatase in African swine fever virus.
Albuminuria
Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury.
Albuminuria
PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.
Albuminuria
Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.
Albuminuria
Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes.
Alopecia
p66Shc Is a Negative Regulator of Fc{varepsilon}RI-Dependent Signaling in Mast Cells.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Alopecia Areata
Association between PTPN22 C1858T polymorphism and alopecia areata risk.
Alopecia Areata
Genetic variant association of PTPN22, CTLA4, IL2RA, as well as HLA frequencies in susceptibility to alopecia areata.
Alopecia Areata
Protein tyrosine phosphatase nonreceptor type 22 gene polymorphism in alopecia areata: Does it have an association with disease severity?
Alopecia Areata
PTPN22 gene polymorphism in Egyptian alopecia areata patients and its impact on response to diphencyprone immunotherapy.
Alopecia Areata
PTPN22 profile indicates a novel risk group in Alopecia areata.
Alopecia Areata
The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies.
Alopecia Areata
The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata.
Alopecia Areata
The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.
alpha-n-acetylgalactosaminide alpha-2,6-sialyltransferase deficiency
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Alveolar Bone Loss
Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model.
Alveolar Bone Loss
Functionalized nanoparticles containing MKP-1 agonists reduce periodontal bone loss.
Alzheimer Disease
A Link Between Alzheimer's and Type II Diabetes Mellitus? Ca+2 -Mediated Signal Control and Protein Localization.
Alzheimer Disease
A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data.
Alzheimer Disease
Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.
Alzheimer Disease
Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease.
Alzheimer Disease
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.
Alzheimer Disease
Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
Alzheimer Disease
Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.
Alzheimer Disease
Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling.
Alzheimer Disease
Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice.
Alzheimer Disease
Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol.
Alzheimer Disease
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
Alzheimer Disease
CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase.
Alzheimer Disease
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
Alzheimer Disease
Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease.
Alzheimer Disease
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Alzheimer Disease
Dedicated to inge grundke-iqbal.
Alzheimer Disease
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).
Alzheimer Disease
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Alzheimer Disease
Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.
Alzheimer Disease
Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.
Alzheimer Disease
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.
Alzheimer Disease
Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons.
Alzheimer Disease
Enhanced expression of protein phosphatase 2A associated with hyper-phosphorylation of histone H1 in Alzheimer's disease brain.
Alzheimer Disease
Erratum to: Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease.
Alzheimer Disease
Exploring the Therapeutic Potential of Protein Tyrosine Phosphatase 1B in hAPP-J20 Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3.
Alzheimer Disease
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.
Alzheimer Disease
I1PP2A Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A.
Alzheimer Disease
Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus.
Alzheimer Disease
Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease.
Alzheimer Disease
Implication of novel bis-imidazopyridines for management of Alzheimer's disease and establishment of its role on protein phosphatase 2A activity in brain.
Alzheimer Disease
Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.
Alzheimer Disease
Inhibitory evaluation of oligonol on ?-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and ?-secretase 1 related to diabetes and Alzheimer's disease.
Alzheimer Disease
Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease.
Alzheimer Disease
Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells.
Alzheimer Disease
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
Alzheimer Disease
Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain.
Alzheimer Disease
Microcystin-Leucine-Arginine Induces Tau Pathology Through B? Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3? Phosphorylation.
Alzheimer Disease
MKP-1 reduces A? generation and alleviates cognitive impairments in Alzheimer's disease models.
Alzheimer Disease
Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets.
Alzheimer Disease
Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid ?-Associated Alzheimer's Disease in Mice.
Alzheimer Disease
Neuroprotective effects of donepezil against A?42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3? and nAChRs activity.
Alzheimer Disease
Novel therapeutic strategies for neurodegenerative disease.
Alzheimer Disease
Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology.
Alzheimer Disease
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
Alzheimer Disease
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Alzheimer Disease
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
Alzheimer Disease
PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.
Alzheimer Disease
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells.
Alzheimer Disease
Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease.
Alzheimer Disease
Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease.
Alzheimer Disease
Protein phosphatase 2A dysfunction in Alzheimer's disease.
Alzheimer Disease
Protein phosphatase 2A in Alzheimer's disease.
Alzheimer Disease
Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease.
Alzheimer Disease
Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus.
Alzheimer Disease
Reduced levels of the tyrosine phosphatase STEP block ? amyloid-mediated GluA1/GluA2 receptor internalization.
Alzheimer Disease
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.
Alzheimer Disease
Role of Protein Phosphatase 2A in Alzheimer's Disease.
Alzheimer Disease
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.
Alzheimer Disease
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Alzheimer Disease
Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease.
Alzheimer Disease
Substrate-Based Fragment Identification for the Development of Selective, Nonpeptidic Inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase.
Alzheimer Disease
Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.
Alzheimer Disease
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.
Alzheimer Disease
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
Alzheimer Disease
The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease.
Alzheimer Disease
The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer's Disease and Other Neurological Disorders.
Alzheimer Disease
The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.
Alzheimer Disease
Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.
Alzheimer Disease
Tyrosine phosphatase STEP61 negatively regulates amyloid ?-mediated ERK/CREB signaling pathways via ?7 nicotinic acetylcholine receptors.
Alzheimer Disease
Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3? and WNT signalling pathways.
Alzheimer Disease
X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Amyotrophic Lateral Sclerosis
Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome.
Anaphylaxis
Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids.
Anaphylaxis
PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice.
Anaphylaxis
Protein tyrosine phosphatase 1B (PTP1B) is dispensable for IgE-mediated cutaneous reaction in vivo.
Anaphylaxis
SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis.
Anaphylaxis
Sirt1 negatively regulates Fc?RI-mediated mast cell activation through AMPK- and PTP1B-dependent processes.
Anaphylaxis
TU-572, a potent and selective CD45 inhibitor, suppresses IgE-mediated anaphylaxis and murine contact hypersensitivity reactions.
Anemia
A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells.
Anemia
Chicken anemia virus VP2 is a novel dual specificity protein phosphatase.
Anemia
Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.
Anemia
Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Anemia
Phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin, haptoglobin, and G6PD phenotypes.
Anemia
[Studies of the acid phosphatase activity of erythrocytes in anemia.]
Anemia, Aplastic
PTPN22 620W allele is not associated with aplastic anemia.
Anemia, Hemolytic, Autoimmune
Histiocytic medullary reticulosis with parallel increases in serum acid phosphatase and disease activity.
Anemia, Hemolytic, Autoimmune
The role of glucocorticoid in SIRP alpha and SHP-1 gene expression in AIHA patients.
Anemia, Hemolytic, Autoimmune
The role of glucocorticoid in SIRPalpha and SHP-1 gene expression in AIHA patients.
Anemia, Pernicious
Genome-wide association study identifies five risk loci for pernicious anemia.
Anemia, Sickle Cell
Phenotypic and quantitative relationship of red cell acid phosphatase with haemoglobin, haptoglobin, and G6PD phenotypes.
Aneurysm
Atypical coronary artery aneurysms due to Kawasaki disease in Noonan syndrome with a novel PTPN11 mutation.
Ankylosis
Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model.
Anodontia
Orodental, Facial and Clinical Features of Mutation-Positive Noonan Syndrome: A Monocentric Study.
Anthrax
Reduced Expression of CD45 Protein-tyrosine Phosphatase Provides Protection against Anthrax Pathogenesis.
Anti-Glomerular Basement Membrane Disease
Podocyte involvement in human immune crescentic glomerulonephritis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
PTPN22 R620W polymorphism in the ANCA-associated vasculitides.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The PTPN22 R620W polymorphism in anti-neutrophil cytoplasmic antibody-associated vasculitis in Mexican Mestizos.
Antiphospholipid Syndrome
Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.
Antiphospholipid Syndrome
PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results.
Aortic Aneurysm
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Aortic Coarctation
Alteration of p66shc is associated with endothelial dysfunction in the abdominal aortic coarctation of rats.
Aortic Coarctation
PTPN11 mutations play a minor role in isolated congenital heart disease.
Aortic Valve Stenosis
Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts.
Arrhythmias, Cardiac
[Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one].
Arteriovenous Malformations
Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14.
Arteriovenous Malformations
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
Arteritis
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Arteritis
Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis.
Arteritis
Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis.
Arteritis
New insights into the pathogenesis of giant cell arteritis and hopes for the clinic.
Arteritis
PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis.
Arthritis
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Arthritis
A Highly Sensitive Electrochemiluminescence Biosensor for Pyrophosphatase Detection Based on Click Chemistry-Triggered Hybridization Chain Reaction in Homogeneous Solution.
Arthritis
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.
Arthritis
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
Arthritis
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Arthritis
Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population.
Arthritis
Association of PTPN22 Gene Polymorphisms with Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population.
Arthritis
Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
Arthritis
Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
Arthritis
Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis.
Arthritis
Differential Expression of CD148 on leucocyte subsets in inflammatory arthritis.
Arthritis
Dual Specificity Phosphatase 1 null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis.
Arthritis
Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.
Arthritis
Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
Arthritis
Frequency of human leukocyte antigens class II-DR alleles (HLA-DRB1) in Argentinian patients with early arthritis.
Arthritis
Gaucher disease: comparative study of acid phosphatase and glucocerebrosidase in normal and type-1 Gaucher tissues.
Arthritis
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
Arthritis
Genome-wide analysis of histone H3 lysine 4 trimethylation by ChIP-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients.
Arthritis
In situ formation of fluorescent polydopamine catalyzed by peroxidase-mimicking FeCo-LDH for pyrophosphate ion and pyrophosphatase activity detection.
Arthritis
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Arthritis
Localisation of vitronectin receptor immunoreactivity and tartrate resistant acid phosphatase activity in synovium from patients with inflammatory or degenerative arthritis.
Arthritis
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Arthritis
Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation.
Arthritis
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Arthritis
Molecular cytogenetic characterization of two independent karyotypic anomalies in a patient with severe mental retardation and juvenile idiopathic arthritis.
Arthritis
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Arthritis
No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.
Arthritis
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis.
Arthritis
Overlap of disease susceptibility loci for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
Arthritis
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.
Arthritis
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Arthritis
PTPN22: the archetypal non-HLA autoimmunity gene.
Arthritis
Receptor Protein Tyrosine Phosphatase ?-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Arthritis
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Arthritis
Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Arthritis
Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients.
Arthritis
Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients.
Arthritis
Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients.
Arthritis
RPTP? phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
Arthritis
SHP-1, a novel peptide isolated from seahorse inhibits collagen release through the suppression of collagenases 1 and 3, nitric oxide products regulated by NF-kappaB/p38 kinase.
Arthritis
Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population.
Arthritis
STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.
Arthritis
Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators.
Arthritis
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
Arthritis
The Association between PTPN22 Genetic Polymorphism and Juvenile Idiopathic Arthritis (JIA) Susceptibility: An Updated Meta-Analysis.
Arthritis
The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.
Arthritis
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.
Arthritis
The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis.
Arthritis
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Arthritis
The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome.
Arthritis
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Arthritis
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Arthritis
The systemic autoinflammatory diseases: inborn errors of the innate immune system.
Arthritis
[Anti-inflammatory effect of Cu-Zn superoxide dismutase on carrageenin-induced arthritis in rabbits]
Arthritis
[Study of acid phosphatase activity in synovial fluid and serum of patients with rheumatoid polyarthritis]
Arthritis, Experimental
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
Arthritis, Experimental
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
Arthritis, Experimental
Inhibition of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 reduces the severity of collagen-induced arthritis.
Arthritis, Infectious
[Content of desoxyribose and acid phosphatase activity in the blood serum of patients with infectious arthritis during electrosleep therapy]
Arthritis, Juvenile
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Arthritis, Juvenile
Acid phosphatase activity in the synovial fluid of children with juvenile rheumatoid arthritis.
Arthritis, Juvenile
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
Arthritis, Juvenile
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Arthritis, Juvenile
Association of juvenile idiopathic arthritis with PTPN22 rs2476601 is specific to females in a Greek population.
Arthritis, Juvenile
Association of PTPN22 Gene Polymorphisms with Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population.
Arthritis, Juvenile
Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
Arthritis, Juvenile
Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.
Arthritis, Juvenile
Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
Arthritis, Juvenile
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Arthritis, Juvenile
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Arthritis, Juvenile
Molecular cytogenetic characterization of two independent karyotypic anomalies in a patient with severe mental retardation and juvenile idiopathic arthritis.
Arthritis, Juvenile
No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.
Arthritis, Juvenile
Overlap of disease susceptibility loci for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
Arthritis, Juvenile
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Arthritis, Juvenile
PTPN22: the archetypal non-HLA autoimmunity gene.
Arthritis, Juvenile
Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients.
Arthritis, Juvenile
Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients.
Arthritis, Juvenile
STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.
Arthritis, Juvenile
The Association between PTPN22 Genetic Polymorphism and Juvenile Idiopathic Arthritis (JIA) Susceptibility: An Updated Meta-Analysis.
Arthritis, Juvenile
The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis.
Arthritis, Juvenile
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.
Arthritis, Juvenile
The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis.
Arthritis, Juvenile
The relationship of the immune response mediator genes polymorphic variants with the methotrexate efficacy in juvenile idiopathic arthritis.
Arthritis, Juvenile
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Arthritis, Psoriatic
Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis.
Arthritis, Psoriatic
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Arthritis, Psoriatic
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.
Arthritis, Psoriatic
Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis.
Arthritis, Psoriatic
PTPN22 C1858T and the risk of psoriasis: a meta-analysis.
Arthritis, Psoriatic
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.
Arthritis, Psoriatic
[Progress in genetic research on psoriatic arthritis].
Arthritis, Rheumatoid
1858 C/T Polymorphism of the Protein Tyrosine Phosphatase Nonreceptor 22 Gene and Rheumatoid Arthritis Risk in Europeans: A Meta-analysis.
Arthritis, Rheumatoid
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Arthritis, Rheumatoid
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Arthritis, Rheumatoid
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
Arthritis, Rheumatoid
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Arthritis, Rheumatoid
A non-parametric method for building predictive genetic tests on high-dimensional data.
Arthritis, Rheumatoid
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.
Arthritis, Rheumatoid
Acid phosphatase activity in the synovial fluid of patients with rheumatoid arthritis and other joint disorders.
Arthritis, Rheumatoid
Activity of lysosomal enzymes and glycogen content of phytohemagglutinin-stimulated lymphocytes in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum.
Arthritis, Rheumatoid
Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1[*]0404 haplotype in rheumatoid arthritis.
Arthritis, Rheumatoid
Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides.
Arthritis, Rheumatoid
Application of bivariate mixed counting process models to genetic analysis of rheumatoid arthritis severity.
Arthritis, Rheumatoid
Application of sequential haplotype scan methods to case-control data.
Arthritis, Rheumatoid
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
Arthritis, Rheumatoid
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Arthritis, Rheumatoid
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Arthritis, Rheumatoid
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
Arthritis, Rheumatoid
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.
Arthritis, Rheumatoid
Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in a Latvian population.
Arthritis, Rheumatoid
Association of PTPN22 (rs2476601) and STAT4 (rs7574865) polymorphisms with Rheumatoid Arthritis in the Western Algerian population.
Arthritis, Rheumatoid
Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients.
Arthritis, Rheumatoid
Association of PTPN22 1858C?T polymorphism, HLA-DRB1 shared epitope and autoantibodies with rheumatoid arthritis.
Arthritis, Rheumatoid
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.
Arthritis, Rheumatoid
Association of PTPN22 Haplotypes (-1123G>C/+1858C>T) with Rheumatoid Arthritis in Western Mexican Population.
Arthritis, Rheumatoid
Association of PTPN22 haplotypes with Graves' disease.
Arthritis, Rheumatoid
Association of PTPN22 rs2476601 and EGFR rs17337023 Gene polymorphisms and rheumatoid arthritis in Zahedan, Southeast Iran.
Arthritis, Rheumatoid
Association of PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with rheumatoid arthritis: A meta-analysis update.
Arthritis, Rheumatoid
Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran.
Arthritis, Rheumatoid
Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.
Arthritis, Rheumatoid
Association of PTPN22 with Rheumatoid Arthritis Among South Asians in the UK.
Arthritis, Rheumatoid
Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect.
Arthritis, Rheumatoid
Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis.
Arthritis, Rheumatoid
Association of STAT4 rs7574865 and PTPN22 rs2476601 polymorphisms with rheumatoid arthritis and non-systemically reacting antibodies in Egyptian patients.
Arthritis, Rheumatoid
Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
Arthritis, Rheumatoid
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Arthritis, Rheumatoid
Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.
Arthritis, Rheumatoid
Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients.
Arthritis, Rheumatoid
Association of the PTPN22 gene polymorphism with autoantibody positivity in Turkish rheumatoid arthritis patients.
Arthritis, Rheumatoid
Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort.
Arthritis, Rheumatoid
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.
Arthritis, Rheumatoid
Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.
Arthritis, Rheumatoid
Associations between PTPRC rs10919563 A/G and FCGR2A R131H polymorphisms and responsiveness to TNF blockers in rheumatoid arthritis: a meta-analysis.
Arthritis, Rheumatoid
Associations between the PTPN22 1858C->T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis: results from a 10-year longitudinal study.
Arthritis, Rheumatoid
Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis.
Arthritis, Rheumatoid
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Arthritis, Rheumatoid
Biomarker Approach Towards Rheumatoid Arthritis Treatment.
Arthritis, Rheumatoid
CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians.
Arthritis, Rheumatoid
Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis.
Arthritis, Rheumatoid
Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis.
Arthritis, Rheumatoid
Corrigendum to "CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians" [Hum. Immunol. 77 (2016) 522-526].
Arthritis, Rheumatoid
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.
Arthritis, Rheumatoid
Death Receptor 5-Targeted Depletion of Interleukin-23-Producing Macrophages, Th17, and Th1/17 Associated With Defective Tyrosine Phosphatase in Mice and Patients With Rheumatoid Arthritis.
Arthritis, Rheumatoid
Development and application of a PCR-HRM molecular diagnostic method of SNPs linked with TNF inhibitor efficacy.
Arthritis, Rheumatoid
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Arthritis, Rheumatoid
Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.
Arthritis, Rheumatoid
EOMES-positive CD4
Arthritis, Rheumatoid
Epidemiology: Interpreting studies of interactions between RA risk factors.
Arthritis, Rheumatoid
Essential role of MAPK phosphatase-1 in the negative control of innate immune responses.
Arthritis, Rheumatoid
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Arthritis, Rheumatoid
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
Arthritis, Rheumatoid
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Arthritis, Rheumatoid
Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
Arthritis, Rheumatoid
Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.
Arthritis, Rheumatoid
Evidence of cis-acting regulatory variation in PTPN22 in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids.
Arthritis, Rheumatoid
Expression of peptidylarginine deiminase 4 and protein tyrosine phosphatase nonreceptor type 22 in the synovium of collagen-induced arthritis rats.
Arthritis, Rheumatoid
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Arthritis, Rheumatoid
Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
Arthritis, Rheumatoid
Frequency of human leukocyte antigens class II-DR alleles (HLA-DRB1) in Argentinian patients with early arthritis.
Arthritis, Rheumatoid
Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
Arthritis, Rheumatoid
Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.
Arthritis, Rheumatoid
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Arthritis, Rheumatoid
Genetic epidemiology of rheumatoid arthritis.
Arthritis, Rheumatoid
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
Arthritis, Rheumatoid
Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
Arthritis, Rheumatoid
Genome-wide gene-based analysis of rheumatoid arthritis-associated interaction with PTPN22 and HLA-DRB1.
Arthritis, Rheumatoid
Genome-wide Study Identifies Association between HLA-B?55:01 and Self-Reported Penicillin Allergy.
Arthritis, Rheumatoid
Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis.
Arthritis, Rheumatoid
Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.
Arthritis, Rheumatoid
Identification of novel putative rheumatoid arthritis susceptibility genes via analysis of rare variants.
Arthritis, Rheumatoid
Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.
Arthritis, Rheumatoid
Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study.
Arthritis, Rheumatoid
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Arthritis, Rheumatoid
Inhibition of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 reduces the severity of collagen-induced arthritis.
Arthritis, Rheumatoid
Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis, Rheumatoid
Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.
Arthritis, Rheumatoid
IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.
Arthritis, Rheumatoid
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Arthritis, Rheumatoid
Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.
Arthritis, Rheumatoid
Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.
Arthritis, Rheumatoid
Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.
Arthritis, Rheumatoid
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Arthritis, Rheumatoid
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Arthritis, Rheumatoid
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Arthritis, Rheumatoid
Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population.
Arthritis, Rheumatoid
Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1.
Arthritis, Rheumatoid
Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis.
Arthritis, Rheumatoid
Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.
Arthritis, Rheumatoid
Mitogen-activated protein kinase phosphatase-1: function and regulation in bone and related tissues.
Arthritis, Rheumatoid
Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis.
Arthritis, Rheumatoid
Modeling the effect of PTPN22 in rheumatoid arthritis.
Arthritis, Rheumatoid
Modeling the effect of susceptibility factors (HLA and PTPN22) in rheumatoid arthritis.
Arthritis, Rheumatoid
Modulation of PTPN2/22 Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn's Disease and Rheumatoid Arthritis.
Arthritis, Rheumatoid
Need for clarification of data in the recent meta-analysis about 1858 C/T Polymorphism of the Protein Tyrosine Phosphatase Nonreceptor 22 Gene and Rheumatoid Arthritis Risk.
Arthritis, Rheumatoid
NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.
Arthritis, Rheumatoid
No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey.
Arthritis, Rheumatoid
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.
Arthritis, Rheumatoid
Pathogenesis and treatment of autoimmune rheumatic diseases.
Arthritis, Rheumatoid
Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.
Arthritis, Rheumatoid
Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.
Arthritis, Rheumatoid
Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.
Arthritis, Rheumatoid
Protective Effect of Pinitol Against Inflammatory Mediators of Rheumatoid Arthritis via Inhibition of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22).
Arthritis, Rheumatoid
Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
Arthritis, Rheumatoid
Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) +1858 C>T gene polymorphism in Egyptian cases with rheumatoid arthritis.
Arthritis, Rheumatoid
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.
Arthritis, Rheumatoid
Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts.
Arthritis, Rheumatoid
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Arthritis, Rheumatoid
Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders.
Arthritis, Rheumatoid
Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.
Arthritis, Rheumatoid
PTPN14 phosphatase and YAP promote TGF? signalling in rheumatoid synoviocytes.
Arthritis, Rheumatoid
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.
Arthritis, Rheumatoid
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Arthritis, Rheumatoid
PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.
Arthritis, Rheumatoid
PTPN22 -1123G>C polymorphism and anti-cyclic citrullinated protein antibodies in rheumatoid arthritis.
Arthritis, Rheumatoid
PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.
Arthritis, Rheumatoid
PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis.
Arthritis, Rheumatoid
PTPN22 1858C>T polymorphism is associated with increased CD154 expression and higher CD4+ T cells percentage in rheumatoid arthritis patients.
Arthritis, Rheumatoid
PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.
Arthritis, Rheumatoid
PTPN22 and rheumatoid arthritis: gratifying replication.
Arthritis, Rheumatoid
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Arthritis, Rheumatoid
PTPN22 gene polymorphism and susceptibility to rheumatoid arthritis (RA): Updated systematic review and meta-analysis.
Arthritis, Rheumatoid
PTPN22 gene polymorphism in Behçet's disease.
Arthritis, Rheumatoid
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.
Arthritis, Rheumatoid
PTPN22 Is a Critical Regulator of Fc? Receptor-Mediated Neutrophil Activation.
Arthritis, Rheumatoid
Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation.
Arthritis, Rheumatoid
PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
Arthritis, Rheumatoid
PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.
Arthritis, Rheumatoid
PTPN22 R620W genotype-phenotype correlation analysis and gene-environment interaction study in early rheumatoid arthritis: results from the ESPOIR cohort.
Arthritis, Rheumatoid
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Arthritis, Rheumatoid
PTPN22 splice forms: a new role in rheumatoid arthritis.
Arthritis, Rheumatoid
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Arthritis, Rheumatoid
PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis.
Arthritis, Rheumatoid
PTPN22: its role in SLE and autoimmunity.
Arthritis, Rheumatoid
PTPN22: the archetypal non-HLA autoimmunity gene.
Arthritis, Rheumatoid
PTPN22?+788 G>A (R263Q) Polymorphism is Associated with mRNA Expression but it is not a Susceptibility Marker for Rheumatoid Arthritis Patients from Western Mexico.
Arthritis, Rheumatoid
PTPome profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival.
Arthritis, Rheumatoid
PTPRC mutation associated with response to anti-tNF therapy in rheumatoid arthritis.
Arthritis, Rheumatoid
PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy.
Arthritis, Rheumatoid
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Arthritis, Rheumatoid
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.
Arthritis, Rheumatoid
Regulation of autoimmune and anti-tumour T cell responses by PTPN22.
Arthritis, Rheumatoid
Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase.
Arthritis, Rheumatoid
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Arthritis, Rheumatoid
Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.
Arthritis, Rheumatoid
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.
Arthritis, Rheumatoid
Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele.
Arthritis, Rheumatoid
Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients.
Arthritis, Rheumatoid
Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.
Arthritis, Rheumatoid
rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis-a possible interface?
Arthritis, Rheumatoid
Single Nucleotide Polymorphism rs 2476601 of PTPN22 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population.
Arthritis, Rheumatoid
Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population.
Arthritis, Rheumatoid
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
Arthritis, Rheumatoid
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Arthritis, Rheumatoid
Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.
Arthritis, Rheumatoid
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.
Arthritis, Rheumatoid
Targeting Protein Tyrosine Phosphatase PTP-PEST for Therapeutic Intervention in Acute Myocardial Infarction.
Arthritis, Rheumatoid
Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population.
Arthritis, Rheumatoid
The +1858C/T PTPN22 gene polymorphism confers genetic susceptibility to rheumatoid arthritis in Mexican population from the Western Mexico.
Arthritis, Rheumatoid
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
Arthritis, Rheumatoid
The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update.
Arthritis, Rheumatoid
The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis.
Arthritis, Rheumatoid
The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals.
Arthritis, Rheumatoid
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.
Arthritis, Rheumatoid
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.
Arthritis, Rheumatoid
The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico.
Arthritis, Rheumatoid
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Arthritis, Rheumatoid
The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage.
Arthritis, Rheumatoid
The potential of PTPN22 as a therapeutic target for rheumatoid arthritis.
Arthritis, Rheumatoid
The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.
Arthritis, Rheumatoid
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Arthritis, Rheumatoid
The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.
Arthritis, Rheumatoid
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
Arthritis, Rheumatoid
The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis.
Arthritis, Rheumatoid
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
Arthritis, Rheumatoid
The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.
Arthritis, Rheumatoid
The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.
Arthritis, Rheumatoid
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Arthritis, Rheumatoid
The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in caucasian case-control samples.
Arthritis, Rheumatoid
The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.
Arthritis, Rheumatoid
The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status.
Arthritis, Rheumatoid
The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis.
Arthritis, Rheumatoid
The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome.
Arthritis, Rheumatoid
The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.
Arthritis, Rheumatoid
The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.
Arthritis, Rheumatoid
The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
Arthritis, Rheumatoid
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.
Arthritis, Rheumatoid
The TT Genotype of the STAT4 rs7574865 Polymorphism Is Associated with High Disease Activity and Disability in Patients with Early Arthritis.
Arthritis, Rheumatoid
The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.
Arthritis, Rheumatoid
TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.
Arthritis, Rheumatoid
Understanding the genetic contribution to rheumatoid arthritis.
Arthritis, Rheumatoid
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
Arthritis, Rheumatoid
Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis.
Arthritis, Rheumatoid
[Acid phosphatase activity and the autoimmune processes in rheumatism and rheumatoid arthritis]
Arthritis, Rheumatoid
[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan].
Arthritis, Rheumatoid
[Genetics and genomics in rheumatoid arthritis (RA): An update].
Arthritis, Rheumatoid
[Polymorphic markers of certain genes in the development of dry keratoconjunctivitis in patients with rheumatoid arthritis and Sjogren's syndrome].
Arthritis, Rheumatoid
[PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis susceptibility in Caucasian population: a meta-analysis].
Arthritis, Rheumatoid
[Relevance of the gene variant PTPN22 620W for rheumatology]
Asphyxia Neonatorum
Changes in lysosomal hydrolases from cord blood of vigorous and asphyxiated Nigerian newborn infants.
Asthma
Analyses of shared genetic factors between asthma and obesity in children.
Asthma
Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children.
Asthma
Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.
Asthma
Body mass and glucocorticoid response in asthma.
Asthma
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.
Asthma
Corticosteroids and ?(2) -agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms.
Asthma
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma.
Asthma
Effects of genetic factors to inhaled corticosteroid response in children with asthma: a literature review.
Asthma
Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.
Asthma
Genes to diseases (G2D) computational method to identify asthma candidate genes.
Asthma
Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1.
Asthma
Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma.
Asthma
Inhibitors of PDE4, but Not PDE3, Increase ?2-agonist-induced Expression of Anti-inflammatory MKP-1 in Airway Smooth Muscle Cells.
Asthma
LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE.
Asthma
Long-Acting ?2-Agonists Increase Fluticasone Propionate-Induced Mitogen-Activated Protein Kinase Phosphatase 1 (MKP-1) in Airway Smooth Muscle Cells.
Asthma
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
Asthma
Mechanism of glutamine inhibition of cytosolic phospholipase A2 (cPLA2 ): Evidence of physical interaction between glutamine-induced MAPK phosphatase-1 and cPLA2.
Asthma
Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma.
Asthma
Network study of nasal transcriptome profiles reveals master regulator genes of asthma.
Asthma
Proteasomal inhibition upregulates the endogenous MAPK deactivator MKP-1 in human airway smooth muscle: mechanism of action and effect on cytokine secretion.
Asthma
Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders.
Asthma
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma.
Asthma
Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability.
Asthma
SHP-1 As a Critical Regulator of Mycoplasma pneumoniae-Induced Inflammation in Human Asthmatic Airway Epithelial Cells.
Asthma
SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lung.
Asthma
src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
Asthma
Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators.
Asthma
The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
Asthma
The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma.
Asthma
The GPx1-PTP1B-PP2A Axis: A Key Determinant of Airway Inflammation and Alveolar Destruction.
Asthma
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
Asthma
The polymorphisms of protein-tyrosine phosphatase receptor-type delta gene and its association with pediatric asthma in the Taiwanese population.
Asthma
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.
Asthma
Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation.
Asthma
Vitamin D levels, lung function, and steroid response in adult asthma.
Asthma
[Acid phosphatase activity of bronchial asthma patients during treatment at a health resort]
Astrocytoma
A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase micro.
Astrocytoma
An acid phosphatase in the plasma membranes of human astrocytoma showing marked specificity toward phosphotyrosine protein.
Astrocytoma
CDC25B, Ki-67, and p53 expressions in reactive gliosis and astrocytomas.
Astrocytoma
Cellular and molecular characterization of IDH1-mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFR? activation.
Astrocytoma
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.
Astrocytoma
Cytokine-induced transcription of protein-tyrosine-phosphatases in human astrocytoma cells.
Astrocytoma
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.
Astrocytoma
Expression and activation of signal regulatory protein alpha on astrocytomas.
Astrocytoma
Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas.
Astrocytoma
Expression of transmembrane protein tyrosine phosphatase gamma (PTPgamma) in normal and neoplastic human tissues.
Astrocytoma
FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS.
Astrocytoma
Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.
Astrocytoma
Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes.
Astrocytoma
Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition.
Astrocytoma
Low-Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature.
Astrocytoma
Optic nerve pilomyxoid astrocytoma in a patient with Noonan syndrome.
Astrocytoma
Pilocytic astrocytoma in a child with Noonan syndrome.
Astrocytoma
Prognostic significance of CDC25B expression in gliomas.
Astrocytoma
Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma.
Ataxia
Analysis of the CHK2 gene in lymphoid malignancies.
Ataxia
Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway.
Ataxia
Caveolin-1, cellular senescence and pulmonary emphysema.
Ataxia
D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation.
Ataxia
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients.
Ataxia
Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3beta release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells.
Ataxia
Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.
Ataxia Telangiectasia
4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.
Ataxia Telangiectasia
Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-X(L) and survivin.
Ataxia Telangiectasia
Arsenite induces prominent mitotic arrest via inhibition of G2 checkpoint activation in CGL-2 cells.
Ataxia Telangiectasia
Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation.
Ataxia Telangiectasia
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.
Ataxia Telangiectasia
Chk2 activation dependence on Nbs1 after DNA damage.
Ataxia Telangiectasia
Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis.
Ataxia Telangiectasia
Ethanol metabolism activates cell cycle checkpoint kinase, Chk2.
Ataxia Telangiectasia
Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells.
Ataxia Telangiectasia
Hypoxic preconditioning decreases nuclear factor ?B activity via Disrupted in Schizophrenia-1.
Ataxia Telangiectasia
Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition.
Ataxia Telangiectasia
Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.
Ataxia Telangiectasia
Microwave hyperthermia promotes caspase?3-dependent apoptosis and induces G2/M checkpoint arrest via the ATM pathway in non?small cell lung cancer cells.
Ataxia Telangiectasia
N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
Ataxia Telangiectasia
PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.
Ataxia Telangiectasia
PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway.
Ataxia Telangiectasia
S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells.
Ataxia Telangiectasia
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Ataxia Telangiectasia
The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
Ataxia Telangiectasia
TLC388 Induces DNA Damage and G2 Phase Cell Cycle Arrest in Human Non-Small Cell Lung Cancer Cells.
Atherosclerosis
Activity of two enzymes associated with apoptosis and cell aging in arterial hypertension.
Atherosclerosis
Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study.
Atherosclerosis
Association of protein tyrosine phosphatase-n1 polymorphisms with coronary calcified plaque in the diabetes heart study.
Atherosclerosis
Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN.
Atherosclerosis
Atherosclerosis and PTPN22: A Study in Coronary Artery Disease.
Atherosclerosis
Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis
Correlation between SHP-1 and carotid plaque vulnerability in humans.
Atherosclerosis
Decreased p66Shc promoter methylation in patients with end-stage renal disease.
Atherosclerosis
Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.
Atherosclerosis
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Atherosclerosis
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease.
Atherosclerosis
Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP.
Atherosclerosis
Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.
Atherosclerosis
Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
Atherosclerosis
Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.
Atherosclerosis
Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.
Atherosclerosis
Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.
Atherosclerosis
Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels.
Atherosclerosis
Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.
Atherosclerosis
Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE(-/-) mouse model of atherosclerosis with alterations in IL10/AMPK? pathway.
Atherosclerosis
Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice.
Atherosclerosis
P66shc and its role in ischemic cardiovascular diseases.
Atherosclerosis
p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.
Atherosclerosis
Pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) protects against atherosclerotic plaque formation in the LDLR(-/-) mouse model of atherosclerosis.
Atherosclerosis
Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models.
Atherosclerosis
Protein tyrosine phosphatase LMW-PTP exhibits distinct roles between vascular endothelial and smooth muscle cells.
Atherosclerosis
Protein tyrosine phosphatase SHP-2 is positively involved in platelet-derived growth factor-signaling in vascular neointima formation via the reactive oxygen species-related pathway.
Atherosclerosis
Protein Tyrosine Phosphatase SHP-2 Is Positively Involved in Platelet-Derived Growth Factor-Signaling in Vascular Neointima Formation via the Reactive Oxygen Species-Related Pathway.
Atherosclerosis
PTPN2 negatively regulates macrophage inflammation in atherosclerosis.
Atherosclerosis
PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals.
Atherosclerosis
Regulation of Src homology 2-containing protein tyrosine phosphatase by advanced glycation end products: the role on atherosclerosis in diabetes.
Atherosclerosis
Role of PTP-1B in aortic smooth muscle cell motility and tyrosine phosphorylation of focal adhesion proteins.
Atherosclerosis
Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
Atherosclerosis
Serum protein signature of coronary artery disease in type 2 diabetes mellitus.
Atherosclerosis
Targeting Angiopoietin in Retinal Vascular Diseases: A Literature Review and Summary of Clinical Trials Involving Faricimab.
Atherosclerosis
Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.
Atrial Fibrillation
Genotype-phenotype analysis and natural history of left ventricular hypertrophy in LEOPARD syndrome.
Autoimmune Diseases
1858 C/T Polymorphism of the Protein Tyrosine Phosphatase Nonreceptor 22 Gene and Rheumatoid Arthritis Risk in Europeans: A Meta-analysis.
Autoimmune Diseases
A biosynthetic pathway for anandamide.
Autoimmune Diseases
A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.
Autoimmune Diseases
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Autoimmune Diseases
A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population.
Autoimmune Diseases
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Autoimmune Diseases
A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes.
Autoimmune Diseases
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
Autoimmune Diseases
A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.
Autoimmune Diseases
A three-dimensional chemical phase pharmacophore mapping, QSAR modelling and electronic feature analysis of benzofuran salicylic acid derivatives as LYP inhibitors.
Autoimmune Diseases
A variant of PTPN22 gene conferring risk to autoimmune diseases may protect against tuberculosis.
Autoimmune Diseases
A126: Clusters of Autoimmune Diseases in Children and the Role of PTPN22 C1858T Gene Polymorphism in Pediatric Polyautoimmunity.
Autoimmune Diseases
Allele and haplotype frequency distribution in PTPN22 gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases.
Autoimmune Diseases
An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum.
Autoimmune Diseases
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.
Autoimmune Diseases
Analysis of PTPN22, ZFAT and MYO9B polymorphisms in Turner Syndrome and risk of autoimmune disease.
Autoimmune Diseases
Anti-ganglioside autoantibodies in type 1 diabetes.
Autoimmune Diseases
Anti-parietal cell antibodies and pernicious anemia in patients with type 1 diabetes mellitus and multiethnic background.
Autoimmune Diseases
Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome.
Autoimmune Diseases
Are other protein tyrosine phosphatases than PTPN22 associated with autoimmunity?
Autoimmune Diseases
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.
Autoimmune Diseases
Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population.
Autoimmune Diseases
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.
Autoimmune Diseases
Association between a gain-of-function variant of PTPN22 and rejection in liver transplantation.
Autoimmune Diseases
Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.
Autoimmune Diseases
Association between PTPN22 C1858T polymorphism and alopecia areata risk.
Autoimmune Diseases
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Autoimmune Diseases
Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis.
Autoimmune Diseases
Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance.
Autoimmune Diseases
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
Autoimmune Diseases
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
Autoimmune Diseases
Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo.
Autoimmune Diseases
Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.
Autoimmune Diseases
Association of protein tyrosine phosphatase, non-receptor type 22 +1858C?T polymorphism and susceptibility to vitiligo: Systematic review and meta-analysis.
Autoimmune Diseases
Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.
Autoimmune Diseases
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.
Autoimmune Diseases
Association of PTPN22 haplotypes with Graves' disease.
Autoimmune Diseases
Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population.
Autoimmune Diseases
Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran.
Autoimmune Diseases
Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease.
Autoimmune Diseases
Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population.
Autoimmune Diseases
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Autoimmune Diseases
Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.
Autoimmune Diseases
Association of the FAM167A-BLK region with systemic sclerosis.
Autoimmune Diseases
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Autoimmune Diseases
Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population.
Autoimmune Diseases
Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis.
Autoimmune Diseases
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.
Autoimmune Diseases
Association of TNF-?, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil.
Autoimmune Diseases
Associations of single nucleotide polymorphisms of PTPN22 and Ctla4 genes with the risk of allergic rhinitis in a Chinese Han population.
Autoimmune Diseases
Autoantibodies specific for different isoforms of CD45 in systemic lupus erythematosus.
Autoimmune Diseases
Autoimmune associations and autoantibody screening show focused recognition in patient subgroups with generalized myasthenia gravis.
Autoimmune Diseases
Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study.
Autoimmune Diseases
Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22).
Autoimmune Diseases
Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.
Autoimmune Diseases
Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-? receptor signaling.
Autoimmune Diseases
Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset.
Autoimmune Diseases
Biochemical and Functional Studies of Lymphoid-Specific Tyrosine Phosphatase (Lyp) Variants S201F and R266W.
Autoimmune Diseases
C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition.
Autoimmune Diseases
C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?
Autoimmune Diseases
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.
Autoimmune Diseases
Classical Examples of the Concept of the ASIA Syndrome.
Autoimmune Diseases
Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening.
Autoimmune Diseases
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
Autoimmune Diseases
Conjugation of Antisense Oligonucleotides to PEGylated Carbon Nanotubes Enables Efficient Knockdown of PTPN22 in T Lymphocytes.
Autoimmune Diseases
Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland.
Autoimmune Diseases
Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2.
Autoimmune Diseases
Current concepts in the genetic diagnostics of rheumatoid arthritis.
Autoimmune Diseases
Cutting Edge: Protein Phosphatase 2A Confers Susceptibility to Autoimmune Disease through an IL-17-Dependent Mechanism.
Autoimmune Diseases
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
Autoimmune Diseases
Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors.
Autoimmune Diseases
Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.
Autoimmune Diseases
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Autoimmune Diseases
Differential nanoscale organisation of LFA-1 modulates T cell migration.
Autoimmune Diseases
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
Autoimmune Diseases
Do inhibitory immune receptors play a role in the etiology of autoimmune disease?
Autoimmune Diseases
Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children.
Autoimmune Diseases
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
Autoimmune Diseases
Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis.
Autoimmune Diseases
EOMES-positive CD4
Autoimmune Diseases
Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis.
Autoimmune Diseases
Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients.
Autoimmune Diseases
Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.
Autoimmune Diseases
Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients.
Autoimmune Diseases
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection.
Autoimmune Diseases
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Autoimmune Diseases
Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
Autoimmune Diseases
Frequency of islet cell autoantibodies (IA-2 and GAD) in young Brazilian type 1 diabetes patients.
Autoimmune Diseases
Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.
Autoimmune Diseases
Gender-specific association of the PTPN22 C1858T polymorphism with achalasia.
Autoimmune Diseases
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Autoimmune Diseases
Genetic progress towards the molecular basis of autoimmunity.
Autoimmune Diseases
Genetics of type 1 diabetes in Asian and Caucasian populations.
Autoimmune Diseases
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Autoimmune Diseases
Genome-wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A, and Identification of ZBTB10 and Three Distinct HLA Associations.
Autoimmune Diseases
Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils.
Autoimmune Diseases
Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
Autoimmune Diseases
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility.
Autoimmune Diseases
Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.
Autoimmune Diseases
Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells.
Autoimmune Diseases
Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22.
Autoimmune Diseases
Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Autoimmune Diseases
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Autoimmune Diseases
In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation.
Autoimmune Diseases
Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.
Autoimmune Diseases
Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.
Autoimmune Diseases
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Autoimmune Diseases
Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.
Autoimmune Diseases
IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.
Autoimmune Diseases
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Autoimmune Diseases
Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.
Autoimmune Diseases
Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Autoimmune Diseases
Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.
Autoimmune Diseases
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Autoimmune Diseases
Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.
Autoimmune Diseases
MAP kinase phosphatase 1 is necessary for T cell activation and function.
Autoimmune Diseases
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Autoimmune Diseases
MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Autoimmune Diseases
Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation.
Autoimmune Diseases
Multifocal motor neuropathy is not associated with genetic variation in PTPN22, BANK1, Blk, FCGR2B, CD1A/E, and TAG-1 genes.
Autoimmune Diseases
Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.
Autoimmune Diseases
Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele.
Autoimmune Diseases
Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease.
Autoimmune Diseases
New developments in genetics of myositis.
Autoimmune Diseases
No association of PTPN22 R620 W gene polymorphism with rheumatic heart disease and systemic lupus erythematosus.
Autoimmune Diseases
No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome.
Autoimmune Diseases
Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL.
Autoimmune Diseases
Novel associations for hypothyroidism include known autoimmune risk loci.
Autoimmune Diseases
Novel missense mutation in PTPN22 in a Chinese pedigree with Hashimoto's thyroiditis.
Autoimmune Diseases
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
Autoimmune Diseases
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Autoimmune Diseases
Overlap of disease susceptibility loci for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA).
Autoimmune Diseases
Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease.
Autoimmune Diseases
p66Shc Is a Negative Regulator of Fc{varepsilon}RI-Dependent Signaling in Mast Cells.
Autoimmune Diseases
Pathogenesis of primary adrenal insufficiency.
Autoimmune Diseases
Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A.
Autoimmune Diseases
Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.
Autoimmune Diseases
Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain.
Autoimmune Diseases
Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures.
Autoimmune Diseases
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphism in pulmonary tuberculosis in the Indian population.
Autoimmune Diseases
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Autoimmune Diseases
Protein tyrosine phosphatase PTPN22 regulates IL-1? dependent Th17 responses by modulating dectin-1 signaling in mice.
Autoimmune Diseases
Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.
Autoimmune Diseases
Protein tyrosine phosphatases in autoimmunity.
Autoimmune Diseases
PTPN22 1858 C/T Exon Polymorphism is not Associated with Graves' Disease in Kashmiri population.
Autoimmune Diseases
PTPN22 1858T is not a risk factor for North American Pemphigus vulgaris.
Autoimmune Diseases
PTPN22 620W allele is not associated with aplastic anemia.
Autoimmune Diseases
PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.
Autoimmune Diseases
PTPN22 allele polymorphisms in 15 Chinese populations.
Autoimmune Diseases
PTPN22 alters the development of regulatory T cells in the thymus.
Autoimmune Diseases
PTPN22 and autoimmune disease.
Autoimmune Diseases
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.
Autoimmune Diseases
PTPN22 and CTLA-4 gene polymorphisms in resected thymomas and thymus for myasthenia gravis.
Autoimmune Diseases
PTPN22 and myasthenia gravis: replication in an Italian population and meta-analysis of literature data.
Autoimmune Diseases
PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes.
Autoimmune Diseases
PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.
Autoimmune Diseases
PTPN22 C1858T polymorphism in women with endometriosis.
Autoimmune Diseases
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Autoimmune Diseases
PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Autoimmune Diseases
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
Autoimmune Diseases
PTPN22 gene polymorphism as a genetic risk factor for primary immune thrombocytopenia in Egyptian children.
Autoimmune Diseases
PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.
Autoimmune Diseases
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.
Autoimmune Diseases
PTPN22 inhibition resets defective human central B cell tolerance.
Autoimmune Diseases
PTPN22 Is a Critical Regulator of Fc? Receptor-Mediated Neutrophil Activation.
Autoimmune Diseases
PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.
Autoimmune Diseases
Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation.
Autoimmune Diseases
PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis.
Autoimmune Diseases
PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling.
Autoimmune Diseases
PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome.
Autoimmune Diseases
PTPN22 profile indicates a novel risk group in Alopecia areata.
Autoimmune Diseases
PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.
Autoimmune Diseases
PTPN22 R620W polymorphism in the ANCA-associated vasculitides.
Autoimmune Diseases
PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus.
Autoimmune Diseases
PTPN22 splice forms: a new role in rheumatoid arthritis.
Autoimmune Diseases
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Autoimmune Diseases
PTPN22: its role in SLE and autoimmunity.
Autoimmune Diseases
PTPN22: the archetypal non-HLA autoimmunity gene.
Autoimmune Diseases
R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity.
Autoimmune Diseases
Recent advances in genetic predisposition of myasthenia gravis.
Autoimmune Diseases
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Autoimmune Diseases
Regulation of autoimmune and anti-tumour T cell responses by PTPN22.
Autoimmune Diseases
Regulation of signal transduction by the Fc gamma receptor family members and their involvement in autoimmunity.
Autoimmune Diseases
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Autoimmune Diseases
Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CLBL genes.
Autoimmune Diseases
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.
Autoimmune Diseases
Role of C1858T polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian children and adolescents with type 1 diabetes.
Autoimmune Diseases
Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
Autoimmune Diseases
Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.
Autoimmune Diseases
Single Nucleotide Polymorphism rs 2476601 of PTPN22 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population.
Autoimmune Diseases
Single Nucleotide Polymorphisms of PTPN22 Gene in Iranian Patients with Ulcerative Colitis.
Autoimmune Diseases
Single-cell profiling reveals dendritic cell signatures associated with autoimmune inflammation.
Autoimmune Diseases
Small amplicons high resolution melting analysis (SA-HRMA) allows successful genotyping of acid phosphatase 1 (ACP1) polymorphisms in the Italian population.
Autoimmune Diseases
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Autoimmune Diseases
STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients.
Autoimmune Diseases
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Autoimmune Diseases
Substrate Specificity of Lymphoid-specific Tyrosine Phosphatase (Lyp) and Identification of Src Kinase-associated Protein of 55 kDa Homolog (SKAP-HOM) as a Lyp Substrate.
Autoimmune Diseases
Susceptibility influence of a PTPN22 haplotype with thyroid autoimmunity in Koreans.
Autoimmune Diseases
Systemic inhibition of PTPN22 augments anticancer immunity.
Autoimmune Diseases
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Autoimmune Diseases
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.
Autoimmune Diseases
The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.
Autoimmune Diseases
The association of PTPN22 (rs2476601) and IL2RA (rs11594656) polymorphisms with T1D in Egyptian children.
Autoimmune Diseases
The association of PTPN22 R620W polymorphism is stronger with late-onset AChR-myasthenia gravis in Turkey.
Autoimmune Diseases
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.
Autoimmune Diseases
The association of the PTPN22 620W polymorphism with Behcet's disease.
Autoimmune Diseases
The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals.
Autoimmune Diseases
The Autoimmune-Associated Single Nucleotide Polymorphism Within PTPN22 Correlates With Clinical Outcome After Lung Transplantation.
Autoimmune Diseases
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling.
Autoimmune Diseases
The autoimmunity-related polymorphism PTPN22 1858C/T is associated with anti-titin antibody-positive myasthenia gravis.
Autoimmune Diseases
The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls.
Autoimmune Diseases
The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese.
Autoimmune Diseases
The common, autoimmunity-predisposing 620Arg > Trp variant of PTPN22 modulates macrophage function and morphology.
Autoimmune Diseases
The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus.
Autoimmune Diseases
The genetic basis of autoantibody production.
Autoimmune Diseases
The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits.
Autoimmune Diseases
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Autoimmune Diseases
The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3.
Autoimmune Diseases
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Autoimmune Diseases
The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete.
Autoimmune Diseases
The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.
Autoimmune Diseases
The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis.
Autoimmune Diseases
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.
Autoimmune Diseases
The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease.
Autoimmune Diseases
The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.
Autoimmune Diseases
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
Autoimmune Diseases
The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.
Autoimmune Diseases
The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.
Autoimmune Diseases
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Autoimmune Diseases
The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations.
Autoimmune Diseases
The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.
Autoimmune Diseases
The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.
Autoimmune Diseases
The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.
Autoimmune Diseases
The Role of Heat Shock Proteins in Type 1 Diabetes.
Autoimmune Diseases
The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura.
Autoimmune Diseases
The role of PTPN22 in autoimmunity: learning from mice.
Autoimmune Diseases
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.
Autoimmune Diseases
The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.
Autoimmune Diseases
The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
Autoimmune Diseases
Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
Autoimmune Diseases
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
Autoimmune Diseases
Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes.
Autoimmune Diseases
Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population.
Autoimmune Diseases
Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
Autoimmune Diseases
[Latent forms of adult-onset autoimmune polyglandular syndrome: diagnosis and management of patients].
Azoospermia
Decreased Expression of CDC25A in Azoospermia as the Etiology of Spermatogenesis Failure.
Bacterial Infections
Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila.
Bacterial Infections
Correlation of acid phosphatase activity with degree of bacterial infection in HELA cells.
Bacterial Infections
Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection.
Bacterial Infections
IL-34 regulates the inflammatory response and anti-bacterial immune defense of Japanese flounder Paralichthys olivaceus.
Bacterial Infections
Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection.
Bacterial Infections
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.
Bacterial Infections
MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response.
Bacterial Infections
Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.
Bacterial Infections
Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes.
Bacterial Infections
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphism in pulmonary tuberculosis in the Indian population.
Bacterial Infections
PTPN22 and invasive bacterial disease.
Bacterial Infections
SHP-1 suppresses the antiviral innate immune response by targeting TRAF3.
Bacterial Infections
The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations.
Bacterial Infections
[Classification and etiology of hyperthyroidism].
Basal Cell Nevus Syndrome
Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins.
Behcet Syndrome
A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2.
Behcet Syndrome
Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease.
Behcet Syndrome
No Association of PTPN22 Polymorphisms with Susceptibility to Ocular Behcet's Disease in Two Chinese Han Populations.
Behcet Syndrome
The association of the PTPN22 620W polymorphism with Behcet's disease.
beta-Thalassemia
Red cell acid phosphatase activity in carriers of beta-thalassemia trait and glucose-6-phosphate dehydrogenase deficiency.
Blast Crisis
Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation.
Blast Crisis
Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells.
Blast Crisis
Redirecting traffic using the XPO1 police.
Blast Crisis
ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia.
Blast Crisis
Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.
Blister
Acid hydrolases in blister fluid. I. Characterization and quantification of acid phosphatase.
Blister
Inhibition of 5-alpha-reductase activity induces stromal remodeling and smooth muscle de-differentiation in adult gerbil ventral prostate.
Blister
Programmed cell death in the larval salivary glands of Apis mellifera (Hymenoptera, Apidae).
Blood Group Incompatibility
[Acid phosphatase activity in the neutrophils and peripheral lymphocytes in normal pregnancy and pregnancies complicated by RH-HR blood group incompatibility and toxemia]
Bluetongue
Cellular Casein Kinase 2 and Protein Phosphatase 2A Modulate Replication Site Assembly of Bluetongue Virus.
Bone Diseases
Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates.
Bone Diseases
MKP-1 Knockout Does not Prevent Glucocorticoid-Induced Bone Disease in Mice.
Bone Diseases, Metabolic
Identification of Differential Genes Expression Profiles and Pathways of Bone Marrow Mesenchymal Stem Cells of Adolescent Idiopathic Scoliosis Patients by Microarray and Integrated Gene Network Analysis.
Bone Diseases, Metabolic
New Variants in Enpp1 and Ptpn6 Genes Cause Low Bone Density, Crystal-Related Arthropathy and Vascular Calcification.
Bone Diseases, Metabolic
Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis.
Bone Diseases, Metabolic
Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide.
Bone Diseases, Metabolic
The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice.
Bone Neoplasms
Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia.
Bone Resorption
A quantitative cytochemical assay for osteoclast acid phosphatase activity in foetal rat calvaria.
Bone Resorption
Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions.
Bone Resorption
An osteoclastic protein-tyrosine phosphatase may play a role in differentiation and activity of human monocytic U-937 cell-derived, osteoclast-like cells.
Bone Resorption
Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss.
Bone Resorption
Biochemical markers of bone turnover for the clinical investigation of osteoporosis.
Bone Resorption
Biochemical markers of bone turnover.
Bone Resorption
Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function.
Bone Resorption
Bone composition and metabolism after hyperbaric oxygenation in rats with 1-hydroxyethylidene-1,1-bisphosphonate-induced rickets.
Bone Resorption
Bone resorption in chronic otitis media. A light-microscopical and histochemical investigation of acid phosphatase activity.
Bone Resorption
Bone resorption in experimental otosclerosis in rats.
Bone Resorption
Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption.
Bone Resorption
Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts.
Bone Resorption
Critical role of MKP-1 in lipopolysaccharide-induced osteoclast formation through CXCL1 and CXCL2.
Bone Resorption
Crocin attenuates methylglyoxal-induced osteoclast dysfunction by regulating glyoxalase, oxidative stress, and mitochondrial function.
Bone Resorption
Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
Bone Resorption
Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model.
Bone Resorption
Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants.
Bone Resorption
Effects of moderate intensity static magnetic fields on osteoclastic differentiation in mouse bone marrow cells.
Bone Resorption
Effects of nicotine on bone during orthodontic tooth movement in male rats. Histological and immunohistochemical study.
Bone Resorption
Galectin-3 is essential for proper bone cell differentiation and activity, bone remodeling and biomechanical competence in mice.
Bone Resorption
Gender differences in serum markers of bone resorption in healthy subjects and patients with disorders affecting bone.
Bone Resorption
Influence of irradiation on the osteoinductive potential of demineralized bone matrix.
Bone Resorption
Inhibition of osteoclastic acid phosphatase abolishes bone resorption.
Bone Resorption
Ipriflavone modulates IGF-I but is unable to restore bone in rats.
Bone Resorption
Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite: a light and electron microscopic observation using immunohistochemistry for PGP 9.5.
Bone Resorption
Novel ipriflavone receptors coupled to calcium influx regulate osteoclast differentiation and function.
Bone Resorption
Osteogenic activity of yellow flag iris (Iris pseudacorus) extract modulating differentiation of osteoblasts and osteoclasts.
Bone Resorption
Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption.
Bone Resorption
Preventive effects of flaxseed and sesame oil on bone loss in ovariectomized rats.
Bone Resorption
Protein phosphatase 2A as a new target for downregulating osteoclastogenesis and alleviating titanium particle-induced bone resorption.
Bone Resorption
Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts.
Bone Resorption
PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis.
Bone Resorption
Pulsed electromagnetic fields inhibit osteoclast differentiation in RAW264.7 macrophages via suppression of the protein kinase B/mammalian target of rapamycin signaling pathway.
Bone Resorption
Quantification of osteoclastic resorption of the bovine otic capsule in vitro by an enzyme-linked immunosorbent assay.
Bone Resorption
Strontium ranelate decreases receptor activator of nuclear factor-?B ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor.
Bone Resorption
T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice.
Bone Resorption
T Cell Protein Tyrosine Phosphatase in Osteoimmunology.
Bone Resorption
T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts.
Bone Resorption
Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice.
Bone Resorption
The Antiosteoporosis Effects of Zhuanggu Guanjie Pill In Vitro and In Vivo.
Bone Resorption
The effect of carbonic anhydrase inhibition on calcium and bone homeostasis in healthy postmenopausal women.
Bone Resorption
The effect of dental plaque grown in the presence of xylitol or sucrose on bone resorption in vitro.
Bone Resorption
The effects of dietary calcium during lactation on lead in bone mobilization: implications for toxicology.
Bone Resorption
The importance of the prenyl group in the activities of osthole in enhancing bone formation and inhibiting bone resorption in vitro.
Bone Resorption
The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice.
Bone Resorption
Tooth hard tissue stimulates bone remodeling as a potential motive force during tooth eruption.
Bone Resorption
Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo.
Bone Resorption
Tyrosine-protein phosphatase non-receptor type 2 inhibits alveolar bone resorption in diabetic periodontitis via dephosphorylating CSF1 receptor.
Bone Resorption
[ALKALINE AND ACID PHOSPHATASE ACTIVITY IN PROCESSES OF BONE FORMATION AND BONE RESORPTION (EXPERIMENTAL STUDY).]
Bradycardia
Genotype-phenotype analysis and natural history of left ventricular hypertrophy in LEOPARD syndrome.
Bradycardia
Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function.
Bradycardia
SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation.
Brain Abscess
[Change in acid phosphatase activity in meningitis and brain abscess.]
Brain Concussion
Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes.
Brain Death
Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A.
Brain Diseases
Developmental epileptic encephalopathy with hypomyelination and brain atrophy associated with PTPN23 variants affecting the assembly of UsnRNPs.
Brain Diseases
Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.
Brain Diseases
Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
Brain Diseases
Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing.
Brain Diseases
Mutations of PTPN23 in developmental and epileptic encephalopathy.
Brain Diseases
The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1.
Brain Edema
Tristetraprolin attenuates brain edema in a rat model of cerebral hemorrhage.
Brain Injuries
A peptide mimetic of tyrosine phosphatase STEP as a potential therapeutic agent for treatment of cerebral ischemic stroke.
Brain Injuries
Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes.
Brain Injuries
Combinational Approach of Genetic SHP-1 Suppression and Voluntary Exercise Promotes Corticospinal Tract Sprouting and Motor Recovery Following Brain Injury.
Brain Injuries
Comparison of RPTP zeta/beta, phosphacan, and trkB mRNA expression in the developing and adult rat nervous system and induction of RPTP zeta/beta and phosphacan mRNA following brain injury.
Brain Injuries
Ferulic acid attenuates the injury-induced decrease of protein phosphatase 2A subunit B in ischemic brain injury.
Brain Injuries
Melatonin attenuates decrease of protein phosphatase 2A subunit B in ischemic brain injury.
Brain Injuries
Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.
Brain Injuries
Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.
Brain Injuries
The protein tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons and reactive astrocytes.
Brain Injuries
Tyrosine phosphatase inhibition attenuates early brain injury after subarachnoid hemorrhage in rats.
Brain Injuries, Traumatic
Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice.
Brain Injuries, Traumatic
P13BP, a calpain-2-mediated breakdown product of PTPN13, is a novel blood biomarker for Traumatic Brain Injury.
Brain Injuries, Traumatic
Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.
Brain Injuries, Traumatic
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Brain Ischemia
Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.
Brain Ischemia
Curcumin treatment recovery the decrease of protein phosphatase 2A subunit B induced by focal cerebral ischemia in Sprague-Dawley rats.
Brain Ischemia
Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.
Brain Ischemia
Focal Cerebral Ischemia Reduces Protein Phosphatase 2A Subunit B Expression in Brain Tissue and HT22 Cells.
Brain Ischemia
Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice.
Brain Ischemia
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Brain Ischemia
Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.
Brain Ischemia
Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition.
Brain Ischemia
Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice.
Brain Ischemia
Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.
Brain Ischemia
Phosphorylation of tau protein over time in rats subjected to transient brain ischemia.
Brain Ischemia
PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus.
Brain Ischemia
Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia.
Brain Ischemia
Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia.
Brain Ischemia
Tyrosine phosphatase inhibition attenuates early brain injury after subarachnoid hemorrhage in rats.
Brain Neoplasms
A role for receptor tyrosine phosphatase zeta in glioma cell migration.
Brain Neoplasms
Acid phosphatase activity in human brain tumours.
Brain Neoplasms
Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.
Brain Neoplasms
Association of protein phosphatase 2A with its substrate vimentin intermediate filaments in 9L rat brain tumor cells.
Brain Neoplasms
Low-Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature.
Brain Neoplasms
Noonan syndrome, PTPN11 mutations, and brain tumors. A clinical report and review of the literature.
Brain Neoplasms
Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.
Brain Neoplasms
The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway.
Brain Neoplasms
[A histochemical study of the acid phosphatase activity of macroglial brain tumors]
Branchio-Oto-Renal Syndrome
Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent.
Breast Carcinoma In Situ
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Breast Diseases
Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk.
Breast Diseases
The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14.
Breast Neoplasms
17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells.
Breast Neoplasms
17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways.
Breast Neoplasms
3,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation.
Breast Neoplasms
3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells.
Breast Neoplasms
3,3'-Diindolylmethane negatively regulates Cdc25A and induces a G2/M arrest by modulation of microRNA 21 in human breast cancer cells: retraction.
Breast Neoplasms
6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.
Breast Neoplasms
A bioinformatics-based strategy identifies c-Myc and Cdc25A as candidates for the Apmt mammary tumor latency modifiers.
Breast Neoplasms
A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.
Breast Neoplasms
A high-molecular weight complex with acid phosphatase activity in human breast cancer.
Breast Neoplasms
A microtiter enzyme-linked immunosorbent assay for protein tyrosine phosphatase.
Breast Neoplasms
A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells.
Breast Neoplasms
A novel deep autoencoder based survival analysis approach for microarray dataset.
Breast Neoplasms
A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.
Breast Neoplasms
A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma.
Breast Neoplasms
Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis.
Breast Neoplasms
Aberrant PTPRO methylation in tumor tissues as a potential biomarker that predicts clinical outcomes in breast cancer patients.
Breast Neoplasms
Acid phosphatase activity in the cytosol fraction of the breast cancer tissue.
Breast Neoplasms
Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells.
Breast Neoplasms
Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase.
Breast Neoplasms
Activation of Src and transformation by an RPTP? splice mutant found in human tumours.
Breast Neoplasms
Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells.
Breast Neoplasms
Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530.
Breast Neoplasms
Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer.
Breast Neoplasms
An Aza-Cope Reactivity-Based Fluorescent Probe for Imaging Formaldehyde in Living Cells.
Breast Neoplasms
An RNA aptamer that selectively inhibits the enzymatic activity of protein tyrosine phosphatase 1B in vitro.
Breast Neoplasms
Anti-tumor activity of SL4 against breast cancer cells: induction of G2/M arrest through modulation of the MAPK-dependent p21 signaling pathway.
Breast Neoplasms
Antiestrogens increase protein tyrosine phosphatase activity in human breast cancer cells.
Breast Neoplasms
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
Breast Neoplasms
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi.
Breast Neoplasms
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Breast Neoplasms
Association of PTP1B with Outcomes of Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy.
Breast Neoplasms
Association of PTPN1 polymorphisms with breast cancer risk: A case-control study in Chinese females.
Breast Neoplasms
Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors.
Breast Neoplasms
BSSV: Bayesian based somatic structural variation identification with whole genome DNA-seq data.
Breast Neoplasms
c-Jun N-terminal kinase inactivation by mitogen-activated protein kinase phosphatase 1 determines resistance to taxanes and anthracyclines in breast cancer.
Breast Neoplasms
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Breast Neoplasms
CDC 25A gene 263C/T, -350C/T, and -51C/G polymorphisms in breast carcinoma.
Breast Neoplasms
CDC25A pathway toward tumorigenesis: Molecular targets of CDC25A in cell-cycle regulation.
Breast Neoplasms
CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment.
Breast Neoplasms
Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells.
Breast Neoplasms
CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer.
Breast Neoplasms
Cell cycle dysregulation influences survival in high risk breast cancer patients.
Breast Neoplasms
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
Breast Neoplasms
Changes in protein tyrosine phosphatase type IVA member 1 and zinc finger protein 36 C3H type-like 1 expression demonstrate altered estrogen and progestin effect in medroxyprogesterone acetate-resistant and estrogen-independent breast cancer cell models.
Breast Neoplasms
Characterization of low molecular weight protein tyrosine phosphatase isoforms in human breast cancer epithelial cell lines.
Breast Neoplasms
Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation.
Breast Neoplasms
CIP2A is associated with human breast cancer aggressivity.
Breast Neoplasms
Clinical importance of phosphatase of regenerating liver-3 expression in breast cancer.
Breast Neoplasms
Clinical significance of sCIP2A levels in breast cancer.
Breast Neoplasms
Clinicopathological significance of PTPN12 expression in human breast cancer.
Breast Neoplasms
Coexpression and coregulation analysis of time-series gene expression data in estrogen-induced breast cancer cell.
Breast Neoplasms
Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.
Breast Neoplasms
Combined expression of metastasis related markers Naa10p, SNCG and PRL-3 and its prognostic value in breast cancer patients.
Breast Neoplasms
Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.
Breast Neoplasms
Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites.
Breast Neoplasms
Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.
Breast Neoplasms
Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.
Breast Neoplasms
Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica.
Breast Neoplasms
D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.
Breast Neoplasms
Decreased total MKP-1 protein levels predict poor prognosis in breast cancer.
Breast Neoplasms
Deregulation of protein phosphatase 2A inhibitor SET is associated with malignant progression in breast cancer.
Breast Neoplasms
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status.
Breast Neoplasms
Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis.
Breast Neoplasms
Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines.
Breast Neoplasms
Docosahexaenoic Acid Inhibits PTP1B Phosphatase and the Viability of MCF-7 Breast Cancer Cells.
Breast Neoplasms
Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.
Breast Neoplasms
Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis.
Breast Neoplasms
DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death.
Breast Neoplasms
EBP50 suppresses the proliferation of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc.
Breast Neoplasms
Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression.
Breast Neoplasms
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance.
Breast Neoplasms
Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors.
Breast Neoplasms
Elimination of ALDH+ breast tumor initiating cells by docosahexanoic acid and/or gamma tocotrienol through SHP-1 inhibition of Stat3 signaling.
Breast Neoplasms
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells.
Breast Neoplasms
Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells.
Breast Neoplasms
Epithelial Protein-Tyrosine Phosphatase 1B (PTP1B) Contributes to the Induction of Mammary Tumors by HER2/Neu but is not Essential for Tumor Maintenance.
Breast Neoplasms
erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line.
Breast Neoplasms
ERBB2 and PTPN2 gene copy numbers as prognostic factors in HER2-positive metastatic breast cancer treated with trastuzumab.
Breast Neoplasms
ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
Breast Neoplasms
Erratum to: Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells.
Breast Neoplasms
Erratum: Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity.
Breast Neoplasms
Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation.
Breast Neoplasms
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
Breast Neoplasms
Estrogens and PTP1B Function in a Novel Pathway to Regulate Aromatase Enzymatic Activity in Breast Cancer Cells.
Breast Neoplasms
Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.
Breast Neoplasms
Evaluation of drug-targetable genes by defining modes of abnormality in gene expression.
Breast Neoplasms
Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role.
Breast Neoplasms
Exogenous phosphotyrosine modulates epidermal growth factor receptor tyrosine phosphorylation.
Breast Neoplasms
Exploring drivers of gene expression in the Cancer Genome Atlas.
Breast Neoplasms
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Breast Neoplasms
Expression and Function of the Protein Tyrosine Phosphatase Receptor J (PTPRJ) in Normal Mammary Epithelial Cells and Breast Tumors.
Breast Neoplasms
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Breast Neoplasms
Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy.
Breast Neoplasms
Expression of cdc25A and cdc25B phosphatase in breast carcinoma.
Breast Neoplasms
Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer.
Breast Neoplasms
Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis.
Breast Neoplasms
Expression of PRL-3 regulates proliferation and invasion of breast cancer cells in vitro.
Breast Neoplasms
Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo.
Breast Neoplasms
Expression of receptor protein tyrosine phosphatase ? is a risk factor for triple negative breast cancer relapse.
Breast Neoplasms
Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer.
Breast Neoplasms
Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors.
Breast Neoplasms
Expression Profiling during Mammary Epithelial Cell Three-Dimensional Morphogenesis Identifies PTPRO as a Novel Regulator of Morphogenesis and ErbB2-Mediated Transformation.
Breast Neoplasms
Extracellular signal-regulated kinase 1/2 and protein phosphatase 2A are involved in the antiproliferative activity of conjugated linoleic acid in MCF-7 cells.
Breast Neoplasms
Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7.
Breast Neoplasms
Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.
Breast Neoplasms
Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity.
Breast Neoplasms
Functions of Shp2 in cancer.
Breast Neoplasms
Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).
Breast Neoplasms
Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells.
Breast Neoplasms
Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium.
Breast Neoplasms
Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells.
Breast Neoplasms
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
Breast Neoplasms
Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.
Breast Neoplasms
Green Tea Catechins Induce Inhibition of PTP1B Phosphatase in Breast Cancer Cells with Potent Anti-Cancer Properties: In Vitro Assay, Molecular Docking, and Dynamics Studies.
Breast Neoplasms
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
Breast Neoplasms
HePTP promotes migration and invasion in triple-negative breast cancer cells via activation of Wnt/?-catenin signaling.
Breast Neoplasms
High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design.
Breast Neoplasms
Histochemical staining of protein-tyrosine phosphatase activity in primary human mammary carcinoma: relationship with established prognostic indicators.
Breast Neoplasms
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines.
Breast Neoplasms
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.
Breast Neoplasms
Identifying the role of PTPN12 expression in predicting the efficacy of capecitabine to neoadjuvant chemotherapy in breast cancer treatment.
Breast Neoplasms
IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation.
Breast Neoplasms
Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues.
Breast Neoplasms
Implication of protein tyrosine phosphatase 1B in MCF-7 cell proliferation and resistance to 4-OH tamoxifen.
Breast Neoplasms
Increased metastasis with loss of E2F2 in Myc-driven tumors.
Breast Neoplasms
Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells.
Breast Neoplasms
Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin.
Breast Neoplasms
Inhibition of a specific N-glycosylation activity results in attenuation of breast carcinoma cell invasiveness-related phenotypes: inhibition of epidermal growth factor-induced dephosphorylation of focal adhesion kinase.
Breast Neoplasms
Inhibition of androgen receptor and Cdc25A phosphatase as a combination targeted therapy in molecular apocrine breast cancer.
Breast Neoplasms
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells.
Breast Neoplasms
Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential.
Breast Neoplasms
Inhibitory Activity of Iron Chelators ATA and DFO on MCF-7 Breast Cancer Cells and Phosphatases PTP1B and SHP2.
Breast Neoplasms
Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis.
Breast Neoplasms
Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.
Breast Neoplasms
Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents.
Breast Neoplasms
Isolation of two sesquiterpene glycosides from Sapindus mukorossi Gaertn. with cytotoxic properties and analysis of their mechanism based on network pharmacology.
Breast Neoplasms
Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells.
Breast Neoplasms
Knockdown of dual specificity phosphatase 4 enhances the chemosensitivity of MCF-7 and MCF-7/ADR breast cancer cells to doxorubicin.
Breast Neoplasms
LAR-PTPase cDNA transfection suppression of tumor growth of neu oncogene-transformed human breast carcinoma cells.
Breast Neoplasms
Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
Breast Neoplasms
Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2.
Breast Neoplasms
Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206.
Breast Neoplasms
Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer.
Breast Neoplasms
Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
Breast Neoplasms
Low Expression of Tyrosine-protein Phosphatase Nonreceptor Type 12 is Associated with Lymph Node Metastasis and Poor Prognosis in Operable Triple-negative Breast Cancer.
Breast Neoplasms
Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism.
Breast Neoplasms
Low Molecular Weight Protein Tyrosine Phosphatase Slow Isoform Knockdown in MDA-MB-435 Cells Decreases RAW 264.7 Osteoclastic Differentiation.
Breast Neoplasms
Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.
Breast Neoplasms
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Breast Neoplasms
Mechanisms of antineoplastic action of somatostatin analogs.
Breast Neoplasms
Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells.
Breast Neoplasms
MicroRNA miR-24 Enhances Tumor Invasion and Metastasis by Targeting PTPN9 and PTPRF to Promote EGF Signaling.
Breast Neoplasms
MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration.
Breast Neoplasms
MicroRNA-99a-5p suppresses breast cancer progression and cell-cycle pathway through downregulating CDC25A.
Breast Neoplasms
MiR-19b suppresses PTPRG to promote breast tumorigenesis.
Breast Neoplasms
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
Breast Neoplasms
Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin.
Breast Neoplasms
Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.
Breast Neoplasms
MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer.
Breast Neoplasms
MKP1 mediates resistance to therapy in HER2-positive breast tumors.
Breast Neoplasms
Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase.
Breast Neoplasms
MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells.
Breast Neoplasms
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.
Breast Neoplasms
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Breast Neoplasms
NCAPG upregulation mediated by four microRNAs combined with activation of the p53 signaling pathway is a predictor of poor prognosis in patients with breast cancer.
Breast Neoplasms
Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
Breast Neoplasms
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.
Breast Neoplasms
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.
Breast Neoplasms
Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.
Breast Neoplasms
Novel PROTACs for degradation of SHP2 protein.
Breast Neoplasms
Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells.
Breast Neoplasms
Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer.
Breast Neoplasms
Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells.
Breast Neoplasms
Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica.
Breast Neoplasms
Overexpression of CDC25A associated with poor prognosis in breast cancer
Breast Neoplasms
Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome.
Breast Neoplasms
Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.
Breast Neoplasms
Overexpression of the Protein Tyrosine Phosphatase PRL-2 Correlates with Breast Tumor Formation and Progression.
Breast Neoplasms
Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression.
Breast Neoplasms
p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression.
Breast Neoplasms
p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres.
Breast Neoplasms
Parathyroid hormone-related protein regulates tumor-relevant genes in breast cancer cells.
Breast Neoplasms
Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C.
Breast Neoplasms
Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains.
Breast Neoplasms
Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration.
Breast Neoplasms
Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer.
Breast Neoplasms
Physalis angulata induced G2/M phase arrest in human breast cancer cells.
Breast Neoplasms
PP2A regulates signaling through hormonal receptors in breast cancer with important therapeutic implications.
Breast Neoplasms
PPAR? inhibits breast cancer progression by upregulating PTPRF expression.
Breast Neoplasms
PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.
Breast Neoplasms
PRL-3 promotes breast cancer progression by downregulating p14
Breast Neoplasms
PRL-3, an Emerging Marker of Carcinogenesis, is Strongly Associated with Poor Prognosis.
Breast Neoplasms
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Breast Neoplasms
Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/DUSP1).
Breast Neoplasms
Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer.
Breast Neoplasms
Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients.
Breast Neoplasms
Prognostic Significance of Metastatic Lymph Nodes Ratio (MLNR) Combined with Protein-Tyrosine Phosphatase H1 (PTPH1) Expression in Operable Breast Invasive Ductal Carcinoma.
Breast Neoplasms
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
Breast Neoplasms
Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells.
Breast Neoplasms
Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer.
Breast Neoplasms
Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells.
Breast Neoplasms
Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk.
Breast Neoplasms
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Breast Neoplasms
Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer.
Breast Neoplasms
Protein Tyrosine Phosphatase 1B Inhibitors from the Stems of Akebia quinata.
Breast Neoplasms
Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.
Breast Neoplasms
Protein tyrosine phosphatase activity as a diagnostic parameter in breast cancer.
Breast Neoplasms
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
Breast Neoplasms
Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer.
Breast Neoplasms
Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting I?B?.
Breast Neoplasms
Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer.
Breast Neoplasms
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Breast Neoplasms
Protein tyrosine phosphatase PTPN9 negatively regulates ErbB2 and EGFR signaling in breast cancer cells.
Breast Neoplasms
Protein tyrosine phosphatase receptor type O expression in the tumor niche correlates with reduced tumor growth, angiogenesis, circulating tumor cells and metastasis of breast cancer.
Breast Neoplasms
Protein tyrosine phosphatase receptor-type ? acts as a negative regulator suppressing breast cancer.
Breast Neoplasms
Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2.
Breast Neoplasms
Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis.
Breast Neoplasms
Protein tyrosine phosphatase-1B and T-cell protein tyrosine phosphatase regulate IGF-2-induced MCF-7 cell migration.
Breast Neoplasms
Protein tyrosine phosphatases as potential therapeutic targets.
Breast Neoplasms
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
Breast Neoplasms
Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.
Breast Neoplasms
Protein-tyrosine phosphatase H1 increases breast cancer sensitivity to antiestrogens by dephosphorylating estrogen receptor at Tyr537.
Breast Neoplasms
Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells.
Breast Neoplasms
Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors.
Breast Neoplasms
PTP LAR expression compared to prognostic indices in metastatic and non-metastatic breast cancer.
Breast Neoplasms
PTP-PEST phosphatase variations in human cancer.
Breast Neoplasms
PTP1B expression is an independent positive prognostic factor in human breast cancer.
Breast Neoplasms
PTP1B markedly promotes breast cancer progression and is regulated by miR-193a-3p.
Breast Neoplasms
PTP1B phosphatase as a novel target of oleuropein activity in MCF-7 breast cancer model.
Breast Neoplasms
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Breast Neoplasms
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Breast Neoplasms
PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells.
Breast Neoplasms
PTP1B: a double agent in metabolism and oncogenesis.
Breast Neoplasms
PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.
Breast Neoplasms
PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study.
Breast Neoplasms
PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase.
Breast Neoplasms
PTPN12 Affects Nasopharyngeal Carcinoma Cell Proliferation and Migration Through Regulating EGFR.
Breast Neoplasms
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.
Breast Neoplasms
PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness.
Breast Neoplasms
PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer.
Breast Neoplasms
PTPRA facilitates cancer growth and migration via the TNF-?-mediated PTPRA-NF-?B pathway in MCF-7 breast cancer cells.
Breast Neoplasms
PTPRJ Haplotypes and Colorectal Cancer Risk.
Breast Neoplasms
PTPRN2 and PLC?1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling.
Breast Neoplasms
PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy.
Breast Neoplasms
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.
Breast Neoplasms
PTPRT Could Be a Treatment Predictive and Prognostic Biomarker for Breast Cancer.
Breast Neoplasms
Purification and characterization of a rat liver protein-tyrosine phosphatase with sequence similarity to src-homology region 2.
Breast Neoplasms
Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP ?1/SHP-2 signaling system.
Breast Neoplasms
Regulation of acidification and apoptosis by SHP-1 and Bcl-2.
Breast Neoplasms
Repression of breast cancer cell growth by proteasome inhibitors in vitro: impact of mitogen-activated protein kinase phosphatase 1.
Breast Neoplasms
Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK.
Breast Neoplasms
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
Breast Neoplasms
Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells.
Breast Neoplasms
Role of intracellular Ca2+ in the epidermal growth factor induced inhibition of protein tyrosine phosphatase activity in a breast cancer cell line.
Breast Neoplasms
Role of PRL-3, Snail, Cytokeratin and Vimentin expression in epithelial mesenchymal transition in breast carcinoma.
Breast Neoplasms
Role of the Cdc25A phosphatase in human breast cancer.
Breast Neoplasms
Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells.
Breast Neoplasms
Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase.
Breast Neoplasms
SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment.
Breast Neoplasms
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.
Breast Neoplasms
SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro.
Breast Neoplasms
Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells.
Breast Neoplasms
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.
Breast Neoplasms
Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3.
Breast Neoplasms
Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2.
Breast Neoplasms
Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.
Breast Neoplasms
Targeting protein-tyrosine phosphatases in breast cancer.
Breast Neoplasms
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Breast Neoplasms
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.
Breast Neoplasms
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Breast Neoplasms
The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells.
Breast Neoplasms
The correlation of PTPN4 expression with prognosis in breast cancer.
Breast Neoplasms
The effect of treatment with 4-hydroxyandrostenedione or medroxyprogesterone acetate on human breast tumour regression.
Breast Neoplasms
The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
Breast Neoplasms
The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14.
Breast Neoplasms
The function of the protein tyrosine phosphatase SHP-1 in cancer.
Breast Neoplasms
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling.
Breast Neoplasms
The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer.
Breast Neoplasms
The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis.
Breast Neoplasms
The p52 isoform of SHC1 is a key driver of breast cancer initiation.
Breast Neoplasms
The plasma peptides of breast versus ovarian cancer.
Breast Neoplasms
The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer.
Breast Neoplasms
The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells.
Breast Neoplasms
The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis.
Breast Neoplasms
The receptor protein tyrosine phosphatase (RPTP)beta/zeta is expressed in different subtypes of human breast cancer.
Breast Neoplasms
The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment.
Breast Neoplasms
The semiquantitative bone scintigraphy index correlates with serum tartrate-resistant acid phosphatase activity in breast cancer patients with bone metastasis.
Breast Neoplasms
The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
Breast Neoplasms
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
Breast Neoplasms
Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.
Breast Neoplasms
Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.
Breast Neoplasms
Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER).
Breast Neoplasms
Tyrosine phosphatase PTP? contributes to HER2-evoked breast tumor initiation and maintenance.
Breast Neoplasms
Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.
Breast Neoplasms
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Breast Neoplasms
Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4.
Breast Neoplasms
Uncovering a tumor suppressor for triple-negative breast cancers.
Breast Neoplasms
Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression.
Breast Neoplasms
[Bioinformatic analysis of direct protein targets of aspirin against human breast cancer proliferation].
Breast Neoplasms
[Corrigendum] Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.
Breast Neoplasms
[Inhibitory effect of SHP-1 gene transfer on the proliferation of breast cancer cell line MDA-MB-231]
Breast Neoplasms
[PTPL1, a proapoptotic protein tyrosine phosphatase in breast cancers]
Breast Neoplasms
[Retrovirus-mediated SHP-1 gene expression in human breast cancer MDA-MB-231 cells]
Bronchiolitis
Alveolar Macrophage Phenotype and Compartmentalization Drive Different Pulmonary Changes in Mouse Strains Exposed to Cigarette Smoke.
Bronchiolitis
Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
Bronchitis
Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus.
Bronchitis, Chronic
[Elastase and acid phosphatase activity in bronchoalveolar lavage fluid during chronic bronchitis]
Bronchopulmonary Dysplasia
Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans.
Bronchopulmonary Dysplasia
Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.
Brucellosis
A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats.
Brucellosis
PTPN22 C1858T polymorphism and human brucellosis.
Burkitt Lymphoma
A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells.
Burkitt Lymphoma
Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?
Burkitt Lymphoma
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Burkitt Lymphoma
Fcgamma receptor-mediated inhibition of human B cell activation: the role of SHP-2 phosphatase.
Burkitt Lymphoma
Oncogenic mechanisms in Burkitt lymphoma.
Burkitt Lymphoma
Regulation of CD45 expression in human leukemia cells.
Burkitt Lymphoma
Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma.
calpain-2 deficiency
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Candidiasis
Association of the lymphoid protein tyrosine phosphatase, R620W variant, with chronic mucocutaneous candidiasis.
Candidiasis
DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment.
Candidiasis, Chronic Mucocutaneous
Association of the lymphoid protein tyrosine phosphatase, R620W variant, with chronic mucocutaneous candidiasis.
Carcinogenesis
2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets.
Carcinogenesis
?TrCP-dependent degradation of CDC25B phosphatase at the metaphase-anaphase transition is a pre-requisite for correct mitotic exit.
Carcinogenesis
A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.
Carcinogenesis
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
Carcinogenesis
A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation.
Carcinogenesis
A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization.
Carcinogenesis
A novel mechanism of indole-3-carbinol effects on breast carcinogenesis involves induction of Cdc25A degradation.
Carcinogenesis
A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.
Carcinogenesis
Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma.
Carcinogenesis
Aberrant promoter 2 methylation?mediated downregulation of protein tyrosine phosphatase, non?receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Carcinogenesis
Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin.
Carcinogenesis
Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer.
Carcinogenesis
Alteration of gene expression during radiation-induced resistance and tumorigenesis in NIH3T3 cells revealed by cDNA microarrays: involvement of MDM2 and CDC25B.
Carcinogenesis
Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression.
Carcinogenesis
Association of PTP1B with Outcomes of Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy.
Carcinogenesis
Beyond the metabolic function of PTP1B.
Carcinogenesis
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.
Carcinogenesis
Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.
Carcinogenesis
CDC25A pathway toward tumorigenesis: Molecular targets of CDC25A in cell-cycle regulation.
Carcinogenesis
CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
Carcinogenesis
CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment.
Carcinogenesis
Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.
Carcinogenesis
CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci.
Carcinogenesis
Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.
Carcinogenesis
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase.
Carcinogenesis
Cell Transformation by PTP1B Truncated Mutants Found in Human Colon and Thyroid Tumors.
Carcinogenesis
Characterization of low molecular weight protein tyrosine phosphatase isoforms in human breast cancer epithelial cell lines.
Carcinogenesis
Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells.
Carcinogenesis
Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.
Carcinogenesis
CIP2A facilitates the G1/S cell cycle transition via B-Myb in human papillomavirus 16 oncoprotein E6-expressing cells.
Carcinogenesis
Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors.
Carcinogenesis
Clinicopathological significance of PTPN12 expression in human breast cancer.
Carcinogenesis
Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis.
Carcinogenesis
Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.
Carcinogenesis
CyclinD-CDK4/6 complexes phosphorylate CDC25A and regulate its stability.
Carcinogenesis
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.
Carcinogenesis
Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.
Carcinogenesis
Differential effects of peripheral and transitional prostatic stromal cells on tumorigenesis.
Carcinogenesis
Differential molecular signature alterations of RBSP3, LIMD1 and CDC25A in normal oral epithelium during oral tumorigenesis.
Carcinogenesis
Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study.
Carcinogenesis
Dissecting molecular events in thyroid neoplasia provides evidence for distinct evolution of follicular thyroid adenoma and carcinoma.
Carcinogenesis
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Carcinogenesis
Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation.
Carcinogenesis
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
Carcinogenesis
Dual-specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis.
Carcinogenesis
DUSP4 inhibits autophagic cell death in PTC by inhibiting JNK-BCL2-Beclin1 signaling.
Carcinogenesis
Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling.
Carcinogenesis
Epithelial Protein-Tyrosine Phosphatase 1B (PTP1B) Contributes to the Induction of Mammary Tumors by HER2/Neu but is not Essential for Tumor Maintenance.
Carcinogenesis
Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis.
Carcinogenesis
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
Carcinogenesis
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
Carcinogenesis
Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma.
Carcinogenesis
Expression and Function of the Protein Tyrosine Phosphatase Receptor J (PTPRJ) in Normal Mammary Epithelial Cells and Breast Tumors.
Carcinogenesis
Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma.
Carcinogenesis
Expression of CDC25 phosphatases in human gastric cancer.
Carcinogenesis
Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis.
Carcinogenesis
Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases.
Carcinogenesis
Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix.
Carcinogenesis
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Carcinogenesis
Extensive somatic L1 retrotransposition in colorectal tumors.
Carcinogenesis
Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis.
Carcinogenesis
Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Carcinogenesis
Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients.
Carcinogenesis
Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7.
Carcinogenesis
Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma.
Carcinogenesis
Functional STR within PTPN11: a novel potential risk factor for colorectal cancer.
Carcinogenesis
Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Carcinogenesis
Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
Carcinogenesis
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development.
Carcinogenesis
Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.
Carcinogenesis
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
Carcinogenesis
Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23.
Carcinogenesis
Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases.
Carcinogenesis
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
Carcinogenesis
Helicobacter Pylori CagA and Gastric Carcinogenesis.
Carcinogenesis
Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis.
Carcinogenesis
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.
Carcinogenesis
High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas.
Carcinogenesis
High-risk human papillomavirus type 16 E7 oncogene associates with Cdc25A over-expression in oral squamous cell carcinoma.
Carcinogenesis
Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations.
Carcinogenesis
Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis.
Carcinogenesis
Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis.
Carcinogenesis
Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest.
Carcinogenesis
Identification of differentially expressed genes and functional annotations associated with metastases of the uveal melanoma.
Carcinogenesis
Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3.
Carcinogenesis
Identification of proteins suppressing the functions of oncogenic phosphatase of regenerating liver 1 and 3.
Carcinogenesis
Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells.
Carcinogenesis
IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma.
Carcinogenesis
In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL).
Carcinogenesis
In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets.
Carcinogenesis
Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint.
Carcinogenesis
Increased expression and phosphorylation of sh-ptp2 (syp) in human gastric carcinomas.
Carcinogenesis
Increased expression of SHP-1 is associated with local recurrence after radiotherapy in patients with nasopharyngeal carcinoma.
Carcinogenesis
Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.
Carcinogenesis
Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma.
Carcinogenesis
Inhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer.
Carcinogenesis
Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway.
Carcinogenesis
Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis.
Carcinogenesis
Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma.
Carcinogenesis
Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents.
Carcinogenesis
Involvement of the protein tyrosine phosphatase PTP1C in cellular physiology, autoimmunity and oncogenesis.
Carcinogenesis
Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.
Carcinogenesis
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Carcinogenesis
Kinetic characterization of bovine lung low-molecular-weight protein tyrosine phosphatase.
Carcinogenesis
Knockdown of Cdc25B in renal cell carcinoma is associated with decreased malignant features.
Carcinogenesis
LncRNA TCONS_00004099-derived microRNA regulates oncogenesis through PTPRF in gliomas.
Carcinogenesis
Loss of protein phosphatase 2A regulatory subunit B56? promotes spontaneous tumorigenesis in vivo.
Carcinogenesis
Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.
Carcinogenesis
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
Carcinogenesis
Loss of SHP-2 activity in CD4(+) T cells promotes melanoma progression and metastasis.
Carcinogenesis
Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility.
Carcinogenesis
Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.
Carcinogenesis
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Carcinogenesis
Low Molecular Weight Protein Tyrosine Phosphatase Isoforms Regulate Breast Cancer Cells Migration through a RhoA Dependent Mechanism.
Carcinogenesis
Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Carcinogenesis
Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia.
Carcinogenesis
miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
Carcinogenesis
MiR-19b suppresses PTPRG to promote breast tumorigenesis.
Carcinogenesis
miR-338-3p functions as a tumor suppressor in gastric cancer by targeting PTP1B.
Carcinogenesis
miR-383 Down-Regulates the Oncogene CIP2A to Influence Glioma Proliferation and Invasion.
Carcinogenesis
miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells.
Carcinogenesis
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer.
Carcinogenesis
Mkp-1 is required for chemopreventive activity of butylated hydroxyanisole and resveratrol against colitis-associated colon tumorigenesis.
Carcinogenesis
Molecular Analysis of the Interaction between Human PTPN21 and the Oncoprotein E7 from Human Papillomavirus Genotype 18.
Carcinogenesis
Molecular analysis of the protein tyrosine phosphatase gamma gene in human lung cancer cell lines.
Carcinogenesis
Molecular events in the early phases of prostate carcinogenesis.
Carcinogenesis
Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer.
Carcinogenesis
Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans.
Carcinogenesis
NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway.
Carcinogenesis
On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.
Carcinogenesis
Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.
Carcinogenesis
Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation.
Carcinogenesis
p27(kip1) Upregulated by hnRNPC1/2 Antagonizes CagA (a Virulence Factor of Helicobacter pylori)-Mediated Pathogenesis.
Carcinogenesis
p38? Mitogen-activated Protein Kinase Signals through Phosphorylating Its Phosphatase PTPH1 in Regulating Ras Protein Oncogenesis and Stress Response.
Carcinogenesis
p63 regulates cell proliferation and cell cycle progression?associated genes in stromal cells of giant cell tumor of the bone.
Carcinogenesis
p66Shc Aging Protein in Control of Fibroblasts Cell Fate.
Carcinogenesis
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Carcinogenesis
PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase.
Carcinogenesis
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.
Carcinogenesis
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration.
Carcinogenesis
Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.
Carcinogenesis
Phosphorylation of protein phosphatase 2A facilitated an early stage of chemical carcinogenesis.
Carcinogenesis
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.
Carcinogenesis
Posttranscriptional Inhibition of Protein Tyrosine Phosphatase Nonreceptor Type 23 by Staphylococcal Nuclease and Tudor Domain Containing 1: Implications for Hepatocellular Carcinoma.
Carcinogenesis
Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.
Carcinogenesis
PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo.
Carcinogenesis
Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Naïve Prostate Cancer.
Carcinogenesis
Prevention of liver carcinogenesis by Amarogentin through modulation of G1/S cell cycle check point and induction of apoptosis.
Carcinogenesis
Primary Epithelioid Angiosarcoma of Finger Masquerading as Epithelioid Hemangioma: Report of a Case and Analysis of Mutational Pattern in Epithelioid Hemangiomas and Angiosarcomas by Next-generation Sequencing.
Carcinogenesis
Pristimerin inhibits glioma progression by targeting AGO2 and PTPN1 expression via miR-542-5p.
Carcinogenesis
PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.
Carcinogenesis
PRL-3, an Emerging Marker of Carcinogenesis, is Strongly Associated with Poor Prognosis.
Carcinogenesis
PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal.
Carcinogenesis
Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer.
Carcinogenesis
Prognostic significance of CDC25B expression in gliomas.
Carcinogenesis
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53.
Carcinogenesis
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Carcinogenesis
Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.
Carcinogenesis
Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.
Carcinogenesis
Protein tyrosine phosphatase epsilon and Neu-induced mammary tumorigenesis.
Carcinogenesis
Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice.
Carcinogenesis
Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC.
Carcinogenesis
Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
Carcinogenesis
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
Carcinogenesis
Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling.
Carcinogenesis
Prox1 suppresses the proliferation of neuroblastoma cells via a dual action in p27-Kip1 and Cdc25A.
Carcinogenesis
PTP1B and TC-PTP: regulators of transformation and tumorigenesis.
Carcinogenesis
PTP1B expression contributes to gastric cancer progression.
Carcinogenesis
PTP1B promotes the malignancy of ovarian cancer cells in a JNK-dependent mechanism.
Carcinogenesis
PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446.
Carcinogenesis
PTP1B: a double agent in metabolism and oncogenesis.
Carcinogenesis
PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.
Carcinogenesis
PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis.
Carcinogenesis
PTPL1 suppresses lung cancer cell migration via inhibiting TGF-?1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT.
Carcinogenesis
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.
Carcinogenesis
PTPN13/PTPL1: An Important Regulator of Tumor Aggressiveness.
Carcinogenesis
PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling.
Carcinogenesis
PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis.
Carcinogenesis
PTPRA facilitates cancer growth and migration via the TNF-?-mediated PTPRA-NF-?B pathway in MCF-7 breast cancer cells.
Carcinogenesis
PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.
Carcinogenesis
PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma.
Carcinogenesis
PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2.
Carcinogenesis
Rapid destruction of human Cdc25A in response to DNA damage.
Carcinogenesis
Recent Patents Related to Phosphorylation Signaling Pathway on Cancer.
Carcinogenesis
Reciprocal allosteric regulation of p38? and PTPN3 involves a PDZ domain-modulated complex formation.
Carcinogenesis
Reduced tumorigenicity of murine leukemia cells expressing protein-tyrosine phosphatase, PTPepsilon C.
Carcinogenesis
Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis.
Carcinogenesis
Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.
Carcinogenesis
Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1.
Carcinogenesis
Role of PTPRJ genotype in papillary thyroid carcinoma risk.
Carcinogenesis
Role of SHP2 in hematopoiesis and leukemogenesis.
Carcinogenesis
SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.
Carcinogenesis
Selective elimination of cancer cells by the adenovirus E4orf4 protein in a Drosophila cancer model: a new paradigm for cancer therapy.
Carcinogenesis
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Carcinogenesis
SHP-2, SH2-containing protein tyrosine phosphatase-2.
Carcinogenesis
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.
Carcinogenesis
Shp2 confers cisplatin resistance in small cell lung cancer via an AKT-mediated increase in CA916798.
Carcinogenesis
Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic ?-Catenin, PIK3CA and MET.
Carcinogenesis
Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development.
Carcinogenesis
Silibinin Retards Colitis-associated Carcinogenesis by Repression of Cdc25C in Mouse Model.
Carcinogenesis
Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells.
Carcinogenesis
SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis.
Carcinogenesis
STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma.
Carcinogenesis
Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.
Carcinogenesis
Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
Carcinogenesis
Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase.
Carcinogenesis
Structure and functions of His domain protein tyrosine phosphatase in receptor trafficking and cancer.
Carcinogenesis
Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme.
Carcinogenesis
Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase.
Carcinogenesis
TAFs contributes the function of PTPN2 in colorectal carcinogenesis through activating JAK/STAT signaling pathway.
Carcinogenesis
Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development.
Carcinogenesis
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Carcinogenesis
The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.
Carcinogenesis
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.
Carcinogenesis
The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells.
Carcinogenesis
The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity.
Carcinogenesis
The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability.
Carcinogenesis
The Expression of p66Shc Protein in Benign, Premalignant, and Malignant Gastrointestinal Lesions.
Carcinogenesis
The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population.
Carcinogenesis
The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer.
Carcinogenesis
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Carcinogenesis
The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging.
Carcinogenesis
The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer.
Carcinogenesis
The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis.
Carcinogenesis
The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
Carcinogenesis
The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
Carcinogenesis
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
Carcinogenesis
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.
Carcinogenesis
The receptor-like protein tyrosine phosphatase alpha: a role in cell proliferation and oncogenesis.
Carcinogenesis
The role of Cdc25A in the regulation of cell proliferation and apoptosis.
Carcinogenesis
The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review.
Carcinogenesis
The role of Helicobacter pylori CagA in gastric carcinogenesis.
Carcinogenesis
The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis.
Carcinogenesis
The role of T-cell protein tyrosine phosphatase in epithelial carcinogenesis.
Carcinogenesis
The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
Carcinogenesis
The two faces of PTP1B in cancer.
Carcinogenesis
The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis.
Carcinogenesis
The tyrosine343 residue of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.
Carcinogenesis
Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.
Carcinogenesis
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.
Carcinogenesis
Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.
Carcinogenesis
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3.
Carcinogenesis
Tumor-suppressive Function of Protein-tyrosine Phosphatase Non-receptor Type 23 in Testicular Germ Cell Tumors Is Lost upon Overexpression of miR142-3p microRNA.
Carcinogenesis
Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells.
Carcinogenesis
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Carcinogenesis
Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.
Carcinogenesis
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
Carcinogenesis
Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damage.
Carcinogenesis
Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.
Carcinogenesis
YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma.
Carcinogenesis
YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process.
Carcinogenesis
[As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]
Carcinogenesis
[Corrigendum] Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.
Carcinogenesis
[Effect of methylation inhibitor in the treatment of leukemia].
Carcinogenesis
[Establishment of a colorectal cancer cell line with PRL-3 and CDH22 gene knock-down by lentivirus-mediated RNA interference.]
Carcinogenesis
[Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer]
Carcinogenesis
[Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma]
Carcinogenesis
[Expressions and significances of PRL-3 and RhoC in A549 cell].
Carcinogenesis
[P66shc action on resistance of colon carcinoma RKO cells to oxidative stress].
Carcinogenesis
[Screening and identification of tumor related genes in early stages of transformed NIH3T3 cells associated with overexpressed PTPalpha]
Carcinoid Tumor
Prostatic acid phosphatase activity in carcinoid tumors.
Carcinoid Tumor
Transmembrane protein tyrosine phosphatase IA-2 (ICA512) is expressed in human midgut carcinoids but is not detectable in normal enterochromaffin cells.
Carcinoma
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Carcinoma
A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.
Carcinoma
A simple immunohistochemical method for the detection of prostatic acid phosphatase.
Carcinoma
Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients.
Carcinoma
Aberrant promoter 2 methylation?mediated downregulation of protein tyrosine phosphatase, non?receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Carcinoma
Accessibility to DNA in carcinoma chromatin is promoted by nanomolar okadaic acid: effect on AT-rich DNA binding proteins.
Carcinoma
Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth.
Carcinoma
Acid phosphatase activity as a test for gastric carcinoma.
Carcinoma
Acid phosphatase activity in carcinoma of the bronchus.
Carcinoma
Acid phosphatase in prostatic tissue homogenates from patients with benign prostatic hyperplasia and prostatic carcinoma.
Carcinoma
Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis.
Carcinoma
AlloDriver: a method for the identification and analysis of cancer driver targets.
Carcinoma
Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene.
Carcinoma
Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.
Carcinoma
An immunological model connecting the pathogenesis of stress, depression and carcinoma.
Carcinoma
Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma.
Carcinoma
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Carcinoma
Aqueous extracts of Fructus Ligustri Lucide induce gastric carcinoma cell apoptosis and G2/M cycle arrest.
Carcinoma
Association Between Methylation of SHP-1 Isoform I and SSTR2A Promoter Regions with Breast and Prostate Carcinoma Development.
Carcinoma
Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells.
Carcinoma
Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.
Carcinoma
Association of Tyrosine PRL-3 Phosphatase Protein Expression with Peritoneal Metastasis of Gastric Carcinoma and Prognosis.
Carcinoma
Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.
Carcinoma
Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1.
Carcinoma
Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells.
Carcinoma
Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase.
Carcinoma
Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A.
Carcinoma
Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein.
Carcinoma
c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas.
Carcinoma
Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers.
Carcinoma
Cancerous Inhibitor of Protein Phosphatase 2A as a Molecular Marker for Aggressiveness and Survival in Oral Squamous Cell Carcinoma.
Carcinoma
Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin.
Carcinoma
Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers.
Carcinoma
Cdc25A phosphatase suppresses apoptosis induced by serum deprivation.
Carcinoma
CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.
Carcinoma
CDC25B: relationship with angiogenesis and prognosis in non-small cell lung carcinoma.
Carcinoma
Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR.
Carcinoma
Changes of enzyme activities recognized in lymphocytes from patients with carcinoma of the gastrointestinal tract.
Carcinoma
Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes.
Carcinoma
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus.
Carcinoma
Combination of celecoxib and calyculin-A inhibits epithelial-mesenchymal transition in human oral cancer cells.
Carcinoma
Comparative analysis of a panel of biomarkers related to protein phosphatase 2A between laryngeal squamous cell carcinoma tissues and adjacent normal tissues.
Carcinoma
Comparative evaluation of serum acid phosphatase, urinary cholesterol, and androgens in diagnosis of prostatic cancer.
Carcinoma
Constitutive suppression of PRL-3 inhibits invasion and proliferation of gastric cancer cell in vitro and in vivo.
Carcinoma
Control of acid phosphatase activity in human prostatic carcinoma cell cultures by serum.
Carcinoma
Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas.
Carcinoma
Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carcinoma.
Carcinoma
D9S168 microsatellite alteration predicts a poor prognosis in patients with clear cell renal cell carcinoma and correlates with the down-regulation of protein tyrosine phosphatase receptor delta.
Carcinoma
Decreased acid phosphatase activity in prostate secretion associated with prostatic carcinoma.
Carcinoma
Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma.
Carcinoma
Decreased expression of protein tyrosine phosphatase non-receptor type 12 is involved in the proliferation and recurrence of bladder transitional cell carcinoma.
Carcinoma
DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients.
Carcinoma
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Carcinoma
Differential expression of cdc25 cell-cycle-activating phosphatases in human colorectal carcinoma.
Carcinoma
Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.
Carcinoma
Discrimination between normal, hyperplastic and malignant human prostatic tissues by enzymatic profiles.
Carcinoma
Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line.
Carcinoma
Downregulation of Snail by DUSP1 Impairs Cell Migration and Invasion through the Inactivation of JNK and ERK and Is Useful as a Predictive Factor in the Prognosis of Prostate Cancer.
Carcinoma
Dual-specificity phosphatase 6 genetic variants associated with risk of lung squamous cell carcinoma in Han Chinese.
Carcinoma
E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression.
Carcinoma
Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells.
Carcinoma
Effect of VTCN1 on progression and metastasis of ovarian carcinoma in vitro and vivo.
Carcinoma
Effects of let-7c on the proliferation of ovarian carcinoma cells by targeted regulation of CDC25a gene expression.
Carcinoma
Electron microscopic studies on the acid phosphatase activity in rats with transplantable Guerin epithelioma.
Carcinoma
Elevated protein-tyrosine-phosphatase activity in human colon-carcinoma.
Carcinoma
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Carcinoma
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts.
Carcinoma
Epigenetically silenced PTPRO functions as a prognostic marker and tumor suppressor in human lung squamous cell carcinoma.
Carcinoma
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma.
Carcinoma
Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.
Carcinoma
Etodolac, a selective cyclo-oxygenase-2 inhibitor, enhances carboplatin-induced apoptosis of human tongue carcinoma cells by down-regulation of FAP-1 expression.
Carcinoma
Evidence for coupling of phosphotyrosine phosphatase to gonadotropin-releasing hormone receptor in ovarian carcinoma membrane.
Carcinoma
Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma.
Carcinoma
Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma.
Carcinoma
Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma.
Carcinoma
Expression and clinical role of protein of regenerating liver (PRL) phosphatases in ovarian carcinoma.
Carcinoma
Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.
Carcinoma
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Carcinoma
Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma.
Carcinoma
Expression of cdc25A and cdc25B proteins in thyroid neoplasms.
Carcinoma
Expression of cdc25B and cdc25A in medullary thyroid carcinoma: cdc25B expression level predicts a poor prognosis.
Carcinoma
Expression of cell regulatory proteins in ovarian borderline tumors.
Carcinoma
Expression of Dual-Specificity Phosphatase 2 (DUSP2) in Patients with Serous Ovarian Carcinoma and in SKOV3 and OVCAR3 Cells In Vitro.
Carcinoma
Expression of human prostatic acid phosphatase activity and the growth of prostate carcinoma cells.
Carcinoma
Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma.
Carcinoma
Expression of oxidized protein tyrosine phosphatase and ?H2AX predicts poor survival of gastric carcinoma patients.
Carcinoma
Expression of p21(Waf1/Cip1) predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.
Carcinoma
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma.
Carcinoma
Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix.
Carcinoma
Expression of PRL-1 nuclear PTPase is associated with proliferation in liver but with differentiation in intestine.
Carcinoma
Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis.
Carcinoma
Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer.
Carcinoma
Expression of the membrane protein tyrosine phosphatase CD148 in human tissues.
Carcinoma
Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells.
Carcinoma
Expression of the transmembrane protein tyrosine phosphatase RPTPalpha in human oral squamous cell carcinoma.
Carcinoma
Expression patterns of cyclin E, cyclin A and CDC25 phosphatases in laryngeal carcinogenesis.
Carcinoma
Expressions of Src homology 2 domain-containing phosphatase and its clinical significance in laryngeal carcinoma.
Carcinoma
Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence.
Carcinoma
FAP-1 and NF-?B expressions in oral squamous cell carcinoma as potential markers for chemo-radio sensitivity and prognosis.
Carcinoma
FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis.
Carcinoma
Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3beta release from Cdc25C and Chk2 activation in human bladder transitional carcinoma cells.
Carcinoma
Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck.
Carcinoma
Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.
Carcinoma
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase ?, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.
Carcinoma
Helicobacter pylori-related host gene polymorphisms associated with susceptibility of gastric carcinogenesis: a two-stage case-control study in Chinese.
Carcinoma
High expression of Cdc25B and low expression of 14-3-3? is associated with the development and poor prognosis in urothelial carcinoma of bladder.
Carcinoma
High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.
Carcinoma
High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study.
Carcinoma
High PTPN13 expression in high grade serous ovarian carcinoma is associated with a better patient outcome.
Carcinoma
High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma.
Carcinoma
High-risk human papillomavirus type 16 E7 oncogene associates with Cdc25A over-expression in oral squamous cell carcinoma.
Carcinoma
Histochemical staining of protein-tyrosine phosphatase activity in primary human mammary carcinoma: relationship with established prognostic indicators.
Carcinoma
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis.
Carcinoma
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.
Carcinoma
Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases.
Carcinoma
Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.
Carcinoma
Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC.
Carcinoma
Identification of Differentially Expressed Genes Involved in the Formation of Multicellular Tumor Spheroids by HT-29 Colon Carcinoma Cells.
Carcinoma
Identification of pivotal cellular factors involved in HPV-induced dysplastic and neoplastic cervical pathologies.
Carcinoma
Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells.
Carcinoma
Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma.
Carcinoma
Immunohistochemical Detection of Hematopoietic Cell-specific Protein-Tyrosine Phosphatase (Tyrosine Phosphatase SHP-1) in a Series of Endometrioid and Serous Endometrial Carcinoma.
Carcinoma
Immunohistochemical localization of FAP-1, an inhibitor of Fas-mediated apoptosis, in normal and neoplastic human tissues.
Carcinoma
Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway.
Carcinoma
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors.
Carcinoma
Increased expression and phosphorylation of sh-ptp2 (syp) in human gastric carcinomas.
Carcinoma
Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.
Carcinoma
Increased Expression of the PRL-3 Gene in Human Oral Squamous Cell Carcinoma and Dysplasia Tissues.
Carcinoma
Increased mRNA expression of the receptor-like protein tyrosine phosphatase alpha in late stage colon carcinomas.
Carcinoma
Increased prostate-type acid phosphatase activity in serum and typical bone lesions simulating the presence of prostatic carcinoma.
Carcinoma
Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells.
Carcinoma
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
Carcinoma
Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis.
Carcinoma
Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP.
Carcinoma
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Carcinoma
Knockdown of Cdc25B in renal cell carcinoma is associated with decreased malignant features.
Carcinoma
Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B.
Carcinoma
Label-Free Detection of Protein Tyrosine Phosphatase 1B (PTP1B) by Using a Rationally Designed Förster Resonance Energy Transfer (FRET) Probe.
Carcinoma
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients.
Carcinoma
LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-?B.
Carcinoma
Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma.
Carcinoma
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
Carcinoma
Loss of Tyrosine Phosphatase Delta Promotes Gastric Cancer Progression via Signal Transducer and Activator of Transcription 3 Pathways.
Carcinoma
Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.
Carcinoma
Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene.
Carcinoma
Methylaervine as Potential Lead Compound against Cervical Carcinoma: Pharmacologic Mechanism Prediction based on Network Pharmacology.
Carcinoma
Methylation and expression of PTPN22 in esophageal squamous cell carcinoma.
Carcinoma
Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells.
Carcinoma
MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B.
Carcinoma
MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression.
Carcinoma
MicroRNA-194 promotes the growth, migration, and invasion of ovarian carcinoma cells by targeting protein tyrosine phosphatase nonreceptor type 12.
Carcinoma
MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A.
Carcinoma
MiR-214 inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by targeting CDC25B.
Carcinoma
MiR-450a-5p inhibits autophagy and enhances radiosensitivity by targeting dual-specificity phosphatase 10 in esophageal squamous cell carcinoma.
Carcinoma
miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC).
Carcinoma
miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3.
Carcinoma
MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9.
Carcinoma
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Carcinoma
Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells.
Carcinoma
Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin.
Carcinoma
MKP-1 is required to limit myeloid-cell mediated oral squamous cell carcinoma progression and regional extension.
Carcinoma
Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents.
Carcinoma
Molecular cloning, characterization, and chromosomal localization of a novel protein-tyrosine phosphatase, HPTP eta.
Carcinoma
Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.
Carcinoma
Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
Carcinoma
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Carcinoma
Neutrophil acid phosphatase activity in patients with gastric or rectum carcinoma during surgical treatment.
Carcinoma
Overexpression of CDC25A and CDC25B in head and neck cancers.
Carcinoma
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
Carcinoma
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Carcinoma
Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery.
Carcinoma
Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.
Carcinoma
Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.
Carcinoma
Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance.
Carcinoma
Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer.
Carcinoma
Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas.
Carcinoma
p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy.
Carcinoma
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Carcinoma
p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas.
Carcinoma
p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.
Carcinoma
Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.
Carcinoma
PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation.
Carcinoma
PECAM-1 shedding during apoptosis generates a membrane-anchored truncated molecule with unique signaling characteristics.
Carcinoma
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.
Carcinoma
Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma.
Carcinoma
Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.
Carcinoma
Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells.
Carcinoma
Phosphoamino acid phosphatases in normal and cancerous tissues of the human uterus, cervix and ovary.
Carcinoma
Phosphotyrosine Phosphatase Activity in Ovarian Carcinoma Cells : Stimulation by GnRH in Plasma Membrane.
Carcinoma
Physalis angulata induced G2/M phase arrest in human breast cancer cells.
Carcinoma
Polymorphism in protein tyrosine phosphatase receptor delta is associated with the risk of clear cell renal cell carcinoma.
Carcinoma
Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer.
Carcinoma
Preferential allelic deletion of RBSP3, LIMD1 and CDC25A in head and neck squamous cell carcinoma: Implication in cancer screening and early detection.
Carcinoma
PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer.
Carcinoma
PRL-3 phosphatase is implicated in ovarian cancer growth.
Carcinoma
PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.
Carcinoma
PRL-3, an Emerging Marker of Carcinogenesis, is Strongly Associated with Poor Prognosis.
Carcinoma
Prognostication of prostatic carcinoma by serum acid phosphatase activity.
Carcinoma
Progress in the correlation between PTPN12 gene expression and human tumors.
Carcinoma
Prooxidant Properties of p66shc Are Mediated by Mitochondria in Human Cells.
Carcinoma
Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells.
Carcinoma
Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants.
Carcinoma
Protein tyrosine phosphatase 4A2 expression predicts overall and disease-free survival of human breast cancer and is associated with estrogen and progestin receptor status.
Carcinoma
Protein tyrosine phosphatase ? enhances proliferation by increasing ?-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells.
Carcinoma
Protein tyrosine phosphatase alpha regulates cell detachment and cell death profiles induced by nitric oxide donors in the A431 human carcinoma cell line.
Carcinoma
Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.
Carcinoma
Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting I?B?.
Carcinoma
Protein tyrosine phosphatase nonreceptor type 12 suppresses the proliferation of renal cell carcinoma by inhibiting the activity of the PI3K/mTOR pathway.
Carcinoma
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Carcinoma
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma
Protein tyrosine phosphatase, receptor type B is a potential biomarker and facilitates cervical cancer metastasis via epithelial-mesenchymal transition.
Carcinoma
Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma.
Carcinoma
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Carcinoma
PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity.
Carcinoma
PTP1B Contributes to Calreticulin-Induced Metastatic Phenotypes in Esophageal Squamous Cell Carcinoma.
Carcinoma
PTP1B promotes the malignancy of ovarian cancer cells in a JNK-dependent mechanism.
Carcinoma
PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinoma.
Carcinoma
PTPN12 inhibits oral squamous epithelial carcinoma cell proliferation and invasion and can be used as a prognostic marker.
Carcinoma
PTPN13 acts as a tumor suppressor in clear cell renal cell carcinoma by inactivating Akt signaling.
Carcinoma
PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.
Carcinoma
PTPN3 inhibits the growth and metastasis of clear cell renal cell carcinoma via inhibition of PI3K/AKT signaling.
Carcinoma
PTPN9 promotes cell proliferation and invasion in Eca109 cells and is negatively regulated by microRNA-126.
Carcinoma
PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma.
Carcinoma
Purification and characterization of a rat liver protein-tyrosine phosphatase with sequence similarity to src-homology region 2.
Carcinoma
Radiotherapy-induced signal transduction.
Carcinoma
Rapid (one-shot) staining method for two-color multiparametric DNA flow cytometric analysis of carcinomas using staining for cytokeratin and leukocyte common antigen.
Carcinoma
Rapid induction of p21WAF1 but delayed down-regulation of Cdc25A in the TGF-beta-induced cell cycle arrest of gastric carcinoma cells.
Carcinoma
Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.
Carcinoma
Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.
Carcinoma
Receptor-type Protein tyrosine phosphatase ? regulates met phosphorylation and function in head and neck squamous cell carcinoma.
Carcinoma
Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma.
Carcinoma
Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors.
Carcinoma
Regulation of the expression of prostatic acid phosphatase in LNCaP human prostate carcinoma cells.
Carcinoma
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx.
Carcinoma
Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.
Carcinoma
Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTP? and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma.
Carcinoma
Retinoic acid induced repression of AP-1 activity is mediated by protein phosphatase 2A in ovarian carcinoma cells.
Carcinoma
Retraction of: Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China; DOI: 10.1089/gtmb.2016.0194.
Carcinoma
Separation and characterization of epithelial cells from prostates and prostatic carcinomas: a review.
Carcinoma
Separation of cells with histochemically demonstrable acid phosphatase activity from suspensions of cells from human prostatic carcinomas in an isokinetic gradient of Ficoll in tissue culture medium.
Carcinoma
SHP-1 is involved in neuronal differentiation of P19 embryonic carcinoma cells.
Carcinoma
Significance of PTPRZ1 and CIN85 expression in cervical carcinoma.
Carcinoma
Silencing Fas-associated phosphatase 1 expression enhances efficiency of chemotherapy for colon carcinoma with oxaliplatin.
Carcinoma
Simultaneous flow cytometric deoxyribonucleic acid and acid phosphatase analysis of benign and malignant lesions of the prostate.
Carcinoma
Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China.
Carcinoma
Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages.
Carcinoma
Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas.
Carcinoma
Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5.
Carcinoma
Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination.
Carcinoma
Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation.
Carcinoma
Subcellular localisation of Cdc25A determines cell fate.
Carcinoma
Suppression of metastatic potential of high-metastatic Lewis lung carcinoma cells by vanadate, an inhibitor of tyrosine phosphatase, through inhibiting cell-substrate adhesion.
Carcinoma
Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer.
Carcinoma
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma
The association and prognostic relevance of cancerous inhibitor of protein phosphatase 2A and inflammation in tongue squamous cell carcinoma.
Carcinoma
The carboxyl-terminal tyrosine residue of protein-tyrosine phosphatase alpha mediates association with focal adhesion plaques.
Carcinoma
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.
Carcinoma
The Chalcone Flavokawain B Induces G(2)/M Cell-Cycle Arrest and Apoptosis in Human Oral Carcinoma HSC-3 Cells through the Intracellular ROS Generation and Downregulation of the Akt/p38 MAPK Signaling Pathway.
Carcinoma
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers.
Carcinoma
The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population.
Carcinoma
The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging.
Carcinoma
The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma.
Carcinoma
The phosphatase PTPN1/PTP1B is a candidate marker of better chemotherapy response in metastatic high-grade serous carcinoma.
Carcinoma
The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity.
Carcinoma
The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma.
Carcinoma
The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase.
Carcinoma
The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma.
Carcinoma
The tyrosine phosphatase HD-PTP (PTPN23) is degraded by calpains in a calcium-dependent manner.
Carcinoma
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Carcinoma
The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stress.
Carcinoma
Theaflavins induce G2/M arrest by modulating expression of p21(waf1/cip1), cdc25C and cyclin B in human prostate carcinoma PC-3 cells.
Carcinoma
Tissue-specific alterations of PRL-1 and PRL-2 expression in cancer.
Carcinoma
TNFalpha-mediated cell death is independent of cdc25A.
Carcinoma
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.
Carcinoma
Tumor necrosis factor-alpha: a continuum of liability between insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus and carcinoma (review).
Carcinoma
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
Carcinoma
Tyrosine phosphorylation translocates beta-catenin from cell-->cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function.
Carcinoma
Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Carcinoma
Tyrosyl kinase activity is inversely related to prostatic acid phosphatase activity in two human prostate carcinoma cell lines.
Carcinoma
Ultrastructural localization of acid phosphatase in human laryngeal carcinoma.
Carcinoma
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase.
Carcinoma
[Acid phosphatase activity in breast dysplasias and in carcinomas of the breast]
Carcinoma
[Change of acid phosphatase activity in granulocytes from patients with carcinomas of the gastrointestinal tract]
Carcinoma
[Construction of a lentiviral vector for RNA interference of PRL-3 gene and its stable expression in SW480 cells]
Carcinoma
[Construction of the life cycle of Angiostrongylus cantonensis in laboratory]
Carcinoma
[Diurnal variation of the elevated acid phosphatase activity in cases of prostate carcinoma (author's transl)]
Carcinoma
[Electron microscopic studies on the acid phosphatase activity in rats with transplantable Guérin epithelioma]
Carcinoma
[ERK1/2 and p38 kinases are important regulators in P2Y receptor-mediated prostate cancer invasion]
Carcinoma
[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]
Carcinoma
[Expression of PTPRZ1 in oral squamous cell carcinoma originated from oral submucous fibrosis and its clinical significance].
Carcinoma
[Expression of tyrosine phosphatase containing C-src homology SH-2 in benign prostate hyperplasia]
Carcinoma
[Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma]
Carcinoma
[Molecular portrait of human kidney carcinomas: the gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells]
Carcinoma
[Study on the expression and significance of Galectin-3 and CDC25B mRNA in human gastric carcinoma]
Carcinoma
[The clinical significance of PRL-3,VEGF expression in sinonasalsquamous cell carcinoma].
Carcinoma
[The expression of MKP-1 and p-ERK(1/2) in primary ovarian epithelial tumor tissues]
Carcinoma
[The relationship between histological classification of lung cancer and protein tyrosine phosphatase.]
Carcinoma, Adenoid Cystic
PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma.
Carcinoma, Adenosquamous
[The relationship between histological classification of lung cancer and protein tyrosine phosphatase.]
Carcinoma, Ductal
Clinicopathological significance of dual-specificity protein phosphatase 4 expression in invasive ductal carcinoma of the breast.
Carcinoma, Ductal
Expression and Function of the Protein Tyrosine Phosphatase Receptor J (PTPRJ) in Normal Mammary Epithelial Cells and Breast Tumors.
Carcinoma, Ductal
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Carcinoma, Ductal
Prognostic Significance of Metastatic Lymph Nodes Ratio (MLNR) Combined with Protein-Tyrosine Phosphatase H1 (PTPH1) Expression in Operable Breast Invasive Ductal Carcinoma.
Carcinoma, Ehrlich Tumor
[Inhibition of pinocytosis and of acid phosphatase activity caused by lack of serum in the culture medium of Ehrlich ascites tumor cells (author's transl)]
Carcinoma, Embryonal
Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells.
Carcinoma, Embryonal
Differential expression of a novel murine non-receptor protein tyrosine phosphatase during differentiation of P19 embryonal carcinoma cells.
Carcinoma, Embryonal
Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells.
Carcinoma, Embryonal
Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation.
Carcinoma, Endometrioid
Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway.
Carcinoma, Hepatocellular
A bromopyrrole-containing diterpene alkaloid from the Okinawan marine sponge Agelas nakamurai activates the insulin pathway in Huh-7 human hepatoma cells by inhibiting protein tyrosine phosphatase 1B.
Carcinoma, Hepatocellular
A Cdc25A antagonizing K vitamin inhibits hepatocyte DNA synthesis in vitro and in vivo.
Carcinoma, Hepatocellular
A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo to advance hepatocellular carcinoma therapy.
Carcinoma, Hepatocellular
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Carcinoma, Hepatocellular
A fluorescent probe for monitoring PTP-PEST enzymatic activity.
Carcinoma, Hepatocellular
A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3.
Carcinoma, Hepatocellular
Accomplices in Crime: The Diabolical Liaison between PTP1B and Ras in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis.
Carcinoma, Hepatocellular
Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression.
Carcinoma, Hepatocellular
Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A.
Carcinoma, Hepatocellular
Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome.
Carcinoma, Hepatocellular
Cdc25A and ERK interaction: EGFR-independent ERK activation by a protein phosphatase Cdc25A inhibitor, compound 5.
Carcinoma, Hepatocellular
CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.
Carcinoma, Hepatocellular
Cell hydration and mTOR-dependent signalling.
Carcinoma, Hepatocellular
Changes of expressions of phosphotyrosine phosphatases in rat hepatocellular carcinoma induced by 3'-methyl-4-dimethylamino-azobenzene.
Carcinoma, Hepatocellular
CIP2A Is Highly Expressed in Hepatocellular Carcinoma and Predicts Poor Prognosis.
Carcinoma, Hepatocellular
CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
Carcinoma, Hepatocellular
Decreased expression and prognostic role of mitogen-activated protein kinase phosphatase 4 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy.
Carcinoma, Hepatocellular
Development of a gene therapy strategy to target hepatocellular carcinoma based inhibition of protein phosphatase 2A using the ?-fetoprotein promoter enhancer and pgk promoter: an in vitro and in vivo study.
Carcinoma, Hepatocellular
Development of a time-resolved fluorescent assay for measuring tyrosine-phosphorylated proteins in cells.
Carcinoma, Hepatocellular
Differential regulation of mRNAs encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase C.
Carcinoma, Hepatocellular
Diosmin induces cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and blocks tumour growth in xenografted nude mice
Carcinoma, Hepatocellular
Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression.
Carcinoma, Hepatocellular
Dissociation of PTPase levels from their modulation of insulin receptor signal transduction.
Carcinoma, Hepatocellular
Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Downregulated Expression of PTPN9 Contributes to Human Hepatocellular Carcinoma Growth and Progression.
Carcinoma, Hepatocellular
Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
Carcinoma, Hepatocellular
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Carcinoma, Hepatocellular
Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Dual-Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence After Surgery in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
Carcinoma, Hepatocellular
Effect of tumor necrosis factor-alpha on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein-tyrosine phosphatases.
Carcinoma, Hepatocellular
EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa.
Carcinoma, Hepatocellular
Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Carcinoma, Hepatocellular
Enhancement of protein tyrosine phosphatase activity in the proliferation of cloned rat hepatoma H4-II-E cells: suppressive role of endogenous regucalcin.
Carcinoma, Hepatocellular
Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes.
Carcinoma, Hepatocellular
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine?induced liver cancer via inhibition of cell division cycle 25A.
Carcinoma, Hepatocellular
Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A.
Carcinoma, Hepatocellular
Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.
Carcinoma, Hepatocellular
Estrogen sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Carcinoma, Hepatocellular
Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Exploring the cause of the inhibitor 4AX attaching to binding site disrupting protein tyrosine phosphatase 4A1 trimerization by molecular dynamic simulation.
Carcinoma, Hepatocellular
Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues.
Carcinoma, Hepatocellular
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice.
Carcinoma, Hepatocellular
Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.
Carcinoma, Hepatocellular
Functional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populations.
Carcinoma, Hepatocellular
Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.
Carcinoma, Hepatocellular
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatitis B virus X protein mutant HBx?127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.
Carcinoma, Hepatocellular
Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.
Carcinoma, Hepatocellular
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
Carcinoma, Hepatocellular
Hyperosmotic induction of the mitogen-activated protein kinase phosphatase MKP-1 in H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis.
Carcinoma, Hepatocellular
Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase.
Carcinoma, Hepatocellular
Identification of key genes in hepatocellular carcinoma and validation of the candidate gene, cdc25a, using gene set enrichment analysis, meta?analysis and cross?species comparison.
Carcinoma, Hepatocellular
IL-6 promotes PD-L1 expression in monocytes and macrophages by decreasing protein tyrosine phosphatase receptor type O expression in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines.
Carcinoma, Hepatocellular
Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition.
Carcinoma, Hepatocellular
Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas.
Carcinoma, Hepatocellular
Inhibition of the transmembrane protein tyrosine phosphatase lar by 3S-peptide-I enhances insulin receptor phosphorylation in intact cells.
Carcinoma, Hepatocellular
Initiation and maintenance of CNTF-Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors.
Carcinoma, Hepatocellular
Insulin dependent apolipoprotein B degradation and phosphatidylinositide 3-kinase activation with microsomal translocation are restored in McArdle RH7777 cells following serum deprivation.
Carcinoma, Hepatocellular
Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells.
Carcinoma, Hepatocellular
Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR.
Carcinoma, Hepatocellular
Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.
Carcinoma, Hepatocellular
Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade.
Carcinoma, Hepatocellular
Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Involvement of Cdc25A phosphatase in Hep3B hepatoma cell growth inhibition induced by novel K vitamin analogs.
Carcinoma, Hepatocellular
Involvement of receptor tyrosine phosphatase DEP-1 mediated PI3K-cofilin signaling pathway in Sorafenib-induced cytoskeletal rearrangement in hepatoma cells.
Carcinoma, Hepatocellular
Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone.
Carcinoma, Hepatocellular
IRE1? links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells.
Carcinoma, Hepatocellular
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.
Carcinoma, Hepatocellular
Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression.
Carcinoma, Hepatocellular
Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment.
Carcinoma, Hepatocellular
Localization of acid phosphatase activity in well-differentiated hepatocellular carcinoma 146.
Carcinoma, Hepatocellular
Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP).
Carcinoma, Hepatocellular
Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice.
Carcinoma, Hepatocellular
Methylation of gene encoding the growth suppressor protein tyrosine phosphatase receptor-type O (PTPRO) in human hepatocellular carcinoma and identification of VCP as its bona fide substrate.
Carcinoma, Hepatocellular
Microcystin-LR induces a wide variety of biochemical changes in the A549 human non-small cell lung cancer cell line: Roles for protein phosphatase 2A and its substrates.
Carcinoma, Hepatocellular
MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
MicroRNA-328 enhances cellular motility through posttranscriptional regulation of PTPRJ in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-186 Inhibits Liver Cancer Stem Cells Expansion via Targeting PTPN11.
Carcinoma, Hepatocellular
miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest.
Carcinoma, Hepatocellular
miR-206 inhibits cell proliferation, invasion, and migration by down-regulating PTP1B in hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-532-3p promotes hepatocellular carcinoma progression by targeting PTPRT.
Carcinoma, Hepatocellular
miR-631 Inhibits Intrahepatic Metastasis of Hepatocellular Carcinoma by Targeting PTPRE.
Carcinoma, Hepatocellular
miR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB.
Carcinoma, Hepatocellular
MiR-675 Promotes the Growth of Hepatocellular Carcinoma Cells Through the Cdc25A Pathway.
Carcinoma, Hepatocellular
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Carcinoma, Hepatocellular
NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A.
Carcinoma, Hepatocellular
Okadaic acid promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells by inhibiting protein phosphatase 2A.
Carcinoma, Hepatocellular
Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway.
Carcinoma, Hepatocellular
Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Osmotic regulation of MAP-kinase activities and gene expression in H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Osmotic regulation of MG-132-induced MAP-kinase phosphatase MKP-1 expression in H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells.
Carcinoma, Hepatocellular
Overexpression of CDC25A phosphatase is associated with hypergrowth activity and poor prognosis of human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by insulin or insulin-like growth factor-I.
Carcinoma, Hepatocellular
p66Shc promotes HCC progression in the tumor microenvironment via STAT3 signaling.
Carcinoma, Hepatocellular
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes.
Carcinoma, Hepatocellular
PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo.
Carcinoma, Hepatocellular
Posttranscriptional Inhibition of Protein Tyrosine Phosphatase Nonreceptor Type 23 by Staphylococcal Nuclease and Tudor Domain Containing 1: Implications for Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth.
Carcinoma, Hepatocellular
PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK.
Carcinoma, Hepatocellular
Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Protein phosphatase 2A mediates JS-K-induced apoptosis by affecting Bcl-2 family proteins in human hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase 1B dephosphorylates PITX1 and regulates p120RasGAP in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition.
Carcinoma, Hepatocellular
Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase receptor type D (PTPRD)-mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review.
Carcinoma, Hepatocellular
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
Carcinoma, Hepatocellular
Protein-tyrosine phosphatase activity in human adipocytes is strongly correlated with insulin-stimulated glucose uptake and is a target of insulin-induced oxidative inhibition.
Carcinoma, Hepatocellular
PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients.
Carcinoma, Hepatocellular
PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas.
Carcinoma, Hepatocellular
PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.
Carcinoma, Hepatocellular
Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.
Carcinoma, Hepatocellular
RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Role of endogenous regucalcin in protein tyrosine phosphatase regulation in the cloned rat hepatoma cells (H4-II-E).
Carcinoma, Hepatocellular
SC-60, a dimer-based sorafenib derivative, shows a better anti-hepatocellular carcinoma effect than sorafenib in a preclinical hepatocellular carcinoma model.
Carcinoma, Hepatocellular
Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate in vitro.
Carcinoma, Hepatocellular
SHP-1 Acts as a Tumor Suppressor in Hepatocarcinogenesis and HCC Progression.
Carcinoma, Hepatocellular
SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Small interfering RNA targeting CDC25B inhibits liver tumor growth in vitro and in vivo.
Carcinoma, Hepatocellular
SNHG16 as the miRNA let-7b-5p sponge facilitates the G2/M and epithelial-mesenchymal transition by regulating CDC25B and HMGA2 expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Suppressed MKP-1 is an independent predictor of outcome in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3.
Carcinoma, Hepatocellular
Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells.
Carcinoma, Hepatocellular
Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO.
Carcinoma, Hepatocellular
Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells.
Carcinoma, Hepatocellular
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas.
Carcinoma, Hepatocellular
Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer.
Carcinoma, Hepatocellular
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
Carcinoma, Hepatocellular
TGF-?1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death.
Carcinoma, Hepatocellular
The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver.
Carcinoma, Hepatocellular
The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N-acetylglucosaminyltransferase V.
Carcinoma, Hepatocellular
The HNF1?-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1.
Carcinoma, Hepatocellular
The MAP kinase phosphatase-1 MKP-1/DUSP1 is a regulator of human liver response to transplantation.
Carcinoma, Hepatocellular
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Carcinoma, Hepatocellular
The protein tyrosine phosphatase LAR has a major impact on insulin receptor dephosphorylation.
Carcinoma, Hepatocellular
The selective reduction in PTPdelta expression in hepatomas.
Carcinoma, Hepatocellular
The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling.
Carcinoma, Hepatocellular
The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases.
Carcinoma, Hepatocellular
The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Transient and sustained ERK phosphorylation and nuclear translocation in growth control.
Carcinoma, Hepatocellular
TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B.
Carcinoma, Hepatocellular
Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance.
Carcinoma, Hepatocellular
Upregulation of protein tyrosine phosphatase type IVA member 3 (PTP4A3/PRL-3) is associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5'flanking region.
Carcinoma, Hepatocellular
Zanthoxylum avicennae extracts induce cell apoptosis through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells and block tumor growth in xenografted nude mice.
Carcinoma, Hepatocellular
Zanthoxylum avicennae extracts inhibit cell proliferation through protein phosphatase 2A activation in HA22T human hepatocellular carcinoma cells in vitro and in vivo.
Carcinoma, Hepatocellular
[Correlation between inhibitory effect of Manumycin on human hepatoma cancer cell HepG2 and Ras signal transduction pathway]
Carcinoma, Hepatocellular
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
Carcinoma, Hepatocellular
[Effect of ultraviolet radiation on lysosomal acid phosphatase activity Zajdela ascitic hepatoma]
Carcinoma, Hepatocellular
[Gene therapy using a dominant negative form of the protein phosphatase 2A catalytic subunit a driven by a hepatoma tissue-specific promoter achieves effective growth inhibition of hepatoma cells].
Carcinoma, Hepatocellular
[Mechanism of regulation of hepatoma cell cycle by XPD/P44 subcomplex : an in vitro experiment]
Carcinoma, Hepatocellular
[The distribution of acid phosphatase activity in the ultrastructures of liver cells during the development of induced hepatoma]
Carcinoma, Intraductal, Noninfiltrating
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Carcinoma, Lewis Lung
Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants.
Carcinoma, Lewis Lung
Suppression of metastatic potential of high-metastatic Lewis lung carcinoma cells by vanadate, an inhibitor of tyrosine phosphatase, through inhibiting cell-substrate adhesion.
Carcinoma, Mucoepidermoid
Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus.
Carcinoma, Non-Small-Cell Lung
Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers.
Carcinoma, Non-Small-Cell Lung
CDC25B: relationship with angiogenesis and prognosis in non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.
Carcinoma, Non-Small-Cell Lung
Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway.
Carcinoma, Non-Small-Cell Lung
Dual Specificity Phosphatase 6 (DUSP6) Polymorphism Predicts Prognosis of Inoperable Non-Small Cell Lung Cancer after Chemoradiotherapy.
Carcinoma, Non-Small-Cell Lung
Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Erratum to: The role of SHP-1 promoter 2 hypermethylation detection of lymph node micrometastasis in resectable stage I non-small cell lung cancer as a prognostic marker of disease recurrence.
Carcinoma, Non-Small-Cell Lung
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Carcinoma, Non-Small-Cell Lung
Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Genomic data from NSCLC tumors reveals correlation between SHP-2 activity and PD-L1 expression and suggests synergy in combining SHP-2 and PD-1/PD-L1 inhibitors.
Carcinoma, Non-Small-Cell Lung
High expression of CIP2A protein is associated with tumor aggressiveness in stage I-III NSCLC and correlates with poor prognosis.
Carcinoma, Non-Small-Cell Lung
Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis.
Carcinoma, Non-Small-Cell Lung
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition.
Carcinoma, Non-Small-Cell Lung
Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4.
Carcinoma, Non-Small-Cell Lung
Microcystin-LR induces a wide variety of biochemical changes in the A549 human non-small cell lung cancer cell line: Roles for protein phosphatase 2A and its substrates.
Carcinoma, Non-Small-Cell Lung
MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc.
Carcinoma, Non-Small-Cell Lung
MicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU.
Carcinoma, Non-Small-Cell Lung
MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK.
Carcinoma, Non-Small-Cell Lung
miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.
Carcinoma, Non-Small-Cell Lung
MiR-365 enhances the radiosensitivity of non-small cell lung cancer cells through targeting CDC25A.
Carcinoma, Non-Small-Cell Lung
Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients.
Carcinoma, Non-Small-Cell Lung
Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Novel PROTACs for degradation of SHP2 protein.
Carcinoma, Non-Small-Cell Lung
Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc.
Carcinoma, Non-Small-Cell Lung
Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.
Carcinoma, Non-Small-Cell Lung
PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic value of dual-specificity phosphatase 6 expression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PTPL1 suppresses lung cancer cell migration via inhibiting TGF-?1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT.
Carcinoma, Non-Small-Cell Lung
PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies.
Carcinoma, Non-Small-Cell Lung
Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2.
Carcinoma, Non-Small-Cell Lung
SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A.
Carcinoma, Non-Small-Cell Lung
SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD-1-Resistant Model of Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Shp2 regulates migratory behavior and response to EGFR-TKIs through ERK1/2 pathway activation in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo.
Carcinoma, Non-Small-Cell Lung
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
The role of SHP-1 promoter 2 hypermethylation detection of lymph node micrometastasis in resectable stage I non-small cell lung cancer as a prognostic marker of disease recurrence.
Carcinoma, Non-Small-Cell Lung
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC.
Carcinoma, Non-Small-Cell Lung
[Expression and clinical significance of SHP2 in the tumor tissues of smokers with lung cancer]
Carcinoma, Non-Small-Cell Lung
[Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene].
Carcinoma, Non-Small-Cell Lung
[Expressions and significances of PRL-3 and RhoC in A549 cell].
Carcinoma, Ovarian Epithelial
Dual specificity phosphatase 6 as a new therapeutic target candidate for epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
PTN signaling: Components and mechanistic insights in human ovarian cancer.
Carcinoma, Ovarian Epithelial
[Analysis of gene expression profiles among 3 epithelial ovarian tumor subtypes using cDNA and tissue microarrays]
Carcinoma, Papillary
Induction of thyroid neoplasms in the rat. A histochemical, immunohistochemical, autoradiographic and ultrastructural study.
Carcinoma, Renal Cell
A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.
Carcinoma, Renal Cell
D9S168 microsatellite alteration predicts a poor prognosis in patients with clear cell renal cell carcinoma and correlates with the down-regulation of protein tyrosine phosphatase receptor delta.
Carcinoma, Renal Cell
Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Expression Analysis of Tyrosine Phosphatase Genes at Different Stages of Renal Cell Carcinoma.
Carcinoma, Renal Cell
Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Knockdown of Cdc25B in renal cell carcinoma is associated with decreased malignant features.
Carcinoma, Renal Cell
Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B.
Carcinoma, Renal Cell
Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas.
Carcinoma, Renal Cell
MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B.
Carcinoma, Renal Cell
MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A.
Carcinoma, Renal Cell
Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.
Carcinoma, Renal Cell
PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation.
Carcinoma, Renal Cell
Polymorphism in protein tyrosine phosphatase receptor delta is associated with the risk of clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Progress in the correlation between PTPN12 gene expression and human tumors.
Carcinoma, Renal Cell
Protein tyrosine phosphatase ? enhances proliferation by increasing ?-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells.
Carcinoma, Renal Cell
Protein tyrosine phosphatase nonreceptor type 12 suppresses the proliferation of renal cell carcinoma by inhibiting the activity of the PI3K/mTOR pathway.
Carcinoma, Renal Cell
PTPN13 acts as a tumor suppressor in clear cell renal cell carcinoma by inactivating Akt signaling.
Carcinoma, Renal Cell
PTPN3 inhibits the growth and metastasis of clear cell renal cell carcinoma via inhibition of PI3K/AKT signaling.
Carcinoma, Renal Cell
Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.
Carcinoma, Renal Cell
Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTP? and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma.
Carcinoma, Renal Cell
Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages.
Carcinoma, Renal Cell
Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation.
Carcinoma, Renal Cell
The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
A combined electron-microscope and cytochemical study of acid phosphatase activity in human cervical squamous carcinoma.
Carcinoma, Squamous Cell
Accumulation of cytoplasmic CDC25A in cutaneous squamous cell carcinoma leads to a dependency on CDC25A for cancer cell survival and tumor growth.
Carcinoma, Squamous Cell
Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis.
Carcinoma, Squamous Cell
AlloDriver: a method for the identification and analysis of cancer driver targets.
Carcinoma, Squamous Cell
Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.
Carcinoma, Squamous Cell
An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.
Carcinoma, Squamous Cell
Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers.
Carcinoma, Squamous Cell
CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.
Carcinoma, Squamous Cell
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus.
Carcinoma, Squamous Cell
Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.
Carcinoma, Squamous Cell
Downregulation of cell division cycle 25 homolog C reduces the radiosensitivity and proliferation activity of esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Dual-specificity phosphatase 6 genetic variants associated with risk of lung squamous cell carcinoma in Han Chinese.
Carcinoma, Squamous Cell
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity.
Carcinoma, Squamous Cell
Epigenetically silenced PTPRO functions as a prognostic marker and tumor suppressor in human lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression of p21(Waf1/Cip1) predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.
Carcinoma, Squamous Cell
Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix.
Carcinoma, Squamous Cell
Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck.
Carcinoma, Squamous Cell
High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma.
Carcinoma, Squamous Cell
Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway.
Carcinoma, Squamous Cell
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Carcinoma, Squamous Cell
LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-?B.
Carcinoma, Squamous Cell
Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.
Carcinoma, Squamous Cell
Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene.
Carcinoma, Squamous Cell
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Carcinoma, Squamous Cell
Overexpression of CDC25A and CDC25B in head and neck cancers.
Carcinoma, Squamous Cell
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
Carcinoma, Squamous Cell
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Carcinoma, Squamous Cell
Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.
Carcinoma, Squamous Cell
p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy.
Carcinoma, Squamous Cell
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Carcinoma, Squamous Cell
Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells.
Carcinoma, Squamous Cell
Preferential allelic deletion of RBSP3, LIMD1 and CDC25A in head and neck squamous cell carcinoma: Implication in cancer screening and early detection.
Carcinoma, Squamous Cell
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Squamous Cell
Protein tyrosine phosphatase, receptor type B is a potential biomarker and facilitates cervical cancer metastasis via epithelial-mesenchymal transition.
Carcinoma, Squamous Cell
Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion.
Carcinoma, Squamous Cell
PTPN12 inhibits oral squamous epithelial carcinoma cell proliferation and invasion and can be used as a prognostic marker.
Carcinoma, Squamous Cell
Receptor-type Protein tyrosine phosphatase ? regulates met phosphorylation and function in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx.
Carcinoma, Squamous Cell
Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor.
Carcinoma, Squamous Cell
Significance of PTPRZ1 and CIN85 expression in cervical carcinoma.
Carcinoma, Squamous Cell
Systematic Analysis of Sex-Linked Molecular Alterations and Therapies in Cancer.
Carcinoma, Squamous Cell
Targeting 14-3-3?-CDC25A interactions to trigger apoptotic cell death in skin cancer.
Carcinoma, Squamous Cell
The association and prognostic relevance of cancerous inhibitor of protein phosphatase 2A and inflammation in tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma.
Carcinoma, Squamous Cell
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Carcinoma, Squamous Cell
[The clinical significance of PRL-3,VEGF expression in sinonasalsquamous cell carcinoma].
Carcinoma, Squamous Cell
[The relationship between histological classification of lung cancer and protein tyrosine phosphatase.]
Carcinoma, Transitional Cell
Decreased expression of protein tyrosine phosphatase non-receptor type 12 is involved in the proliferation and recurrence of bladder transitional cell carcinoma.
Carcinosarcoma
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.
Cardiomegaly
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.
Cardiomegaly
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
Cardiomegaly
Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort.
Cardiomegaly
Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways.
Cardiomegaly
Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway.
Cardiomegaly
Dual-Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1.
Cardiomegaly
Dual-specificity Phosphatase 9 protects against Cardiac Hypertrophy by targeting ASK1.
Cardiomegaly
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice.
Cardiomegaly
Growing old, angiotensin II, cardiac hypertrophy, and death: making the connection with p66Shc.
Cardiomegaly
Inhibition of HDAC3 prevents diabetic cardiomyopathy in OVE26 mice via epigenetic regulation of DUSP5-ERK1/2 pathway.
Cardiomegaly
Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy.
Cardiomegaly
Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes.
Cardiomegaly
mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?
Cardiomyopathies
A rasopathy phenotype with severe congenital hypertrophic obstructive cardiomyopathy associated with a PTPN11 mutation and a novel variant in SOS1.
Cardiomyopathies
Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway.
Cardiomyopathies
Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
Cardiomyopathies
Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation.
Cardiomyopathies
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Cardiomyopathies
Genotype-phenotype correlations in Noonan syndrome.
Cardiomyopathies
Hyperthrophic cardiomyopathy and the PTPN11 gene.
Cardiomyopathies
Intravenous Gene Therapy With Pim-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling.
Cardiomyopathies
Leopard syndrome: the potential cardiac defect underlying skin phenotypes.
Cardiomyopathies
Lysosomal glycogen storage disease with normal acid maltase with early fatal outcome.
Cardiomyopathies
Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia.
Cardiomyopathies
Noonan Syndrome Case Report: PTPN11 and Other Potential Genetic Factors Contributing to Lethal Hypertrophic Right Ventricular Cardiomyopathy.
Cardiomyopathies
Noonan syndrome: clinical aspects and molecular pathogenesis.
Cardiomyopathies
Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.
Cardiomyopathy, Dilated
Centrosome-associated CDC25B is a novel disease-causing gene for a syndrome with cataracts, dilated cardiomyopathy, and multiple endocrinopathies.
Cardiomyopathy, Dilated
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
Cardiomyopathy, Dilated
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Cardiomyopathy, Dilated
Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A.
Cardiomyopathy, Dilated
No association between transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77C>G) and idiopathic dilated cardiomyopathy.
Cardiomyopathy, Dilated
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.
Cardiomyopathy, Hypertrophic
A novel heterozygous MAP2K1 mutation in a patient with Noonan syndrome with multiple lentigines.
Cardiomyopathy, Hypertrophic
A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
A rasopathy phenotype with severe congenital hypertrophic obstructive cardiomyopathy associated with a PTPN11 mutation and a novel variant in SOS1.
Cardiomyopathy, Hypertrophic
Cardiac defects, morbidity and mortality in patients affected by RASopathies. CARNET study results.
Cardiomyopathy, Hypertrophic
Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.
Cardiomyopathy, Hypertrophic
Combined PTPN11 and MYBPC3 Gene Mutations in an Adult Patient with Noonan Syndrome and Hypertrophic Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines.
Cardiomyopathy, Hypertrophic
Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations.
Cardiomyopathy, Hypertrophic
Familial LEOPARD Syndrome With Hypertrophic Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Genotype-phenotype correlation analysis in Japanese patients with Noonan syndrome.
Cardiomyopathy, Hypertrophic
Implantable cardioverter defibrillator for progressive hypertrophic cardiomyopathy in a patient with LEOPARD syndrome and a novel PTPN11 mutation Gln510His.
Cardiomyopathy, Hypertrophic
In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
Is sudden cardiac death predictable in LEOPARD syndrome?
Cardiomyopathy, Hypertrophic
LEOPARD Syndrome Caused by Tyr279Cys Mutation in the PTPN11 Gene.
Cardiomyopathy, Hypertrophic
LEOPARD syndrome in an infant with severe hypertrophic cardiomyopathy and PTPN11 mutation.
Cardiomyopathy, Hypertrophic
Mutation screening of the PTPN11 gene in hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.
Cardiomyopathy, Hypertrophic
Pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: the multifaceted consequences of PTPN11 mutations.
Cardiomyopathy, Hypertrophic
PTPN11 and KRAS gene analysis in patients with Noonan and Noonan-like syndromes.
Cardiomyopathy, Hypertrophic
PTPN11 gene mutation and severe neonatal hypertrophic cardiomyopathy: what is the link?
Cardiomyopathy, Hypertrophic
PTPN11 gene mutations: linking the Gln510Glu mutation to the "LEOPARD syndrome phenotype".
Cardiomyopathy, Hypertrophic
PTPN11 Mutation Associated with Aortic Dilation and Hypertrophic Cardiomyopathy in a Pediatric Patient with Noonan Syndrome.
Cardiomyopathy, Hypertrophic
PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes.
Cardiomyopathy, Hypertrophic
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.
Cardiomyopathy, Hypertrophic
PTPN11 mutations play a minor role in isolated congenital heart disease.
Cardiomyopathy, Hypertrophic
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
Cardiomyopathy, Hypertrophic
RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it.
Cardiomyopathy, Hypertrophic
Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations.
Cardiomyopathy, Hypertrophic
The PTPN11 gene is not implicated in nonsyndromic hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic
The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.
Cardiomyopathy, Hypertrophic
The spectrum of genetic variants and phenotypic features of Southeast Asian patients with Noonan syndrome.
Cardiotoxicity
Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein.
Cardiovascular Diseases
Acid phosphatase, genetic polymorphism and cardiovascular risk factors in a pediatric population.
Cardiovascular Diseases
Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm.
Cardiovascular Diseases
Angiotensin (1-7) Inhibits Ang II-mediated ERK1/2 Activation by Stimulating MKP-1 Activation in Vascular Smooth Muscle Cells.
Cardiovascular Diseases
Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
Cardiovascular Diseases
Atorvastatin enhances endothelial adherens junctions through promoting VE-PTP gene transcription and reducing VE-cadherin-Y731 phosphorylation.
Cardiovascular Diseases
Cardiovascular determinants of life span.
Cardiovascular Diseases
Coronary Artery Disease: Evidence of Interaction between PTPN22 and p53 Genetic Polymorphisms.
Cardiovascular Diseases
DNA methylation of the p66Shc promoter is decreased in placental tissue from women delivering intrauterine growth restricted neonates.
Cardiovascular Diseases
Dual role of endothelial nitric oxide synthase in oxidized LDL-induced, p66Shc-mediated oxidative stress in cultured human endothelial cells.
Cardiovascular Diseases
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.
Cardiovascular Diseases
Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein.
Cardiovascular Diseases
Lethal presentation of neurofibromatosis and Noonan syndrome.
Cardiovascular Diseases
Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.
Cardiovascular Diseases
Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype.
Cardiovascular Diseases
Mitogen-activated protein kinase phosphatase-1: A critical phosphatase manipulating mitogen-activated protein kinase signaling in cardiovascular disease (Review).
Cardiovascular Diseases
New aspects of p66Shc in ischemia reperfusion injury and cardiovascular diseases.
Cardiovascular Diseases
Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.
Cardiovascular Diseases
Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C.
Cardiovascular Diseases
P66shc and its role in ischemic cardiovascular diseases.
Cardiovascular Diseases
Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction.
Cardiovascular Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Cardiovascular Diseases
Recent advance on PTP1B inhibitors and their biomedical applications.
Cardiovascular Diseases
Role of protein tyrosine phosphatase 1B in cardiovascular diseases.
Cardiovascular Diseases
Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
Cardiovascular Diseases
Structure-functional implications of longevity protein p66Shc in health and disease.
Cardiovascular Diseases
The role of p66Shc deletion in age-associated arterial dysfunction and disease states.
Cardiovascular Diseases
The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
Carotid Artery Injuries
Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.
Carotid Stenosis
Correlation between SHP-1 and carotid plaque vulnerability in humans.
Cataract
Acid phosphatase localization in the equatorial region of human lenses.
Cataract
Centrosome-associated CDC25B is a novel disease-causing gene for a syndrome with cataracts, dilated cardiomyopathy, and multiple endocrinopathies.
Cataract
Expanding the clinical spectrum of ocular anomalies in Noonan syndrome: Axenfeld-anomaly in a child with PTPN11 mutation.
Cataract
Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.
Cataract
Ultrastructural cytochemistry: effect of Sorbinil on arylsulfatases in cataractous lenses.
Cataract
Ultrastructure and acid phosphatase activity in hereditary cataracts of deer mice.
Celiac Disease
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
Celiac Disease
An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum.
Celiac Disease
Association of PTPN22 rs2476601 Polymorphism with Rheumatoid Arthritis and Celiac Disease in Khuzestan Province, Southwestern Iran.
Celiac Disease
Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease.
Celiac Disease
C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition.
Celiac Disease
Celiac disease as an autoimmune condition.
Celiac Disease
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Celiac Disease
Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children.
Celiac Disease
Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children.
Celiac Disease
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Celiac Disease
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Celiac Disease
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Celiac Disease
The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.
Cell Transformation, Neoplastic
Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).
Central Nervous System Diseases
The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-?) and Src homology region 2 domain-containing phosphatase-1 (SHP-1).
Cerebellar Ataxia
Chromosomal localization of an SH2 containing tyrosine phosphatase (SH-PTP3) gene to chromosome 12q24.1.
Cerebellar Ataxia
PTPRR Protein Tyrosine Phosphatase Isoforms and Locomotion of Vesicles and Mice.
Cerebral Hemorrhage
A cannabinoid receptor 2 agonist reduces blood-brain barrier damage via induction of MKP-1 after intracerebral hemorrhage in rats.
Cerebral Hemorrhage
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells.
Cerebral Hemorrhage
Noonan Syndrome with Multiple Lentigines and PTPN11 Mutation: A Case with Intracerebral Hemorrhage.
Cerebral Hemorrhage
Tristetraprolin attenuates brain edema in a rat model of cerebral hemorrhage.
Cerebral Infarction
Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation.
Cerebral Infarction
PTPRG is an ischemia risk locus essential for HCO3--dependent regulation of endothelial function and tissue perfusion.
Cervical Intraepithelial Neoplasia
Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia.
Cervical Intraepithelial Neoplasia
SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon-? production.
Chagas Disease
Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.
Chagas Disease
Biochemical characterization of a protein tyrosine phosphatase from Trypanosoma cruzi involved in metacyclogenesis and cell invasion.
Chagas Disease
Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease.
Chemical and Drug Induced Liver Injury
A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.
Chemical and Drug Induced Liver Injury
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Cherubism
Neurofibromatosis presenting with a cherubism phenotype.
Cherubism
Noonan-like syndrome mutations in PTPN11 in patients diagnosed with cherubism.
Cholangiocarcinoma
Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in Patients.
Cholangiocarcinoma
Expression and Prognostic Value of PRL-3 in Human Intrahepatic Cholangiocarcinoma.
Cholangiocarcinoma
High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma.
Cholangiocarcinoma
Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis.
Cholangiocarcinoma
MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN.
Cholangiocarcinoma
Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway.
Cholangiocarcinoma
PTPN3 acts as a tumor suppressor and boosts TGF-? signaling independent of its phosphatase activity.
Cholangiocarcinoma
PTPN3 mutations and HBV may exert synergistic effects in the origin of the intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
The effect of internal biliary drainage on bile pigment accumulation and acid phosphatase activity in human liver during obstructive jaundice.
Cholangiocarcinoma
The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Coactivity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma.
Cholangiocarcinoma
[Expression and clinical significance of PTPN14 in cholangiocarcinoma].
Cholangitis
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Cholangitis, Sclerosing
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Cholangitis, Sclerosing
Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis.
Cholera
Atomic resolution crystal structure of VcLMWPTP-1 from Vibrio cholerae O395: insights into a novel mode of dimerization in the low molecular weight protein tyrosine phosphatase family.
Cholera
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.
Cholesteatoma
Alkaline and acid phosphatase activity in postauricular skin and cholesteatoma epithelium.
Cholesteatoma
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Cholesteatoma, Middle Ear
[Expression and significance of PTEN, P-ERK and P-AKT in the middle ear cholesteatoma].
Choline Deficiency
Intestinal immune responses of Jian carp against Aeromonas hydrophila depressed by choline deficiency: Varied change patterns of mRNA levels of cytokines, tight junction proteins and related signaling molecules among three intestinal segments.
Chondroma
A rare association of pathological variant of Alport's syndrome caused by hemizygous 5' splice mutation in intron 10 of COL4A5 gene with metachondromatosis due to heterozygous missense variation in protein tyrosine phosphatase nonreceptor type 11 gene.
Chondroma
Chondrosarcoma in Metachondromatosis: A Rare Case Report.
Chondroma
Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.
Chondroma
Metachondromatosis: more than just multiple osteochondromas.
Chondroma
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Chondroma
SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.
Chondrosarcoma
miRNA-497 Negatively Regulates the Growth and Motility of Chondrosarcoma Cells by Targeting Cdc25A.
Chordoma
Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma.
Chordoma
Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish.
Choriocarcinoma
Dampening of IFN-gamma-inducible gene expression in human choriocarcinoma cells is due to phosphatase-mediated inhibition of the JAK/STAT-1 pathway.
Choriocarcinoma
The protein-tyrosine phosphatase, SRC homology-2 domain containing protein tyrosine phosphatase-2, is a crucial mediator of exogenous insulin-like growth factor signaling to human trophoblast.
Choriocarcinoma
Vanadate regulates the insulin mitogenic effect by modulating SHP-2 association with insulin receptor substrate 1 in JAr human choriocarcinoma cells.
Choroid Plexus Neoplasms
Papillary Tumor of the Pineal Region: A Distinct Molecular Entity.
Choroid Plexus Neoplasms
Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors.
Chronic Kidney Disease-Mineral and Bone Disorder
Nature of mononuclear cells positive for acid phosphatase activity in bone marrow of patients with renal osteodystrophy.
Chronic Urticaria
Association Between PTPN22 Polymorphisms and IgE Responses to Staphylococcal Superantigens in Chronic Urticaria.
Chronic Urticaria
Association of PTPN22 single nucleotide polymorphisms with chronic spontaneous urticaria.
Churg-Strauss Syndrome
PTPN22 R620W polymorphism in the ANCA-associated vasculitides.
Cleft Palate
Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.
Cleft Palate
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.
Cleft Palate
[Molecular mechanism of cleft palate induced by retionic acid]
Coinfection
Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor.
Coinfection
Evaluation of Primitive Murine Hematopoietic Stem and Progenitor Cell Transduction In Vitro and In Vivo by Recombinant Adeno-Associated Virus Vector Serotypes 1 Through 5.
Coinfection
Evaluation of primitive murine hematopoietic stem and progenitor cell transduction in vitro and in vivo by recombinant adeno-associated virus vector serotypes 1 through 5.
Coinfection
Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.
Coinfection
Mitogen Activated Protein Kinase Phosphatase 2, MKP-2, regulates the Inflammatory Response in Sepsis.
Coinfection
Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells.
Coinfection
Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: mechanism of transduction.
Colitis
Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis.
Colitis
Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.
Colitis
Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.
Colitis
Deletion of Protein Tyrosine Phosphatase Nonreceptor Type 2 in Intestinal Epithelial Cells Results in Upregulation of the Related Phosphatase Protein Tyrosine Phosphatase Nonreceptor Type 23.
Colitis
Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Colitis
Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.
Colitis
Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation: Trichuris muris-induced colitis genetic study.
Colitis
Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis.
Colitis
Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats.
Colitis
Increased expression of midkine in the rat colon during healing of experimental colitis.
Colitis
Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse.
Colitis
Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.
Colitis
l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1.
Colitis
Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.
Colitis
Loss of PTPN22 promotes intestinal inflammation by compromising granulocyte-mediated anti-bacterial defense.
Colitis
Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.
Colitis
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
Colitis
Mkp-1 cross-talks with Nrf2/Ho-1 pathway protecting against intestinal inflammation.
Colitis
Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis.
Colitis
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Colitis
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis.
Colitis
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Colitis
Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells.
Colitis
Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
Colitis
Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.
Colitis
Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.
Colitis
Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.
Colitis
PTPN2 controls differentiation of CD4(+) T cells and limits intestinal inflammation and intestinal dysbiosis.
Colitis
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Colitis
PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis.
Colitis
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.
Colitis
Selective Sequestration of STAT1 in the Cytoplasm via Phosphorylated SHP-2 Ameliorates Murine Experimental Colitis.
Colitis
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Colitis
SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis.
Colitis
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.
Colitis
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Colitis
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
Colitis
Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells.
Colitis
[Free Radical Production and Production Mechanism in the Early and Advanced Stages of Gastrointestinal Lesions].
Colitis
[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].
Colitis, Ulcerative
Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene.
Colitis, Ulcerative
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Colitis, Ulcerative
Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.
Colitis, Ulcerative
Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.
Colitis, Ulcerative
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.
Colitis, Ulcerative
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Colitis, Ulcerative
Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.
Colitis, Ulcerative
Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice.
Colitis, Ulcerative
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
Colitis, Ulcerative
Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase.
Colitis, Ulcerative
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Colitis, Ulcerative
Mkp-1 cross-talks with Nrf2/Ho-1 pathway protecting against intestinal inflammation.
Colitis, Ulcerative
Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis.
Colitis, Ulcerative
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Colitis, Ulcerative
Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population.
Colitis, Ulcerative
Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.
Colitis, Ulcerative
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Colitis, Ulcerative
PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
Colitis, Ulcerative
PTPRO exaggerates inflammation in ulcerative colitis through TLR4/NF-?B pathway.
Colitis, Ulcerative
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Colitis, Ulcerative
rs2476601 polymorphism in PTPN22 is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.
Colitis, Ulcerative
SHP-2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host-Microbiota Homeostasis.
Colitis, Ulcerative
Single Nucleotide Polymorphisms of PTPN22 Gene in Iranian Patients with Ulcerative Colitis.
Colitis, Ulcerative
The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.
Colitis, Ulcerative
The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease.
Colitis, Ulcerative
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
Colitis-Associated Neoplasms
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Colitis-Associated Neoplasms
The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
Colonic Neoplasms
2-D Difference in gel electrophoresis combined with Pro-Q Diamond staining: a successful approach for the identification of kinase/phosphatase targets.
Colonic Neoplasms
5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Colonic Neoplasms
A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.
Colonic Neoplasms
Activation of PERK Contributes to Apoptosis and G2/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells .
Colonic Neoplasms
Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.
Colonic Neoplasms
Can dehydroepiandrostenedione (DHEA) target PRL-3 to prevent colon cancer metastasis?
Colonic Neoplasms
Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3? pathway in colon cancer.
Colonic Neoplasms
Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells.
Colonic Neoplasms
CIP2A Is a Predictor of Poor Prognosis in Colon Cancer.
Colonic Neoplasms
Combined Phenotype of 4 Markers Improves Prognostic Value of Patients With Colon Cancer.
Colonic Neoplasms
Comparative quantitation of aberrant glycoforms by lectin-based glycoprotein enrichment coupled with multiple-reaction monitoring mass spectrometry.
Colonic Neoplasms
Cordyceps militaris Grown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells.
Colonic Neoplasms
Cytokine associated sensitivity of colon carcinoma cells to FasR-mediated cytotoxicity of CTL.
Colonic Neoplasms
Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.
Colonic Neoplasms
DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients.
Colonic Neoplasms
Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.
Colonic Neoplasms
DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells.
Colonic Neoplasms
Down-regulation of Cdc25c, CDK1 and Cyclin B1 and Up-regulation of Wee1 by Curcumin Promotes Human Colon Cancer Colo 205 Cell Entry into G2/M-phase of Cell Cycle.
Colonic Neoplasms
Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer.
Colonic Neoplasms
Elevated expression of the cdc25A protein phosphatase in colon cancer.
Colonic Neoplasms
Elevated protein-tyrosine-phosphatase activity in human colon-carcinoma.
Colonic Neoplasms
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Colonic Neoplasms
Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer.
Colonic Neoplasms
Extracellular domain dependence of PTPalpha transforming activity.
Colonic Neoplasms
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.
Colonic Neoplasms
Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1.
Colonic Neoplasms
Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.
Colonic Neoplasms
Gene Expression Along with Genomic Copy Number Variation and Mutational Analysis Were Used to Develop a 9-Gene Signature for Estimating Prognosis of COAD.
Colonic Neoplasms
Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.
Colonic Neoplasms
HOXD13 promotes the malignant progression of colon cancer by upregulating PTPRN2.
Colonic Neoplasms
Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.
Colonic Neoplasms
Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening.
Colonic Neoplasms
Identification of target proteins of N-acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration.
Colonic Neoplasms
Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells.
Colonic Neoplasms
Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells.
Colonic Neoplasms
Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.
Colonic Neoplasms
Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate.
Colonic Neoplasms
Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer.
Colonic Neoplasms
Interleukin-2 enhances susceptibility of colon cancer cells to FasR mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression.
Colonic Neoplasms
Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.
Colonic Neoplasms
LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.
Colonic Neoplasms
Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.
Colonic Neoplasms
Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.
Colonic Neoplasms
microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells.
Colonic Neoplasms
miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer.
Colonic Neoplasms
Mitogen-activated protein kinase phosphatase-1 inhibition and sustained extracellular signal-regulated kinase 1/2 activation in camptothecin-induced human colon cancer cell death.
Colonic Neoplasms
Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice.
Colonic Neoplasms
Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer.
Colonic Neoplasms
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Colonic Neoplasms
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Colonic Neoplasms
Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.
Colonic Neoplasms
NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway.
Colonic Neoplasms
Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon cancer metastasis.
Colonic Neoplasms
Potential involvement of protein phosphatase 2A in temsirolimus-mediated resensitization to cetuximab in colon cancer cells.
Colonic Neoplasms
Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.
Colonic Neoplasms
PRL-3 activates NF-?B signaling pathway by interacting with RAP1.
Colonic Neoplasms
PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer.
Colonic Neoplasms
PRL-3 promotes telomere deprotection and chromosomal instability.
Colonic Neoplasms
PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling.
Colonic Neoplasms
PRL-3: a metastasis-associated phosphatase in search of a function.
Colonic Neoplasms
Prognostic value of PRL-3 overexpression in early stages of colonic cancer.
Colonic Neoplasms
Protein expression following gamma-irradiation relevant to growth arrest and apoptosis in colon cancer cells.
Colonic Neoplasms
Protein phosphatase 2A is essential to maintain active Wnt signaling and its A? tumor suppressor subunit is not expressed in colon cancer cells.
Colonic Neoplasms
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Colonic Neoplasms
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Colonic Neoplasms
PTP1B Contributes to the Oncogenic Properties of Colon Cancer Cells through Src Activation.
Colonic Neoplasms
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Colonic Neoplasms
PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.
Colonic Neoplasms
PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study.
Colonic Neoplasms
PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.
Colonic Neoplasms
PTPN12 Affects Nasopharyngeal Carcinoma Cell Proliferation and Migration Through Regulating EGFR.
Colonic Neoplasms
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Colonic Neoplasms
Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers.
Colonic Neoplasms
PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.
Colonic Neoplasms
pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1).
Colonic Neoplasms
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Colonic Neoplasms
Receptor-type protein tyrosine phosphatase ? directly dephosphorylates CD133 and regulates downstream AKT activation.
Colonic Neoplasms
Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.
Colonic Neoplasms
SHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial-Mesenchymal Transition.
Colonic Neoplasms
SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer.
Colonic Neoplasms
Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells.
Colonic Neoplasms
Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.
Colonic Neoplasms
Structural modification of Fas C-terminal tripeptide and its effects on the inhibitory activity of Fas/FAP-1 binding.
Colonic Neoplasms
Substrate stiffness and the receptor-type tyrosine-protein phosphatase alpha regulate spreading of colon cancer cells through cytoskeletal contractility.
Colonic Neoplasms
Sulforaphene suppresses growth of colon cancer-derived tumors via induction of glutathione depletion and microtubule depolymerization.
Colonic Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Colonic Neoplasms
Temsirolimus enhances the efficacy of cetuximab in colon cancer through a CIP2A-dependent mechanism.
Colonic Neoplasms
The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.
Colonic Neoplasms
The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis.
Colonic Neoplasms
The mycotoxin patulin decreases expression of density-enhanced phosphatase-1 by down-regulating PPAR? in human colon cancer cells.
Colonic Neoplasms
The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
Colonic Neoplasms
The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.
Colonic Neoplasms
The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK.
Colonic Neoplasms
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Colonic Neoplasms
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
Colonic Neoplasms
Tyrosine phosphatase inhibitor-3 sensitizes melanoma and colon cancer to biotherapeutics and chemotherapeutics.
Colonic Neoplasms
Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44.
Colonic Neoplasms
Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.
Colonic Neoplasms
WiNTRLINC1/ASCL2/c-Myc Axis Characteristics of Colon Cancer with Differentiated Histology at Young Onset and Essential for Cell Viability.
Colonic Neoplasms
[Development of anti cancer drugs targeted on Fas-mediated apoptosis signal]
Colonic Neoplasms
[Effects of phosphatase of regenerating liver cell-3 gene silence by RNA interference on the expression of matrix metalloproteinases-2,-9 in human colon cancer cells]
Colonic Neoplasms
[P66shc action on resistance of colon carcinoma RKO cells to oxidative stress].
Colorectal Neoplasms
3'-hydroxy-4'-methoxy-?-methyl-?-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Colorectal Neoplasms
A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion.
Colorectal Neoplasms
A missense variant in PTPN12 associated with the risk of colorectal cancer by modifying Ras/MEK/ERK signaling.
Colorectal Neoplasms
A novel platform for detection of CK+ and CK- CTCs.
Colorectal Neoplasms
A phosphatase associated with metastasis of colorectal cancer.
Colorectal Neoplasms
A retrospective cohort study of clinical value of PRL-3 in stage III human colorectal cancer.
Colorectal Neoplasms
A screen of FDA-approved drugs identifies inhibitors of protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3).
Colorectal Neoplasms
An epigenetic role for PRL-3 as a regulator of H3K9 methylation in colorectal cancer.
Colorectal Neoplasms
Analysis of Potential Alterations Affecting SETBP1 as a Novel Contributing Mechanism to Inhibit PP2A in Colorectal Cancer Patients.
Colorectal Neoplasms
B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A.
Colorectal Neoplasms
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy.
Colorectal Neoplasms
Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review.
Colorectal Neoplasms
Catalytic domain of PRL-3 plays an essential role in tumor metastasis: formation of PRL-3 tumors inside the blood vessels.
Colorectal Neoplasms
CCL26 Participates in the PRL-3-Induced Promotion of Colorectal Cancer Invasion by Stimulating Tumor-Associated Macrophage Infiltration.
Colorectal Neoplasms
CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
Colorectal Neoplasms
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual specificity phosphatase 1.
Colorectal Neoplasms
Circular RNA circ_0007142 Facilitates Colorectal Cancer Progression by Modulating CDC25A Expression via miR-122-5p.
Colorectal Neoplasms
Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer.
Colorectal Neoplasms
Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer.
Colorectal Neoplasms
Corrigendum: Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.
Colorectal Neoplasms
Critical relevance of genomic gains of PRL-3/EGFR/c-myc pathway genes in liver metastasis of colorectal cancer.
Colorectal Neoplasms
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket.
Colorectal Neoplasms
Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients.
Colorectal Neoplasms
DNA copy number changes at 8q11-24 in metastasized colorectal cancer.
Colorectal Neoplasms
Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.
Colorectal Neoplasms
Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.
Colorectal Neoplasms
Downregulation of PTPRH (Sap-1) in colorectal tumors.
Colorectal Neoplasms
Dual specificity phosphatase 5 is a novel prognostic indicator for patients with advanced colorectal cancer.
Colorectal Neoplasms
DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death.
Colorectal Neoplasms
Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells.
Colorectal Neoplasms
Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1.
Colorectal Neoplasms
Erratum: B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A: Erratum.
Colorectal Neoplasms
Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins.
Colorectal Neoplasms
Expression levels and associations of five long non-coding RNAs in gastric cancer and their clinical significance.
Colorectal Neoplasms
Expression of Concern: Upregulation of microRNA-497-5p inhibits colorectal cancer cell proliferation and invasion via targeting PTPN3.
Colorectal Neoplasms
Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy.
Colorectal Neoplasms
Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis.
Colorectal Neoplasms
Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.
Colorectal Neoplasms
Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.
Colorectal Neoplasms
Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.
Colorectal Neoplasms
Functional STR within PTPN11: a novel potential risk factor for colorectal cancer.
Colorectal Neoplasms
Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases.
Colorectal Neoplasms
Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis.
Colorectal Neoplasms
Germline Epigenetic Silencing of the Tumor Suppressor Gene PTPRJ in Early-Onset Familial Colorectal Cancer.
Colorectal Neoplasms
High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases.
Colorectal Neoplasms
High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study.
Colorectal Neoplasms
High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues.
Colorectal Neoplasms
Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells.
Colorectal Neoplasms
Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness.
Colorectal Neoplasms
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Colorectal Neoplasms
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Colorectal Neoplasms
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
Colorectal Neoplasms
Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues.
Colorectal Neoplasms
Immunohistochemical assessment of PRL-3 (PTP4A3) expression in tumor buds, invasion front, central region of tumor and metastases of colorectal cancer.
Colorectal Neoplasms
Increased mRNA expression of the receptor-like protein tyrosine phosphatase alpha in late stage colon carcinomas.
Colorectal Neoplasms
Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome.
Colorectal Neoplasms
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Colorectal Neoplasms
Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer.
Colorectal Neoplasms
Interleukin-34 sustains pro-tumorigenic signals in colon cancer tissue.
Colorectal Neoplasms
KCNN4 channels participate in the EMT induced by PRL-3 in colorectal cancer.
Colorectal Neoplasms
Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1.
Colorectal Neoplasms
Levels of expression of pleiotrophin and protein tyrosine phosphatase zeta are decreased in human colorectal cancers.
Colorectal Neoplasms
Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9.
Colorectal Neoplasms
LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.
Colorectal Neoplasms
Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.
Colorectal Neoplasms
Loss of tyrosine phosphatase SHP2 activity promotes growth of colorectal carcinoma HCT-116 cells.
Colorectal Neoplasms
Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer.
Colorectal Neoplasms
Mass spectrometry study of PRL-3 phosphatase inactivation by disulfide bond formation and cysteine into glycine conversion.
Colorectal Neoplasms
Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase receptor type J in familial colorectal cancer.
Colorectal Neoplasms
Mesenchymal and Phosphatase of Regenerating Liver-3 Status in Circulating Tumor Cells May Serve as a Crucial Prognostic Marker for Assessing Relapse or Metastasis in Postoperative Patients With Colorectal Cancer.
Colorectal Neoplasms
Meta-analysis of association between Arg326Gln (rs1503185) and Gln276Pro (rs1566734) polymorphisms of PTPRJ gene and cancer risk.
Colorectal Neoplasms
Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells.
Colorectal Neoplasms
MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review.
Colorectal Neoplasms
miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer.
Colorectal Neoplasms
MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1.
Colorectal Neoplasms
MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer.
Colorectal Neoplasms
Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.
Colorectal Neoplasms
Mitogen-activated protein kinase phosphatase-1 (MKP-1) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastatic colorectal cancer patients.
Colorectal Neoplasms
Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW-PTP) restores sensitivity to apoptosis during colon carcinogenesis: Studies in vitro and in vivo, in an Apc-driven model of colon cancer.
Colorectal Neoplasms
Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention.
Colorectal Neoplasms
Mutational analysis of FLASH and PTPN13 genes in colorectal carcinomas.
Colorectal Neoplasms
Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
Colorectal Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Colorectal Neoplasms
Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma.
Colorectal Neoplasms
Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis.
Colorectal Neoplasms
Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers.
Colorectal Neoplasms
PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer.
Colorectal Neoplasms
Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects.
Colorectal Neoplasms
Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.
Colorectal Neoplasms
Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer.
Colorectal Neoplasms
Polypyrimidine tract-binding protein 1-mediated down-regulation of ATG10 facilitates metastasis of colorectal cancer cells.
Colorectal Neoplasms
Preparation and characterization of monoclonal antibody against protein tyrosine phosphatase PRL-3.
Colorectal Neoplasms
PRL phosphatases as potential molecular targets in cancer.
Colorectal Neoplasms
PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.
Colorectal Neoplasms
PRL-3 exerts oncogenic functions in myeloid leukemia cells via aberrant dephosphorylation of stathmin and activation of STAT3 signaling.
Colorectal Neoplasms
PRL-3 expression in metastatic cancers.
Colorectal Neoplasms
PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism.
Colorectal Neoplasms
PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo.
Colorectal Neoplasms
PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness.
Colorectal Neoplasms
PRL-3 phosphatase is implicated in ovarian cancer growth.
Colorectal Neoplasms
PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly.
Colorectal Neoplasms
PRL-3 promotes ubiquitination and degradation of AURKA and colorectal cancer progression via dephosphorylation of FZR1.
Colorectal Neoplasms
PRL-3, an Emerging Marker of Carcinogenesis, is Strongly Associated with Poor Prognosis.
Colorectal Neoplasms
Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.
Colorectal Neoplasms
Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development.
Colorectal Neoplasms
Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition.
Colorectal Neoplasms
Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer.
Colorectal Neoplasms
PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma.
Colorectal Neoplasms
PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study.
Colorectal Neoplasms
PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis.
Colorectal Neoplasms
PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.
Colorectal Neoplasms
PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma.
Colorectal Neoplasms
PTPN6 promotes chemosensitivity of colorectal cancer cells via inhibiting the SP1/MAPK signalling pathway.
Colorectal Neoplasms
PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer.
Colorectal Neoplasms
PTPRB promotes metastasis of colorectal carcinoma via inducing epithelial-mesenchymal transition.
Colorectal Neoplasms
PTPRJ Haplotypes and Colorectal Cancer Risk.
Colorectal Neoplasms
PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC.
Colorectal Neoplasms
PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
Colorectal Neoplasms
PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients.
Colorectal Neoplasms
Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis.
Colorectal Neoplasms
Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma.
Colorectal Neoplasms
Retraction: Upregulation of microRNA-497-5p inhibits colorectal cancer cell proliferation and invasion via targeting PTPN3.
Colorectal Neoplasms
RING-Finger Protein 6 Amplification Activates JAK/STAT3 Pathway by Modifying SHP-1 Ubiquitylation and Associates with Poor Outcome in Colorectal Cancer.
Colorectal Neoplasms
SHP-1 is a target of regorafenib in colorectal cancer.
Colorectal Neoplasms
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.
Colorectal Neoplasms
SHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial-Mesenchymal Transition.
Colorectal Neoplasms
SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Colorectal Neoplasms
SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A.
Colorectal Neoplasms
Snail as a key regulator of PRL-3 gene in colorectal cancer.
Colorectal Neoplasms
Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer.
Colorectal Neoplasms
Structural insights into molecular function of the metastasis-associated phosphatase PRL-3.
Colorectal Neoplasms
The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer.
Colorectal Neoplasms
The Expression of p66Shc Protein in Benign, Premalignant, and Malignant Gastrointestinal Lesions.
Colorectal Neoplasms
The Expression of the Phosphatase Regenerating Liver 3 Gene is Associated with Outcome in Patients with Colorectal Cancer.
Colorectal Neoplasms
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers.
Colorectal Neoplasms
The extended spectrum of RAS-MAPK pathway mutations in colorectal cancer.
Colorectal Neoplasms
The function of the protein tyrosine phosphatase SHP-1 in cancer.
Colorectal Neoplasms
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation.
Colorectal Neoplasms
The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth.
Colorectal Neoplasms
The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
Colorectal Neoplasms
The PTPN13 Y2081D (T>G) (rs989902) polymorphism is associated with an increased risk of sporadic colorectal cancer.
Colorectal Neoplasms
The Suppressing Effects of Dkk3 Expression on Aggressiveness and Tumorigenesis of Colorectal Cancer.
Colorectal Neoplasms
The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.
Colorectal Neoplasms
The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas.
Colorectal Neoplasms
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.
Colorectal Neoplasms
Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.
Colorectal Neoplasms
Tumor-associated macrophages (TAMs) depend on Shp2 for their anti-tumor roles in colorectal cancer.
Colorectal Neoplasms
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
Colorectal Neoplasms
Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells.
Colorectal Neoplasms
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
Colorectal Neoplasms
Up-regulation of microRNA-497-5p inhibits colorectal cancer cell proliferation and invasion via targeting PTPN3.
Colorectal Neoplasms
Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.
Colorectal Neoplasms
Vemurafenib downmodulates aggressiveness mediators of colorectal cancer (CRC): Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP), Protein Tyrosine Phosphatase 1B (PTP1B) and Transforming Growth Factor ? (TGF?).
Colorectal Neoplasms
[Cloning of human PRL-3 gene and construction of its prokaryotic expression vector]
Colorectal Neoplasms
[Construction of a lentiviral vector for RNA interference of PRL-3 gene and its stable expression in SW480 cells]
Colorectal Neoplasms
[Construction of the life cycle of Angiostrongylus cantonensis in laboratory]
Colorectal Neoplasms
[Establishment of a colorectal cancer cell line with PRL-3 and CDH22 gene knock-down by lentivirus-mediated RNA interference.]
Colorectal Neoplasms
[Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance].
Colorectal Neoplasms
[Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma]
Colorectal Neoplasms
[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]
Colorectal Neoplasms
[Expression of the zinc finger transcriptional factor Snail in colorectal carcinoma and its significance]
Colorectal Neoplasms
[Tumor markers for colorectal cancer]
Colorectal Neoplasms, Hereditary Nonpolyposis
Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer.
Communicable Diseases
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Congenital Abnormalities
Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity and calvarial defects in mice.
Congenital Abnormalities
Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal deformity model.
Congenital Abnormalities
Genotype-phenotype correlations in Noonan syndrome.
Congenital Abnormalities
Pathogenesis of adolescent idiopathic scoliosis in girls - a double neuro-osseous theory involving disharmony between two nervous systems, somatic and autonomic expressed in the spine and trunk: possible dependency on sympathetic nervous system and hormones with implications for medical therapy.
Congenital Abnormalities
Phenotypic spectrum of 80 Greek patients referred as Noonan syndrome and PTPN11 mutation analysis: the value of initial clinical assessment.
Congenital Abnormalities
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Shp2 function in hematopoietic stem cell biology and leukemogenesis.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Connective Tissue Diseases
PTPN22: the archetypal non-HLA autoimmunity gene.
Connective Tissue Diseases
The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients.
Corneal Dystrophies, Hereditary
Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis.
Corneal Dystrophies, Hereditary
Association of Transcription Factor 4 (TCF4) and Protein Tyrosine Phosphatase, Receptor Type G (PTPRG) with Corneal Dystrophies in Southern Chinese.
Coronary Artery Disease
Atherosclerosis and PTPN22: A Study in Coronary Artery Disease.
Coronary Artery Disease
Coronary Artery Disease: Evidence of Interaction between PTPN22 and p53 Genetic Polymorphisms.
Coronary Artery Disease
Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism.
Coronary Artery Disease
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease.
Coronary Artery Disease
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.
Coronary Artery Disease
Modulation of bone marrow-derived endothelial progenitor cell activity by protein tyrosine phosphatases.
Coronary Artery Disease
Search for genetic variants in the p66Shc longevity gene by PCR-single strand conformational polymorphism in patients with early-onset cardiovascular disease.
Coronary Artery Disease
The 981C>T polymorphism in protein tyrosine phosphatase 1B is associated with decreased risk of coronary artery disease in Chinese Han population.
Coronary Artery Disease
The p66shc gene expression in peripheral blood monocytes is increased in patients with coronary artery disease.
Coronary Artery Disease
The protein tyrosine phosphatase receptor type f (PTPRF) locus is associated with coronary artery disease in type 2 diabetes.
Coronary Disease
The expression of p66shc in peripheral blood monocytes is increased in patients with coronary heart disease and correlated with endothelium-dependent vasodilatation.
Costello Syndrome
Clinical and molecular characterization of children with Noonan syndrome and other RASopathies in Argentina.
Costello Syndrome
Exclusion of PTPN11 mutations in Costello syndrome: further evidence for distinct genetic etiologies for Noonan, cardio-facio-cutaneous and Costello syndromes.
Costello Syndrome
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
Costello Syndrome
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.
Costello Syndrome
Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.
Costello Syndrome
No mutation in the gene for Noonan syndrome, PTPN11, in 18 patients with Costello syndrome.
Costello Syndrome
Spectrum of Mutations in Noonan Syndrome and Their Correlation with Phenotypes.
Craniofacial Abnormalities
Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.
Craniosynostoses
A de novo balanced translocation t(7;12)(p21.2;p12.3) in a patient with Saethre-Chotzen-like phenotype downregulates TWIST and an osteoclastic protein-tyrosine phosphatase, PTP-oc.
Craniosynostoses
Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype.
Craniosynostoses
Evidence that homozygous PTPRD gene microdeletion causes trigonocephaly, hearing loss, and intellectual disability.
Crohn Disease
A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.
Crohn Disease
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.
Crohn Disease
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
Crohn Disease
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Crohn Disease
Association Between the PTPN2 Gene and Crohn's Disease: Dissection of Potential Causal Variants.
Crohn Disease
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Crohn Disease
Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.
Crohn Disease
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.
Crohn Disease
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Crohn Disease
Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.
Crohn Disease
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Crohn Disease
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
Crohn Disease
Expression of the membrane protein tyrosine phosphatase CD148 in human tissues.
Crohn Disease
Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn's Disease: On the Way to Personalized Medicine?
Crohn Disease
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.
Crohn Disease
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.
Crohn Disease
Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.
Crohn Disease
Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase.
Crohn Disease
Inflammatory Bowel Diseases: the genetic revolution.
Crohn Disease
Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion.
Crohn Disease
Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-?-Induced Signaling in Human Monocytes.
Crohn Disease
Loss of PTPN22 promotes intestinal inflammation by compromising granulocyte-mediated anti-bacterial defense.
Crohn Disease
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Crohn Disease
Mkp-1 cross-talks with Nrf2/Ho-1 pathway protecting against intestinal inflammation.
Crohn Disease
Modulation of PTPN2/22 Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn's Disease and Rheumatoid Arthritis.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Crohn Disease
Protection of epithelial barrier function by the Crohn's disease associated gene, protein tyrosine phosphatase N2.
Crohn Disease
Protein tyrosine phosphatase N2 regulates TNF?-induced signalling and cytokine secretion in human intestinal epithelial cells.
Crohn Disease
Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-?-induced cytokine signaling in THP-1 monocytes.
Crohn Disease
Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells.
Crohn Disease
PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.
Crohn Disease
PTPN2 controls differentiation of CD4(+) T cells and limits intestinal inflammation and intestinal dysbiosis.
Crohn Disease
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Crohn Disease
PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
Crohn Disease
PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.
Crohn Disease
PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis.
Crohn Disease
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Crohn Disease
rs2476601 polymorphism in PTPN22 is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.
Crohn Disease
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Crohn Disease
The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.
Crohn Disease
The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease.
Crohn Disease
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
Crohn Disease
Variants of CARD15, TNFA and PTPN22 and susceptibility to Crohn's disease in the Czech population: high frequency of the CARD15 1007fs.
Cross Infection
A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury.
Cryptorchidism
Co-occurring SHOC2 and PTPN11 mutations in a patient with severe/complex Noonan syndrome-like phenotype.
Cryptorchidism
New Mutations Associated with Rasopathies in a Central European Population and Genotype-Phenotype Correlations.
Cryptorchidism
[Clinical and genetic analysis of Noonan syndrome in 20 children].
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Cystadenoma
Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma.
Cystic Fibrosis
Activation of cardiac chloride conductance by the tyrosine kinase inhibitor, genistein.
Cystic Fibrosis
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis.
Cystic Fibrosis
Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation.
Cystic Fibrosis
Expression and regulation of chloride channels in neonatal rat cardiomyocytes.
Cystic Fibrosis
Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin.
Cystic Fibrosis
Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel.
Cystic Fibrosis
Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection.
Cystic Fibrosis
Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.
Cystic Fibrosis
The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.
Cystic Fibrosis
The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line.
Cystic Fibrosis
The +1858 C/T Polymorphism in the PTPN22 Gene Is Associated with Cystic Fibrosis Patients in Northeast Mexico.
Cystic Fibrosis
ZnT8 antibodies in patients with cystic fibrosis: An expression of secondary beta-cell damage?
Cysts
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Cysts
Characterization of low molecular weight protein tyrosine phosphatases of Entamoeba histolytica.
Cysts
Excystation of Giardia muris induced by a phosphate-bicarbonate medium: localization of acid phosphatase.
Cysts
Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure.
Cysts
Histochemistry and ultrastructure of the metacercarial cyst of Bolbogonotylus corkumi (Trematoda: Cryptogonimidae).
Cysts
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
Cysts
MicroRNAs in cholangiociliopathies.
Cysts
PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.
Cysts
Therapeutic Targets In Polycystic Liver Disease.
Cysts
[The characteristics of chemical composition of content of unicameral bone cysts depending on their growth stage].
Dandy-Walker Syndrome
Array-based molecular karyotyping in fetuses with isolated brain malformations identifies disease-causing CNVs.
Deafness
A C-terminal nonsense mutation links PTPRQ with autosomal-dominant hearing loss, DFNA73.
Deafness
A reduction in Ptprq associated with specific features of the deafness phenotype of the miR-96 mutant mouse diminuendo.
Deafness
Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene.
Deafness
Hair Bundle Defects and Loss of Function in the Vestibular End Organs of Mice Lacking the Receptor-Like Inositol Lipid Phosphatase PTPRQ.
Deafness
Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment.
Deafness
Identification of Novel PTPRQ and MYO1A Mutations in An Iranian Pedigree with Autosomal Recessive Hearing Loss.
Deafness
Identification of Two Novel Compound Heterozygous PTPRQ Mutations Associated with Autosomal Recessive Hearing Loss in a Chinese Family.
Deafness
IRS2-deficient mice show sensorineural hearing loss that is delayed by concomitant PTP1B loss of function.
Deafness
Leopard syndrome: the potential cardiac defect underlying skin phenotypes.
Deafness
Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction.
Deafness
Proband Whole-Exome Sequencing Identified Genes Responsible for Autosomal Recessive Non-Syndromic Hearing Loss in 33 Chinese Nuclear Families.
Deafness
PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome.
Death, Sudden, Cardiac
Is sudden cardiac death predictable in LEOPARD syndrome?
Dehydration
Cell hydration and mTOR-dependent signalling.
Dehydration
Glucagon-induced expression of the MAP kinase phosphatase MKP-1 in rat hepatocytes.
Dehydration
Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective.
Dementia
Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.
Dementia
Beneficial Effect of Protein Tyrosine Phosphatase Inhibitor and Phytoestrogen in Dyslipidemia-Induced Vascular Dementia in Ovariectomized Rats.
Dementia
Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies.
Dementia
Expression changes of growth-associated protein-43 (GAP-43) and mitogen-activated protein kinase phosphatase-1 (MKP-1) and in hippocampus of streptozotocin-induced diabetic cognitive impairment rats.
Dementia
Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation.
Dementia
Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats.
Dementia
The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer's Disease and Other Neurological Disorders.
Dementia, Vascular
Attenuation of hyperhomocysteinemia induced vascular dementia by sodium orthovanadate perhaps via PTP1B: Pertinent downstream outcomes.
Dementia, Vascular
Beneficial Effect of Protein Tyrosine Phosphatase Inhibitor and Phytoestrogen in Dyslipidemia-Induced Vascular Dementia in Ovariectomized Rats.
Demyelinating Diseases
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Demyelinating Diseases
Accelerated Axonal Loss Following Acute CNS Demyelination in Mice Lacking Protein Tyrosine Phosphatase Receptor Type Z.
Demyelinating Diseases
Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Demyelinating Diseases
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Demyelinating Diseases
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination.
Demyelinating Diseases
Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease.
Demyelinating Diseases
Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells.
Demyelinating Diseases
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Demyelinating Diseases
Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.
Demyelinating Diseases
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.
Demyelinating Diseases
Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Demyelinating Diseases
Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia.
Demyelinating Diseases
Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination.
Demyelinating Diseases
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
Demyelinating Diseases
The control of reactive oxygen species production by SHP-1 in oligodendrocytes.
Dengue
Protein tyrosine phosphatase, opisthorchiasis and dengue: A proteomics interrelationship.
Dengue
Tyrosine kinase/phosphatase inhibitors decrease dengue virus production in HepG2 cells.
Dental Calculus
[Deposition of tartar in human teeth and acid phosphatase activity in saliva]
Dental Calculus
[Tartar deposit and salivary acid phosphatase activity in man]
Dental Caries
Dental caries: Genetic and protein interactions.
Dental Caries
[The correlation between salivary acid phosphatase activity and dental caries]
Dental Plaque
The effect of dental plaque grown in the presence of xylitol or sucrose on bone resorption in vitro.
Dermatitis
Critical role for mast cell Stat5 activity in skin inflammation.
Dermatitis
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
Dermatitis
Protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1-derived peptide recombinant protein tyrosine phosphatase (AP-rPTP), alleviates both atopic dermatitis-like and psoriasis-like dermatitis.
Dermatitis, Atopic
Genetic control of serum IgE levels: a study of low molecular weight protein tyrosine phosphatase.
Dermatitis, Atopic
Licoricidin Abrogates T-Cell Activation by Modulating PTPN1 Activity and Attenuates Atopic Dermatitis In Vivo.
Dermatitis, Atopic
Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders.
Dermatitis, Atopic
PTPN22 polymorphisms may indicate a role for this gene in atopic dermatitis in West Highland white terriers.
Dermatitis, Contact
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Dermatitis, Phototoxic
Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.
Dermatomyositis
Concomitance of basophilia, ribonucleic acid and acid phosphatase activity in regenerating muscle fibres.
Dermatomyositis
The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients.
Diabetes Complications
Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms.
Diabetes Complications
Inhibitory activity of Aralia continentalis roots on protein tyrosine phosphatase 1B and rat lens aldose reductase.
Diabetes Complications
Marine algae as a prospective source for antidiabetic compounds - A brief review.
Diabetes Complications
p66Shc gene expression in peripheral blood mononuclear cells and progression of diabetic complications.
Diabetes Complications
Protein Tyrosine Phosphatase 1B and ?-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae, Ecklonia stolonifera and Eisenia bicyclis.
Diabetes Complications
Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.
Diabetes Complications
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Diabetes Insipidus
Acid phosphatase activity in the rat neurohypophysis during increased levels of gonadothrophic hormones, in diabetes insipidus (Bratteboro strain) and after water loading.
Diabetes Mellitus
25-Hydroxyvitamin D
Diabetes Mellitus
A Computer-Driven Scaffold-Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2-a]quinoxaline Core.
Diabetes Mellitus
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Diabetes Mellitus
A Link Between Alzheimer's and Type II Diabetes Mellitus? Ca+2 -Mediated Signal Control and Protein Localization.
Diabetes Mellitus
A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.
Diabetes Mellitus
Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Diabetes Mellitus
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.
Diabetes Mellitus
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.
Diabetes Mellitus
An Integrated Computational Approach for Plant-Based Protein Tyrosine Phosphatase Non-Receptor Type 1 Inhibitors.
Diabetes Mellitus
An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.
Diabetes Mellitus
An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.
Diabetes Mellitus
Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome.
Diabetes Mellitus
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides.
Diabetes Mellitus
Association of genetic variants with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus.
Diabetes Mellitus
Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs.
Diabetes Mellitus
Association of PTPN1 polymorphisms with breast cancer risk: A case-control study in Chinese females.
Diabetes Mellitus
Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents.
Diabetes Mellitus
Association of the PTPN22 gene (+1858C/T, -1123G/C) polymorphisms with type 1 diabetes mellitus: A systematic review and meta-analysis.
Diabetes Mellitus
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.
Diabetes Mellitus
Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.
Diabetes Mellitus
Carbazole alkaloids from the fruits of Clausena anisum-olens with potential PTP1B and ?-glucosidase inhibitory activities.
Diabetes Mellitus
Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus.
Diabetes Mellitus
Characteristics of the interaction mechanisms of procyanidin B1 and procyanidin B2 with protein tyrosine phosphatase-1B: Analysis by kinetics, spectroscopy methods and molecular docking.
Diabetes Mellitus
Concurrent extrahepatic autoimmune disorders: unexplored dimension of autoimmune liver disease in children.
Diabetes Mellitus
Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKC?/p66Shc axis and activation of FOXO-3a.
Diabetes Mellitus
Cytosolic Low Molecular Weight Protein-Tyrosine Phosphatase Activity and Clinical Manifestations of Diabetes.
Diabetes Mellitus
Deletion of AT2 Receptor Prevents SHP-1-Induced VEGF Inhibition and Improves Blood Flow Reperfusion in Diabetic Ischemic Hindlimb.
Diabetes Mellitus
Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B.
Diabetes Mellitus
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Diabetes Mellitus
Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies.
Diabetes Mellitus
Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors.
Diabetes Mellitus
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties.
Diabetes Mellitus
Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent.
Diabetes Mellitus
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.
Diabetes Mellitus
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Diabetes Mellitus
Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents.
Diabetes Mellitus
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Diabetes Mellitus
Ficus deltoidea extract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism.
Diabetes Mellitus
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Diabetes Mellitus
Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus.
Diabetes Mellitus
Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.
Diabetes Mellitus
Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.
Diabetes Mellitus
Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes.
Diabetes Mellitus
Genomic structure of mouse IA-2: comparison with its human homologue.
Diabetes Mellitus
Glucose Uptake Activities of Bis (2, 3-Dibromo-4, 5-Dihydroxybenzyl) Ether, a Novel Marine Natural Product from Red Alga Odonthaliacorymbifera with Protein Tyrosine Phosphatase 1B Inhibition, In Vitro and In Vivo.
Diabetes Mellitus
Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type 1 diabetic patients.
Diabetes Mellitus
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Diabetes Mellitus
Human protein tyrosine phosphatase 1B inhibitors: QSAR by genetic function approximation.
Diabetes Mellitus
Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes.
Diabetes Mellitus
IA-2A positivity rate at manifestation of type 1 diabetes mellitus in Slovak children culminates in September.
Diabetes Mellitus
Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan.
Diabetes Mellitus
Identification of lipid-like salicylic acid-based derivatives as potent and membrane-permeable PTP1B inhibitors.
Diabetes Mellitus
Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation.
Diabetes Mellitus
Identification of PTP1B regulators from Cymbopogon citratus and its enrichment analysis for diabetes mellitus.
Diabetes Mellitus
In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications-A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B.
Diabetes Mellitus
In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
Diabetes Mellitus
In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes.
Diabetes Mellitus
In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B.
Diabetes Mellitus
Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients.
Diabetes Mellitus
Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.
Diabetes Mellitus
Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.
Diabetes Mellitus
Inhibitors of protein tyrosine phosphatase 1B (PTP1B).
Diabetes Mellitus
Inhibitors of Protein Tyrosine Phosphatase 1B from Marine Natural Products.
Diabetes Mellitus
Inhibitory Effects of Secondary Metabolites from the Lichen Stereocaulon evolutum on Protein Tyrosine Phosphatase 1B.
Diabetes Mellitus
Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese.
Diabetes Mellitus
Insulin gene profile cycles with season of birth of future diabetic children and their relatives.
Diabetes Mellitus
Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.
Diabetes Mellitus
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Diabetes Mellitus
Isolation and Characterization of Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Polyphenolic Compounds From
Diabetes Mellitus
Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.
Diabetes Mellitus
Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus.
Diabetes Mellitus
Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition.
Diabetes Mellitus
Metabolic Diseases Drug Discovery-Strategic Research Institute's Third International World Summit. Dipeptidyl peptidase-IV inhibitors 26-27 July 2004, San Diego, CA, USA.
Diabetes Mellitus
Methylation pattern variation between goats and rats during the onset of puberty.
Diabetes Mellitus
Novel homozygous AIRE mutation in a German patient with severe APECED.
Diabetes Mellitus
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.
Diabetes Mellitus
Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control.
Diabetes Mellitus
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Diabetes Mellitus
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Diabetes Mellitus
Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B.
Diabetes Mellitus
Optimization of extraction parameters of PTP1? (protein tyrosine phosphatase 1?), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM).
Diabetes Mellitus
P66Shc expression in diabetic rat retina.
Diabetes Mellitus
Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder.
Diabetes Mellitus
Pharmacological inhibition of protein tyrosine phosphatase 1B: a promising strategy for the treatment of obesity and type 2 diabetes mellitus.
Diabetes Mellitus
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551.
Diabetes Mellitus
Potential Inhibitors of Protein Tyrosine Phosphatase (PTP1B) Enzyme: Promising Target for Type-II Diabetes Mellitus.
Diabetes Mellitus
Potential Utility of Sodium Selenate as an Adjunct to Metformin in Treating Type II Diabetes Mellitus in Rats: A Perspective on Protein Tyrosine Phosphatase.
Diabetes Mellitus
Prediction of future rheumatoid arthritis.
Diabetes Mellitus
Protein tyrosine Phosphatase (PTP1B): A promising Drug Target against life threatening ailments.
Diabetes Mellitus
Protein tyrosine phosphatase 1B inhibitors: A molecular level legitimate approach for the management of diabetes mellitus.
Diabetes Mellitus
Protein Tyrosine Phosphatase 1B inhibitors: a novel therapeutic strategy for the management of type 2 diabetes mellitus.
Diabetes Mellitus
Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.
Diabetes Mellitus
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.
Diabetes Mellitus
Protein tyrosine phosphatase activity in insulin-resistant rodent Psammomys obesus.
Diabetes Mellitus
Protein Tyrosine Phosphatase Non-receptor 22 Gene C1858T Polymorphism in Patients with Coexistent Type 2 Diabetes and Hashimoto's Thyroiditis.
Diabetes Mellitus
Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
Diabetes Mellitus
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Diabetes Mellitus
Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.
Diabetes Mellitus
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction.
Diabetes Mellitus
PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.
Diabetes Mellitus
PTPN2 gene polymorphisms are associated with type 1 diabetes mellitus in Brazilian subjects?
Diabetes Mellitus
PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus.
Diabetes Mellitus
QSAR Study on a Series of Protein Tyrosine Phosphatase 1B Inhibitors.
Diabetes Mellitus
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Diabetes Mellitus
Role of protein tyrosine phosphatase 1B inhibitor in central insulin resistance and associated cognitive deficits.
Diabetes Mellitus
Serum acid phosphatase activity in diabetes mellitus.
Diabetes Mellitus
Sesquiterpenoids with PTP1B Inhibitory Activity and Cytotoxicity from the Edible Mushroom Pleurotus citrinopileatus.
Diabetes Mellitus
Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population.
Diabetes Mellitus
Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.
Diabetes Mellitus
Synthesis and Biological Evaluation of Analogues of Butyrolactone I as PTP1B Inhibitors.
Diabetes Mellitus
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Diabetes Mellitus
T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus.
Diabetes Mellitus
The -1123G>C Variant of PTPN22 Gene Promoter is Associated with Latent Autoimmune Diabetes in Adult Chinese Hans.
Diabetes Mellitus
The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.
Diabetes Mellitus
The genetic basis of graves' disease.
Diabetes Mellitus
The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.
Diabetes Mellitus
The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population.
Diabetes Mellitus
The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity.
Diabetes Mellitus
The Role of PTPN22 C1858T Gene Polymorphism in Diabetes Mellitus Type 1: First Evaluation in Greek Children and Adolescents.
Diabetes Mellitus
The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil.
Diabetes Mellitus
Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth.
Diabetes Mellitus
Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype.
Diabetes Mellitus
Validation Of Formylchromane Derivatives As Ptp 1b Inhibitors By Pharmacophore Modeling, Atom Based 3d-Qsar And Docking Studies.
Diabetes Mellitus
Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research.
Diabetes Mellitus
[Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]
Diabetes Mellitus
[Association of the C1858T polymorphism of the PTPN22 gene with type 1 diabetes]
Diabetes Mellitus
[Content of different cytokines in the blood of healthy children and their siblings who are either.positive or negative for diabetes-associated autoantibodies (GADA, 1A-2A, IAA)]
Diabetes Mellitus
[Effects of rare islet autoantibodies on islet function in patients with latent autoimmune diabetes in adults].
Diabetes Mellitus
[PTP1B inhibitory activities of bromophenol derivatives from algae]
Diabetes Mellitus
[STUDY OF THE PTPN22 GENE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN THE AZERBAIJANI POPULATION].
Diabetes Mellitus, Experimental
Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats.
Diabetes Mellitus, Type 1
A comparison of serum and EDTA plasma in the measurement of glutamic acid decarboxylase autoantibodies (GADA) and autoantibodies to islet antigen-2 (IA-2A) using the RSR radioimmunoassay (RIA) and enzyme linked immunosorbent assay (ELISA) kits.
Diabetes Mellitus, Type 1
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Diabetes Mellitus, Type 1
A functional polymorphism of Ptpn22 is associated with type 1 diabetes in the BioBreeding rat.
Diabetes Mellitus, Type 1
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
Diabetes Mellitus, Type 1
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Diabetes Mellitus, Type 1
A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes.
Diabetes Mellitus, Type 1
A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) is associated with Type 1 diabetes in a Chinese population.
Diabetes Mellitus, Type 1
A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes.
Diabetes Mellitus, Type 1
A radioligand-binding assay for detecting antibodies specific for proinsulin and insulin using 35S-proinsulin.
Diabetes Mellitus, Type 1
A Simple Screening Method for Individuals at Risk of Developing Type 1 Diabetes: Measurement of Islet Cell Autoantibodies (GADA, IA-2A, and IAA) on Dried Capillary Blood Spots Collected on Filter Paper.
Diabetes Mellitus, Type 1
A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.
Diabetes Mellitus, Type 1
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.
Diabetes Mellitus, Type 1
A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.
Diabetes Mellitus, Type 1
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Diabetes Mellitus, Type 1
A variable degree of autoimmunity in the pedigree of a patient with type 1 diabetes homozygous for the PTPN22 1858T variant.
Diabetes Mellitus, Type 1
Absence of avidity maturation of autoantibodies to the protein tyrosine phosphatase-like IA-2 molecule and glutamic acid decarboxylase (GAD65) during progression to type 1 diabetes.
Diabetes Mellitus, Type 1
Age-specific levels of diabetes-related GAD and IA-2 antibodies in healthy children and adults.
Diabetes Mellitus, Type 1
Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis.
Diabetes Mellitus, Type 1
An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms.
Diabetes Mellitus, Type 1
An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.
Diabetes Mellitus, Type 1
An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.
Diabetes Mellitus, Type 1
Analysis of candidate susceptibility genes in canine diabetes.
Diabetes Mellitus, Type 1
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
Diabetes Mellitus, Type 1
Analysis of PTPN22 C1858T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran.
Diabetes Mellitus, Type 1
Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.
Diabetes Mellitus, Type 1
Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.
Diabetes Mellitus, Type 1
Antibodies to the tyrosine phosphatase-like protein IA-2 are highly associated with IDDM, but not with autoimmune endocrine diseases or stiff man syndrome.
Diabetes Mellitus, Type 1
Are zinc transporter type 8 antibodies a marker of autoimmune thyroiditis in non-obese adults with new-onset diabetes?
Diabetes Mellitus, Type 1
Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach.
Diabetes Mellitus, Type 1
Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F.
Diabetes Mellitus, Type 1
Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.
Diabetes Mellitus, Type 1
Association between IA-2 autoantibody epitope specificities and age of onset in Japanese patients with autoimmune diabetes.
Diabetes Mellitus, Type 1
Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.
Diabetes Mellitus, Type 1
Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population.
Diabetes Mellitus, Type 1
Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis.
Diabetes Mellitus, Type 1
Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.
Diabetes Mellitus, Type 1
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
Diabetes Mellitus, Type 1
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.
Diabetes Mellitus, Type 1
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians.
Diabetes Mellitus, Type 1
Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis.
Diabetes Mellitus, Type 1
Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents.
Diabetes Mellitus, Type 1
Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population.
Diabetes Mellitus, Type 1
Association of PTPN22+1858C/T polymorphism with Type 1 diabetes in the North Indian population.
Diabetes Mellitus, Type 1
Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study.
Diabetes Mellitus, Type 1
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Diabetes Mellitus, Type 1
Association of the PTPN22 gene (+1858C/T, -1123G/C) polymorphisms with type 1 diabetes mellitus: A systematic review and meta-analysis.
Diabetes Mellitus, Type 1
Association of the PTPN22/LYP gene with type 1 diabetes.
Diabetes Mellitus, Type 1
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.
Diabetes Mellitus, Type 1
Association of TNF-?, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil.
Diabetes Mellitus, Type 1
Association of variants in PTPN22, CTLA-4, IL2-RA, and INS genes with type 1 diabetes in Emiratis.
Diabetes Mellitus, Type 1
Association Studies of the GPR103 and BCL2L15 Genes in Autoimmune Thyroid Disease in the Japanese Population.
Diabetes Mellitus, Type 1
Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes.
Diabetes Mellitus, Type 1
Autoantibodies and HLA susceptibility markers in Canadian first-degree relatives of patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies.
Diabetes Mellitus, Type 1
Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2.
Diabetes Mellitus, Type 1
Autoantibodies to multiple islet autoantigens in patients with abrupt onset type 1 diabetes and diabetes diagnosed with urinary glucose screening.
Diabetes Mellitus, Type 1
Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy.
Diabetes Mellitus, Type 1
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.
Diabetes Mellitus, Type 1
Autoantibodies to tissue transglutaminase in patients from eastern India with malnutrition-modulated diabetes mellitus, insulin-dependent diabetes mellitus, and non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Autoimmune diagnostics in diabetes mellitus.
Diabetes Mellitus, Type 1
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Diabetes Mellitus, Type 1
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.
Diabetes Mellitus, Type 1
Autonomic function and autoantibodies to autonomic nervous structures, glutamic acid decarboxylase and islet tyrosine phosphatase in adolescent patients with IDDM.
Diabetes Mellitus, Type 1
Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility.
Diabetes Mellitus, Type 1
BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic ?-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.
Diabetes Mellitus, Type 1
Biochemical markers of type 1 diabetes: clinical use.
Diabetes Mellitus, Type 1
BLOCK-BASED BAYESIAN EPISTASIS ASSOCIATION MAPPING WITH APPLICATION TO WTCCC TYPE 1 DIABETES DATA.
Diabetes Mellitus, Type 1
Boswellic extracts and 11-keto-ß-boswellic acids prevent type 1 and type 2 diabetes mellitus by suppressing the expression of proinflammatory cytokines.
Diabetes Mellitus, Type 1
CD11a expression and soluble ICAM-1 levels in peripheral blood in high-risk and overt type 1 diabetes subjects.
Diabetes Mellitus, Type 1
Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.
Diabetes Mellitus, Type 1
Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
Diabetes Mellitus, Type 1
Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH.
Diabetes Mellitus, Type 1
Coincidence of PTPN22 c.1858CC and FCRL3 -169CC genotypes as a biomarker of preserved residual ?-cell function in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Combined measurement of diabetes mellitus immunological markers: an assessment of its benefits in adult-onset patients.
Diabetes Mellitus, Type 1
Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM. The DENIS Study Group. Deutsche Nikotinamid Interventions-Studie.
Diabetes Mellitus, Type 1
Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera.
Diabetes Mellitus, Type 1
Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study.
Diabetes Mellitus, Type 1
Conjugation of Antisense Oligonucleotides to PEGylated Carbon Nanotubes Enables Efficient Knockdown of PTPN22 in T Lymphocytes.
Diabetes Mellitus, Type 1
Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens.
Diabetes Mellitus, Type 1
Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians.
Diabetes Mellitus, Type 1
Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skåne study.
Diabetes Mellitus, Type 1
Course of islet autoantibody titers during Ig-immunoadsorption in a patient with newly diagnosed type 1 diabetes.
Diabetes Mellitus, Type 1
COVID-19 infection as a trigger for new-onset type 1 diabetes in a susceptible individual - or just coincidence?
Diabetes Mellitus, Type 1
CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes.
Diabetes Mellitus, Type 1
Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM.
Diabetes Mellitus, Type 1
CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.
Diabetes Mellitus, Type 1
Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKC?/p66Shc axis and activation of FOXO-3a.
Diabetes Mellitus, Type 1
Daily vegetable intake during pregnancy negatively associated to islet autoimmunity in the offspring-The ABIS study.
Diabetes Mellitus, Type 1
Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Deletion of the secretory vesicle proteins IA-2 and IA-2{beta} disrupts circadian rhythms of cardiovascular and physical activity.
Diabetes Mellitus, Type 1
Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.
Diabetes Mellitus, Type 1
Detection of autoantibodies to the diabetes-associated antigen IA-2 by a sensitive enzyme-linked immunosorbent assay.
Diabetes Mellitus, Type 1
Developmental expression and localization of IA-2 mRNA in mouse neuroendocrine tissues.
Diabetes Mellitus, Type 1
Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.
Diabetes Mellitus, Type 1
Differences in prevalence of antibodies to GAD and IA-2 and their titers at diagnosis in children with slowly and rapidly progressive forms of type 1 diabetes.
Diabetes Mellitus, Type 1
Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.
Diabetes Mellitus, Type 1
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Diabetes Mellitus, Type 1
Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies.
Diabetes Mellitus, Type 1
Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes.
Diabetes Mellitus, Type 1
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.
Diabetes Mellitus, Type 1
Distinct genetic and immunological features in patients with onset of IDDM before and after age 40.
Diabetes Mellitus, Type 1
Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.
Diabetes Mellitus, Type 1
Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
Diabetes Mellitus, Type 1
Does the relative risk for type 1 diabetes conferred by HLA-DQ, INS, and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section?
Diabetes Mellitus, Type 1
Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children.
Diabetes Mellitus, Type 1
Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes.
Diabetes Mellitus, Type 1
Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of ?-cell Autoimmunity.
Diabetes Mellitus, Type 1
Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes.
Diabetes Mellitus, Type 1
Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plants.
Diabetes Mellitus, Type 1
Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis.
Diabetes Mellitus, Type 1
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Diabetes Mellitus, Type 1
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
Diabetes Mellitus, Type 1
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Diabetes Mellitus, Type 1
Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct.
Diabetes Mellitus, Type 1
Exploiting novel tailored immunotherapies of type 1 diabetes: Short interfering RNA delivered by cationic liposomes enables efficient down-regulation of variant PTPN22 gene in T lymphocytes.
Diabetes Mellitus, Type 1
Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases.
Diabetes Mellitus, Type 1
Expression, characterization, processing and immunogenicity of an insulin-dependent diabetes mellitus autoantigen, IA-2, in Sf-9 cells.
Diabetes Mellitus, Type 1
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Diabetes Mellitus, Type 1
Fine mapping of diabetes-associated IA-2 specific autoantibodies.
Diabetes Mellitus, Type 1
Frequency of islet cell autoantibodies (IA-2 and GAD) in young Brazilian type 1 diabetes patients.
Diabetes Mellitus, Type 1
Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.
Diabetes Mellitus, Type 1
GADA Titer-Related Risk for Organ-Specific Autoimmunity in LADA Subjects Subdivided according to Gender (NIRAD Study 6).
Diabetes Mellitus, Type 1
GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives.
Diabetes Mellitus, Type 1
Gammadelta T-cells alterations in the peripheral blood of high risk diabetes type 1 subjects with subclinical pancreatic B-cells impairment.
Diabetes Mellitus, Type 1
Genetic Analysis of Adult-Onset Autoimmune Diabetes.
Diabetes Mellitus, Type 1
Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.
Diabetes Mellitus, Type 1
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Diabetes Mellitus, Type 1
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West.
Diabetes Mellitus, Type 1
Genetic developments in autoimmune thyroid disease: an evolutionary process.
Diabetes Mellitus, Type 1
Genetic differences between type 1 diabetes with and without other autoimmune diseases.
Diabetes Mellitus, Type 1
Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
Diabetes Mellitus, Type 1
Genetic susceptibility to type 1 diabetes.
Diabetes Mellitus, Type 1
Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 1
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.
Diabetes Mellitus, Type 1
Genetics of type 1 diabetes in Asian and Caucasian populations.
Diabetes Mellitus, Type 1
Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
Diabetes Mellitus, Type 1
Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN).
Diabetes Mellitus, Type 1
Genotypes of cytosolic low-molecular-weight protein-tyrosine-phosphatase correlate with age at onset of type 1 diabetes in a sex-specific manner.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase and ICA512/IA-2 autoantibodies as disease markers and relationship to residual beta-cell function and glycemic control in young type 1 diabetic patients.
Diabetes Mellitus, Type 1
Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds.
Diabetes Mellitus, Type 1
High frequency of diabetes-specific autoantibodies in parents of children with type 1 diabetes. DENIS study group.
Diabetes Mellitus, Type 1
High T cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes.
Diabetes Mellitus, Type 1
HLA-DR, HLA-DQB1 and PTPN22 gene polymorphism: association with age at onset for autoimmune diabetes.
Diabetes Mellitus, Type 1
Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.
Diabetes Mellitus, Type 1
Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.
Diabetes Mellitus, Type 1
IA-2 and IA-2beta: the immune response in IDDM.
Diabetes Mellitus, Type 1
IA-2 antibodies--a sensitive marker of IDDM with clinical onset in childhood and adolescence. Childhood Diabetes in Finland Study Group.
Diabetes Mellitus, Type 1
IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes.
Diabetes Mellitus, Type 1
IA-2 autoantibodies restricted to the IgG4 subclass are associated with protection from type 1 diabetes.
Diabetes Mellitus, Type 1
IA-2 combined epitope assay: a new, highly sensitive approach to evaluate IA-2 humoral autoimmunity in type 1 diabetes.
Diabetes Mellitus, Type 1
IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
IA-2A positivity rate at manifestation of type 1 diabetes mellitus in Slovak children culminates in September.
Diabetes Mellitus, Type 1
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
Diabetes Mellitus, Type 1
Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.
Diabetes Mellitus, Type 1
Identification and functional analysis of mutations in the hepatocyte nuclear factor-1alpha gene in anti-islet autoantibody-negative Japanese patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Diabetes Mellitus, Type 1
Identification of monogenic gene mutations in Japanese subjects diagnosed with type 1B diabetes between >5 and 15.1 years of age.
Diabetes Mellitus, Type 1
Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.
Diabetes Mellitus, Type 1
Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2.
Diabetes Mellitus, Type 1
In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation.
Diabetes Mellitus, Type 1
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms.
Diabetes Mellitus, Type 1
Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease.
Diabetes Mellitus, Type 1
Influence of sex and age at onset on autoantibodies against insulin, GAD65 and IA2 in recent onset type 1 diabetic patients.
Diabetes Mellitus, Type 1
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Diabetes Mellitus, Type 1
Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese.
Diabetes Mellitus, Type 1
Insulin gene profile cycles with season of birth of future diabetic children and their relatives.
Diabetes Mellitus, Type 1
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.
Diabetes Mellitus, Type 1
Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.
Diabetes Mellitus, Type 1
Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young (DAISY).
Diabetes Mellitus, Type 1
Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?
Diabetes Mellitus, Type 1
Islet cell related antibodies and type 1 diabetes associated with echovirus 30 epidemic: a case report.
Diabetes Mellitus, Type 1
Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.
Diabetes Mellitus, Type 1
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Diabetes Mellitus, Type 1
Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.
Diabetes Mellitus, Type 1
Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
Diabetes Mellitus, Type 1
Low Frequencies of Autoimmunity-Associated PTPN22 Polymorphisms in MODY Patients, Including Those Transiently Expressing Islet Cell Autoantibodies.
Diabetes Mellitus, Type 1
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
Diabetes Mellitus, Type 1
Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.
Diabetes Mellitus, Type 1
Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2.
Diabetes Mellitus, Type 1
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic {beta}-cell responses to the viral by-product double stranded RNA.
Diabetes Mellitus, Type 1
Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories.
Diabetes Mellitus, Type 1
Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes.
Diabetes Mellitus, Type 1
Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.
Diabetes Mellitus, Type 1
Molecular mechanisms of autoimmunity.
Diabetes Mellitus, Type 1
Monoclonal antibody 76F distinguishes IA-2 from IA-2beta and overlaps an autoantibody epitope.
Diabetes Mellitus, Type 1
Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity.
Diabetes Mellitus, Type 1
Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.
Diabetes Mellitus, Type 1
No evidence for association of PTPN22 R620W functional variant C1858T with type 1 diabetes in Asian Indians.
Diabetes Mellitus, Type 1
No evidence of autoimmunity in 6-year-old children immunized at birth with recombinant hepatitis B vaccine.
Diabetes Mellitus, Type 1
No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.
Diabetes Mellitus, Type 1
Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.
Diabetes Mellitus, Type 1
Novel homozygous AIRE mutation in a German patient with severe APECED.
Diabetes Mellitus, Type 1
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.
Diabetes Mellitus, Type 1
Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation.
Diabetes Mellitus, Type 1
Pancreatic autoantibodies, HLA DR and PTPN22 polymorphisms in first degree relatives of patients with type 1 diabetes and multiethnic background.
Diabetes Mellitus, Type 1
Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.
Diabetes Mellitus, Type 1
Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder.
Diabetes Mellitus, Type 1
Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood.
Diabetes Mellitus, Type 1
Polymorphism rs2476601 in the PTPN22 gene is associated with type 1 diabetes in children from the South Region of Brazil.
Diabetes Mellitus, Type 1
Population-based and family-based studies on the protein tyrosine phosphatase non-receptor 22 gene polymorphism and type 1 diabetes: a meta-analysis.
Diabetes Mellitus, Type 1
Predicting progression to diabetes in islet autoantibody positive children.
Diabetes Mellitus, Type 1
Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers.
Diabetes Mellitus, Type 1
Prediction of type 1 diabetes among siblings of affected children and in the general population.
Diabetes Mellitus, Type 1
Prediction of type 1 diabetes postpartum in patients with gestational diabetes mellitus by combined islet cell autoantibody screening: a prospective multicenter study.
Diabetes Mellitus, Type 1
Predictive value of human leukocyte antigen class II typing for the development of islet autoantibodies and insulin-dependent diabetes postpartum in women with gestational diabetes.
Diabetes Mellitus, Type 1
Preserved Proinsulin Production in Homozygous PTPN 22 C1858T Variant Type 1 Diabetes: A Possible Explanation for Absence of Overt Ketoacidosis Despite Omission of Exogenous Insulin.
Diabetes Mellitus, Type 1
Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
Diabetes Mellitus, Type 1
Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.
Diabetes Mellitus, Type 1
Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetes.
Diabetes Mellitus, Type 1
Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.
Diabetes Mellitus, Type 1
PTPN2 gene polymorphisms are associated with type 1 diabetes mellitus in Brazilian subjects?
Diabetes Mellitus, Type 1
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Diabetes Mellitus, Type 1
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
Diabetes Mellitus, Type 1
PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic ?-cell apoptosis via regulation of the BH3-only protein Bim.
Diabetes Mellitus, Type 1
PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.
Diabetes Mellitus, Type 1
PTPN22 1858T Allele is Associated with Younger Age at Onset of Type 1 Diabetes and Unrelated to Subsequent Thyroid Autoimmunity.
Diabetes Mellitus, Type 1
Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.
Diabetes Mellitus, Type 1
PTPN22 and CTLA-4 Polymorphisms are Associated with Polyglandular Autoimmunity.
Diabetes Mellitus, Type 1
PTPN22 and islet-specific autoimmunity: What have the mouse models taught us?
Diabetes Mellitus, Type 1
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Diabetes Mellitus, Type 1
PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Diabetes Mellitus, Type 1
PTPN22 Gene Polymorphism (C1858T) Is Associated with Susceptibility to Type 1 Diabetes: A Meta-Analysis of 19,495 Cases and 25,341 Controls.
Diabetes Mellitus, Type 1
Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation.
Diabetes Mellitus, Type 1
PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.
Diabetes Mellitus, Type 1
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Diabetes Mellitus, Type 1
PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant.
Diabetes Mellitus, Type 1
PTPN22 Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 1
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Diabetes Mellitus, Type 1
PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients.
Diabetes Mellitus, Type 1
PTPN22: its role in SLE and autoimmunity.
Diabetes Mellitus, Type 1
Regulation of autoimmune and anti-tumour T cell responses by PTPN22.
Diabetes Mellitus, Type 1
Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.
Diabetes Mellitus, Type 1
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Diabetes Mellitus, Type 1
Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes.
Diabetes Mellitus, Type 1
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Diabetes Mellitus, Type 1
Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis.
Diabetes Mellitus, Type 1
Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype.
Diabetes Mellitus, Type 1
Role of C1858T polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian children and adolescents with type 1 diabetes.
Diabetes Mellitus, Type 1
Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
Diabetes Mellitus, Type 1
Role of the C1858T polymorphism of protein tyrosine phosphatase non-receptor type 22 (PTPN22) in children and adolescents with type 1 diabetes.
Diabetes Mellitus, Type 1
Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.
Diabetes Mellitus, Type 1
Screening for preclinical type 1 diabetes in a discrete population with an apparent increased disease incidence.
Diabetes Mellitus, Type 1
Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population.
Diabetes Mellitus, Type 1
Sex-specific association of the human PTPN22 1858T-allele with type 1 diabetes.
Diabetes Mellitus, Type 1
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Diabetes Mellitus, Type 1
Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody.
Diabetes Mellitus, Type 1
Single-cell profiling reveals dendritic cell signatures associated with autoimmune inflammation.
Diabetes Mellitus, Type 1
Soluble adhesion molecules in Finnish schoolchildren with signs of preclinical type 1 diabetes.
Diabetes Mellitus, Type 1
Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice.
Diabetes Mellitus, Type 1
Stability of proICA512/IA-2 and Its Targeting to Insulin Secretory Granules Require ?4-Sheet-Mediated Dimerization of Its Ectodomain in the Endoplasmic Reticulum.
Diabetes Mellitus, Type 1
Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Susceptibility influence of a PTPN22 haplotype with thyroid autoimmunity in Koreans.
Diabetes Mellitus, Type 1
Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.
Diabetes Mellitus, Type 1
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): Association between a promoter polymorphism and type 1 diabetes in Asian populations.
Diabetes Mellitus, Type 1
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): Association between a promoter polymorphism and type 1 diabetes in Asian populations. American Journal of Medical Genetics 140A:586-593 (2006).
Diabetes Mellitus, Type 1
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Diabetes Mellitus, Type 1
T cell reactivity to DR*0401- and DQ*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetes.
Diabetes Mellitus, Type 1
T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse.
Diabetes Mellitus, Type 1
T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents.
Diabetes Mellitus, Type 1
T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.
Diabetes Mellitus, Type 1
Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes.
Diabetes Mellitus, Type 1
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.
Diabetes Mellitus, Type 1
Temporal trends of HLA, CTLA-4 and PTPN22 genotype frequencies among type 1 diabetes in Continental Italy.
Diabetes Mellitus, Type 1
Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population.
Diabetes Mellitus, Type 1
The -1123G>C Variant of PTPN22 Gene Promoter is Associated with Latent Autoimmune Diabetes in Adult Chinese Hans.
Diabetes Mellitus, Type 1
The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.
Diabetes Mellitus, Type 1
The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2.
Diabetes Mellitus, Type 1
The association between rs1893217, rs478582 in PTPN2 and T1D risk with different diagnosed age, and related clinical characteristics in Chinese Han population.
Diabetes Mellitus, Type 1
The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.
Diabetes Mellitus, Type 1
The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis.
Diabetes Mellitus, Type 1
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females.
Diabetes Mellitus, Type 1
The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2?, Are Crucial to Autoantibody Binding in Type 1 Diabetes.
Diabetes Mellitus, Type 1
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Diabetes Mellitus, Type 1
The genetic basis of graves' disease.
Diabetes Mellitus, Type 1
The IA-2 interactome.
Diabetes Mellitus, Type 1
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.
Diabetes Mellitus, Type 1
The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing.
Diabetes Mellitus, Type 1
The Potential Role of PTPN-22 C1858T Gene Polymorphism in the Pathogenesis of Type 1 Diabetes in Saudi Population.
Diabetes Mellitus, Type 1
The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.
Diabetes Mellitus, Type 1
The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3.
Diabetes Mellitus, Type 1
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Diabetes Mellitus, Type 1
The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort.
Diabetes Mellitus, Type 1
The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.
Diabetes Mellitus, Type 1
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
Diabetes Mellitus, Type 1
The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.
Diabetes Mellitus, Type 1
The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.
Diabetes Mellitus, Type 1
The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.
Diabetes Mellitus, Type 1
The relationship between humoral and cellular immunity to IA-2 in IDDM.
Diabetes Mellitus, Type 1
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Diabetes Mellitus, Type 1
The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
Diabetes Mellitus, Type 1
The Role of Heat Shock Proteins in Type 1 Diabetes.
Diabetes Mellitus, Type 1
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.
Diabetes Mellitus, Type 1
The rs1893217 (T/C) polymorphism in PTPN2 gene is not associated with type 1 diabetes mellitus in subjects from Southern Brazil.
Diabetes Mellitus, Type 1
Thyroid autoimmunity in 72 children with type 1 diabetes mellitus: relationship with pancreatic autoimmunity and child growth.
Diabetes Mellitus, Type 1
Time-resolved fluorescence imaging in islet cell autoantibody quantitation.
Diabetes Mellitus, Type 1
Time-resolved immunofluorometric dual-label assay for simultaneous detection of autoantibodies to GAD65 and IA-2 in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes.
Diabetes Mellitus, Type 1
Tumor necrosis factor-alpha: a continuum of liability between insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus and carcinoma (review).
Diabetes Mellitus, Type 1
Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens.
Diabetes Mellitus, Type 1
Two-step islet autoantibody screening for risk assessment of type 1 diabetes in relatives.
Diabetes Mellitus, Type 1
Type 1 diabetes in the BB rat: a polygenic disease.
Diabetes Mellitus, Type 1
Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells.
Diabetes Mellitus, Type 1
Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype.
Diabetes Mellitus, Type 1
Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes.
Diabetes Mellitus, Type 1
Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
Diabetes Mellitus, Type 1
Vaccinations may induce diabetes-related autoantibodies in one-year-old children.
Diabetes Mellitus, Type 1
Women diagnosed with gestational diabetes mellitus do not carry antibodies against minor islet cell antigens.
Diabetes Mellitus, Type 1
Young age and HLA markers enhance the risk of progression to type 1 diabetes in antibody-positive siblings of diabetic children.
Diabetes Mellitus, Type 1
[Association of the C1858T polymorphism of the PTPN22 gene with type 1 diabetes]
Diabetes Mellitus, Type 1
[Content of different cytokines in the blood of healthy children and their siblings who are either.positive or negative for diabetes-associated autoantibodies (GADA, 1A-2A, IAA)]
Diabetes Mellitus, Type 1
[IA-2 and anti-GAD antibodies in patients with newly diagnosed type 1 diabetes and their first degree relatives]
Diabetes Mellitus, Type 1
[Molecular genetics of autoimmune diabetes.]
Diabetes Mellitus, Type 1
[Plasma levels of interleukin-1beta, interleukin-2 and interleukin-4 in recently diagnosed type 1 diabetic children and their association with beta-pancreatic autoantibodies]
Diabetes Mellitus, Type 1
[Relevance of the gene variant PTPN22 620W for rheumatology]
Diabetes Mellitus, Type 1
[Research progress of several protein tyrosine phosphatases in diabetes.]
Diabetes Mellitus, Type 1
[STUDY OF THE PTPN22 GENE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN THE AZERBAIJANI POPULATION].
Diabetes Mellitus, Type 2
1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population.
Diabetes Mellitus, Type 2
25-Hydroxyvitamin D
Diabetes Mellitus, Type 2
3D-QSAR Studies on a Series of 2,4-Thiazolidinedione Derivatives: A Self-Organizing Molecular Field Analysis Approach to Design Novel PTP 1B Inhibitors.
Diabetes Mellitus, Type 2
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Diabetes Mellitus, Type 2
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Diabetes Mellitus, Type 2
A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway.
Diabetes Mellitus, Type 2
A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro.
Diabetes Mellitus, Type 2
A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin.
Diabetes Mellitus, Type 2
A protein tyrosine phosphatase 1B activity inhibitor from the fruiting bodies of Ganoderma lucidum (Fr.) Karst and its hypoglycemic potency on streptozotocin-induced type 2 diabetic mice.
Diabetes Mellitus, Type 2
A simple and visible colorimetric method through Zr(4+)-phosphate coordination for the assay of protein tyrosine phosphatase 1B and screening of its inhibitors.
Diabetes Mellitus, Type 2
Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans.
Diabetes Mellitus, Type 2
Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes.
Diabetes Mellitus, Type 2
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.
Diabetes Mellitus, Type 2
Altered basal and insulin-stimulated phosphotyrosine phosphatase (PTPase) activity in skeletal muscle from NIDDM patients compared with control subjects.
Diabetes Mellitus, Type 2
Altered PTPRD DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
Diabetes Mellitus, Type 2
Amelioration of insulin resistance in diabetic ob/ob mice by a new type of orally active insulin-mimetic vanadyl complex: bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S(2)O(2)) coordination mode.
Diabetes Mellitus, Type 2
An Integrated Computational Approach for Plant-Based Protein Tyrosine Phosphatase Non-Receptor Type 1 Inhibitors.
Diabetes Mellitus, Type 2
An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications.
Diabetes Mellitus, Type 2
An RNA aptamer that selectively inhibits the enzymatic activity of protein tyrosine phosphatase 1B in vitro.
Diabetes Mellitus, Type 2
Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.
Diabetes Mellitus, Type 2
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides.
Diabetes Mellitus, Type 2
Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don.
Diabetes Mellitus, Type 2
Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice.
Diabetes Mellitus, Type 2
Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action?
Diabetes Mellitus, Type 2
Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.
Diabetes Mellitus, Type 2
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Diabetes Mellitus, Type 2
Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis.
Diabetes Mellitus, Type 2
Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes.
Diabetes Mellitus, Type 2
Association of the PTPN1 gene with type 2 diabetes and insulin resistance.
Diabetes Mellitus, Type 2
Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.
Diabetes Mellitus, Type 2
Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.
Diabetes Mellitus, Type 2
Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients.
Diabetes Mellitus, Type 2
Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study.
Diabetes Mellitus, Type 2
Cellular effects of small molecule PTP1B inhibitors on insulin signaling.
Diabetes Mellitus, Type 2
Characteristics of Food Protein-Derived Antidiabetic Bioactive Peptides: A Literature Update.
Diabetes Mellitus, Type 2
Characteristics of the interaction mechanisms of procyanidin B1 and procyanidin B2 with protein tyrosine phosphatase-1B: Analysis by kinetics, spectroscopy methods and molecular docking.
Diabetes Mellitus, Type 2
Classification of inhibitors of protein tyrosine phosphatase 1B using molecular structure based descriptors.
Diabetes Mellitus, Type 2
Combined Neural Inactivation of SOCS-3 and PTP-1B Reveal Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance.
Diabetes Mellitus, Type 2
CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors.
Diabetes Mellitus, Type 2
Computational Insight into Protein Tyrosine Phosphatase 1B Inhibition: A Case Study of the Combined Ligand- and Structure-Based Approach.
Diabetes Mellitus, Type 2
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
Diabetes Mellitus, Type 2
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
Diabetes Mellitus, Type 2
Curcumin and Cinnamaldehyde as PTP1B Inhibitors With Antidiabetic and Anticancer Potential.
Diabetes Mellitus, Type 2
Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Design and Synthesis of Imidazolidine-2,4-Dione Derivatives as Selective Inhibitors by Targeting Protein Tyrosine Phosphatase-1B Over T-Cell Protein Tyrosine Phosphatase.
Diabetes Mellitus, Type 2
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.
Diabetes Mellitus, Type 2
Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes.
Diabetes Mellitus, Type 2
Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Diabetes Mellitus, Type 2
Development of an automated protein-tyrosine phosphatase 1B inhibition assay and the screening of putative insulin-enhancing vanadium(IV) and zinc(II) complexes.
Diabetes Mellitus, Type 2
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Diabetes Mellitus, Type 2
Discovery of 2-ethoxy-4-(methoxymethyl)benzamide derivatives as potent and selective PTP1B inhibitors.
Diabetes Mellitus, Type 2
Discovery of 5-(3-bromo-2-(2,3-dibromo-4,5-dimethoxybenzyl)-4,5-dimethoxybenzylidene)thiazolidine-2,4-dione as a novel potent protein tyrosine phosphatase 1B inhibitor with antidiabetic properties.
Diabetes Mellitus, Type 2
Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent.
Diabetes Mellitus, Type 2
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site.
Diabetes Mellitus, Type 2
Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase.
Diabetes Mellitus, Type 2
Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.
Diabetes Mellitus, Type 2
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.
Diabetes Mellitus, Type 2
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.
Diabetes Mellitus, Type 2
Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.
Diabetes Mellitus, Type 2
Dual targeting of PTP1B and glucosidases with new bifunctional iminosugar inhibitors to address type 2 diabetes.
Diabetes Mellitus, Type 2
Effect of insulin on protein phosphatase 2A expression in muscle in type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo.
Diabetes Mellitus, Type 2
Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes.
Diabetes Mellitus, Type 2
Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.
Diabetes Mellitus, Type 2
Establishment of a cell-based drug screening model for identifying down-regulators of Protein Tyrosine Phosphatase 1B expression.
Diabetes Mellitus, Type 2
Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents.
Diabetes Mellitus, Type 2
Ficus deltoidea extract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism.
Diabetes Mellitus, Type 2
Flavonoids as potent allosteric inhibitors of protein tyrosine phosphatase 1B: molecular dynamics simulation and free energy calculation.
Diabetes Mellitus, Type 2
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Diabetes Mellitus, Type 2
Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus.
Diabetes Mellitus, Type 2
Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound.
Diabetes Mellitus, Type 2
Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.
Diabetes Mellitus, Type 2
GADA Titer-Related Risk for Organ-Specific Autoimmunity in LADA Subjects Subdivided according to Gender (NIRAD Study 6).
Diabetes Mellitus, Type 2
Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
Diabetes Mellitus, Type 2
Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.
Diabetes Mellitus, Type 2
Genetic variants in PTPRD and risk of gestational diabetes mellitus.
Diabetes Mellitus, Type 2
Genetic variation in receptor protein tyrosine phosphatase {sigma} is associated with type 2 diabetes in Swedish Caucasians.
Diabetes Mellitus, Type 2
Genistein-derivatives from Tetracera scandens stimulate glucose-uptake in L6 myotubes.
Diabetes Mellitus, Type 2
Haplo-Insufficiency of the Insulin Receptor in the presence of a splice-site mutation in Ppp2r2a results in a novel di-genic mouse model of type 2 diabetes.
Diabetes Mellitus, Type 2
High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans.
Diabetes Mellitus, Type 2
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Diabetes Mellitus, Type 2
Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes.
Diabetes Mellitus, Type 2
Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling.
Diabetes Mellitus, Type 2
IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71).
Diabetes Mellitus, Type 2
Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).
Diabetes Mellitus, Type 2
Identification of Autoantibody Negative Autoimmune Type 2 Diabetes Patients.
Diabetes Mellitus, Type 2
Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor.
Diabetes Mellitus, Type 2
Identification of lipid-like salicylic acid-based derivatives as potent and membrane-permeable PTP1B inhibitors.
Diabetes Mellitus, Type 2
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.
Diabetes Mellitus, Type 2
Improved glucose-stimulated insulin secretion by intra-islet inhibition of protein-tyrosine phosphatase 1B expression in rats fed a high-fat diet.
Diabetes Mellitus, Type 2
In silico investigations on the binding efficacy and allosteric mechanism of six different natural product compounds towards PTP1B inhibition through docking and molecular dynamics simulations.
Diabetes Mellitus, Type 2
In silico modeling of protein tyrosine phosphatase 1B inhibitors with cellular activity.
Diabetes Mellitus, Type 2
In silico modelling and molecular dynamics simulation studies of thiazolidine based PTP1B inhibitors.
Diabetes Mellitus, Type 2
In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
Diabetes Mellitus, Type 2
In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes.
Diabetes Mellitus, Type 2
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Diabetes Mellitus, Type 2
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum.
Diabetes Mellitus, Type 2
Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.
Diabetes Mellitus, Type 2
Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans.
Diabetes Mellitus, Type 2
Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta.
Diabetes Mellitus, Type 2
Inhibition of Protein Tyrosine Phosphatase 1B by Prenylated Isoflavonoids Isolated from the Stem Bark of Erythrina addisoniae1.
Diabetes Mellitus, Type 2
Inhibition of Protein Tyrosine Phosphatase 1B by Ursane-Type Triterpenes Isolated from Symplocos paniculata.
Diabetes Mellitus, Type 2
Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.
Diabetes Mellitus, Type 2
Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.
Diabetes Mellitus, Type 2
Inhibitors of protein tyrosine phosphatase 1B (PTP1B).
Diabetes Mellitus, Type 2
Inhibitory Effects of Secondary Metabolites from the Lichen Stereocaulon evolutum on Protein Tyrosine Phosphatase 1B.
Diabetes Mellitus, Type 2
Insight into the PTP1B Inhibitory Activity of Arylbenzofurans: An In Vitro and In Silico Study.
Diabetes Mellitus, Type 2
Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.
Diabetes Mellitus, Type 2
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors.
Diabetes Mellitus, Type 2
Islet autoantibodies in Latvian subjects with non-insulin-dependent diabetes mellitus: slow-onset type 1 diabetes or polyendocrine autoimmunity?
Diabetes Mellitus, Type 2
Islet cell antibodies and glutamic acid decarboxylase antibodies, but not the clinical phenotype, help to identify type 1(1/2) diabetes in patients presenting with type 2 diabetes.
Diabetes Mellitus, Type 2
Kinetics and molecular docking studies of pimarane-type diterpenes as protein tyrosine phosphatase (PTP1B) inhibitors from Aralia continentalis roots.
Diabetes Mellitus, Type 2
Lack of association between polymorphisms in the gene encoding protein tyrosine phosphatase 1B (PTPN1) and risk of Type 2 diabetes.
Diabetes Mellitus, Type 2
Lack of association of PTPN1 gene polymorphisms with type 2 diabetes in south Indians.
Diabetes Mellitus, Type 2
Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
Diabetes Mellitus, Type 2
LMW-PTP modulates glucose metabolism in cancer cells.
Diabetes Mellitus, Type 2
Low Frequencies of Autoimmunity-Associated PTPN22 Polymorphisms in MODY Patients, Including Those Transiently Expressing Islet Cell Autoantibodies.
Diabetes Mellitus, Type 2
Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.
Diabetes Mellitus, Type 2
Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Measuring gene-gene interaction using Kullback-Leibler divergence.
Diabetes Mellitus, Type 2
Metabolic Diseases Drug Discovery-Strategic Research Institute's Third International World Summit. Dipeptidyl peptidase-IV inhibitors 26-27 July 2004, San Diego, CA, USA.
Diabetes Mellitus, Type 2
Missense mutation of Pro387Leu in protein tyrosine phosphatase-1B (PTP-1B) is not associated with type 2 diabetes in a Chinese Han population.
Diabetes Mellitus, Type 2
New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting ?-glucosidase and the PTP-1B signaling pathway.
Diabetes Mellitus, Type 2
New prenylated flavanones from Erythrina abyssinica with Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity.
Diabetes Mellitus, Type 2
Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B.
Diabetes Mellitus, Type 2
Novel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents.
Diabetes Mellitus, Type 2
Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.
Diabetes Mellitus, Type 2
Novel protein tyrosine phosphatase 1B inhibitors: interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control.
Diabetes Mellitus, Type 2
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Diabetes Mellitus, Type 2
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Diabetes Mellitus, Type 2
Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica.
Diabetes Mellitus, Type 2
Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Optimization of extraction parameters of PTP1? (protein tyrosine phosphatase 1?), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM).
Diabetes Mellitus, Type 2
p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress.
Diabetes Mellitus, Type 2
Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes.
Diabetes Mellitus, Type 2
Pharmacological inhibition of protein tyrosine phosphatase 1B: a promising strategy for the treatment of obesity and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551.
Diabetes Mellitus, Type 2
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Diabetes Mellitus, Type 2
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.
Diabetes Mellitus, Type 2
Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits.
Diabetes Mellitus, Type 2
Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.
Diabetes Mellitus, Type 2
PPAR-?2 and PTPRD gene polymorphisms influence type 2 diabetes patients' response to pioglitazone in China.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018).
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B (PTP1B) inhibitory constituents from the aerial parts of Tradescantia spathacea Sw.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitors for diabetes.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitors: A molecular level legitimate approach for the management of diabetes mellitus.
Diabetes Mellitus, Type 2
Protein Tyrosine Phosphatase 1B inhibitors: a novel therapeutic strategy for the management of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitory activity of amentoflavone and its cellular effect on tyrosine phosphorylation of insulin receptors.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity.
Diabetes Mellitus, Type 2
Protein Tyrosine Phosphatase Non-receptor 22 Gene C1858T Polymorphism in Patients with Coexistent Type 2 Diabetes and Hashimoto's Thyroiditis.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase-1B in diabetes.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatase-1B modulates pancreatic ?-cell mass.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases as potential therapeutic targets.
Diabetes Mellitus, Type 2
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases: the quest for negative regulators of insulin action.
Diabetes Mellitus, Type 2
Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.
Diabetes Mellitus, Type 2
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Diabetes Mellitus, Type 2
Protein-tyrosine phosphatase 1B substrates and metabolic regulation.
Diabetes Mellitus, Type 2
Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.
Diabetes Mellitus, Type 2
PTP1B and TC-PTP: regulators of transformation and tumorigenesis.
Diabetes Mellitus, Type 2
PTP1B and TCPTP: Non-redundant phosphatases in insulin signaling and glucose homeostasis.
Diabetes Mellitus, Type 2
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.
Diabetes Mellitus, Type 2
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery.
Diabetes Mellitus, Type 2
PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta).
Diabetes Mellitus, Type 2
PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity.
Diabetes Mellitus, Type 2
PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 - 2014).
Diabetes Mellitus, Type 2
PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza.
Diabetes Mellitus, Type 2
PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica.
Diabetes Mellitus, Type 2
PTP1B Inhibitory Secondary Metabolites from Marine-Derived Fungal Strains Penicillium spp. and Eurotium sp.
Diabetes Mellitus, Type 2
PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes.
Diabetes Mellitus, Type 2
QSAR Studies of PTP1B Inhibitors: Recent Advances and Perspectives.
Diabetes Mellitus, Type 2
Quantitative evaluation of PTPN22 copy number variation by digital droplet PCR and association with type 2 diabetes risk.
Diabetes Mellitus, Type 2
Reactions of 1,3-Diketones with a Dipeptide Isothiazolidin-3-one: Toward Agents That Covalently Capture Oxidized Protein Tyrosine Phosphatase 1B.
Diabetes Mellitus, Type 2
Recent advances in protein tyrosine phosphatase 1B inhibitors.
Diabetes Mellitus, Type 2
Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for Type 2 diabetes.
Diabetes Mellitus, Type 2
Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes.
Diabetes Mellitus, Type 2
Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.
Diabetes Mellitus, Type 2
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Diabetes Mellitus, Type 2
Replication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a Japanese population.
Diabetes Mellitus, Type 2
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Diabetes Mellitus, Type 2
Role of protein tyrosine phosphatase-1B in diabetes and obesity.
Diabetes Mellitus, Type 2
Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches.
Diabetes Mellitus, Type 2
Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase.
Diabetes Mellitus, Type 2
Sesquiterpenoids with PTP1B Inhibitory Activity and Cytotoxicity from the Edible Mushroom Pleurotus citrinopileatus.
Diabetes Mellitus, Type 2
SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes.
Diabetes Mellitus, Type 2
Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.
Diabetes Mellitus, Type 2
Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.
Diabetes Mellitus, Type 2
Structure determination of T cell protein-tyrosine phosphatase.
Diabetes Mellitus, Type 2
Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors.
Diabetes Mellitus, Type 2
Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues.
Diabetes Mellitus, Type 2
Sulphonamides as inhibitors of protein tyrosine phosphatase 1B: a three-dimensional quantitative structure-activity relationship study using self-organizing molecular field analysis approach.
Diabetes Mellitus, Type 2
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Synthesis and Biological Evaluation of Analogues of Butyrolactone I as PTP1B Inhibitors.
Diabetes Mellitus, Type 2
Synthesis and biological evaluation of novel N-aryl-?-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of ?-glucosidase and protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Synthesis of triazole-linked beta-C-glycosyl dimers as inhibitors of PTP1B.
Diabetes Mellitus, Type 2
Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.
Diabetes Mellitus, Type 2
Synthesis, In Vitro Evaluation and Molecular Docking of the 5-Acetyl-2-aryl-6-hydroxybenzo[b]furans against Multiple Targets Linked to Type 2 Diabetes.
Diabetes Mellitus, Type 2
T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice.
Diabetes Mellitus, Type 2
Technology evaluation: ISIS-113715, Isis.
Diabetes Mellitus, Type 2
The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.
Diabetes Mellitus, Type 2
The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency.
Diabetes Mellitus, Type 2
The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
The protein tyrosine phosphatase receptor type f (PTPRF) locus is associated with coronary artery disease in type 2 diabetes.
Diabetes Mellitus, Type 2
The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity.
Diabetes Mellitus, Type 2
The role of protein-tyrosine phosphatase 1B in integrin signaling.
Diabetes Mellitus, Type 2
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding.
Diabetes Mellitus, Type 2
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Diabetes Mellitus, Type 2
The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Diabetes Mellitus, Type 2
The two faces of PTP1B in cancer.
Diabetes Mellitus, Type 2
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Diabetes Mellitus, Type 2
Tumor necrosis factor-alpha: a continuum of liability between insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus and carcinoma (review).
Diabetes Mellitus, Type 2
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
Diabetes Mellitus, Type 2
Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes.
Diabetes Mellitus, Type 2
Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies.
Diabetes Mellitus, Type 2
Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Validation Of Formylchromane Derivatives As Ptp 1b Inhibitors By Pharmacophore Modeling, Atom Based 3d-Qsar And Docking Studies.
Diabetes Mellitus, Type 2
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).
Diabetes Mellitus, Type 2
Virtual screening, optimization, and identification of a novel specific PTP-MEG2 inhibitor with potential therapy for T2DM.
Diabetes Mellitus, Type 2
Water-molecule network and active-site flexibility of apo protein tyrosine phosphatase 1B.
Diabetes Mellitus, Type 2
Zinc Supplementation and Strength Exercise in Rats with Type 2 Diabetes: Akt and PTP1B Phosphorylation in Nonalcoholic Fatty Liver.
Diabetes Mellitus, Type 2
[Association of -6735T-->C variant of glucokinase-associated dual-specificity phosphatase 12 gene with type 2 diabetes in Chinese]
Diabetes Mellitus, Type 2
[Effects of rare islet autoantibodies on islet function in patients with latent autoimmune diabetes in adults].
Diabetes Mellitus, Type 2
[Multivariate logistic regression analysis on the risk factors of type 2 diabetes mellitus]
Diabetes Mellitus, Type 2
[PTP1B inhibitory activities of bromophenol derivatives from algae]
Diabetes Mellitus, Type 2
[Research progress of several protein tyrosine phosphatases in diabetes.]
Diabetes Mellitus, Type 2
[Role of protein tyrosine phosphatase 1B in the type 2 diabetes and obesity]
Diabetes Mellitus, Type 2
[Search for Protein Tyrosine Phosphatase 1B Inhibitors from Marine Organisms and Induced Production of New Fungal Metabolites by Modulating Culture Methods].
Diabetes Mellitus, Type 2
[Single nucleotide polymorphism of protein tyrosine phosphatase 1B (PTP-1B) gene. Clinical implications in type 2 diabetes]
Diabetes, Gestational
Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus.
Diabetes, Gestational
Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus.
Diabetes, Gestational
Genetic variants in PTPRD and risk of gestational diabetes mellitus.
Diabetes, Gestational
MiR-6869-5p Induces M2 Polarization by Regulating PTPRO in Gestational Diabetes Mellitus.
Diabetes, Gestational
Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood.
Diabetes, Gestational
[Association of DUSP9 gene polymorphisms with gestational diabetes mellitus].
Diabetic Angiopathies
N?-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction.
Diabetic Cardiomyopathies
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Diabetic Cardiomyopathies
Diabetic cardiomyopathy: a "cardiac stem cell disease" involving p66Shc, an attractive novel molecular target for heart failure therapy.
Diabetic Cardiomyopathies
Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats.
Diabetic Foot
Chinese medicine ulcer oil promotes the healing of diabetic foot ulcers.
Diabetic Ketoacidosis
Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual ?-cell function 1 year after diagnosis of type 1 diabetes.
Diabetic Nephropathies
A novel biphenyl compound, VMNS2e, ameliorates streptozotocin induced diabetic nephropathy in rats.
Diabetic Nephropathies
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.
Diabetic Nephropathies
Author Correction: p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy.
Diabetic Nephropathies
Diabetic nephropathy: Role of podocyte SHP-1 in hyperglycaemic memory.
Diabetic Nephropathies
Dioscorea zingiberensis ameliorates diabetic nephropathy by inhibiting NLRP3 inflammasome and curbing the expression of p66Shc in high-fat diet/streptozotocin-induced diabetic mice.
Diabetic Nephropathies
Expression of SHP-1 Induced by Hyperglycemia Prevents Insulin Actions in Podocytes.
Diabetic Nephropathies
Expression-based network biology identifies alteration in key regulatory pathways of type 2 diabetes and associated risk/complications.
Diabetic Nephropathies
Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 Biological Axis.
Diabetic Nephropathies
Inactivation of p66Shc Decreases Afferent Arteriolar KATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats.
Diabetic Nephropathies
Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.
Diabetic Nephropathies
Lack of evidence for the 1484insG variant at the 3'-UTR of the protein tyrosine phosphatase 1B (PTP1B) gene as a genetic determinant of diabetic nephropathy development in type 1 diabetic patients.
Diabetic Nephropathies
p66Shc mediates high-glucose and angiotensin II-induced oxidative stress renal tubular injury via mitochondrial-dependent apoptotic pathway.
Diabetic Nephropathies
p66Shc regulates podocyte autophagy in high glucose environment through the Notch-PTEN-PI3K/Akt/mTOR pathway.
Diabetic Nephropathies
p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.
Diabetic Nephropathies
p66Shc: A novel biomarker of tubular oxidative injury in patients with diabetic nephropathy.
Diabetic Nephropathies
Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy.
Diabetic Nephropathies
PKC? promotes high glucose induced renal tubular oxidative damage via regulating activation and translocation of p66Shc.
Diabetic Nephropathies
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc.
Diabetic Nephropathies
Protein phosphatases and podocyte function.
Diabetic Nephropathies
PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
Diabetic Nephropathies
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Diabetic Nephropathies
Targeting VE-PTP phosphatase protects the kidney from diabetic injury.
Diabetic Nephropathies
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Diabetic Nephropathies
The PKC?-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy.
Diabetic Nephropathies
TRIM18-Regulated STAT3 Signaling Pathway via PTP1B Promotes Renal Epithelial-Mesenchymal Transition, Inflammation, and Fibrosis in Diabetic Kidney Disease.
Diabetic Nephropathies
Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus.
Diabetic Nephropathies
VE-PTP phosphatase: a new target for diabetic kidney disease.
Diabetic Neuropathies
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
Diabetic Retinopathy
9-cis-retinoic acid improves sensitivity to platelet-derived growth factor-BB via RXR? and SHP-1 in diabetic retinopathy.
Diabetic Retinopathy
?A1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity.
Diabetic Retinopathy
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Diabetic Retinopathy
Adaptor Protein p66Shc: A Link Between Cytosolic and Mitochondrial Dysfunction in the Development of Diabetic Retinopathy.
Diabetic Retinopathy
P66Shc expression in diabetic rat retina.
Diabetic Retinopathy
Vasoinhibins: novel inhibitors of ocular angiogenesis.
Diabetic Retinopathy
[Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]
Digestive System Neoplasms
[Acid phosphatase activity and non-specific esterase D of alpha-naphthyl acetate in the lymphocytes of patients with digestive system neoplasms after surgical treatment]
Distemper
Accumulation of Extracellular Matrix in Advanced Lesions of Canine Distemper Demyelinating Encephalitis.
Diverticulitis
RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.
Down Syndrome
CD26 surface antigen expression on peripheral blood T lymphocytes from children with Down's syndrome (trisomy 21).
Down Syndrome
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.
Down Syndrome
Phosphotyrosine phosphatase activity and haematologic changes in Down's syndrome patients.
Down Syndrome
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia.
Ductus Arteriosus, Patent
PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
Duodenal Ulcer
Helicobacter Pylori CagA and Gastric Carcinogenesis.
Duodenal Ulcer
[CagA tyrosine phosphorylation motif structure and SHP-2 binding ability of Helicobacter pylori studied in stomach cancer and duodenal ulcer cell lines]
Duodenal Ulcer
[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].
Dwarfism
Murine models of life span extension.
Dwarfism
Study on pathogenic genes of dwarfism disease by next-generation sequencing.
Dysentery, Amebic
Acid phosphatase activity in the intestinal wall in experimental amebic colitis.
Dyskinesias
Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease.
Dyskinesias
Shp-2 knockdown prevents l-dopa-induced dyskinesia in a rat model of Parkinson's disease.
Dyslipidemias
ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese.
Dyslipidemias
Cyclocarya paliurus Leaves Tea Improves Dyslipidemia in Diabetic Mice: A Lipidomics-Based Network Pharmacology Study.
Dyslipidemias
Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone.
Dyslipidemias
Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.
Dyslipidemias
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Dyslipidemias
Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol-induced liver dysfunction: Rescue effect of ginger extract.
Dyslipidemias
Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine.
Dyslipidemias
Protein tyrosine phosphatase 1B gene polymorphisms and essential hypertension: a case-control study in Chinese population.
Eczema
An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms.
Ellis-Van Creveld Syndrome
Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit.
Encephalitis
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.
Encephalomyelitis
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Encephalomyelitis
Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice.
Encephalomyelitis
Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Encephalomyelitis
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Encephalomyelitis
CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.
Encephalomyelitis
Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.
Encephalomyelitis
MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells.
Encephalomyelitis
Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.
Encephalomyelitis
Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Encephalomyelitis
Protein tyrosine phosphatase ? regulates autoimmune encephalomyelitis development.
Encephalomyelitis
Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.
Encephalomyelitis
The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration.
Encephalomyelitis, Autoimmune, Experimental
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions.
Encephalomyelitis, Autoimmune, Experimental
Blocking initial infiltration of pioneer CD8(+) T-cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice.
Encephalomyelitis, Autoimmune, Experimental
CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.
Encephalomyelitis, Autoimmune, Experimental
Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells.
Encephalomyelitis, Autoimmune, Experimental
Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.
Encephalomyelitis, Autoimmune, Experimental
Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice.
Encephalomyelitis, Autoimmune, Experimental
The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration.
Encephalomyelitis, Venezuelan Equine
Acid phosphatase activity in mouse brain infected with Venezuelan equine encephalomyelitis virus.
Enchondromatosis
Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome.
Endocrine System Diseases
[Latent forms of adult-onset autoimmune polyglandular syndrome: diagnosis and management of patients].
Endometrial Hyperplasia
Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas.
Endometrial Hyperplasia
Dual-specificity phosphatase 6 predicts the sensitivity of progestin therapy for atypical endometrial hyperplasia.
Endometrial Hyperplasia
Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability.
Endometrial Neoplasms
Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.
Endometrial Neoplasms
Antiproliferative signaling of luteinizing hormone-releasing hormone in human endometrial and ovarian cancer cells through G protein alpha(I)-mediated activation of phosphotyrosine phosphatase.
Endometrial Neoplasms
Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.
Endometrial Neoplasms
Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas.
Endometrial Neoplasms
Dual specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer.
Endometrial Neoplasms
Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells.
Endometrial Neoplasms
Expression of phosphatase of regenerating liver-3 (PRL-3) in endometrioid cancer and lymph nodes metastases.
Endometrial Neoplasms
Gefitinib enhances sensitivity of endometrial cancer cells to progestin therapy via dual-specificity phosphatase 1.
Endometrial Neoplasms
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Endometrial Neoplasms
Immunohistochemical Detection of Hematopoietic Cell-specific Protein-Tyrosine Phosphatase (Tyrosine Phosphatase SHP-1) in a Series of Endometrioid and Serous Endometrial Carcinoma.
Endometrial Neoplasms
Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas.
Endometrial Neoplasms
miR-152 inhibits proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression.
Endometrial Neoplasms
MiR-449a functions as a tumor suppressor in endometrial cancer by targeting CDC25A.
Endometrial Neoplasms
Phosphotyrosine phosphatase-activity in membranes from endometrial carcinoma.
Endometrial Neoplasms
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells.
Endometrial Neoplasms
Precision Therapy for Aggressive Endometrial Cancer by Reactivation of Protein Phosphatase 2A.
Endometrial Neoplasms
Prolactin receptor-linked tyrosine-phosphorylation of membrane-proteins is mediated by GTP-binding protein in endometrial carcinoma and endometrium.
Endometrial Neoplasms
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.
Endometrial Neoplasms
Regulation of PTP1D mRNA by peptide growth factors in the human endometrial cell line HEC-1-A.
Endometrial Neoplasms
Relationship Between CIP2A and Endometrium Cancer.
Endometrial Neoplasms
RNA Sequencing of Carboplatin- and Paclitaxel-Resistant Endometrial Cancer Cells Reveals New Stratification Markers and Molecular Targets for Cancer Treatment.
Endometrial Neoplasms
The Highly Recurrent PP2A A?-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Endometrial Neoplasms
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Endometriosis
An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.
Endometriosis
Association between PTPN22 and endometriosis.
Endometriosis
Association of p53 codon 72 polymorphism with endometriosis.
Endometriosis
Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis.
Endometriosis
Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma.
Endometriosis
Identification of global transcriptome abnormalities and potential biomarkers in eutopic endometria of women with endometriosis: A preliminary study.
Endometriosis
Phosphatase of regenerating liver-3: a novel and promising marker in human endometriosis.
Endometriosis
PRL-3 Is Involved in Estrogen- and IL-6-Induced Migration of Endometrial Stromal Cells From Ectopic Endometrium.
Endometriosis
PTPN22 C1858T polymorphism in women with endometriosis.
Endometriosis
SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis.
Endometriosis
The association of PTPN22 polymorphism with endometriosis: effect of genetic and clinical factors.
Endometriosis
The effect of ACP1, ADA6 and PTPN22 genetic polymorphisms on the association between p53 codon 72 polymorphism and endometriosis.
Endotoxemia
Development and Characterization of an Endotoxemia Model in Zebra Fish.
Endotoxemia
Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia.
Endotoxemia
Mitogen-activated protein kinase phosphatase-1 expression in macrophages is controlled by lymphocytes during macrophage activation.
Endotoxemia
Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-? expression and improves cardiac function during endotoxemia.
Endotoxemia
Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.
Endotoxemia
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Enteritis
Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-?B activation.
Enteritis
Supplementation exogenous bile acid improved growth and intestinal immune function associated with NF-?B and TOR signalling pathways in on-growing grass carp (Ctenopharyngodon idella): Enhancement the effect of protein-sparing by dietary lipid.
Enteritis
Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factor NF-?B and p38 mitogen-activated protein kinase signalling pathways.
Enterocolitis, Necrotizing
Single nucleotide polymorphisms in the dual specificity phosphatase genes and risk of necrotizing enterocolitis in premature infant.
Enterotoxemia
[Activity of various enzymes of the intestinal mucosa in spontaneous colibacteriosis in pigs]
Enterovirus Infections
Enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase IA-2/IAR.
Enterovirus Infections
Enterovirus infection may induce humoral immune response reacting with islet cell autoantigens in humans.
Enzootic Bovine Leukosis
Bovine leukemia virus transmembrane protein gp30 physically associates with the down-regulatory phosphatase SHP-1.
Eosinophilia
Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation.
Eosinophilia
Expression on human eosinophils of CD148: a membrane tyrosine phosphatase. Implications in the effector function of eosinophils.
Eosinophilia
Histological and histochemical examinations of the myocardium of rats kept on low-magnesium diet and treated with cyclophosphamide.
Eosinophilia
The expression of cancerous inhibitor protein phosphatase 2A in chronic rhinosinusitis with nasal polyps.
Ependymoma
Microarray analysis reveals differential gene expression patterns in tumors of the pineal region.
Epidermodysplasia Verruciformis
The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene.
Epilepsies, Myoclonic
Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: exon 1 mutations associate with an early-onset cognitive deficit subphenotype.
Epilepsy
Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling.
Epilepsy
Genetic diagnoses in epilepsy: The impact of dynamic exome analysis in a pediatric cohort.
Epilepsy
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.
Epilepsy
Large De Novo Microdeletion in Epilepsy with Intellectual and Developmental Disabilities, with a Systems Biology Analysis.
Epilepsy
Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89.
Epilepsy
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Epilepsy
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice.
Epilepsy
Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy.
Epilepsy
Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex.
Epilepsy
Upregulated SHP-2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model.
Epilepsy, Post-Traumatic
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Epilepsy, Temporal Lobe
Upregulated SHP-2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model.
Epstein-Barr Virus Infections
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.
Erectile Dysfunction
Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
Escherichia coli Infections
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis.
Escherichia coli Infections
Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection.
Esophageal Achalasia
Association of IL10 promoter polymorphisms with idiopathic achalasia.
Esophageal Achalasia
Gender-specific association of the PTPN22 C1858T polymorphism with achalasia.
Esophageal Neoplasms
Aberrant promoter 2 methylation?mediated downregulation of protein tyrosine phosphatase, non?receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Esophageal Neoplasms
Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.
Esophageal Neoplasms
CDC25B and p53 are independently implicated in radiation sensitivity for human esophageal cancers.
Esophageal Neoplasms
Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma.
Esophageal Neoplasms
Overexpression of CDC25B overrides radiation-induced G2-M arrest and results in increased apoptosis in esophageal cancer cells.
Esophageal Neoplasms
Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery.
Esophageal Neoplasms
Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway.
Esophageal Neoplasms
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Esophageal Neoplasms
Predictive biomarkers for response of esophageal cancer to chemo(radio)therapy: A systematic review and meta-analysis.
Esophageal Neoplasms
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Esophageal Neoplasms
The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers.
Esophageal Squamous Cell Carcinoma
Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients.
Esophageal Squamous Cell Carcinoma
Aberrant promoter 2 methylation?mediated downregulation of protein tyrosine phosphatase, non?receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Anti-CDC25B autoantibody predicts poor prognosis in patients with advanced esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Exosome-derived miR-339-5p mediates radiosensitivity by targeting Cdc25A in locally advanced esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC.
Esophageal Squamous Cell Carcinoma
Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
Methylation and expression of PTPN22 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
MiR-214 inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by targeting CDC25B.
Esophageal Squamous Cell Carcinoma
MiR-450a-5p inhibits autophagy and enhances radiosensitivity by targeting dual-specificity phosphatase 10 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery.
Esophageal Squamous Cell Carcinoma
p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy.
Esophageal Squamous Cell Carcinoma
P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.
Esophageal Squamous Cell Carcinoma
Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer.
Esophageal Squamous Cell Carcinoma
Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PTP1B Contributes to Calreticulin-Induced Metastatic Phenotypes in Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
PTP1B up-regulates EGFR expression by dephosphorylating MYH9 at Y1408 to promote cell migration and invasion in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PTPN9 promotes cell proliferation and invasion in Eca109 cells and is negatively regulated by microRNA-126.
Esophageal Squamous Cell Carcinoma
Retraction of: Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China; DOI: 10.1089/gtmb.2016.0194.
Esophageal Squamous Cell Carcinoma
Single Nucleotide Polymorphisms in the PTPN1 Gene Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma: A Case-Control Study in Inner Mongolia, China.
Esophageal Squamous Cell Carcinoma
The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population.
Esophageal Squamous Cell Carcinoma
Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Essential Hypertension
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Essential Hypertension
Protein tyrosine phosphatase 1B gene polymorphisms and essential hypertension: a case-control study in Chinese population.
Essential Hypertension
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Essential Hypertension
Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
Exanthema
Asthma and allergic symptoms and type 1 diabetes-related autoantibodies in 2.5-yr-old children.
Exostoses
SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.
Exostoses, Multiple Hereditary
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Extranodal Extension
Low expression of SHP-2 is associated with less favorable prostate cancer outcomes.
Eye Burns
[Changes in the acid phosphatase activity of the cornea in the dynamics of a chemical eye burn]
Eye Diseases
Exploring the effect of inhibitor AKB-9778 on VE-PTP by molecular docking and molecular dynamics simulation.
Familial Mediterranean Fever
Lack of the Association of the PTPN22 C1858T Gene Polymorphism With Susceptibility to Familial Mediterranean Fever.
Fanconi Anemia
Enhanced DNA repair and genomic stability identify a novel HIV-related diffuse large B-cell lymphoma signature.
Fasciculation
Chondroitin sulfate proteoglycan phosphacan associates with parallel fibers and modulates axonal extension and fasciculation of cerebellar granule cells.
Fasciculation
Receptor tyrosine phosphatases guide vertebrate motor axons during development.
Fatty Liver
Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.
Fatty Liver
Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma.
Fatty Liver
Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.
Fatty Liver
Polymorphism of Receptor-Type Tyrosine-Protein Phosphatase Delta gene in the development of non-alcoholic fatty liver disease.
Fatty Liver
Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis.
Fatty Liver
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Fatty Liver
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Fatty Liver
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.
Fatty Liver
Structure-functional implications of longevity protein p66Shc in health and disease.
Fatty Liver, Alcoholic
The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.
Fatty Liver, Alcoholic
The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens.
Favism
Small amplicons high resolution melting analysis (SA-HRMA) allows successful genotyping of acid phosphatase 1 (ACP1) polymorphisms in the Italian population.
Fetal Death
Early fetal death associated with compound heterozygosity for Noonan syndrome-causative PTPN11 mutations.
Fetal Diseases
Activation of oxidative stress signaling that is implicated in apoptosis with a mouse model of diabetic embryopathy.
Fetal Growth Retardation
Intrauterine Growth Restriction Affects Hippocampal Dual Specificity Phosphatase 5 Gene Expression and Epigenetic Characteristics.
Fetal Growth Retardation
Intrauterine growth restriction alters T-lymphocyte cell number and dual specificity phosphatase 1 levels in the thymus of newborn and juvenile rats.
Fibroma
Phosphoamino acid phosphatases in normal and cancerous tissues of the human uterus, cervix and ovary.
Fibromatosis, Gingival
Association of mutation in PTPN14 gene and gingival fibromatosis with distinctive facies: a novel finding in whole exome sequencing.
Fibrosarcoma
Attenuation of p38 MAPK activity upon contact inhibition in fibroblasts.
Fibrosarcoma
ERK regulation upon contact inhibition in fibroblasts.
Fibrosarcoma
The fibrinogen-like globe of tenascin-C mediates its interactions with neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta.
Filariasis
Study of human and parasitic factors in relation to bancroftian filariasis in Egypt.
Fluorosis, Dental
MAP kinase phosphatase MKP-1 regulates p-ERK1/2 signaling pathway with fluoride treatment.
Fluorosis, Dental
Moderating Role of TSHR and PTPN22 Gene Polymorphisms in Effects of Excessive Fluoride on Thyroid: a School-Based Cross-Sectional Study.
Food Hypersensitivity
Asthma and allergic symptoms and type 1 diabetes-related autoantibodies in 2.5-yr-old children.
Foot Ulcer
Chinese medicine ulcer oil promotes the healing of diabetic foot ulcers.
Fractures, Spontaneous
Gaucher disease: comparative study of acid phosphatase and glucocerebrosidase in normal and type-1 Gaucher tissues.
Fragile X Syndrome
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).
Fragile X Syndrome
The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.
Frontotemporal Dementia
Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family.
Frontotemporal Dementia
Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations.
Funnel Chest
Giant Cell Lesions in Noonan Syndrome: Case Report and Review of The Literature.
Ganglion Cysts
Induction of protein tyrosine phosphatase epsilon transcripts during NGF-induced neuronal differentiation of PC12D cells and during the development of the cerebellum.
Ganglioneuroma
Recurrent ganglioneuroma in PTPN11-associated Noonan syndrome: A case report and literature review.
Gastritis
Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression.
Gastritis
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.
Gastritis
[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].
Gastritis, Atrophic
SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis.
Gastritis, Atrophic
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.
Gastritis, Atrophic
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.
Gastroenteritis
Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes.
Gastrointestinal Diseases
Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPalpha and RPTPbeta, by Helicobacter pylori m2VacA.
Gastrointestinal Diseases
Dynamics of the WPD loop of the Yersinia protein tyrosine phosphatase.
Gastrointestinal Diseases
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Gastrointestinal Diseases
[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].
Gastrointestinal Neoplasms
Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers.
Gastrointestinal Neoplasms
Sap-1/PTPRH activity is regulated by reversible dimerization.
Gastrointestinal Stromal Tumors
Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects.
Gaucher Disease
ACID PHOSPHATASE ACTIVITY OF SERUM, THROMBOCYTES AND ERYTHROCYTES IN A JUVENILE FORM OF GAUCHER'S DISEASE.
Gaucher Disease
Acid phosphatase in Gaucher's disease.
Gaucher Disease
Age dependency of serum acid phosphatase in controls and Gaucher patients.
Gaucher Disease
Biochemical properties of the tartrate-resistant acid phosphatase activity in Gaucher disease.
Gaucher Disease
Determination of serum acid phosphatase in Gaucher's disease using 4-methylumbelliferyl phosphate.
Gaucher Disease
Gaucher disease: comparative study of acid phosphatase and glucocerebrosidase in normal and type-1 Gaucher tissues.
Gaucher Disease
Multiple forms of acid phosphatase activity in Gaucher's disease.
Gaucher Disease
Sodium taurocholate effect on beta-glucosidase activity: a new approach for identification of Gaucher disease using the synthetic substrate and leucocytes.
Gaucher Disease
The specificity and nature of serum-angiotensin-converting enzyme (serum ACE) elevations in sarcoidosis.
Genetic Diseases, Inborn
Chondrosarcoma in Metachondromatosis: A Rare Case Report.
Genetic Diseases, Inborn
Clinical exome sequencing: results from 2819 samples reflecting 1000 families.
Genetic Diseases, Inborn
Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
Genetic Diseases, Inborn
Engineering Cell-Permeable Proteins through Insertion of Cell-Penetrating Motifs into Surface Loops.
Genetic Diseases, Inborn
Fetal hydrops and the Incremental yield of Next generation sequencing over standard prenatal Diagnostic testing (FIND) study: prospective cohort study and meta-analysis.
Genetic Diseases, Inborn
Metachondromatosis: more than just multiple osteochondromas.
Genetic Diseases, Inborn
Noonan Syndrome and Related Disorders: Genetics and Pathogenesis.
Genetic Diseases, Inborn
Noonan syndrome and related disorders: genetics and pathogenesis.
Genetic Diseases, Inborn
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
Genetic Diseases, Inborn
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Genetic Diseases, Inborn
Severe aortic valvar stenosis in familial Noonan syndrome with mutation of the PTPN11 gene.
Genetic Diseases, Inborn
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
Genetic Diseases, Inborn
The regulation of male fertility by the PTPN11 tyrosine phosphatase.
Giant Cell Arteritis
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Giant Cell Arteritis
Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis.
Giant Cell Arteritis
Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to biopsy-proven giant cell arteritis.
Giant Cell Arteritis
New insights into the pathogenesis of giant cell arteritis and hopes for the clinic.
Giant Cell Arteritis
PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis.
Giant Cell Tumor of Bone
Localization of acid phosphatase activity in a giant cell tumor of bone.
Giant Cell Tumors
Localization of acid phosphatase activity in a giant cell tumor of bone.
Giant Cell Tumors
New model for bone resorption study in vitro: human osteoclast-like cells from giant cell tumors of bone.
Glaucoma
Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model.
Glaucoma
Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection.
Glaucoma
Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.
Glaucoma, Open-Angle
Extracellular Matrix Remodeling in the Retina and Optic Nerve of a Novel Glaucoma Mouse Model.
Glioblastoma
A miR-21 inhibitor enhances apoptosis and reduces G(2)-M accumulation induced by ionizing radiation in human glioblastoma U251 cells.
Glioblastoma
A novel molecular diagnostic of glioblastomas: detection of an extracellular fragment of protein tyrosine phosphatase micro.
Glioblastoma
A role for receptor tyrosine phosphatase zeta in glioma cell migration.
Glioblastoma
CDC25B, Ki-67, and p53 expressions in reactive gliosis and astrocytomas.
Glioblastoma
ceRNA Network Analysis Shows That lncRNA CRNDE Promotes Progression of Glioblastoma Through Sponge mir-9-5p.
Glioblastoma
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha.
Glioblastoma
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.
Glioblastoma
Contactin is expressed in human astrocytic gliomas and mediates repulsive effects.
Glioblastoma
Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies.
Glioblastoma
Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.
Glioblastoma
Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells.
Glioblastoma
Do phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme?
Glioblastoma
Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement.
Glioblastoma
Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas.
Glioblastoma
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.
Glioblastoma
Euxanthone represses the proliferation, migration, and invasion of glioblastoma cells by modulating STAT3/SHP-1 signaling.
Glioblastoma
Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas.
Glioblastoma
Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche.
Glioblastoma
Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment.
Glioblastoma
Gain-Of-Function E76K-Mutant SHP2 Promotes Cell Proliferation, Metastasis, And Tumor Growth In Glioblastoma Through Activation Of The ERK/CREB Pathway.
Glioblastoma
Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition.
Glioblastoma
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Glioblastoma
High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma.
Glioblastoma
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Glioblastoma
Inhibiting protein phosphatase 2A increases the antitumor effect of protein arginine methyltransferase 5 inhibition in models of glioblastoma.
Glioblastoma
Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.
Glioblastoma
Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.
Glioblastoma
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-? pathway.
Glioblastoma
miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma.
Glioblastoma
Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas.
Glioblastoma
Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38?.
Glioblastoma
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Glioblastoma
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.
Glioblastoma
Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.
Glioblastoma
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.
Glioblastoma
Nox4 redox regulation of PTP1B contributes to the proliferation and migration of glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C.
Glioblastoma
Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway.
Glioblastoma
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
Glioblastoma
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death.
Glioblastoma
Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma.
Glioblastoma
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.
Glioblastoma
PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways.
Glioblastoma
Prognosis of patients with multifocal glioblastoma: a case-control study.
Glioblastoma
Prognostic significance of CDC25B expression in gliomas.
Glioblastoma
Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest.
Glioblastoma
Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.
Glioblastoma
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.
Glioblastoma
Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.
Glioblastoma
Protein Tyrosine Phosphatase-1B Inhibition Disrupts IL13R?2-Promoted Invasion and Metastasis in Cancer Cells.
Glioblastoma
Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration.
Glioblastoma
PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity.
Glioblastoma
PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor.
Glioblastoma
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3? and PTP1B in situ.
Glioblastoma
PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.
Glioblastoma
Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy.
Glioblastoma
RNA interference targeting protein tyrosine phosphatase zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma growth in vitro and in vivo.
Glioblastoma
Role of GalNAc4S-6ST in astrocytic tumor progression.
Glioblastoma
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.
Glioblastoma
SHP2 regulates proliferation and tumorigenicity of glioma stem cells.
Glioblastoma
Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.
Glioblastoma
Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma.
Glioblastoma
Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model.
Glioblastoma
Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Glioblastoma
The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway.
Glioblastoma
The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.
Glioblastoma
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.
Glioblastoma
The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.
Glioblastoma
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Glioblastoma
The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.
Glioblastoma
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.
Glioblastoma
Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44.
Glioblastoma
Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation.
Glioma
?1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLC?-PKC pathways.
Glioma
A novel PTPRZ1-ETV1 fusion in gliomas.
Glioma
A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells.
Glioma
A role for receptor tyrosine phosphatase zeta in glioma cell migration.
Glioma
Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
Glioma
Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors.
Glioma
Activation of Jak-Stat and MAPK2 pathways by oncostatin M leads to growth inhibition of human glioma cells.
Glioma
An alternative role for the src-homology-domain-containing phosphotyrosine phosphatase (SH-PTP2) in regulating epidermal-growth-factor-dependent cell growth.
Glioma
Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma.
Glioma
Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells.
Glioma
CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.
Glioma
Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma.
Glioma
Constitutive CHK1 expression drives a pSTAT3-CIP2A circuit that promotes glioblastoma cell survival and growth.
Glioma
Cytochemical distribution of acid phosphatase activity in gliomas cultured in vitro.
Glioma
Dexamethasone reduced invasiveness of human malignant glioblastoma cells through a MAPK phosphatase-1 (MKP-1) dependent mechanism.
Glioma
Dynamin 2 mediates PDGFR?-SHP-2-promoted glioblastoma growth and invasion.
Glioma
EGFR blockade prevents glioma escape from BRAFV600E targeted therapy.
Glioma
Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis.
Glioma
Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.
Glioma
Expression of a receptor protein tyrosine phosphatase in human glial tumors.
Glioma
Genomic changes in progression of low-grade gliomas.
Glioma
Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition.
Glioma
Gossypin Induces G2/M Arrest in Human Malignant Glioma U251 Cells by the Activation of Chk1/Cdc25C Pathway.
Glioma
High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response.
Glioma
Incidence and prognostic value of multiple gene promoter methylations in gliomas.
Glioma
Inhibition of SHP-2 promotes radiosensitivity in glioma.
Glioma
Integrated tumor and germline whole-exome sequencing identifies mutations in MAPK and PI3K pathway genes in an adolescent with rosette-forming glioneuronal tumor of the fourth ventricle.
Glioma
Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules.
Glioma
Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue.
Glioma
Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility.
Glioma
Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway.
Glioma
LncRNA TCONS_00004099-derived microRNA regulates oncogenesis through PTPRF in gliomas.
Glioma
Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.
Glioma
Low-Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature.
Glioma
Lysosomal enzymic activity of astroglial cells.
Glioma
Microarray analysis reveals differential gene expression patterns in tumors of the pineal region.
Glioma
MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation.
Glioma
MiR-16-5p is frequently down-regulated in astrocytic gliomas and modulates glioma cell proliferation, apoptosis and response to cytotoxic therapy.
Glioma
miR-34c inhibits proliferation of glioma by targeting PTP1B.
Glioma
Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas.
Glioma
Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Glioma
Natural HLA class I ligands from glioblastoma: extending the options for immunotherapy.
Glioma
Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma.
Glioma
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis.
Glioma
Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex.
Glioma
PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells.
Glioma
Pristimerin inhibits glioma progression by targeting AGO2 and PTPN1 expression via miR-542-5p.
Glioma
Prognostic significance of CDC25B expression in gliomas.
Glioma
Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest.
Glioma
Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility.
Glioma
Protein tyrosine phosphatases in glioma biology.
Glioma
PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.
Glioma
Pten signaling in gliomas.
Glioma
PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study.
Glioma
PTPH1 promotes tumor growth and metastasis in human glioma.
Glioma
PTPIP51 levels in glioblastoma cells depend on inhibition of the EGF-receptor.
Glioma
PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3? and PTP1B in situ.
Glioma
PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival.
Glioma
PTPN2 induced by inflammatory response and oxidative stress contributed to glioma progression.
Glioma
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Glioma
Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo.
Glioma
Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes.
Glioma
Reduced phosphorylation of Stat3 at Ser-727 mediated by Casein Kinase 2 - Protein Phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells.
Glioma
Roles and potential clinical applications of intermediate filament proteins in brain tumors.
Glioma
Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells.
Glioma
SHP-2 Activating Mutation Promotes Malignant Biological Behaviors of Glioma Cells.
Glioma
SHP-2-upregulated ZEB1 is important for PDGFR?-driven glioma epithelial-mesenchymal transition and invasion in mice and humans.
Glioma
Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma.
Glioma
Small-Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview.
Glioma
Soluble protein tyrosine phosphatase receptor type Z (PTPRZ) in cerebrospinal fluid is a potential diagnostic marker for glioma.
Glioma
Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Glioma
The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation.
Glioma
The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.
Glioma
The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas.
Glioma
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Glioma
The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas.
Glioma
Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma.
Glioma
Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth.
Glioma
UBE2D3 Activates SHP-2 Ubiquitination to Promote Glycolysis and Proliferation of Glioma via Regulating STAT3 Signaling Pathway.
Glioma
Whole-transcriptome sequencing profiling identifies functional and prognostic signatures in patients with PTPRZ1-MET fusion-negative secondary glioblastoma multiforme.
Glioma, Subependymal
A First Case Report of Subependymoma in PTPN11 Mutation-Associated Noonan Syndrome.
Glomerulonephritis
Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B.
Glomerulonephritis
Expression of B cell receptor-associated signaling molecules in human lupus.
Glomerulonephritis
Glomerular epithelial-mesenchymal transdifferentiation in pauci-immune crescentic glomerulonephritis.
Glomerulonephritis
Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis.
Glomerulonephritis
Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis.
Glomerulonephritis
PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein.
Glomerulonephritis, IGA
Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy.
Glomerulosclerosis, Focal Segmental
Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis.
Glomerulosclerosis, Focal Segmental
Podocyte proteins in Galloway-Mowat syndrome.
Glucagonoma
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Glucagonoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Glucose Intolerance
A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.
Glucose Intolerance
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action.
Glucose Intolerance
Combined Neural Inactivation of SOCS-3 and PTP-1B Reveal Additive, Synergistic, and Factor-Specific Roles in the Regulation of Body Energy Balance.
Glucose Intolerance
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.
Glucose Intolerance
Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice.
Glucose Intolerance
Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats.
Glucose Intolerance
Endocrine regulation of energy metabolism by the skeleton.
Glucose Intolerance
Frequency of latent autoimmune diabetes in adults in Asian patients diagnosed as type 2 diabetes in Birmingham, United Kingdom.
Glucose Intolerance
Genetic variation in receptor protein tyrosine phosphatase {sigma} is associated with type 2 diabetes in Swedish Caucasians.
Glucose Intolerance
Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.
Glucose Intolerance
Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B.
Glucose Intolerance
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Glucose Intolerance
p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.
Glucose Intolerance
Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
Glucose Intolerance
Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.
Glucose Intolerance
Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.
Glucose Intolerance
Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice.
Glucose Intolerance
Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.
Glucose Intolerance
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.
Glucose Intolerance
To binge or not to binge: Binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red cell acid phosphatase activity in carriers of beta-thalassemia trait and glucose-6-phosphate dehydrogenase deficiency.
Glucosephosphate Dehydrogenase Deficiency
Red cell acid phosphatase activity in carriers of beta-thalassemia trait and glucose-6-phosphate dehydrogenase deficiency.
glutamate-5-semialdehyde dehydrogenase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Glycogen Storage Disease
Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases.
Glycogen Storage Disease Type II
Acid phosphatase-positive globular inclusions is a good diagnostic marker for two patients with adult-onset Pompe disease lacking disease specific pathology.
Goiter
DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis.
Goiter
Moderating Role of TSHR and PTPN22 Gene Polymorphisms in Effects of Excessive Fluoride on Thyroid: a School-Based Cross-Sectional Study.
Goiter
p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling.
Goiter
[Changes in the lactate dehydrogenase and alkaline and acid phosphatase activity in the arterial and venous blood serum and thyroid tissue in different forms of goiter]
Goiter
[Histochemical characteristics of some oxidation-reduction hydrolytic enzymes in different forms of goiter]
Graft vs Host Disease
Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies.
Graft vs Host Disease
The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations.
Gram-Negative Bacterial Infections
Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.
Gram-Positive Bacterial Infections
Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.
Gram-Positive Bacterial Infections
The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.
Granular Cell Tumor
Granular cell tumor of the scrotum in a child with Noonan syndrome.
Granular Cell Tumor
Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.
Granular Cell Tumor
Noonan syndrome with multiple lentigines with PTPN11 (T468M) gene mutation accompanied with solitary granular cell tumor.
Granuloma
A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1.
Granuloma
T-cell subsets in cutaneous sarcoidosis.
Granulomatosis with Polyangiitis
PTPN22 R620W polymorphism in the ANCA-associated vasculitides.
Granulomatosis with Polyangiitis
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
Graves Disease
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Graves Disease
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Graves Disease
An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population.
Graves Disease
Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.
Graves Disease
Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.
Graves Disease
Association of PTPN22 haplotypes with Graves' disease.
Graves Disease
Association of PTPN22 polymorphism and its correlation with Graves' disease susceptibility in Polish adult population-A preliminary study.
Graves Disease
Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population.
Graves Disease
Association Studies of the GPR103 and BCL2L15 Genes in Autoimmune Thyroid Disease in the Japanese Population.
Graves Disease
Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population.
Graves Disease
Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.
Graves Disease
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Graves Disease
Genetic developments in autoimmune thyroid disease: an evolutionary process.
Graves Disease
Genetic heterogeneity of susceptibility gene in different ethnic populations: refining association study of PTPN22 for Graves' disease in a Chinese Han population.
Graves Disease
Genetics of Thyroid Disorders.
Graves Disease
Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset.
Graves Disease
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Graves Disease
p66Shc expression in proliferating thyroid cells is regulated by thyrotropin receptor signaling.
Graves Disease
Polymorphisms of the genes CTLA4, PTPN22, CD40, and PPARG and their roles in Graves' disease: susceptibility and clinical features.
Graves Disease
Preliminary evidence for interaction of PTPN12 polymorphism with TSHR genotype and association with Graves' ophthalmopathy.
Graves Disease
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.
Graves Disease
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Graves Disease
PTPN22 1858 C/T Exon Polymorphism is not Associated with Graves' Disease in Kashmiri population.
Graves Disease
PTPN22 and CTLA-4 Polymorphisms are Associated with Polyglandular Autoimmunity.
Graves Disease
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
Graves Disease
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Graves Disease
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Graves Disease
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.
Graves Disease
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Graves Disease
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Graves Disease
The Relationship between PTPN22 R620W Polymorphisms and the Susceptibility to Autoimmune Thyroid Diseases: An Updated Meta-analysis.
Graves Disease
Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.
Hamartoma
Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.
Hamartoma
Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.
Hamartoma
Systemic lupus erythematosus in a patient with PTEN hamartoma tumour syndrome.
Hamartoma Syndrome, Multiple
Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.
Hamartoma Syndrome, Multiple
Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.
Hamartoma Syndrome, Multiple
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
Hamartoma Syndrome, Multiple
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice.
Hamartoma Syndrome, Multiple
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast.
Hamartoma Syndrome, Multiple
Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.
Hamartoma Syndrome, Multiple
Systemic lupus erythematosus in a patient with PTEN hamartoma tumour syndrome.
Hamartoma Syndrome, Multiple
The expanding role of PTEN in neoplasia: a molecule for all seasons? Commentary re: M. A. Davies, et al., Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin. Cancer Res., 8: 1904-1914, 2002.
Hashimoto Disease
Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.
Hashimoto Disease
DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis.
Hashimoto Disease
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Hashimoto Disease
PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.
Hashimoto Disease
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
Head and Neck Neoplasms
Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.
Head and Neck Neoplasms
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.
Head and Neck Neoplasms
Intratumor microvessel density in biopsy specimens predicts local response of hypopharyngeal cancer to radiotherapy.
Head and Neck Neoplasms
Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.
Head and Neck Neoplasms
Overexpression of CDC25A and CDC25B in head and neck cancers.
Head and Neck Neoplasms
Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc.
Head and Neck Neoplasms
Protein Tyrosine Phosphatase Receptor S Acts as a Metastatic Suppressor in Malignant Peripheral Nerve Sheath Tumor via Profilin 1-Induced Epithelial-Mesenchymal Transition.
Head and Neck Neoplasms
S-Nitrosylation of mitogen activated protein kinase phosphatase-1 suppresses radiation-induced apoptosis.
Hearing Loss
A C-terminal nonsense mutation links PTPRQ with autosomal-dominant hearing loss, DFNA73.
Hearing Loss
Autosomal Recessive Congenital Sensorineural Hearing Loss due to a Novel Compound Heterozygous PTPRQ Mutation in a Chinese Family.
Hearing Loss
Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms.
Hearing Loss
Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.
Hearing Loss
Evidence that homozygous PTPRD gene microdeletion causes trigonocephaly, hearing loss, and intellectual disability.
Hearing Loss
Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.
Hearing Loss
External ear anomalies and hearing impairment in Noonan Syndrome.
Hearing Loss
First confirmatory study on PTPRQ as an autosomal dominant non-syndromic hearing loss gene.
Hearing Loss
Hair Bundle Defects and Loss of Function in the Vestibular End Organs of Mice Lacking the Receptor-Like Inositol Lipid Phosphatase PTPRQ.
Hearing Loss
Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment.
Hearing Loss
Identification of Novel PTPRQ and MYO1A Mutations in An Iranian Pedigree with Autosomal Recessive Hearing Loss.
Hearing Loss
Identification of Two Novel Compound Heterozygous PTPRQ Mutations Associated with Autosomal Recessive Hearing Loss in a Chinese Family.
Hearing Loss
LEOPARD Syndrome Without Hearing Loss or Pulmonary Stenosis: A Report of 2 Cases.
Hearing Loss
Molecular and phenotypic spectrum of Noonan syndrome in Chinese patients.
Hearing Loss
Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction.
Hearing Loss
Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84.
Hearing Loss
Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss.
Hearing Loss
Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder.
Hearing Loss
Rosiglitazone Improves Glucocorticoid Resistance in a Sudden Sensorineural Hearing Loss by Promoting MAP Kinase Phosphatase-1 Expression.
Hearing Loss
Spectrum and frequencies of non GJB2 gene mutations in Czech patients with early non-syndromic hearing loss detected by gene panel NGS and whole-exome sequencing.
Hearing Loss
When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).
Hearing Loss
Whole-exome sequencing identified a novel heterozygous mutation of SALL1 and a new homozygous mutation of PTPRQ in a Chinese family with Townes-Brocks syndrome and hearing loss.
Hearing Loss
[Case report and diagnosis of Noonan syndrome with multiple lentigines with deafness as its main clinical feature].
Hearing Loss, Sensorineural
A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population.
Hearing Loss, Sensorineural
Autosomal Recessive Congenital Sensorineural Hearing Loss due to a Novel Compound Heterozygous PTPRQ Mutation in a Chinese Family.
Hearing Loss, Sensorineural
Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms.
Hearing Loss, Sensorineural
Identification of Two Novel Compound Heterozygous PTPRQ Mutations Associated with Autosomal Recessive Hearing Loss in a Chinese Family.
Hearing Loss, Sensorineural
IRS2-deficient mice show sensorineural hearing loss that is delayed by concomitant PTP1B loss of function.
Hearing Loss, Sensorineural
LEOPARD Syndrome with PTPN11 Gene Mutation Showing Six Cardinal Symptoms of LEOPARD.
Hearing Loss, Sensorineural
Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss.
Heart Arrest
Early glycogen synthase kinase-3? and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway.
Heart Defects, Congenital
A novel heterozygous MAP2K1 mutation in a patient with Noonan syndrome with multiple lentigines.
Heart Defects, Congenital
Atrioventricular canal defect in patients with RASopathies.
Heart Defects, Congenital
Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort.
Heart Defects, Congenital
Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.
Heart Defects, Congenital
Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines.
Heart Defects, Congenital
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
Heart Defects, Congenital
Germ-line and somatic PTPN11 mutations in human disease.
Heart Defects, Congenital
Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders.
Heart Defects, Congenital
Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma.
Heart Defects, Congenital
Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
Heart Defects, Congenital
Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome.
Heart Defects, Congenital
PTPN11 mutations play a minor role in isolated congenital heart disease.
Heart Defects, Congenital
PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.
Heart Defects, Congenital
Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta.
Heart Defects, Congenital
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
Heart Defects, Congenital
SHP-2 regulates growth factor dependent vascular signalling and function.
Heart Defects, Congenital
The genetics of congenital heart disease: a review of recent developments.
Heart Defects, Congenital
The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.
Heart Diseases
Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.
Heart Diseases
Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
Heart Diseases
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
Heart Diseases
Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.
Heart Diseases
Pyrrolo[1,2-a]quinoxal-5-inium salts and 4,5-dihydropyrrolo[1,2-a]quinoxalines: Synthesis, activity and computational docking for protein tyrosine phosphatase 1B.
Heart Failure
Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort.
Heart Failure
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Heart Failure
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Heart Failure
Diabetic cardiomyopathy: a "cardiac stem cell disease" involving p66Shc, an attractive novel molecular target for heart failure therapy.
Heart Failure
Differential gene expression in skeletal muscle after induction of heart failure: impact of cytokines on protein phosphatase 2A expression.
Heart Failure
Distinct signaling functions for Shc isoforms in the heart.
Heart Failure
Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice.
Heart Failure
Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B-deficient mice.
Heart Failure
Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data.
Heart Failure
Gene Deletion of Protein Tyrosine Phosphatase 1B Protects Against Sepsis-Induced Cardiovascular Dysfunction and Mortality.
Heart Failure
Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.
Heart Failure
Implantable cardioverter defibrillator for progressive hypertrophic cardiomyopathy in a patient with LEOPARD syndrome and a novel PTPN11 mutation Gln510His.
Heart Failure
Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure.
Heart Failure
Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts.
Heart Failure
P66Shc deletion ameliorates oxidative stress and cardiac dysfunction in pressure overload-induced heart failure.
Heart Failure
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.
Heart Failure
Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction.
Heart Failure
Protein Tyrosine Phosphatase-1B inactivation limits aging-associated heart failure in mice.
Heart Failure
Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.
Heart Failure
Role of protein tyrosine phosphatase 1B in cardiovascular diseases.
Heart Failure
The metabolic behaviour of the lymphocytes from serous effusions in various benign internal diseases.
Heart Failure
The NF-kB regulates the SHP-1 expression in monocytes in congestive heart failure.
Heart Failure
[New pharmacological approaches in heart failure: should we treat the endothelium?]
Heart Septal Defects, Atrial
A PTPN11 mutation in a woman with Noonan syndrome and protein-losing enteropathy.
Heart Septal Defects, Atrial
Case report: Noonan syndrome with multiple giant cell lesions and review of the literature.
Heart Septal Defects, Atrial
The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 gene.
Heart Septal Defects, Atrial
The spectrum of genetic variants and phenotypic features of Southeast Asian patients with Noonan syndrome.
Heart Septal Defects, Ventricular
Mosaic partial deletion of PTPN12 in a child with interrupted aortic arch type A.
Hemangioblastoma
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
Hemangioma
Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK.
Hemangioma
Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.
Hemangioma, Cavernous, Central Nervous System
Association of Variants in FCGR2A, PTPN2 and GM-CSF with Cerebral Cavernous Malformation: Potential Biomarkers for Symptomatic Disease.
Hemangioma, Cavernous, Central Nervous System
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.
Hemangiosarcoma
A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS).
Hemangiosarcoma
Angiogenesis-related gene mutations drive a subset of angiosarcomas.
Hemangiosarcoma
Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma.
Hemangiosarcoma
Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
Hematologic Neoplasms
A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.
Hematologic Neoplasms
A First Case Report of Subependymoma in PTPN11 Mutation-Associated Noonan Syndrome.
Hematologic Neoplasms
Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia.
Hematologic Neoplasms
Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia.
Hematologic Neoplasms
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Hematologic Neoplasms
Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.
Hematologic Neoplasms
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling.
Hematologic Neoplasms
High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to non-hodgkin's lymphoma.
Hematologic Neoplasms
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Hematologic Neoplasms
Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation.
Hematologic Neoplasms
Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.
Hematologic Neoplasms
Juvenile myelomonocytic leukemia-associated variants are associated with neo-natal lethal Noonan syndrome.
Hematologic Neoplasms
Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells.
Hematologic Neoplasms
Mutations in tyrosine kinase and tyrosine phosphatase and their relevance to the target therapy in hematologic malignancies.
Hematologic Neoplasms
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.
Hematologic Neoplasms
Noonan Syndrome and Related Disorders: Genetics and Pathogenesis.
Hematologic Neoplasms
Noonan syndrome and related disorders: genetics and pathogenesis.
Hematologic Neoplasms
Protein Tyrosine Phosphatase SHP-2 (PTPN11) in Hematopoiesis and Leukemogenesis.
Hematologic Neoplasms
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group.
Hematologic Neoplasms
PTPN22 Silencing in Human Acute T-Cell Leukemia Cell Line (Jurkat Cell) and its Effect on the Expression of miR-181a and miR-181b.
Hematologic Neoplasms
Recipient PTPN22 -1123 C/C genotype predicts acute graft-versus-host disease after HLA fully matched unrelated bone marrow transplantation for hematologic malignancies.
Hematologic Neoplasms
SHP-1 Protein Tyrosine Phosphatase Associates with the Adaptor Protein CrkL.
Hematologic Neoplasms
SHP-2 and myeloid malignancies.
Hematologic Neoplasms
Structural and functional effects of disease-causing amino acid substitutions affecting residues Ala72 and Glu76 of the protein tyrosine phosphatase SHP-2.
Hematologic Neoplasms
Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase.
Hematologic Neoplasms
Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin.
Hematologic Neoplasms
Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis.
Hematologic Neoplasms
The Fetal Phenotype of Noonan Syndrome Caused by Severe, Cancer-Related PTPN11 Variants.
Hematologic Neoplasms
The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/?-catenin signaling pathway.
Hematologic Neoplasms
The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.
Hematologic Neoplasms
The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.
Hematologic Neoplasms
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Hematologic Neoplasms
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Hematologic Neoplasms
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Hematologic Neoplasms
[Expression and Significance of PTPL1 in Hematological Malignan-cies].
Hematologic Neoplasms
[The Biological Function of SHP2 in Human Disease].
Hemochromatosis
Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes.
Hemochromatosis
Iron content and acid phosphatase activity in hepatic parenchymal lysosomes of patients with hemochromatosis before and after phlebotomy treatment.
Hemorrhagic Fever, Ebola
Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.
Hemorrhagic Stroke
[Blood serum enzymatic spectrum in vascular diseases of the brain]
Hemorrhoids
miR-412-5p targets Xpo1 to regulate angiogenesis in hemorrhoid tissue.
Hepatitis
Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A.
Hepatitis
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.
Hepatitis
[The morphologic basis for the mechanism of increased serum acid phosphatase activity in patients with viral hepatitis]
Hepatitis B
Anti-oncogene PTPN13 inactivation by hepatitis B virus X protein counteracts IGF2BP1 to promote hepatocellular carcinoma progression.
Hepatitis B
CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.
Hepatitis B
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Hepatitis B
Hepatitis B virus X protein impairs ?-interferon signaling via up-regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A.
Hepatitis B
Hepatitis B virus X protein mutant HBx?127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT.
Hepatitis B
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Hepatitis B
Protein phosphatase 2A impairs IFN?-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation.
Hepatitis B
Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1.
Hepatitis B
Suppression of hepatitis B viral gene expression by protein-tyrosine phosphatase PTPN3.
Hepatitis B
[Effect of PTPRD rs2279776 gene and interaction with hepatitis B virus mutations on the risk of hepatocellular carcinoma].
Hepatitis B
[Functional-metabolic activity of the mononuclear phagocyte system of the blood, liver, spleen and skin in children with hepatitis B]
Hepatitis B, Chronic
Association of PTPN22 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.
Hepatitis C
Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy.
Hepatitis C
Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line.
Hepatitis C
Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis.
Hepatitis C
Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.
Hepatitis C
Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-{gamma} production.
Hepatitis C
Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.
Hepatitis C
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.
Hepatitis C
Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase.
Hepatitis C
Protein phosphatase 2A impairs IFN?-induced antiviral activity against the hepatitis C virus through the inhibition of STAT1 tyrosine phosphorylation.
Hepatitis C
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
Hepatitis C
Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients.
Hepatitis C
PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection.
Hepatitis C
Suppression of dual specificity phosphatase I expression inhibits hepatitis C virus replication.
Hepatitis C
The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein.
Hepatitis C, Chronic
Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.
Hepatitis C, Chronic
Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair.
Hepatitis C, Chronic
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.
Hepatitis C, Chronic
PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection.
Hepatitis C, Chronic
Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C.
Hepatitis, Alcoholic
Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice.
Hepatitis, Autoimmune
77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link.
Hepatitis, Autoimmune
Association of STAT4, TGF?1, SH2B3 and PTPN22 polymorphisms with autoimmune hepatitis.
Hepatitis, Autoimmune
C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis.
Hepatitis, Autoimmune
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Hepatoblastoma
Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation.
Hepatoblastoma
In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas.
Hepatoblastoma
The p66shc-mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease.
Hepatolenticular Degeneration
Electron probe microanalysis of liver in Wilson's disease. Simultaneous assay for copper and for lead deposited by acid phosphatase activity in lysosomes.
Hepatolenticular Degeneration
LIVER CELL LYSOSOMES IN WILSON'S DISEASE: ACID PHOSPHATASE ACTIVITY BY LIGHT AND ELECTRON MICROSCOPY.
Hepatolenticular Degeneration
Studies on the pathogenesis of hepatolenticular degeneration. I. Acid phosphatase activity in copper-loaded rat livers.
Hepatomegaly
Biological action of lantadene C, a new hepatotoxicant from Lantana camara var. aculeata.
Hepatomegaly
Effect of polymorphic crystal forms of lantana toxins on icterogenic action in guinea pigs.
Hepatomegaly
Molecular structure, polymorphism, and toxicity of lantadene A, the pentacyclic triterpenoid from the hepatotoxic plant Lantana camara.
Hernias, Diaphragmatic, Congenital
Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants.
Herpes Simplex
Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity.
Herpes Simplex
Role of Cellular Phosphatase cdc25C in Herpes Simplex Virus 1 Replication.
Herpes Simplex
Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries.
Herpes Simplex
The ESCRT-II Subunit EAP20/VPS25 and the Bro1 Domain Proteins HD-PTP and BROX Are Individually Dispensable for Herpes Simplex Virus 1 Replication.
Herpes Simplex
The Interaction of Herpes Simplex Virus 1 Regulatory Protein ICP22 with the cdc25C Phosphatase Is Enabled In Vitro by Viral Protein Kinases US3 and UL13.
Herpes Zoster
ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
Herpes Zoster
The localisation of acid phosphatase activity changes in lysosomes in the adrenal zona fasciculata of intact and hypophysectomized rats following ACTH administration.
Hirschsprung Disease
Downregulation of Protein Tyrosine Phosphatase Receptor Type R Accounts for the Progression of Hirschsprung Disease.
Histiocytic Sarcoma
Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas.
Histiocytic Sarcoma
Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.
Histiocytic Sarcoma
Gain-of-function mutation in PTPN11 in histiocytic sarcomas of Bernese Mountain Dogs.
Histiocytic Sarcoma
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma.
Histiocytic Sarcoma
PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
Histiocytosis
an aggressive multifocal primary CNS histiocytosis with PTPN11 (Shp2) mutation.
Histiocytosis
Response to trametinib of histiocytosis with an activating PTPN11 mutation.
Histiocytosis
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
Histiocytosis, Langerhans-Cell
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
histone deacetylase deficiency
Inhibition of myeloid HDAC2 upregulates glutaredoxin 1 expression, improves protein thiol redox state and protects against high-calorie diet-induced monocyte dysfunction and atherosclerosis.
Hodgkin Disease
A modified version of galectin-9 induces cell cycle arrest and apoptosis of Burkitt and Hodgkin lymphoma cells.
Hodgkin Disease
A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells.
Hodgkin Disease
Acid phosphatase activity in monocytes and sera of patients with Hodgkin's disease.
Hodgkin Disease
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.
Hodgkin Disease
Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations.
Hodgkin Disease
Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin lymphoma and T-cell non-Hodgkin lymphoma.
Hodgkin Disease
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration.
Hodgkin Disease
PTPN1 Is Recurrently Mutated in Lymphoid Cancers.
Hodgkin Disease
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.
Hodgkin Disease
The PTP1B mutant PTP1B?2-4 is a positive regulator of the JAK/STAT signalling pathway in Hodgkin lymphoma.
Hodgkin Disease
[Granulocyte acid phosphatase activity during the course of chronic myeloid leukemia and Hodgkin's disease]
Hodgkin Disease
[Granulocyte acid phosphatase activity in patients with Hodgkin's disease]
HTLV-I Infections
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
HTLV-I Infections
Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.
Huntington Disease
Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.
Huntington Disease
Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.
Huntington Disease
MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
Huntington Disease
Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.
Huntington Disease
Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.
Hydrocephalus
A First Case Report of Subependymoma in PTPN11 Mutation-Associated Noonan Syndrome.
Hydrocephalus
External hydrocephalus as a prenatal feature of noonan syndrome.
Hydrocephalus
Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
Hydrocephalus
Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus.
Hydrocephalus
PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus.
Hydrocephalus, Normal Pressure
PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus.
Hydrops Fetalis
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia.
Hydrops Fetalis
Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings.
Hydrops Fetalis
PTPN11 gene mutation associated with abnormal gonadal determination.
Hydrothorax
Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings.
Hyperalgesia
BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation.
Hyperalgesia
CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway.
Hyperalgesia
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
Hyperalgesia
Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice.
Hyperalgesia
Prooxidant-induced c-Src/nuclear factor kappa B-coupled signalling in sensory ganglia mediates cutaneous hyperalgesia.
Hyperalgesia
Propentofylline reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatase-1: An experimental study in a rat model of acute incisional pain.
Hyperalgesia
Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.
Hyperalgesia
Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain.
Hyperalgesia
Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K.
Hypercholesterolemia
Effect of bis(maltolato) oxovanadium on experimental vascular endothelial dysfunction.
Hypercholesterolemia
Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction.
Hypercholesterolemia
Mechanism of attenuation of diabetes mellitus and hypercholesterolemia induced vascular endothelial dysfunction by protein tyrosine phosphatase inhibition.
Hypercholesterolemia
P66Shc mediates increased platelet activation and aggregation in hypercholesterolemia.
Hypercholesterolemia
Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models.
Hypercholesterolemia
[Prescription of Jingdan Yimin for treatment of metabolic syndrome].
Hyperglycemia
Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy.
Hyperglycemia
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus.
Hyperglycemia
Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.
Hyperglycemia
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Hyperglycemia
Cardiac mitochondrial dysfunction during hyperglycemia-The role of oxidative stress and p66Shc signaling.
Hyperglycemia
Diterpenes from seeds of Phalaris canariensis and their PTP1B inhibitory activity and hypoglycemic effects in streptozotocin-induced diabetic mice.
Hyperglycemia
Effects of PPAR-gamma knock-down and hyperglycemia on insulin signaling in vascular smooth muscle cells from hypertensive rats.
Hyperglycemia
Expression of SHP-1 Induced by Hyperglycemia Prevents Insulin Actions in Podocytes.
Hyperglycemia
Glomerular VEGF resistance induced by PKC?/SHP-1 activation and contribution to diabetic nephropathy.
Hyperglycemia
Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease.
Hyperglycemia
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Hyperglycemia
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Hyperglycemia
Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction.
Hyperglycemia
Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.
Hyperglycemia
Hypomethylation of the promoter of the catalytic subunit of protein phosphatase 2A in response to hyperglycemia.
Hyperglycemia
Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
Hyperglycemia
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.
Hyperglycemia
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.
Hyperglycemia
Integrin-associated protein association with SRC homology 2 domain containing tyrosine phosphatase substrate 1 regulates igf-I signaling in vivo.
Hyperglycemia
IRS2-deficient mice show sensorineural hearing loss that is delayed by concomitant PTP1B loss of function.
Hyperglycemia
Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.
Hyperglycemia
Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.
Hyperglycemia
MAP Kinase Phosphatase 3 (MKP-3) Deficient Mice Are Resistant to Diet Induced-Obesity.
Hyperglycemia
MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis.
Hyperglycemia
Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice.
Hyperglycemia
P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Hyperglycemia
Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes.
Hyperglycemia
Protective effects of Salvia miltiorrhiza injection against learning and memory impairments in streptozotocin-induced diabetic rats.
Hyperglycemia
Protein tyrosine phosphatase 1B is impaired in skeletal muscle of diabetic Psammomys obesus.
Hyperglycemia
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Hyperglycemia
Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.
Hyperglycemia
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
Hyperglycemia
Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.
Hyperglycemia
Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
Hyperglycemia
Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.
Hyperhomocysteinemia
Attenuation of hyperhomocysteinemia induced vascular dementia by sodium orthovanadate perhaps via PTP1B: Pertinent downstream outcomes.
Hyperinsulinism
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Hyperinsulinism
Chronic insulin treatment suppresses PTP1B function, induces increased PDGF signaling, and amplifies neointima formation in the balloon-injured rat artery.
Hyperinsulinism
Effect of Saxagliptin, a Dipeptidyl Peptidase 4 Inhibitor, on Non-Alcoholic Fatty Liver Disease.
Hyperinsulinism
Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes.
Hyperinsulinism
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Hyperinsulinism
Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.
Hyperinsulinism
Insulin-inducible changes in the relative ratio of PTP1B splice variants.
Hyperinsulinism
Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.
Hyperinsulinism
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis.
Hyperinsulinism
Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes.
Hyperlipidemias
P66Shc and vascular endothelial function.
Hyperostosis
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome: is PTPN22 involved?
Hyperparathyroidism
[Blood serum alkaline and acid phosphatase activity in different forms of hyperparathyroidism]
Hypersensitivity
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.
Hypersensitivity
A putative P-type ATPase, Apt1, is involved in stress tolerance and virulence in Cryptococcus neoformans.
Hypersensitivity
Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
Hypersensitivity
Arabidopsis MAP kinase phosphatase 1 and its target MAP kinases 3 and 6 antagonistically determine UV-B stress tolerance, independent of the UVR8 photoreceptor pathway.
Hypersensitivity
Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.
Hypersensitivity
Clinical course of juvenile myelomonocytic leukemia in the blast crisis phase treated by acute myeloid leukemia-oriented chemotherapy and allogeneic hematopoietic stem cell transplantation.
Hypersensitivity
Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines.
Hypersensitivity
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling.
Hypersensitivity
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Hypersensitivity
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
Hypersensitivity
Human Leukocyte Antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 Haplotypes Are Associated with Humoral Responses to Early Food Allergens in Children.
Hypersensitivity
Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.
Hypersensitivity
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
Hypersensitivity
Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.
Hypersensitivity
Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.
Hypersensitivity
Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.
Hypersensitivity
MiR-101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP-1 mediated MAPK pathway.
Hypersensitivity
Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain.
Hypersensitivity
Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice.
Hypersensitivity
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
Hypersensitivity
Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells.
Hypersensitivity
SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis.
Hypersensitivity
Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.
Hypersensitivity
Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model.
Hypersensitivity
Striatal-enriched phosphatase 61 inhibited the nociceptive plasticity in spinal cord dorsal horn of rats.
Hypersensitivity
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Hypersensitivity
Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.
Hypersensitivity
[Acid phosphatase activity in peripheral blood cells in streptococcal allergy of the immediate type]
Hypersensitivity
[Classification and etiology of hyperthyroidism].
Hypertelorism
B56?-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
Hypertelorism
Giant Cell Lesions in Noonan Syndrome: Case Report and Review of The Literature.
Hypertelorism
LEOPARD Syndrome with PTPN11 Gene Mutation Showing Six Cardinal Symptoms of LEOPARD.
Hypertelorism
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.
Hypertension
Activity of two enzymes associated with apoptosis and cell aging in arterial hypertension.
Hypertension
Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate.
Hypertension
Aortic cholesterol esterase and other lysosomal enzyme activities in DOCA-salt, renal and spontaneous hypertension in the rat.
Hypertension
Association of genetic variants with chronic kidney disease in Japanese individuals with or without hypertension or diabetes mellitus.
Hypertension
Berberine attenuates pulmonary arterial hypertension via protein phosphatase 2A signaling pathway both in vivo and in vitro.
Hypertension
Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.
Hypertension
Differences in Oxidative Stress Status and Expression of MKP-1 in Dorsal Medulla of Transgenic Rats with Altered Brain Renin-Angiotensin System.
Hypertension
Distribution of the number of false discoveries in large-scale family-based association testing with application to the association between PTPN1 and hypertension and obesity.
Hypertension
Extracellular signal-regulated kinase 1/2 activation, via downregulation of mitogen-activated protein kinase phosphatase 1, mediates sex differences in desoxycorticosterone acetate-salt hypertension vascular reactivity.
Hypertension
Hypertension: Role of p66Shc in renal vascular dysfunction.
Hypertension
In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes.
Hypertension
Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension.
Hypertension
MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation.
Hypertension
Molecular pathways of aging and hypertension.
Hypertension
Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signalling pathway in mice.
Hypertension
p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.
Hypertension
p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.
Hypertension
Protein tyrosine phosphatase 1B gene polymorphisms and essential hypertension: a case-control study in Chinese population.
Hypertension
PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.
Hypertension
Regulation of mitogen-activated protein kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and potential defects in hypertension.
Hypertension
Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure.
Hypertension
Renal protein phosphatase 2A activity and spontaneous hypertension in rats.
Hypertension
Replication of Genome-Wide Association Signals of Type 2 Diabetes in Han Chinese in a Prospective Cohort.
Hypertension
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
Hypertension
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation.
Hypertension
Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes.
Hypertension
VE-PTP inhibition elicits eNOS phosphorylation to blunt endothelial dysfunction and hypertension in diabetes.
Hypertension
VE-PTP inhibition: a novel therapeutic target for hypertension in diabetic patients.
Hypertension
[Determination of dehydrogenase and acid phosphatase activity in the lymphocytes in hypertension and vasorenal hypertension]
Hypertension, Portal
Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.
Hypertension, Pulmonary
Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia.
Hypertension, Pulmonary
Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.
Hypertension, Pulmonary
MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation.
Hypertension, Pulmonary
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.
Hyperthyroidism
Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves hyperthyroidism.
Hyperthyroidism
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Hyperthyroidism
Specific activities of seminal vesicular phosphomonoesterases and Mg2+-,Ca2+- and Na+/K(+)-adenosine triphosphatases in hypo- and hyperthyroid albino rats.
Hyperthyroidism
[Cytochemical properties of peripheral blood neutrophils in patients with hyperthyroidism]
Hypertriglyceridemia
Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats.
Hypertriglyceridemia
Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.
Hypocalcemia
Hypocalcemia associated with estrogen therapy for metastatic adenocarcinoma of the prostate.
Hypoglycemia
Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia.
Hypoglycemia
Sulphonamides as inhibitors of protein tyrosine phosphatase 1B: a three-dimensional quantitative structure-activity relationship study using self-organizing molecular field analysis approach.
Hypogonadism
Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3?-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.
Hypoparathyroidism
Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.
Hypophosphatasia
Normal circulating acid phosphatase activity in hypophosphatasia.
Hypophosphatasia
Persistently raised serum acid phosphatase activity in a patient with hypophosphatasia: electrophoretic and molecular weight characterisation as type 5.
Hypopigmentation
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
Hypoproteinemia
A PTPN11 mutation in a woman with Noonan syndrome and protein-losing enteropathy.
Hypospadias
[Clinical and genetic analysis of Noonan syndrome in 20 children].
Hypotension
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
Hypotension
Differences in Oxidative Stress Status and Expression of MKP-1 in Dorsal Medulla of Transgenic Rats with Altered Brain Renin-Angiotensin System.
Hypotension
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.
Hypotension
MAP Kinase Phosphatase-1 and Septic Shock.
Hypotension
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.
Hypothyroidism
A phenome-wide association study of 26 mendelian genes reveals phenotypic expressivity of common and rare variants within the general population.
Hypothyroidism
Familial autoimmune thyroid disease and PTPN-22.
Hypothyroidism
Novel associations for hypothyroidism include known autoimmune risk loci.
Hypoxia, Brain
Effect of hypoxia on the expression and activity of mitogen-activated protein (MAP) kinase-phosphatase-1 (MKP-1) and MKP-3 in neuronal nuclei of newborn piglets: the role of nitric oxide.
Hypoxia, Brain
Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model.
Hypoxia, Brain
Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.
Hypoxia-Ischemia, Brain
The cytochemistry of anoxic and anoxic-ischemic encephalopathy in rats. I. Alterations in neuronal lysosomes identified by acid phosphatase activity.
Idiopathic Pulmonary Fibrosis
CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis.
Idiopathic Pulmonary Fibrosis
Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis.
IgA Deficiency
A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population.
IgA Vasculitis
Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.
Immune System Diseases
CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.
Immune System Diseases
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Immune System Diseases
Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Immune System Diseases
Tumor microenvironment related novel signature predict lung adenocarcinoma survival.
Infarction, Middle Cerebral Artery
Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat.
Infarction, Middle Cerebral Artery
Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.
Infections
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection.
Infections
A focused library of protein tyrosine phosphatase inhibitors.
Infections
A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats.
Infections
A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1.
Infections
A translocated protein tyrosine phosphatase of Pseudomonas syringae pv. tomato DC3000 modulates plant defence response to infection.
Infections
Abnormal IFN-gamma-dependent immunoproteasome modulation by Trypanosoma cruzi-infected macrophages.
Infections
Acid phosphatase activity in hemolymph of the migratory grasshopper, Melanoplus sanguinipes, during Beauveria bassiana infection.
Infections
Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation.
Infections
An ecto-protein tyrosine phosphatase of Entamoeba histolytica induces cellular detachment by disruption of actin filaments in HeLa cells.
Infections
Anaplasma phagocytophilum AnkA is tyrosine-phosphorylated at EPIYA motifs and recruits SHP-1 during early infection.
Infections
Anti-tumor necrosis factor ? treatment promotes apoptosis and prevents liver regeneration in a transgenic mouse model of chronic hepatitis C.
Infections
Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer.
Infections
Association of PTPN22 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.
Infections
Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.
Infections
Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese.
Infections
Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.
Infections
Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?
Infections
B Cell-Intrinsic Expression of Interferon Regulatory Factor 1 Supports Chronic Murine Gammaherpesvirus 68 Infection.
Infections
CD40-Modulated Dual-Specificity Phosphatases MAPK Phosphatase (MKP)-1 and MKP-3 Reciprocally Regulate Leishmania major Infection.
Infections
Cdc25A phosphatase suppresses apoptosis induced by serum deprivation.
Infections
CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.
Infections
Celiac disease as an autoimmune condition.
Infections
Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.
Infections
Change in the isoenzyme composition of acid phosphatase in murine peritoneal macrophages exposed to or infected with Trypanosoma cruzi.
Infections
Characterization and kinetic analysis of protein tyrosine phosphatase-H2 from Microplitis demolitor bracovirus.
Infections
Characterization of a protein tyrosine phosphatase as a host factor promoting baculovirus replication in silkworm, Bombyx mori.
Infections
Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in the resistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection.
Infections
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth.
Infections
Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A.
Infections
Classical Examples of the Concept of the ASIA Syndrome.
Infections
Comparative Study of the Ability of Leishmania mexicana Promastigotes and Amastigotes to Alter Macrophage Signalling and Functions.
Infections
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus.
Infections
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Infections
Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major.
Infections
Decrease of acid phosphatase activity in murine peritoneal macrophages infected with Leishmania donovani.
Infections
Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.
Infections
Deletion of the Dual Specific Phosphatase-4 (DUSP-4) Gene Reveals an Essential Non-redundant Role for MAP Kinase Phosphatase-2 (MKP-2) in Proliferation and Cell Survival.
Infections
Differential gene expression of ASUN, NEMF, PTPRC and DHX29: Candidate biomarkers for diagnosis of active and latent tuberculosis.
Infections
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Infections
Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs.
Infections
Downmodulation of Effector Functions in NK Cells upon Toxoplasma gondii Infection.
Infections
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Infections
Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways.
Infections
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Infections
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis.
Infections
Effect of virulent and less virulent strains of Nocardia asteroides on acid-phosphatase activity in alveolar and peritoneal macrophages maintained in vitro.
Infections
Endophyte-mediated effects on the growth and physiology of Achnatherum sibiricum are conditional on both N and P availability.
Infections
Environmental factors related to the induction of beta-cell autoantibodies in 1-yr-old healthy children.
Infections
Enzymatic changes in serum and tissues in fowl infected with a neurotropic-mesogenic strain of Newcastle disease virus.
Infections
Escherichia coli cyclomodulin Cif induces G2 arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway.
Infections
Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium.
Infections
Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis.
Infections
Expression and significance of SHP-2 in human papillomavirus infected cervical cancer.
Infections
Expression of SHP-1 phosphatase indicates post-germinal center cell derivation of B-cell posttransplant lymphoproliferative disorders.
Infections
Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits.
Infections
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection.
Infections
First genome-wide association study of non-severe malaria in two birth cohorts in Benin.
Infections
Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis.
Infections
Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions.
Infections
Genome-wide survey for baculoviral host homologs using the Bombyx genome sequence.
Infections
Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy.
Infections
Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.
Infections
Hepatitis C Virus Enhances the Invasiveness of Hepatocellular Carcinoma via EGFR-Mediated Invadopodia Formation and Activation.
Infections
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.
Infections
Histochemical differentiation of filarial larvae found in Simulium damnosum s.l. in West Africa.
Infections
Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation.
Infections
Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.
Infections
Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5.
Infections
Human genes in TB infection: their role in immune response.
Infections
Hydrolytic enzyme activity in rhesus monkey placenta during early gestational malaria: histochemical studies.
Infections
Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway.
Infections
Identification of a PP2A gene in Bombyx mori with antiviral function against B. mori nucleopolyhedrovirus.
Infections
Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1.
Infections
Identification of lncRNA-155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection.
Infections
Identification of replication-competent HSV-1 Cgal+ strain signaling targets in human hepatoma cells by functional organelle proteomics.
Infections
IFN-alpha beta secreted during infection is necessary but not sufficient for negative feedback regulation of IFN-alpha beta signaling by Mycobacterium tuberculosis.
Infections
Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Infections
Immunological consequences of intestinal helminth infections: antigen presentation and immunosuppression by peritoneal cells.
Infections
Impaired CD45-associated tyrosine phosphatase activity during HIV-1 infection: implications for CD3 and CD4 receptor signalling.
Infections
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.
Infections
Insulin gene profile cycles with season of birth of future diabetic children and their relatives.
Infections
Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs.
Infections
Intracellular acid phosphatase content and ability of different macrophage populations to kill Nocardia asteroides.
Infections
Involvement of MAP-kinases and -phosphatases in uptake and intracellular replication of Listeria monocytogenes in J774 macrophage cells.
Infections
Involvement of protein tyrosine kinases and phosphatases in uptake and intracellular replication of virulent and avirulent Leishmania donovani promastigotes in mouse macrophage cells.
Infections
Involvement of the cellular phosphatase DUSP1 in vaccinia virus infection.
Infections
Isolation of two Locust protein targets of a protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102.
Infections
Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection.
Infections
Legionella pneumophila major acid phosphatase and its role in intracellular infection.
Infections
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice.
Infections
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.
Infections
Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif.
Infections
Malabsorption syndrome observed in the common octopus Octopus vulgaris infected with Aggregata octopiana (Protista: Apicomplexa).
Infections
MAP Kinase Phosphatase-1 and Septic Shock.
Infections
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.
Infections
MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response.
Infections
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana.
Infections
MicroRNA exporter HuR clears the internalized pathogens by promoting pro-inflammatory response in infected macrophages.
Infections
MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a.
Infections
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis.
Infections
MKP-2: out of the DUSP-bin and back into the limelight.
Infections
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Infections
MptpB Promotes Mycobacteria Survival by Inhibiting the Expression of Inflammatory Mediators and Cell Apoptosis in Macrophages.
Infections
Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection.
Infections
Mycobacterium avium Subspecies paratuberculosis Infects and Replicates within Human Monocyte-Derived Dendritic Cells.
Infections
Natural Killer Cell Licensing During Viral Infection.
Infections
New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB.
Infections
Nonreceptor protein tyrosine phosphatases (NRPTPs) gene family associates with the risk of hepatocellular carcinoma in a Chinese hepatitis B virus-related subjects.
Infections
Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.
Infections
Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells.
Infections
Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis.
Infections
Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity.
Infections
Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.
Infections
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Infections
Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.
Infections
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Infections
Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.
Infections
PP2A-dependent control of transcriptionally active FOXO3a in CD8(+) central memory lymphocyte survival requires p47(phox).
Infections
Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
Infections
Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia.
Infections
Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer.
Infections
Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations.
Infections
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function.
Infections
Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses.
Infections
Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling.
Infections
Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection.
Infections
Proteomic identification of plasma protein tyrosine phosphatase alpha and fibronectin associated with liver fluke, Opisthorchis viverrini, infection.
Infections
PTP1B negatively regulates STAT1-independent Pseudomonas aeruginosa killing by macrophages.
Infections
PtpA, a secreted tyrosine phosphatase from Staphylococcus aureus, contributes to virulence and interacts with coronin-1A during infection.
Infections
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
Infections
Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases.
Infections
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
Infections
Recombinant adenovirus of human p66Shc inhibits MCF-7 cell proliferation.
Infections
Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.
Infections
Reduced pathogenicity of a Candida albicans MAP kinase phosphatase (CPP1) mutant in the murine mastitis model.
Infections
Regulation of innate immune response by MAP kinase phosphatase-1.
Infections
Relationship between the diversity of the cagA gene of Helicobacter pylori and gastric cancer in Okinawa, Japan.
Infections
Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production.
Infections
Role of SHP2 Protein Tyrosine Phosphatase in SERT Inhibition by Enteropathogenic E. coli (EPEC).
Infections
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.
Infections
SHP-1 Acts as a Tumor Suppressor in Hepatocarcinogenesis and HCC Progression.
Infections
SHP-1 As a Critical Regulator of Mycoplasma pneumoniae-Induced Inflammation in Human Asthmatic Airway Epithelial Cells.
Infections
SHP-1 plays a crucial role in CD40 signaling reciprocity.
Infections
SHP-1-Dependent Macrophage Differentiation Exacerbates Virus-Induced Myositis.
Infections
Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-?-induced Jak/Stat1 pathway.
Infections
SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells.
Infections
SHP1 tyrosine phosphatase gets involved in host defense against Streptococcus agalactiae infection and BCR signaling pathway in Nile tilapia (Oreochromis niloticus).
Infections
Significance of SHP-1 and SHP-2 Expression in Human Papillomavirus Infected Condyloma acuminatum and Cervical Cancer.
Infections
SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4 in susceptibility to gastric carcinogenesis.
Infections
Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.
Infections
Suppression of dual specificity phosphatase I expression inhibits hepatitis C virus replication.
Infections
Suppression of inflammatory and infection responses in lung macrophages by eucalyptus oil and its constituent 1,8-cineole: Role of pattern recognition receptors TREM-1 and NLRP3, the MAP kinase regulator MKP-1, and NF?B.
Infections
Susceptibility of naïve and differentiated PC12 cells to Japanese encephalitis virus infection.
Infections
T Cell Hypo-Responsiveness against Leishmania major in MAP Kinase Phosphatase (MKP) 2 Deficient C57BL/6 Mice Does Not Alter the Healer Disease Phenotype.
Infections
TGF-?(1) re-programs TLR4 signaling in L. donovani infection: enhancement of SHP-1 and ubiquitin-editing enzyme A20.
Infections
The apo-structure of the low-molecular-weight protein tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development.
Infections
The Aspergillus flavus Phosphatase CDC14 Regulates Development, Aflatoxin Biosynthesis and Pathogenicity.
Infections
The effect of intracellular Chlamydia psittaci on lysosomal enzyme activities in mouse peritoneal macrophages.
Infections
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.
Infections
The hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistance.
Infections
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.
Infections
The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes.
Infections
The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.
Infections
The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication.
Infections
Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.
Infections
Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis.
Infections
Thyroid autoimmunity.
Infections
TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice.
Infections
Transformation of mouse peritoneal macrophages and bone marrow cells by simian virus 40.
Infections
Tyrosine phosphatase MptpA of Mycobacterium tuberculosis inhibits phagocytosis and increases actin polymerization in macrophages.
Infections
Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease.
Infections
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Infections
Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant.
Infections
Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity.
Infections
Weighted gene co-expression network analysis and drug-gene interaction bioinformatics uncover key genes associated with various presentations of malaria infection in African children and major drug candidates.
Infections
Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor-Mediated T-Cell Function by an RNA-Based Mechanism.
Infections
[Network pharmacology study of Yi medicine Jinweitai Capsules in treating gastrointestinal diseases].
Infertility
Acid phosphatase activity in human uterine fluid in relation to infertility.
Infertility
Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice.
Infertility
Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain.
Infertility
P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.
Infertility
Seminal acid phosphatase in relation to fertility.
Infertility
Sustained High Protein-tyrosine Phosphatase 1B Activity in the Sperm of Obese Males Impairs the Sperm Acrosome Reaction.
Infertility
When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).
Infertility
[Clinical and experimental studies on male infertility. 2. Experimental studies. Histochemical demonstration of acid phosphatase activity in the testes of mice and their responce to the drugs for the male infertility (author's transl)]
Infertility
[Expression levels of Cdc2 and Cdc25A mRNA in cattle, yak, and cattle-yak testis]
Infertility, Female
Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.
Infertility, Male
Inhibition of CDC2/Cyclin B1 in response to selenium-induced oxidative stress during spermatogenesis: potential role of Cdc25c and p21.
Infertility, Male
Integrated Analysis of DNA Methylation and mRNA Expression Profiles to Identify Key Genes in Severe Oligozoospermia.
Infertility, Male
Post-transcriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis.
Infertility, Male
Sustained High Protein-tyrosine Phosphatase 1B Activity in the Sperm of Obese Males Impairs the Sperm Acrosome Reaction.
Infertility, Male
The regulation of male fertility by the PTPN11 tyrosine phosphatase.
Infertility, Male
[Clinical and experimental studies on male infertility. 2. Experimental studies. Histochemical demonstration of acid phosphatase activity in the testes of mice and their responce to the drugs for the male infertility (author's transl)]
Inflammatory Bowel Diseases
A cell type-specific role of protein tyrosine phosphatase non-receptor type 2 in regulating ER stress signalling.
Inflammatory Bowel Diseases
Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Inflammatory Bowel Diseases
Association of the protein-tyrosine phosphatase nonreceptor type substrate 1 (PTPNS1) gene with inflammatory bowel disease.
Inflammatory Bowel Diseases
Association of ZAP70 and PTPN6, but Not BANK1 or CLEC2D, with Inflammatory Bowel Disease in the Tunisian Population.
Inflammatory Bowel Diseases
Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.
Inflammatory Bowel Diseases
Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis.
Inflammatory Bowel Diseases
Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.
Inflammatory Bowel Diseases
GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.
Inflammatory Bowel Diseases
Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase.
Inflammatory Bowel Diseases
Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.
Inflammatory Bowel Diseases
Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-?-Induced Signaling in Human Monocytes.
Inflammatory Bowel Diseases
Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.
Inflammatory Bowel Diseases
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
Inflammatory Bowel Diseases
Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Bowel Diseases
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Inflammatory Bowel Diseases
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Inflammatory Bowel Diseases
Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort.
Inflammatory Bowel Diseases
Polymorphisms of PTPN11 coding SHP-2 as biomarkers for ulcerative colitis susceptibility in the Japanese population.
Inflammatory Bowel Diseases
Presence of PTPN2 SNP rs1893217 Enhances the Anti-inflammatory Effect of Spermidine.
Inflammatory Bowel Diseases
Protein tyrosine phosphatase ? targets apical junction complex proteins in the intestine and regulates epithelial permeability.
Inflammatory Bowel Diseases
Protein tyrosine phosphatase non-receptor type 2 and inflammatory bowel disease.
Inflammatory Bowel Diseases
Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy.
Inflammatory Bowel Diseases
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Inflammatory Bowel Diseases
PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.
Inflammatory Bowel Diseases
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Inflammatory Bowel Diseases
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Inflammatory Bowel Diseases
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
Inflammatory Bowel Diseases
rs2476601 polymorphism in PTPN22 is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.
Inflammatory Bowel Diseases
Spermidine stimulates T-cell protein tyrosine phosphatase-mediated protection of intestinal epithelial barrier function.
Inflammatory Bowel Diseases
T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells.
Inflammatory Bowel Diseases
T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus.
Inflammatory Bowel Diseases
The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.
Inflammatory Bowel Diseases
The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.
Inflammatory Bowel Diseases
The JAK inhibitor tofacitinib rescues intestinal barrier defects caused by disrupted epithelial-macrophage interactions.
Inflammatory Bowel Diseases
The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease.
Inflammatory Bowel Diseases
The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasis.
Inflammatory Bowel Diseases
The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
Inflammatory Bowel Diseases
VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-?-induced Intestinal Epithelial Barrier Defects.
Influenza, Human
A role for protein phosphatase 2A in regulating p38 mitogen activated protein kinase activation and tumor necrosis factor-alpha expression during influenza virus infection.
Influenza, Human
Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination.
Influenza, Human
CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein.
Influenza, Human
Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Influenza, Human
Protein Tyrosine Phosphatase SHP2 Suppresses Host Innate Immunity against Influenza A Virus by Regulating EGFR-Mediated Signaling.
Influenza, Human
Targeting cell division cycle 25 homolog B to regulate influenza virus replication.
Influenza, Human
Vaccinations may induce diabetes-related autoantibodies in one-year-old children.
Influenza, Human
[Biological properties of live and inactivated influenza vaccines under experimental conditions]
Influenza, Human
[Change in the acid phosphatase activity of susceptible cells at the early stages of their interaction with Sendai and influenza A2 (Hong Kong) 68 viruses]
Insulin Resistance
(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice.
Insulin Resistance
1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population.
Insulin Resistance
2,4-Thiazolidinediones as PTP 1B Inhibitors: A Mini Review (2012-2018).
Insulin Resistance
A comprehensive review on the antidiabetic activity of flavonoids targeting PTP1B and DPP-4: a structure-activity relationship analysis.
Insulin Resistance
A highly selective and potent PTP-MEG2 inhibitor with therapeutic potential for type 2 diabetes.
Insulin Resistance
A Novel Protein Tyrosine Phosphatase 1B inhibitor with Therapeutic Potential for Insulin Resistance.
Insulin Resistance
A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway.
Insulin Resistance
A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells.
Insulin Resistance
A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.
Insulin Resistance
A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance.
Insulin Resistance
Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans.
Insulin Resistance
Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.
Insulin Resistance
Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats.
Insulin Resistance
Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis.
Insulin Resistance
Adipogenic action of vanadium: a new dimension in treating diabetes.
Insulin Resistance
Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats.
Insulin Resistance
Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes.
Insulin Resistance
Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance.
Insulin Resistance
Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet.
Insulin Resistance
An evolving integrative physiology: skeleton and energy metabolism.
Insulin Resistance
An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).
Insulin Resistance
Angiotensin II-induced insulin resistance and protein tyrosine phosphatases.
Insulin Resistance
Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo.
Insulin Resistance
Anti-Diabetic Activity of 2,3,6-Tribromo-4,5-Dihydroxybenzyl Derivatives from Symphyocladia latiuscula through PTP1B Downregulation and ?-Glucosidase Inhibition.
Insulin Resistance
Anti-diabetic effects of brown algae derived phlorotannins, marine polyphenols through diverse mechanisms.
Insulin Resistance
Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition.
Insulin Resistance
Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice.
Insulin Resistance
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Insulin Resistance
Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.
Insulin Resistance
Association Between First Episode Schizophrenia, Metabolic Syndrome and Insulin Resistance-Related Proteins in Female Balb/C Mice.
Insulin Resistance
Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study.
Insulin Resistance
Association of the PTPN1 gene with type 2 diabetes and insulin resistance.
Insulin Resistance
Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people.
Insulin Resistance
Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells.
Insulin Resistance
Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-?B in C2C12 myotubes.
Insulin Resistance
Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.
Insulin Resistance
Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet.
Insulin Resistance
Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice.
Insulin Resistance
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats.
Insulin Resistance
BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.
Insulin Resistance
Binding properties of marine bromophenols with human protein tyrosine phosphatase 1B: Molecular docking, surface plasmon resonance and cellular insulin resistance study.
Insulin Resistance
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action.
Insulin Resistance
Bis(ethylmaltolato)oxidovanadium(iv) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice.
Insulin Resistance
Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP1B in Zucker rat skeletal muscle in vivo.
Insulin Resistance
BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.
Insulin Resistance
Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B.
Insulin Resistance
Classification of inhibitors of protein tyrosine phosphatase 1B using molecular structure based descriptors.
Insulin Resistance
Combination of the anthocyanidins malvidin and peonidin attenuates lipopolysaccharide-mediated inflammatory gene expression in primary human adipocytes.
Insulin Resistance
Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice.
Insulin Resistance
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes.
Insulin Resistance
Cyclosporine A enhances gluconeogenesis while sirolimus impairs insulin signaling in peripheral tissues after 3 weeks of treatment.
Insulin Resistance
Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane.
Insulin Resistance
Data in support of fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice.
Insulin Resistance
Decrease of miR-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid.
Insulin Resistance
Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone.
Insulin Resistance
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
Insulin Resistance
Depot-specific variation in protein-tyrosine phosphatase activities in human omental and subcutaneous adipose tissue: a potential contribution to differential insulin sensitivity.
Insulin Resistance
Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy.
Insulin Resistance
Design, synthesis, biological evaluation and molecular dynamics simulation studies of (R)-5-methylthiazolidin-4-One derivatives as megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) inhibitors for the treatment of type 2 diabetes.
Insulin Resistance
Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Insulin Resistance
Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats.
Insulin Resistance
Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
Insulin Resistance
Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice.
Insulin Resistance
Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle.
Insulin Resistance
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Insulin Resistance
Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance.
Insulin Resistance
Early growth response-1 negative feedback regulates skeletal muscle postprandial insulin sensitivity via activating Ptp1b transcription.
Insulin Resistance
Early obesity and age-related mimicry of metabolic syndrome in female mice with sex hormonal imbalances.
Insulin Resistance
Early overnutrition impairs insulin signaling in the heart of adult Swiss mice.
Insulin Resistance
Effect of a novel proteoglycan PTP1B inhibitor from Ganoderma lucidum on the amelioration of hyperglycaemia and dyslipidaemia in db/db mice.
Insulin Resistance
Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance.
Insulin Resistance
Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo.
Insulin Resistance
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.
Insulin Resistance
EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition.
Insulin Resistance
Egr-1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia-induced insulin resistance in the liver in type 2 diabetes.
Insulin Resistance
Electroacupuncture Improves Insulin Resistance by Reducing Neuroprotein Y/Agouti-Related Protein Levels and Inhibiting Expression of Protein Tyrosine Phosphatase 1B in Diet-induced Obese Rats.
Insulin Resistance
Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats.
Insulin Resistance
Endocrine regulation of energy metabolism by the skeleton.
Insulin Resistance
Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.
Insulin Resistance
Establishment of a cell-based drug screening model for identifying down-regulators of Protein Tyrosine Phosphatase 1B expression.
Insulin Resistance
Estradiol Protects Neuropeptide Y/Agouti-related Peptide Neurons against Insulin Resistance in Females.
Insulin Resistance
Evaluation of the hypoglycaemic and antioxidant effects of submerged Ganoderma lucidum cultures in type 2 diabetic rats.
Insulin Resistance
Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice.
Insulin Resistance
Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.
Insulin Resistance
Expression of SHP-1 Induced by Hyperglycemia Prevents Insulin Actions in Podocytes.
Insulin Resistance
Fanconi anemia links reactive oxygen species to insulin resistance and obesity.
Insulin Resistance
Ficus deltoidea extract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism.
Insulin Resistance
Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro.
Insulin Resistance
FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice.
Insulin Resistance
Fructose and hepatic insulin resistance.
Insulin Resistance
Fucosterol activates the insulin signaling pathway in insulin resistant HepG2 cells via inhibiting PTP1B.
Insulin Resistance
Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice.
Insulin Resistance
Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound.
Insulin Resistance
Gene Expression of Protein Tyrosine Phosphatase 1B and Endoplasmic Reticulum Stress During Septic Shock.
Insulin Resistance
Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.
Insulin Resistance
Gestational Protein Restriction impairs Glucose Disposal in the Gastrocnemius muscles of Female Rats.
Insulin Resistance
Grape powder extract attenuates tumor necrosis factor alpha-mediated inflammation and insulin resistance in primary cultures of human adipocytes.
Insulin Resistance
Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.
Insulin Resistance
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance.
Insulin Resistance
Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.
Insulin Resistance
Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome?
Insulin Resistance
Hepatic PTP1B Expression Involvement in the Effects of Chinese Medicine Formula Xiao-Gao-Jiang-Zhuo Using an Obese Rat Model.
Insulin Resistance
Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance.
Insulin Resistance
Hepatocyte-specific ptpn6 deletion protects from obesity-linked hepatic insulin resistance.
Insulin Resistance
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Insulin Resistance
High-Resolution Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Vietnamese Plants.
Insulin Resistance
High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans.
Insulin Resistance
Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice.
Insulin Resistance
Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B.
Insulin Resistance
Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.
Insulin Resistance
Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes.
Insulin Resistance
Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
Insulin Resistance
Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor.
Insulin Resistance
Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation.
Insulin Resistance
Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B.
Insulin Resistance
Improved adipose tissue function with initiation of protease inhibitor-only ART.
Insulin Resistance
Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B.
Insulin Resistance
Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue.
Insulin Resistance
Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1.
Insulin Resistance
In silico investigations on the binding efficacy and allosteric mechanism of six different natural product compounds towards PTP1B inhibition through docking and molecular dynamics simulations.
Insulin Resistance
In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.
Insulin Resistance
In vivo antisense activity of ENA oligonucleotides targeting PTP1B mRNA in comparison of that of 2'-MOE-modified oligonucleotides.
Insulin Resistance
In vivo vascular rarefaction and hypertension induced by dexamethasone are related to phosphatase PTP1B activation not endothelial metabolic changes.
Insulin Resistance
Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects.
Insulin Resistance
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Insulin Resistance
Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor.
Insulin Resistance
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Insulin Resistance
Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure-Overloaded Hearts.
Insulin Resistance
Increasing peripheral insulin sensitivity by protein tyrosine phosphatase 1B deletion improves control of blood pressure in obesity.
Insulin Resistance
Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice.
Insulin Resistance
Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro.
Insulin Resistance
Inhibiting protein tyrosine phosphatase 1B to improve regenerative functions of endothelial cells.
Insulin Resistance
Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.
Insulin Resistance
Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study.
Insulin Resistance
Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.
Insulin Resistance
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.
Insulin Resistance
Inhibition of Src homology 2 domain containing protein tyrosine phosphatase as the possible mechanism of metformin-assisted amelioration of obesity induced insulin resistance in high fat diet fed C57BL/6J mice.
Insulin Resistance
Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.
Insulin Resistance
Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice.
Insulin Resistance
Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.
Insulin Resistance
Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway.
Insulin Resistance
Insulin resistance associated to obesity: the link TNF-alpha.
Insulin Resistance
Insulin resistance does not diminish eNOS expression, phosphorylation, or binding to HSP-90.
Insulin Resistance
Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.
Insulin Resistance
Insulin signaling meets mitochondria in metabolism.
Insulin Resistance
Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.
Insulin Resistance
Intestinal insulin resistance and aberrant production of apolipoprotein B48 lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia: evidence for activation of protein tyrosine phosphatase-1B, extracellular signal-related kinase, and sterol regulatory element-binding protein-1c in the fructose-fed hamster intestine.
Insulin Resistance
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
Insulin Resistance
Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.
Insulin Resistance
Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer.
Insulin Resistance
Kinetics and molecular docking studies of pimarane-type diterpenes as protein tyrosine phosphatase (PTP1B) inhibitors from Aralia continentalis roots.
Insulin Resistance
Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.
Insulin Resistance
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior.
Insulin Resistance
Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression.
Insulin Resistance
Leukocyte antigen-related inhibition attenuates palmitate-induced insulin resistance in muscle cells.
Insulin Resistance
Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression.
Insulin Resistance
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
Insulin Resistance
Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
Insulin Resistance
Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors.
Insulin Resistance
Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.
Insulin Resistance
Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.
Insulin Resistance
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance.
Insulin Resistance
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition.
Insulin Resistance
Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus.
Insulin Resistance
Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms.
Insulin Resistance
Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression and consequent hypertriglyceridaemia.
Insulin Resistance
Metabolic diseases drug discovery world summit. July 28-29, 2003, San Diego, CA, USA.
Insulin Resistance
Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.
Insulin Resistance
Metabolic Regulation of Methionine Restriction in Diabetes.
Insulin Resistance
Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.
Insulin Resistance
Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc.
Insulin Resistance
Molecular and cellular mechanisms linking inflammation to insulin resistance and ?-cell dysfunction.
Insulin Resistance
Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: roles of Protein Tyrosine Phosphatase-1B.
Insulin Resistance
Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.
Insulin Resistance
Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions.
Insulin Resistance
MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress.
Insulin Resistance
Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.
Insulin Resistance
Natural Alkaloids and Diabetes Mellitus: A Review.
Insulin Resistance
Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-?B-mediated PTP1B expression.
Insulin Resistance
New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting ?-glucosidase and the PTP-1B signaling pathway.
Insulin Resistance
Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B.
Insulin Resistance
Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity.
Insulin Resistance
Novel Imbricatolic acid derivatives as protein tyrosine phosphatase-1B inhibitors: Design, synthesis, biological evaluation and molecular docking.
Insulin Resistance
Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.
Insulin Resistance
Novel Protein Tyrosine Phosphatase 1B Inhibitor-Geranylated Flavonoid from Mulberry Leaves Ameliorates Insulin Resistance.
Insulin Resistance
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Insulin Resistance
Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice.
Insulin Resistance
Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B.
Insulin Resistance
Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells.
Insulin Resistance
Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation.
Insulin Resistance
Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice.
Insulin Resistance
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
Insulin Resistance
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Insulin Resistance
p66(ShcA): linking mammalian longevity with obesity-induced insulin resistance.
Insulin Resistance
P66SHC and ageing: ROS and TOR?
Insulin Resistance
p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.
Insulin Resistance
Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells.
Insulin Resistance
Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation.
Insulin Resistance
Peroxisome proliferator-activated receptor-gamma agonist improves skeletal muscle insulin signaling in the pregestational intrauterine growth-restricted rat offspring.
Insulin Resistance
Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes.
Insulin Resistance
Pharmacological inhibition of protein tyrosine phosphatase 1B: a promising strategy for the treatment of obesity and type 2 diabetes mellitus.
Insulin Resistance
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Insulin Resistance
Phosphatase activity in rat adipocytes: effects of insulin and insulin resistance.
Insulin Resistance
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
Insulin Resistance
Pimarane Diterpenoids from the Seeds of Caesalpinia minax as PTP1B Inhibitors and Insulin Sensitizers.
Insulin Resistance
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Insulin Resistance
Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis.
Insulin Resistance
PP2A inhibition results in hepatic insulin resistance despite Akt2 activation.
Insulin Resistance
Probing the relationship between insulin sensitivity and longevity using genetically modified mice.
Insulin Resistance
Protein phosphatases and podocyte function.
Insulin Resistance
Protein tyrosine phosphatase 1B (PTP1B) inhibitors as potential anti-diabetes agents: patent review (2015-2018).
Insulin Resistance
Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.
Insulin Resistance
Protein tyrosine phosphatase 1B as a target for the treatment of impaired glucose tolerance and type II diabetes.
Insulin Resistance
Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.
Insulin Resistance
Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances.
Insulin Resistance
Protein tyrosine phosphatase 1B inhibitors: A molecular level legitimate approach for the management of diabetes mellitus.
Insulin Resistance
Protein Tyrosine Phosphatase 1B inhibitors: a novel therapeutic strategy for the management of type 2 diabetes mellitus.
Insulin Resistance
Protein tyrosine phosphatase 1B inhibitory activities of ursane- and lupane-type triterpenes from Sorbus pohuashanensis.
Insulin Resistance
Protein tyrosine phosphatase 1B is impaired in skeletal muscle of diabetic Psammomys obesus.
Insulin Resistance
Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.
Insulin Resistance
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
Insulin Resistance
Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism.
Insulin Resistance
Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities.
Insulin Resistance
Protein tyrosine phosphatase activity in insulin-resistant rodent Psammomys obesus.
Insulin Resistance
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Insulin Resistance
Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
Insulin Resistance
Protein tyrosine phosphatase-1B (PTP-1B) knockdown improves palmitate-induced insulin resistance in C2C12 skeletal muscle cells.
Insulin Resistance
Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population.
Insulin Resistance
Protein tyrosine phosphatase-1B in diabetes.
Insulin Resistance
Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants.
Insulin Resistance
Protein Tyrosine Phosphatases: Potential Role in beta-Cell Insulin Signal Transduction.
Insulin Resistance
Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.
Insulin Resistance
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure.
Insulin Resistance
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Insulin Resistance
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
Insulin Resistance
Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.
Insulin Resistance
Protein-Tyrosine Phosphatase-1B Mediates Sleep Fragmentation-Induced Insulin Resistance and Visceral Adipose Tissue Inflammation in Mice.
Insulin Resistance
Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells.
Insulin Resistance
Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice.
Insulin Resistance
Protein-tyrosine-phosphatase 1B activation is regulated developmentally in muscle of neonatal pigs.
Insulin Resistance
PTP1B and TCPTP: Non-redundant phosphatases in insulin signaling and glucose homeostasis.
Insulin Resistance
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.
Insulin Resistance
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
Insulin Resistance
PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.
Insulin Resistance
PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro.
Insulin Resistance
PTPIP51 interaction with PTP1B and 14-3-3? in adipose tissue of insulin-resistant mice.
Insulin Resistance
PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol.
Insulin Resistance
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Insulin Resistance
PTPRT regulates high-fat diet-induced obesity and insulin resistance.
Insulin Resistance
Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice.
Insulin Resistance
QSAR Studies of PTP1B Inhibitors: Recent Advances and Perspectives.
Insulin Resistance
Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media.
Insulin Resistance
Ramipril increases the protein level of skeletal muscle IRS-1 and alters protein tyrosine phosphatase activity in spontaneously hypertensive rats.
Insulin Resistance
RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass.
Insulin Resistance
Ratanhiaphenol III from Ratanhiae Radix is a PTP1B Inhibitor.
Insulin Resistance
Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes.
Insulin Resistance
Reduced Insulin Resistance Contributes to the Beneficial Effect of Protein Tyrosine Phosphatase-1B Deletion in a Mouse Model of Sepsis.
Insulin Resistance
Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.
Insulin Resistance
Reduction of low molecular weight protein-tyrosine phosphatase expression improves hyperglycemia and insulin sensitivity in obese mice.
Insulin Resistance
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Insulin Resistance
Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.
Insulin Resistance
Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms.
Insulin Resistance
Replication of Genome-Wide Association Signals of Type 2 Diabetes in Han Chinese in a Prospective Cohort.
Insulin Resistance
Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.
Insulin Resistance
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.
Insulin Resistance
RNA sequencing of the human milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation.
Insulin Resistance
Role of protein tyrosine phosphatase 1B in cardiovascular diseases.
Insulin Resistance
Role of protein tyrosine phosphatase 1B inhibitor in central insulin resistance and associated cognitive deficits.
Insulin Resistance
Rosiglitazone attenuates tumor necrosis factor-?-induced protein tyrosine phosphatase-1B production in HepG2 cells.
Insulin Resistance
Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-A(y) mice.
Insulin Resistance
Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation.
Insulin Resistance
SCR-1693 inhibits tau phosphorylation and improves insulin resistance associated cognitive deficits.
Insulin Resistance
Selective hepatic insulin resistance in mice heterozygous for a mitochondrial trifunctional protein defect.
Insulin Resistance
Selective inhibition of PTP1B by Vitalboside A from Syzygium cumini enhances insulin sensitivity and attenuates lipid accumulation via partial agonism to PPAR?: In Vitro and In Silico investigation.
Insulin Resistance
Serum Ceramide Reduction by Blueberry Anthocyanin-Rich Extract Alleviates Insulin Resistance in Hyperlipidemia Mice.
Insulin Resistance
Serum protein signature of coronary artery disease in type 2 diabetes mellitus.
Insulin Resistance
Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight.
Insulin Resistance
SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes.
Insulin Resistance
SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations.
Insulin Resistance
Silencing insulin resistance through SIRT1.
Insulin Resistance
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.
Insulin Resistance
Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans.
Insulin Resistance
Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance.
Insulin Resistance
Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.
Insulin Resistance
Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Insulin Resistance
Statement of Retraction. Iria Nieto-Vázquez, Sonia Fernández-Veledo, Cristina de Alvaro, Cristina M. Rondinone, Angela M. Valverde, and Margarita Lorenzo. Protein-Tyrosine Phosphatase 1B-Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-?-Induced Insulin Resistance. Diabetes 2007;56:404-413. https://doi.org/10.2337/db06-0989.
Insulin Resistance
Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet.
Insulin Resistance
Structure determination of T cell protein-tyrosine phosphatase.
Insulin Resistance
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
Insulin Resistance
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
Insulin Resistance
Sulphonamides as inhibitors of protein tyrosine phosphatase 1B: a three-dimensional quantitative structure-activity relationship study using self-organizing molecular field analysis approach.
Insulin Resistance
Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
Insulin Resistance
Synthesis and biological evaluation of novel N-aryl-?-(benzoazol-2-yl)-sulfanylalkanamides as dual inhibitors of ?-glucosidase and protein tyrosine phosphatase 1B.
Insulin Resistance
Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors.
Insulin Resistance
Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors.
Insulin Resistance
Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
Insulin Resistance
Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors.
Insulin Resistance
Synthesis, molecular docking and PTP1B inhibitory activity of functionalized 4,5-dihydronaphthofurans and dibenzofurans.
Insulin Resistance
T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice.
Insulin Resistance
T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts.
Insulin Resistance
Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice.
Insulin Resistance
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Insulin Resistance
Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes.
Insulin Resistance
TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.
Insulin Resistance
The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance.
Insulin Resistance
The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity.
Insulin Resistance
The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.
Insulin Resistance
The Effects of Total Flavonoids from Buckwheat Flowers and Leaves on Renal Damage and PTP1B Expression in Type 2 Diabetic Rats.
Insulin Resistance
The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency.
Insulin Resistance
The Role of Inflammation in Diabetic Retinopathy.
Insulin Resistance
The Role of MKP-1 in Insulin-Induced Cardioprotection.
Insulin Resistance
The Role of MKP-5 in Adipocyte-Macrophage Interactions during Obesity.
Insulin Resistance
The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
Insulin Resistance
The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance.
Insulin Resistance
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding.
Insulin Resistance
The Shc locus regulates insulin signaling and adiposity in mammals.
Insulin Resistance
The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens.
Insulin Resistance
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities.
Insulin Resistance
TISSUE-SPECIFICITY ON INSULIN ACTION AND RESISTANCE. PAST TO RECENT MECHANISMS.
Insulin Resistance
TNF? increases hypothalamic PTP1B activity via the NF?B pathway in rat hypothalamic organotypic cultures.
Insulin Resistance
To binge or not to binge: Binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling.
Insulin Resistance
Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors.
Insulin Resistance
Transcriptional response of porcine skeletal muscle to feeding a linseed-enriched diet to growing pigs.
Insulin Resistance
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Insulin Resistance
Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A.
Insulin Resistance
Treatment with atorvastatin ameliorates hepatic very-low-density lipoprotein overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster: evidence that reduced hypertriglyceridemia is accompanied by improved hepatic insulin sensitivity.
Insulin Resistance
Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.
Insulin Resistance
Tumor necrosis factor-alpha: a continuum of liability between insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus and carcinoma (review).
Insulin Resistance
Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus.
Insulin Resistance
Vitamin A improves insulin sensitivity by increasing insulin receptor phosphorylation through protein tyrosine phosphatase1B regulation at early age in obese rats of WNIN/Ob strain.
Insulin Resistance
Water Extract of Mungbean (Vigna radiata L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells.
Insulin Resistance
Zinc Supplementation and Strength Exercise in Rats with Type 2 Diabetes: Akt and PTP1B Phosphorylation in Nonalcoholic Fatty Liver.
Insulin Resistance
[Effects of candesartan on expressions of JAK2 and PTP-1B in adipose tissue of high-fat diet-fed rats].
Insulin Resistance
[Effects of flavones of buckwheat flower and leaf on insulin resistance and liver PTP1B in type 2 diabetic rats]
Insulin Resistance
[Free fatty acids promoting PTP1B expression in rat skeletal muscle and hepatic cells]
Insulin Resistance
[Impairments of insulin receptor function in insulin resistant states]
Insulin Resistance
[Investigating the effects of compound WS090152 on non-alcoholic fatty liver in mice].
Insulin Resistance
[Investigation of a compound, compatibility of Rhodiola crenulata, Cordyceps militaris, and Rheum palmatum, on metabolic syndrome treatment I--improving insulin resistance].
Insulin Resistance
[Molecular mechanism and clinical impact of insulin resistance in type 2 diabetes mellitus]
Insulin Resistance
[Prescription of Jingdan Yimin for treatment of metabolic syndrome].
Insulin Resistance
[Study on the mechanism of action of total flavonoids of Litsea coreana for reducing blood glucose level in rat with type 2 diabetes mellitus]
Insulin Resistance
[The effect of different types of bariatric surgery on the metabolic and hormonal parameters in rats with decompensed form of type 2 diabetes mellitus.]
Insulin Resistance
[The protein expression of insulin receptor substrate-1 and protein tyrosine phosphatase with two src-homology II in the adipose tissue from type II diabetic patients]
Insulin Resistance
[The role of protein tyrosine phosphatase (PTP-1B) in insulin resistance]
Insulinoma
Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes. Overlapping specificities to phogrin and ICA512/IA-2.
Insulinoma
Carboxypeptidase-H autoantibodies differentiate a more latent subset of autoimmune diabetes from phenotypic type 2 diabetes among Chinese adults.
Insulinoma
Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase.
Insulinoma
Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus.
Insulinoma
IA-2, a transmembrane protein tyrosine phosphatase, is expressed in human lung cancer cell lines with neuroendocrine phenotype.
Insulinoma
IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.
Insulinoma
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Insulinoma
Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2.
Insulinoma
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
Insulinoma
Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes.
Insulinoma
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.
Insulinoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Insulinoma
Role of immune system in type 1 diabetes mellitus pathogenesis.
Insulinoma
Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients.
Insulinoma
Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera.
Insulinoma
Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin.
Intellectual Disability
B56?-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
Intellectual Disability
Clinical and Molecular Analysis of Patients with RASopathies in Turkish Patients.
Intellectual Disability
Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.
Intellectual Disability
Evidence that homozygous PTPRD gene microdeletion causes trigonocephaly, hearing loss, and intellectual disability.
Intellectual Disability
Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors.
Intellectual Disability
IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase ?.
Intellectual Disability
Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex.
Intellectual Disability
PTPN4 germline variants result in aberrant neurodevelopment and growth.
Intellectual Disability
The tyrosine phosphatase Shp2 in development and cancer.
Intellectual Disability
[Clinical and genetic analysis of Noonan syndrome in 20 children].
Intestinal Neoplasms
Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells.
Intestinal Volvulus
Acid phosphatase activity in the larval stages of Onchocerca volvulus developing in the vector Simulium damnosum.
Intestinal Volvulus
Some observations on onchocerciasis including sowda in the Yemen Arab Republic.
Invasive Fungal Infections
Expression of SHP-1 and SOCS6 in patients with acute leukemia and their clinical implication.
Iron Overload
Iron content and acid phosphatase activity in hepatic parenchymal lysosomes of patients with hemochromatosis before and after phlebotomy treatment.
Iron Overload
Iron overload threatens the growth of osteoblast cells via inhibiting the PI3K/AKT/FOXO3a/DUSP14 signaling pathway.
Ischemic Attack, Transient
Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase.
Ischemic Stroke
A peptide mimetic of tyrosine phosphatase STEP as a potential therapeutic agent for treatment of cerebral ischemic stroke.
Ischemic Stroke
Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.
Ischemic Stroke
Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models.
Ischemic Stroke
PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia.
Ischemic Stroke
PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway.
Ischemic Stroke
Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
Ischemic Stroke
S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke.
Ischemic Stroke
Upregulation of protein phosphatase 2A and NR3A-pleiotropic effect of simvastatin on ischemic stroke rats.
Joint Diseases
Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis.
Joint Diseases
New Variants in Enpp1 and Ptpn6 Genes Cause Low Bone Density, Crystal-Related Arthropathy and Vascular Calcification.
Kallmann Syndrome
Renal agenesis in Kallmann syndrome: a network approach.
Keloid
Alpha-naphthyl acid phosphatase activity in normal human skin and keloids.
Keloid
Multifaceted array-based keloidal gene expression profiling reveals specific MDFI upregulation in keloid lesions.
Keloid
Pleiotrophin is downregulated in human keloids.
Keloid
Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.
Keratitis, Herpetic
[Alkaline and acid phosphatase activity and localization in the eye tissues and fluids in herpetic keratitis]
Keratoacanthoma
An ultrastructural study of the localization of acid phosphatase activity in the untreated and vitamin A acid treated keratoacanthoma.
Keratoconjunctivitis
[Polymorphic markers of certain genes in the development of dry keratoconjunctivitis in patients with rheumatoid arthritis and Sjogren's syndrome].
Keratoconus
Enhanced expression of a transmembrane phosphotyrosine phosphatase (LAR) in keratoconus cultures and corneas.
Keratoconus
Ocular findings in Noonan syndrome: a retrospective cohort study of 105 patients.
Keratoconus
[Study on enhanced leukocyte antigen-related tyrosine phosphatase in keratoconus]
Keratosis
Co-occurring SHOC2 and PTPN11 mutations in a patient with severe/complex Noonan syndrome-like phenotype.
Keratosis
Dermatological manifestations in Noonan syndrome: a prospective multicentric study of 129 patients positive for mutation.
Keratosis
RASopathies: Clinical Diagnosis in the First Year of Life.
Ketosis
Preserved Proinsulin Production in Homozygous PTPN 22 C1858T Variant Type 1 Diabetes: A Possible Explanation for Absence of Overt Ketoacidosis Despite Omission of Exogenous Insulin.
Ketosis
[Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes]
Kidney Cortex Necrosis
Key genes of renal tubular necrosis: a bioinformatics analysis.
Kidney Diseases
Agonistic anti-CD148 monoclonal antibody attenuates diabetic nephropathy in mice.
Kidney Diseases
Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration.
Kidney Diseases
Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc.
Kidney Diseases
p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli.
Kidney Diseases
Role of protein phosphatase 2A in kidney disease (Review).
Kidney Diseases, Cystic
Altered regulation of SHP-2 and PTP 1B tyrosine phosphatases in cystic kidneys from bcl-2 -/- mice.
Kidney Failure, Chronic
Decreased p66Shc promoter methylation in patients with end-stage renal disease.
Kidney Failure, Chronic
Lower p66Shc promoter methylation in subjects with chronic renal failure.
Kidney Neoplasms
Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O.
Kidney Neoplasms
Expression and clinical significance of PTPN12 in clear cell renal cell carcinoma.
Kidney Neoplasms
Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells.
Kidney Neoplasms
microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells.
Kidney Neoplasms
Modulation of bcl-2 family proteins in MAPK independent apoptosis induced by a cdc25 phosphatase inhibitor Cpd 5 in renal cancer cells.
Kidney Neoplasms
Molecular analysis of the protein tyrosine phosphatase gamma gene in human lung cancer cell lines.
Kidney Neoplasms
PTPN3 inhibits the growth and metastasis of clear cell renal cell carcinoma via inhibition of PI3K/AKT signaling.
Kidney Neoplasms
Sodium stibogluconate interacts with IL-2 in anti-Renca tumor action via a T cell-dependent mechanism in connection with induction of tumor-infiltrating macrophages.
Kidney Neoplasms
The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma.
Klatskin Tumor
Induction of MKP-1 prevents the cytotoxic effects of PI3K inhibition in hilar cholangiocarcinoma cells.
Klatskin Tumor
PTPN3 suppresses the proliferation and correlates with favorable prognosis of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation.
Kwashiorkor
Infantile jejunal mucosa in infection and malnutrition.
Lafora Disease
A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2).
Lafora Disease
Abnormal metabolism of glycogen phosphate as a cause for Lafora disease.
Lafora Disease
Advances in the genetics of progressive myoclonus epilepsy.
Lafora Disease
Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease.
Lafora Disease
Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329.
Lafora Disease
Expression, purification and characterization of soluble red rooster laforin as a fusion protein in Escherichia coli.
Lafora Disease
Glycogen and related polysaccharides inhibit the laforin dual-specificity protein phosphatase.
Lafora Disease
Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin.
Lafora Disease
Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.
Lafora Disease
Isolation and characterization of mouse homologue for the human epilepsy gene, EPM2A.
Lafora Disease
Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
Lafora Disease
Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.
Lafora Disease
Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.
Lafora Disease
Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity.
Lafora Disease
Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice.
Lafora Disease
Laforin, a dual specificity protein phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.
Lafora Disease
Molecular characterization of laforin, a dual-specificity protein phosphatase implicated in Lafora disease.
Lafora Disease
Mutational spectrum of the EPM2A gene in progressive myoclonus epilepsy of Lafora: high degree of allelic heterogeneity and prevalence of deletions.
Lafora Disease
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice.
Lafora Disease
The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Lafora Disease
The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2.
Lafora Disease
Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex.
Lambert-Eaton Myasthenic Syndrome
Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome.
Laryngeal Neoplasms
DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
Laryngeal Neoplasms
Functions of Shp2 in cancer.
Latent Autoimmune Diabetes in Adults
Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis.
Latent Autoimmune Diabetes in Adults
Low Frequencies of Autoimmunity-Associated PTPN22 Polymorphisms in MODY Patients, Including Those Transiently Expressing Islet Cell Autoantibodies.
Latent Autoimmune Diabetes in Adults
The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis.
Latent Autoimmune Diabetes in Adults
The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3.
Latent Tuberculosis
Cis-2 and trans-2-eisocenoic fatty acids are novel inhibitors for Mycobacterium tuberculosis Protein tyrosine phosphatase A.
Latent Tuberculosis
Differential gene expression of ASUN, NEMF, PTPRC and DHX29: Candidate biomarkers for diagnosis of active and latent tuberculosis.
Learning Disabilities
Connecting the dots between SHP2 and glutamate receptors.
Learning Disabilities
Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.
Legionnaires' Disease
Identification of putative cytoskeletal protein homologues in the protozoan host Hartmannella vermiformis as substrates for induced tyrosine phosphatase activity upon attachment to the Legionnaires' disease bacterium, Legionella pneumophila.
Leigh Disease
Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway.
Leiomyoma
PTPN22 and uterine leiomyomas.
Leiomyoma
Significant relationship of combined ACP1/PTPN22 genotype variants with the growth of uterine leiomyomas.
Leiomyomatosis
Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma.
Leiomyosarcoma
Leiomyosarcoma of the heart and its pulmonary metastasis, both with prominent osteoclast-like multinucleated giant cells expressing tartrate-resistant acid phosphatase activity.
Leishmaniasis
Crystallization and preliminary crystallographic characterization of LmACR2, an arsenate/antimonate reductase from Leishmania major.
Leishmaniasis
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Leishmaniasis
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice.
Leishmaniasis
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.
Leishmaniasis
Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxide.
Leishmaniasis
Proteases and phosphatases during Leishmania-macrophage interaction: paving the road for pathogenesis.
Leishmaniasis
Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis.
Leishmaniasis
Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production.
Leishmaniasis
Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines.
Leishmaniasis, Visceral
Immunomodulation of dual specificity phosphatase 4 during visceral leishmaniasis.
Leishmaniasis, Visceral
Leishmania infantum-chagasi activates SHP-1 and reduces NFAT5/TonEBP activity in the mouse kidney inner medulla.
Lentigo
Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions.
Lentigo
Clinical and molecular characterization of children with Noonan syndrome and other RASopathies in Argentina.
Lentigo
Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11.
Lentigo
Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2-related disorders.
Lentigo
Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms.
Lentigo
Dermatological manifestations in Noonan syndrome: a prospective multicentric study of 129 patients positive for mutation.
Lentigo
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
Lentigo
Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines.
Lentigo
Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1.
Lentigo
Extensive abdominal lipomatosis in a patient with Noonan/LEOPARD syndrome (Noonan syndrome-Multiple Lentigines).
Lentigo
Familial LEOPARD Syndrome With Hypertrophic Cardiomyopathy.
Lentigo
Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene.
Lentigo
Hypertrophic neuropathy in Noonan syndrome with multiple lentigines.
Lentigo
LEOPARD Syndrome with PTPN11 Gene Mutation Showing Six Cardinal Symptoms of LEOPARD.
Lentigo
Leopard syndrome: a report of five cases from one family in two generations.
Lentigo
Leopard syndrome: the potential cardiac defect underlying skin phenotypes.
Lentigo
Noonan Syndrome with Multiple Lentigines and PTPN11 Mutation: A Case with Intracerebral Hemorrhage.
Lentigo
Noonan syndrome with multiple lentigines with PTPN11 (T468M) gene mutation accompanied with solitary granular cell tumor.
Lentigo
Noonan syndrome: clinical aspects and molecular pathogenesis.
Lentigo
Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation.
Lentigo
Pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: the multifaceted consequences of PTPN11 mutations.
Lentigo
PTPN11 gene mutations: linking the Gln510Glu mutation to the "LEOPARD syndrome phenotype".
Lentigo
PTPN11 mutations in LEOPARD syndrome.
Lentigo
SHP2 sails from physiology to pathology.
Lentigo
Sporadic case of eruptive lentiginosis caused by Thr468Met missense mutation in the PTPN11 gene in a Han Chinese patient: first report and systematic literature review.
Lentigo
Targeting a Pathogenic Cysteine Mutation: Discovery of a Specific Inhibitor of Y279C SHP2.
Lentigo
The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.
Lentigo
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders.
Lentigo
[Molecular genetic mutation analysis of the PTPN11 gene in the multiple lentigines (LEOPARD) syndrome]
LEOPARD Syndrome
A Novel A461S Mutation of PTPN11 in a Female with LEOPARD Syndrome.
LEOPARD Syndrome
A novel PTPN11 gene mutation in a patient with LEOPARD Syndrome.
LEOPARD Syndrome
A novel PTPN11 missense mutation in a patient with LEOPARD syndrome.
LEOPARD Syndrome
A novel PTPN11 mutation in LEOPARD syndrome.
LEOPARD Syndrome
Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive).
LEOPARD Syndrome
Clinical and molecular characterization of children with Noonan syndrome and other RASopathies in Argentina.
LEOPARD Syndrome
Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11.
LEOPARD Syndrome
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
LEOPARD Syndrome
Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2-related disorders.
LEOPARD Syndrome
Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms.
LEOPARD Syndrome
Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.
LEOPARD Syndrome
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.
LEOPARD Syndrome
Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.
LEOPARD Syndrome
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
LEOPARD Syndrome
Distinct and overlapping functions of ptpn11 genes in Zebrafish development.
LEOPARD Syndrome
Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes.
LEOPARD Syndrome
Diversity and Functional Consequences of Germline and Somatic PTPN11 Mutations in Human Disease.
LEOPARD Syndrome
Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines.
LEOPARD Syndrome
Familial aggregation of genetically heterogeneous hypertrophic cardiomyopathy: a boy with LEOPARD syndrome due to PTPN11 mutation and his nonsyndromic father lacking PTPN11 mutations.
LEOPARD Syndrome
Familial cases of atypical clinical features genetically diagnosed as LEOPARD syndrome (multiple lentigines syndrome).
LEOPARD Syndrome
Familial LEOPARD Syndrome With Hypertrophic Cardiomyopathy.
LEOPARD Syndrome
Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
LEOPARD Syndrome
Functions of Shp2 in cancer.
LEOPARD Syndrome
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
LEOPARD Syndrome
Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene.
LEOPARD Syndrome
Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11.
LEOPARD Syndrome
Germline PTPN11 and somatic PIK3CA variant in a boy with megalencephaly-capillary malformation syndrome (MCAP) - pure coincidence?
LEOPARD Syndrome
Hypertrophic neuropathy in Noonan syndrome with multiple lentigines.
LEOPARD Syndrome
Identification of a PTPN11 hot spot mutation in a child with atypical LEOPARD syndrome.
LEOPARD Syndrome
IMAGE CARDIO MED. A patient with LEOPARD syndrome and PTPN11 mutation.
LEOPARD Syndrome
Implantable cardioverter defibrillator for progressive hypertrophic cardiomyopathy in a patient with LEOPARD syndrome and a novel PTPN11 mutation Gln510His.
LEOPARD Syndrome
Is sudden cardiac death predictable in LEOPARD syndrome?
LEOPARD Syndrome
Leopard syndrome caused by heterozygous missense mutation of Tyr 279 Cys in the PTPN11 gene in a sporadic case of Chinese Han.
LEOPARD Syndrome
LEOPARD Syndrome Caused by Tyr279Cys Mutation in the PTPN11 Gene.
LEOPARD Syndrome
LEOPARD syndrome in an infant with severe hypertrophic cardiomyopathy and PTPN11 mutation.
LEOPARD Syndrome
LEOPARD Syndrome with PTPN11 Gene Mutation in Three Family Members Presenting with Different Phenotypes.
LEOPARD Syndrome
LEOPARD Syndrome with PTPN11 Gene Mutation Showing Six Cardinal Symptoms of LEOPARD.
LEOPARD Syndrome
LEOPARD syndrome with recurrent PTPN11 mutation Y279C and different cutaneous manifestations: two case reports and a review of the literature.
LEOPARD Syndrome
LEOPARD Syndrome Without Hearing Loss or Pulmonary Stenosis: A Report of 2 Cases.
LEOPARD Syndrome
LEOPARD Syndrome: A Variant of Noonan Syndrome Strongly Associated With Hypertrophic Cardiomyopathy.
LEOPARD Syndrome
Leopard syndrome: the potential cardiac defect underlying skin phenotypes.
LEOPARD Syndrome
Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation.
LEOPARD Syndrome
mTOR pathway in human cardiac hypertrophy caused by LEOPARD syndrome: a different role compared with animal models?
LEOPARD Syndrome
Multiple giant cell lesions in patients with Noonan syndrome and cardio-facio-cutaneous syndrome.
LEOPARD Syndrome
Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.
LEOPARD Syndrome
New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling.
LEOPARD Syndrome
Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.
LEOPARD Syndrome
Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction.
LEOPARD Syndrome
Noonan Syndrome and Related Disorders: Genetics and Pathogenesis.
LEOPARD Syndrome
Noonan syndrome and related disorders: genetics and pathogenesis.
LEOPARD Syndrome
Noonan Syndrome with Multiple Lentigines and PTPN11 Mutation: A Case with Intracerebral Hemorrhage.
LEOPARD Syndrome
Noonan syndrome with multiple lentigines with PTPN11 (T468M) gene mutation accompanied with solitary granular cell tumor.
LEOPARD Syndrome
Noonan syndrome: clinical aspects and molecular pathogenesis.
LEOPARD Syndrome
P0-Related Protein Accelerates Human Mesenchymal Stromal Cell Migration by Modulating VLA-5 Interactions with Fibronectin.
LEOPARD Syndrome
Pathogenesis of multiple lentigines in LEOPARD syndrome with PTPN11 gene mutation.
LEOPARD Syndrome
Patient with confirmed LEOPARD syndrome developing multiple melanoma.
LEOPARD Syndrome
Pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: the multifaceted consequences of PTPN11 mutations.
LEOPARD Syndrome
Phenotype-genotype correlation in a patient with co-occurrence of Marfan and LEOPARD syndromes.
LEOPARD Syndrome
Phenotypical diversity of patients with LEOPARD syndrome carrying the worldwide recurrent p.Tyr279Cys PTPN11 mutation.
LEOPARD Syndrome
Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development.
LEOPARD Syndrome
Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
LEOPARD Syndrome
Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.
LEOPARD Syndrome
PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.
LEOPARD Syndrome
PTPN11 gene analysis in 74 Brazilian patients with Noonan syndrome or Noonan-like phenotype.
LEOPARD Syndrome
PTPN11 gene mutation associated with abnormal gonadal determination.
LEOPARD Syndrome
PTPN11 mutation manifesting as LEOPARD syndrome associated with hypertrophic plexi and neuropathic pain.
LEOPARD Syndrome
PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes.
LEOPARD Syndrome
PTPN11 mutations in LEOPARD syndrome.
LEOPARD Syndrome
PTPN11 Mutations in LEOPARD Syndrome: Report of Four Cases in Taiwan.
LEOPARD Syndrome
PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience.
LEOPARD Syndrome
PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots?
LEOPARD Syndrome
PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.
LEOPARD Syndrome
Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1.
LEOPARD Syndrome
Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase.
LEOPARD Syndrome
Scalp melanoma in a woman with LEOPARD syndrome: Possible implication of PTPN11 signaling in melanoma pathogenesis.
LEOPARD Syndrome
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
LEOPARD Syndrome
SHP-2 regulates growth factor dependent vascular signalling and function.
LEOPARD Syndrome
Shp2 in myocytes is essential for cardiovascular and neointima development.
LEOPARD Syndrome
Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2-Induced Gastrulation Defects.
LEOPARD Syndrome
SHP2 sails from physiology to pathology.
LEOPARD Syndrome
Spectrum of Mutations in Noonan Syndrome and Their Correlation with Phenotypes.
LEOPARD Syndrome
Structure, Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis.
LEOPARD Syndrome
Syndromic Hearing Loss in Association with PTPN11-Related Disorder: The Experience of Cochlear Implantation in a Child with LEOPARD Syndrome.
LEOPARD Syndrome
Targeting a Pathogenic Cysteine Mutation: Discovery of a Specific Inhibitor of Y279C SHP2.
LEOPARD Syndrome
The case of 17-year-old male with LEOPARD syndrome.
LEOPARD Syndrome
The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.
LEOPARD Syndrome
The regulation of male fertility by the PTPN11 tyrosine phosphatase.
LEOPARD Syndrome
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
LEOPARD Syndrome
The tyrosine phosphatase Shp2 in development and cancer.
LEOPARD Syndrome
Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome.
LEOPARD Syndrome
Visual function in Noonan and LEOPARD syndrome.
LEOPARD Syndrome
[Molecular genetic mutation analysis of the PTPN11 gene in the multiple lentigines (LEOPARD) syndrome]
LEOPARD Syndrome
[Noonan syndrome and Leopard syndrome linked to mutation of the gene PTPN11]
LEOPARD Syndrome
[PTPN11 gene mutation in LEOPARD syndrome]
LEOPARD Syndrome
[The Biological Function of SHP2 in Human Disease].
Leprosy
Analysis of the rs2476601 polymorphism of PTPN22 in Mexican mestizo patients with leprosy.
Leprosy
Macrophage function in leprosy.
Leprosy
Protein tyrosine phosphatase non-receptor type 22 gene polymorphism C1858T is not associated with leprosy in Azerbaijan, Northwest Iran.
Leprosy
Semen biochemistry of leprosy patients.
Leprosy
The role of polymorphic protein tyrosine phosphatase non-receptor type 22 in leprosy.
Leprosy, Lepromatous
Semen biochemistry of leprosy patients.
Leprosy, Paucibacillary
Semen biochemistry of leprosy patients.
Leukemia
(1)H, (15)N and (13)C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase.
Leukemia
2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action.
Leukemia
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia.
Leukemia
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors.
Leukemia
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
Leukemia
A gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Leukemia
A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival.
Leukemia
A toxicogenomic approach for identifying biomarkers for myelosuppressive anemia in rats.
Leukemia
Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia
Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
Leukemia
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Leukemia
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.
Leukemia
Activating PTPN11 mutations play a minor role in pediatric and adult solid tumors.
Leukemia
Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP.
Leukemia
Alterations in tyrosine phosphorylation during the granulocytic maturation of HL-60 leukemia cells.
Leukemia
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Leukemia
Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.
Leukemia
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.
Leukemia
Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells.
Leukemia
Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase.
Leukemia
Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay.
Leukemia
BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.
Leukemia
Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.
Leukemia
Biochemical characterization of tyrosine kinase and phosphotyrosine phosphatase activities of HL-60 leukemia cells.
Leukemia
Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells.
Leukemia
CD14/16 monocyte profiling in juvenile myelomonocytic leukemia.
Leukemia
Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation.
Leukemia
Characterization of SET/I2PP2A Isoforms in Dogs.
Leukemia
Childhood and adolescent lymphoid and myeloid leukemia.
Leukemia
Clinical and molecular epidemiology of neonatal leukemia in brazil.
Leukemia
Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.
Leukemia
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Leukemia
Complete Resolution of Lymphoid Interstitial Pneumonia in a Patient With Juvenile Myelomonocytic Leukemia Treated With Allogeneic Bone Marrow Transplant: Killing 2 Birds With 1 Stone.
Leukemia
Computational identification of microRNAs and their targets in liver cirrhosis.
Leukemia
Cooperation of MLL/AF10(OM-LZ) with PTPN11 activating mutation induced monocytic leukemia with a shorter latency in a mouse bone marrow transplantation model.
Leukemia
Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.
Leukemia
Critical role of Shp2 in tumor growth involving regulation of c-Myc.
Leukemia
Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit ? and MAPK phosphatase-1 expression in human leukemia U937 cells.
Leukemia
Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
Leukemia
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Leukemia
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.
Leukemia
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.
Leukemia
Design of a comprehensive fluorescence in situ hybridization assay for genetic classification of T-cell acute lymphoblastic leukemia.
Leukemia
Different outcomes of allogeneic hematopoietic stem cell transplant in a pair of twins affected by juvenile myelomonocytic leukemia.
Leukemia
Differential expression of protein tyrosine phosphatase genes during phorbol ester-induced differentiation of human leukemia U937 cells.
Leukemia
Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways.
Leukemia
Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines.
Leukemia
Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation.
Leukemia
Diversity and Functional Consequences of Germline and Somatic PTPN11 Mutations in Human Disease.
Leukemia
DNA methylation of membrane bound tyrosine phosphatase genes in acute lymphoblastic leukemia.
Leukemia
Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.
Leukemia
Down-regulation of cyclin B1 and up-regulation of Wee1 by berberine promotes entry of leukemia cells into the G2/M-phase of the cell cycle.
Leukemia
Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis.
Leukemia
DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.
Leukemia
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling.
Leukemia
Effects of extremely low frequency magnetic fields on NGF induced neuronal differentiation of PC12 cells.
Leukemia
Effects of sodium stibogluconate on differentiation and proliferation of human myeloid leukemia cell lines in vitro.
Leukemia
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.
Leukemia
Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells.
Leukemia
Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STAT1 phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-1.
Leukemia
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
Leukemia
Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play.
Leukemia
Evaluation of protein tyrosine phosphatase activity in patients with acute leukemia.
Leukemia
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia.
Leukemia
Expanding the SHOC2 mutation associated phenotype of noonan syndrome with loose anagen hair: Structural brain anomalies and myelofibrosis.
Leukemia
Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2E69K.
Leukemia
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Leukemia
Expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from gamma-ray induced leukemia mice.
Leukemia
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.
Leukemia
Expression of SHP-1 and SOCS6 in patients with acute leukemia and their clinical implication.
Leukemia
Factors affecting acid phosphatase activity in exponential and synchronized L5178Y mouse leukemia cells.
Leukemia
Four-year remission despite umbilical cord graft rejection in juvenile myelomonocytic leukemia with PTPN11 mutations.
Leukemia
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.
Leukemia
Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia.
Leukemia
Functional involvement of PTP-U2L in apoptosis subsequent to terminal differentiation of monoblastoid leukemia cells.
Leukemia
Functional variation of SHP-2 promoter is associated with preterm birth and delayed myelination and motor development in preterm infants.
Leukemia
Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Leukemia
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Leukemia
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Leukemia
Genetic alterations of protein tyrosine phosphatases in human cancers.
Leukemia
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
Leukemia
Genetic disruption of the PI3K regulatory subunits, p85?, p55?, and p50?, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
Leukemia
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.
Leukemia
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.
Leukemia
Germline PTPN11 missense mutation in a case of Noonan syndrome associated with mediastinal and retroperitoneal neuroblastic tumors.
Leukemia
Germline PTPN11 mutation affecting exon 8 in a case of syndromic juvenile myelomonocytic leukemia.
Leukemia
Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association.
Leukemia
HOXA11 plays critical roles in disease progression and response to cytarabine in AML.
Leukemia
Hypophosphorylation of pRB and repression of cyclin D3 and cdc25A during the granulocytic differentiation of human myeloblastic leukemia ML-1 cells.
Leukemia
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.
Leukemia
Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11).
Leukemia
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Leukemia
Increased prostate-type acid phosphatase activity in serum and typical bone lesions simulating the presence of prostatic carcinoma.
Leukemia
Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.
Leukemia
Induction of a Tumor-associated Activating Mutation in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhances Mitochondrial Metabolism, Leading to Oxidative Stress and Senescence.
Leukemia
Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.
Leukemia
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.
Leukemia
Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B.
Leukemia
Inhibition of Phosphotyrosine Phosphatase 1B Causes Resistance in BCR-ABL-Positive Leukemia Cells to the ABL Kinase Inhibitor STI571.
Leukemia
Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Leukemia
Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor.
Leukemia
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia.
Leukemia
Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines.
Leukemia
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.
Leukemia
Juvenile myelomonocytic leukemia with PTPN11 mutation in a 23-month-old girl.
Leukemia
Juvenile myelomonocytic leukemia-associated variants are associated with neo-natal lethal Noonan syndrome.
Leukemia
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Leukemia
LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.
Leukemia
Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation.
Leukemia
Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib.
Leukemia
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Leukemia
Malignant lymphoma of pre-T-cell type terminating in acute myelocytic leukemia. A case report with enzymic and immunologic marker studies.
Leukemia
Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells.
Leukemia
Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2.
Leukemia
Methylation of gene encoding the growth suppressor protein tyrosine phosphatase receptor-type O (PTPRO) in human hepatocellular carcinoma and identification of VCP as its bona fide substrate.
Leukemia
Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
Leukemia
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4.
Leukemia
Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin lymphoma and T-cell non-Hodgkin lymphoma.
Leukemia
Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.
Leukemia
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Leukemia
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
Leukemia
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.
Leukemia
Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations.
Leukemia
Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.
Leukemia
Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia.
Leukemia
Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic ?-cell dysfunction.
Leukemia
Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells.
Leukemia
Negative regulation of immunoreceptor signaling by protein adapters: Shc proteins join the club.
Leukemia
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Leukemia
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Leukemia
Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.
Leukemia
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
Leukemia
Nonsyndromic Juvenile Myelomonocytic Leukemia With PTPN11 Mutation in a 9-Year-old Girl.
Leukemia
Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction.
Leukemia
Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
Leukemia
Novel PROTACs for degradation of SHP2 protein.
Leukemia
Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
Leukemia
Oncophosphosignaling Favors a Glycolytic Phenotype in Human Drug Resistant Leukemia.
Leukemia
Osteopetrosis mimicking juvenile myelomonocytic leukemia.
Leukemia
Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.
Leukemia
Overexpression of SET is a recurrent event associated with poor outcome that contributes to protein phosphatase 2A inhibition in acute myeloid leukemia.
Leukemia
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.
Leukemia
Pediatric myelodysplastic syndrome with inflammatory manifestations: Diagnosis, genetics, treatment, and outcome.
Leukemia
Phorbol ester stimulates the activity of a protein tyrosine phosphatase containing SH2 domains (PTP1C) in HL-60 leukemia cells by increasing gene expression.
Leukemia
Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells.
Leukemia
Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.
Leukemia
Positive regulation of c-Jun N-terminal kinase and TNF-alpha production but not histamine release by SHP-1 in RBL-2H3 mast cells.
Leukemia
Potent activation of phospholipase D by phenylarsine oxide in rat basophilic leukemia (RBL-2H3) cells.
Leukemia
Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice.
Leukemia
Preferential requirement for protein tyrosine phosphatase activity in the 12-O-tetradecanoylphorbol-13-acetate-induced differentiation of human colon cancer cells.
Leukemia
Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias.
Leukemia
Protein Phosphatase 2A as a Potential Target for Treatment of Adult T Cell Leukemia.
Leukemia
Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo.
Leukemia
Protein tyrosine phosphatase epsilonC selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.
Leukemia
Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation.
Leukemia
Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.
Leukemia
Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
Leukemia
Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha.
Leukemia
Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells.
Leukemia
Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells.
Leukemia
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Leukemia
PTPN11 mutation with additional somatic alteration indicates unfavorable outcome in juvenile myelomonocytic leukemia: a retrospective clinical study from a single center.
Leukemia
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group.
Leukemia
PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas.
Leukemia
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Leukemia
PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
Leukemia
PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model.
Leukemia
Quantification of CD24 and CD45 antigens in parallel allows a precise determination of B-cell maturation stages: relevance for the study of B-cell neoplasias.
Leukemia
RAS diseases in children.
Leukemia
Reduced tumorigenicity of murine leukemia cells expressing protein-tyrosine phosphatase, PTPepsilon C.
Leukemia
Regulation of CD45 expression in human leukemia cells.
Leukemia
Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells.
Leukemia
Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.
Leukemia
Respiratory failure, juvenile myelomonocytic leukemia, and neonatal Noonan syndrome.
Leukemia
Reversible phosphorylation in haematological malignancies: Potential role for protein tyrosine phosphatases in treatment?
Leukemia
RNA Sequencing of Carboplatin- and Paclitaxel-Resistant Endometrial Cancer Cells Reveals New Stratification Markers and Molecular Targets for Cancer Treatment.
Leukemia
Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
Leukemia
Role of protein phosphatases in the cancer microenvironment.
Leukemia
Serial investigation of PTPN11 mutation in nonhematopoietic tissues in a patient with juvenile myelomonocytic leukemia who was treated with unrelated cord blood transplantation.
Leukemia
SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasis.
Leukemia
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.
Leukemia
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
Leukemia
Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal.
Leukemia
SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.
Leukemia
Shp2 function in hematopoietic stem cell biology and leukemogenesis.
Leukemia
Shp2, a novel oncogenic tyrosine phosphatase and potential therapeutic target for human leukemia.
Leukemia
Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.
Leukemia
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
Leukemia
Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia.
Leukemia
Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A: evidence for receptor function in heterologous transfectants.
Leukemia
Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP.
Leukemia
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways.
Leukemia
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Leukemia
Targeting Protein Tyrosine Phosphatase SHP2 for the Treatment of PTPN11-Associated Malignancies.
Leukemia
Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.
Leukemia
TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.
Leukemia
TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.
Leukemia
TGFbeta regulates the expression and activities of G2 checkpoint kinases in human myeloid leukemia cells.
Leukemia
The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.
Leukemia
The function of the protein tyrosine phosphatase SHP-1 in cancer.
Leukemia
The molecular basis of leukemia.
Leukemia
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease.
Leukemia
The oncoprotein I-2PP2A/SET negatively regulates the MEK/ERK pathway and cell proliferation.
Leukemia
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
Leukemia
The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Leukemia
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Leukemia
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.
Leukemia
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Leukemia
Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations.
Leukemia
Transient juvenile myelomonocytic leukemia in the setting of PTPN11 mutation and Noonan syndrome with secondary development of monosomy 7.
Leukemia
Two bcr/abl fusion gene products, P210bcr/abl and P190bcr/abl, are equally sensitive to the protein tyrosine phosphatase of mature granulocytes.
Leukemia
Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft.
Leukemia
Tyrosine kinase and phosphotyrosine phosphatase activity in human promyelocytic leukemia cells and human polymorphonuclear leukocytes.
Leukemia
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
Leukemia
Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylation.
Leukemia
[Analysis of PTPN11 Mutation in Children Leukemia and Its Clinical Significance].
Leukemia
[Beta-glucuronidase and acid phosphatase activity in the blast cells of acute lymphoblastic and undifferentiated leukemia patients]
Leukemia
[Characteristics of the diagnosis and treatment of secondary pneumonia in acute leukemia]
Leukemia
[Demethylation effect of inhibitor As2O3 on expression of SHP-1 and C-kit genes in leukemia HL-60 cells].
Leukemia
[Effect of 5-aza-CdR Demethylation on Expression of SHP-1 and C-kit Genes in Leukemia HL-60 Cells].
Leukemia
[Effect of A Methylation Inhibitor 5-aza-2'-deoxycytidine on SHP-1 Gene Expression, Proliferation and Apoptosis in K562 Cells.]
Leukemia
[Effect of arsenic trioxide and 5-aza-2'-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells].
Leukemia
[Effects of protein tyrosine kinase, protein tyrosine phosphatase and protein kinase C on the apoptosis of arsenic trioxide treated NB4 cells and human cortex neurons]
Leukemia
[Expression and clinical value of SHP-1 and c-kit in acute leukemia]
Leukemia
[Immunophenotype analysis of leukemic mantle cell lymphoma].
Leukemia
[Involvement of PTP-U2 in terminal differentiation and apoptosis of leukemia cells]
Leukemia
[Overexpression of Shp-2 is associated with the unlimited growth and apoptosis resistance of p210 bcr-abl-mediated chronic myeloid leukemia]
Leukemia
[Recent progress in the protein-tyrosine phosphatase SHP1 gene: the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias]
Leukemia
[Research progress of protein tyrosine phosphatase SHP-2].
Leukemia
[The expression and clinical significance of hematopoietic cell phosphatase and cysteinyl aspartate-specific proteinase in leukemia]
Leukemia, Erythroblastic, Acute
Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells.
Leukemia, Erythroblastic, Acute
Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes.
Leukemia, Erythroblastic, Acute
Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.
Leukemia, Erythroblastic, Acute
Expression of the protein tyrosine phosphatase beta2 gene in mouse erythroleukemia cells induces terminal erythroid differentiation.
Leukemia, Erythroblastic, Acute
Induction of IW32 erythroleukemia cell differentiation by p53 is dependent on protein tyrosine phosphatase.
Leukemia, Erythroblastic, Acute
Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse embryonal carcinoma (F9) cells.
Leukemia, Erythroblastic, Acute
Induction of specific protein tyrosine phosphatase transcripts during differentiation of mouse erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Protein tyrosine phosphatase-dependent activation of beta-globin and delta-aminolevulinic acid synthase genes in the camptothecin-induced IW32 erythroleukemia cell differentiation.
Leukemia, Hairy Cell
The cytochemistry of tartrate-resistant acid phosphatase. Technical considerations.
Leukemia, Lymphocytic, Chronic, B-Cell
Activation of Protein Tyrosine Phosphatase Receptor Type ? Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells.
Leukemia, Lymphocytic, Chronic, B-Cell
AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis.
Leukemia, Lymphocytic, Chronic, B-Cell
Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy.
Leukemia, Lymphocytic, Chronic, B-Cell
Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib.
Leukemia, Lymphocytic, Chronic, B-Cell
Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.
Leukemia, Lymphocytic, Chronic, B-Cell
p66Shc deficiency in the E?-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape.
Leukemia, Lymphocytic, Chronic, B-Cell
p66Shc deficiency sets the scene for clinically aggressive chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
P66Shc: A Pleiotropic Regulator of B Cell Trafficking and a Gatekeeper in Chronic Lymphocytic Leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
Leukemia, Lymphocytic, Chronic, B-Cell
PRL-2 increases Epo and IL-3 responses in hematopoietic cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Regulation of Selective B Cell Autophagy by the Pro-oxidant Adaptor p66SHC.
Leukemia, Lymphocytic, Chronic, B-Cell
SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts.
Leukemia, Lymphocytic, Chronic, B-Cell
The cytokine midkine and its receptor RPTP? regulate B cell survival in a pathway induced by CD74.
Leukemia, Lymphocytic, Chronic, B-Cell
The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia.
Leukemia, Lymphoid
Loss of Zap-70 and low molecular weight phosphotyrosine phosphatase occurs after therapy in a patient with B-chronic lymphocytic leukemia.
Leukemia, Lymphoid
Quantification of the leukocyte common antigen (CD45) in mature B-cell malignancies.
Leukemia, Lymphoid
[Blood immunoglobulin level and acid phosphatase activity in the lymphocytes in different stages of lymphocytic leukemia according to the Rai classification]
Leukemia, Lymphoid
[Lymphocyte acid phosphatase activity in lymphocytic leukemia studied in tissue culture with the use of diffusion chambers]
Leukemia, Monocytic, Acute
Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay.
Leukemia, Monocytic, Acute
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type ? in chronic myeloid leukemia patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Characterization of a membrane-associated phosphotyrosyl protein phosphatase from the A431 human epidermoid carcinoma cell line.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differential expression of SHP-1 in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Eupolyphaga sinensis Walker inhibits human chronic myeloid leukemia cell K562 growth by inducing G2-M phase cell cycle arrest and targeting EGFR signaling pathway and in S180 tumor-bearing mice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Expression, prognostic significance and mutational analysis of protein tyrosine phosphatase SHP-1 in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Functional polymorphisms in SOCS1 and PTPN22 genes correlate with the response to imatinib treatment in newly diagnosed chronic-phase chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inducible SHP-2 activation confers resistance to imatinib in drug-tolerant chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of Phosphotyrosine Phosphatase 1B Causes Resistance in BCR-ABL-Positive Leukemia Cells to the ABL Kinase Inhibitor STI571.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Overexpression of SET is a recurrent event associated with poor outcome that contributes to protein phosphatase 2A inhibition in acute myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotyrosine phosphatase activity prevents the detection of P210bcr/abl protein in mature cells in chronic myelogenous leukemia even by an immunoblotting technique.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein Tyrosine Phosphatase Receptor Type {gamma} Is a Functional Tumor Suppressor Gene Specifically Downregulated in Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Redirecting traffic using the XPO1 police.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Regulative Loop between ?-catenin and Protein Tyrosine Receptor Type ? in Chronic Myeloid Leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Resveratrol inhibits STAT5 activation through the induction of SHP-1 and SHP-2 tyrosine phosphatases in chronic myelogenous leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
SHP1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome-positive cells derived from patients with chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Effect of arsenic trioxide and 5-aza-2'-deoxycytidine on SHP-1, JAK3, TYK2 gene expression in K562 cells].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Expression of SHP-1 mRNA in Patients with Myelogenous Leukemia and Its Clinical Significance].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Granulocyte acid phosphatase activity during the course of chronic myeloid leukemia and Hodgkin's disease]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Overexpression of Shp-2 is associated with the unlimited growth and apoptosis resistance of p210 bcr-abl-mediated chronic myeloid leukemia]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[SHP-1 gene in the disease progression of chronic myeloid leukemia].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[The expression and clinical significance of hematopoietic cell phosphatase and cysteinyl aspartate-specific proteinase in leukemia]
Leukemia, Myeloid
Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.
Leukemia, Myeloid
Effects of sodium stibogluconate on differentiation and proliferation of human myeloid leukemia cell lines in vitro.
Leukemia, Myeloid
Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines.
Leukemia, Myeloid
Phorbol ester-resistant monoblastoid leukemia cells with a functional mitogen-activated protein kinase cascade but without responsive protein tyrosine phosphatases.
Leukemia, Myeloid
Presence of "prostatic" acid phosphatase in human neutrophils.
Leukemia, Myeloid
PRL-3 exerts oncogenic functions in myeloid leukemia cells via aberrant dephosphorylation of stathmin and activation of STAT3 signaling.
Leukemia, Myeloid
The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.
Leukemia, Myeloid
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Leukemia, Myeloid
Triphenyltin enhances the neutrophilic differentiation of promyelocytic HL-60 cells.
Leukemia, Myeloid
Up-regulation of I-2(PP2A)/SET gene expression in rat primary hepatomas and regenerating livers.
Leukemia, Myeloid
[Expression and Significance of PTPL1 in Hematological Malignan-cies].
Leukemia, Myeloid
[Expression of SHP-1 mRNA in Patients with Myelogenous Leukemia and Its Clinical Significance].
Leukemia, Myeloid, Acute
A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia.
Leukemia, Myeloid, Acute
A Phase I/II Trial of the Combination of Azacitidine and Gemtuzumab Ozogamicin for Treatment of Relapsed Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.
Leukemia, Myeloid, Acute
Acute myeloid leukemia in an adult Noonan syndrome patient with PTPN11 mutation.
Leukemia, Myeloid, Acute
Azacitidine and Sorafenib Therapy in a Pediatric Patient With Refractory Acute Myeloid Leukemia With Monosomy 7 and Somatic PTPN11 Mutation.
Leukemia, Myeloid, Acute
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.
Leukemia, Myeloid, Acute
Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
Leukemia, Myeloid, Acute
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD.
Leukemia, Myeloid, Acute
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Leukemia, Myeloid, Acute
Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature.
Leukemia, Myeloid, Acute
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia.
Leukemia, Myeloid, Acute
Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.
Leukemia, Myeloid, Acute
Dual-specificity phosphatase 10 is fused to MDS1/EVI1-like gene 1 in a case of acute myelogenous leukemia with der1t1;1(p36.3;q21).
Leukemia, Myeloid, Acute
Dynamics of clonal evolution in myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia.
Leukemia, Myeloid, Acute
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.
Leukemia, Myeloid, Acute
Identification of Novel Functional Variants of SIN3A and SRSF1 among Somatic Variants in Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD-negative acute myeloid leukemia.
Leukemia, Myeloid, Acute
Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation.
Leukemia, Myeloid, Acute
Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.
Leukemia, Myeloid, Acute
KIAA1524: A novel MLL translocation partner in acute myeloid leukemia.
Leukemia, Myeloid, Acute
LEO1 is regulated by PRL-3 and mediates its oncogenic properties in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.
Leukemia, Myeloid, Acute
Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia.
Leukemia, Myeloid, Acute
Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients.
Leukemia, Myeloid, Acute
Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.
Leukemia, Myeloid, Acute
Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations.
Leukemia, Myeloid, Acute
Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations.
Leukemia, Myeloid, Acute
Myelodysplastic syndrome with multilineage dysplasia evolving to acute myeloid leukemia: Noonan syndrome with c.218C>T mutation in PTPN11 gene.
Leukemia, Myeloid, Acute
Non-canonical activation of ?-catenin by PRL-3 phosphatase in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Noonan Syndrome and Related Disorders: Genetics and Pathogenesis.
Leukemia, Myeloid, Acute
Noonan syndrome and related disorders: genetics and pathogenesis.
Leukemia, Myeloid, Acute
Overexpression of SET is a recurrent event associated with poor outcome that contributes to protein phosphatase 2A inhibition in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
PRL-2 increases Epo and IL-3 responses in hematopoietic cells.
Leukemia, Myeloid, Acute
PRL-3 exerts oncogenic functions in myeloid leukemia cells via aberrant dephosphorylation of stathmin and activation of STAT3 signaling.
Leukemia, Myeloid, Acute
Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Leukemia, Myeloid, Acute
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group.
Leukemia, Myeloid, Acute
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia.
Leukemia, Myeloid, Acute
SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.
Leukemia, Myeloid, Acute
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
Leukemia, Myeloid, Acute
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
Leukemia, Myeloid, Acute
STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia.
Leukemia, Myeloid, Acute
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Leukemia, Myeloid, Acute
The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.
Leukemia, Myeloid, Acute
The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.
Leukemia, Myeloid, Acute
The protein phosphatase 2A regulatory subunit B55? is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia in a child with Noonan syndrome and clonal duplication of the germline PTPN11 mutation.
Leukemia, Myeloid, Acute
Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Leukemia, Myeloid, Acute
[Effects of PTPN11 on the Biological Characteristics of AML Cells].
Leukemia, Myeloid, Acute
[Expression of SHP-1 mRNA in Patients with Myelogenous Leukemia and Its Clinical Significance].
Leukemia, Myelomonocytic, Chronic
Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action.
Leukemia, Myelomonocytic, Juvenile
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
A gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Leukemia, Myelomonocytic, Juvenile
Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
Leukemia, Myelomonocytic, Juvenile
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.
Leukemia, Myelomonocytic, Juvenile
CD14/16 monocyte profiling in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Childhood and adolescent lymphoid and myeloid leukemia.
Leukemia, Myelomonocytic, Juvenile
Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.
Leukemia, Myelomonocytic, Juvenile
Common acute lymphoblastic leukemia in a girl with genetically confirmed LEOPARD syndrome.
Leukemia, Myelomonocytic, Juvenile
Complete Resolution of Lymphoid Interstitial Pneumonia in a Patient With Juvenile Myelomonocytic Leukemia Treated With Allogeneic Bone Marrow Transplant: Killing 2 Birds With 1 Stone.
Leukemia, Myelomonocytic, Juvenile
Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Different outcomes of allogeneic hematopoietic stem cell transplant in a pair of twins affected by juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling.
Leukemia, Myelomonocytic, Juvenile
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Expanding the SHOC2 mutation associated phenotype of noonan syndrome with loose anagen hair: Structural brain anomalies and myelofibrosis.
Leukemia, Myelomonocytic, Juvenile
Four-year remission despite umbilical cord graft rejection in juvenile myelomonocytic leukemia with PTPN11 mutations.
Leukemia, Myelomonocytic, Juvenile
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.
Leukemia, Myelomonocytic, Juvenile
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Leukemia, Myelomonocytic, Juvenile
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
Leukemia, Myelomonocytic, Juvenile
Genetic disruption of the PI3K regulatory subunits, p85?, p55?, and p50?, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
Leukemia, Myelomonocytic, Juvenile
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia.
Leukemia, Myelomonocytic, Juvenile
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11.
Leukemia, Myelomonocytic, Juvenile
Germline PTPN11 mutation affecting exon 8 in a case of syndromic juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Leukemia, Myelomonocytic, Juvenile
Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Leukemia, Myelomonocytic, Juvenile
Juvenile myelomonocytic leukemia with PTPN11 mutation in a 23-month-old girl.
Leukemia, Myelomonocytic, Juvenile
Juvenile myelomonocytic leukemia-associated variants are associated with neo-natal lethal Noonan syndrome.
Leukemia, Myelomonocytic, Juvenile
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Leukemia, Myelomonocytic, Juvenile
Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation.
Leukemia, Myelomonocytic, Juvenile
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.
Leukemia, Myelomonocytic, Juvenile
Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations.
Leukemia, Myelomonocytic, Juvenile
Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.
Leukemia, Myelomonocytic, Juvenile
Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.
Leukemia, Myelomonocytic, Juvenile
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
Leukemia, Myelomonocytic, Juvenile
Nonsyndromic Juvenile Myelomonocytic Leukemia With PTPN11 Mutation in a 9-Year-old Girl.
Leukemia, Myelomonocytic, Juvenile
Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
Leukemia, Myelomonocytic, Juvenile
Osteopetrosis mimicking juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Pediatric myelodysplastic syndrome with inflammatory manifestations: Diagnosis, genetics, treatment, and outcome.
Leukemia, Myelomonocytic, Juvenile
Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation.
Leukemia, Myelomonocytic, Juvenile
PTPN11 mutation with additional somatic alteration indicates unfavorable outcome in juvenile myelomonocytic leukemia: a retrospective clinical study from a single center.
Leukemia, Myelomonocytic, Juvenile
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group.
Leukemia, Myelomonocytic, Juvenile
RAS diseases in children.
Leukemia, Myelomonocytic, Juvenile
Respiratory failure, juvenile myelomonocytic leukemia, and neonatal Noonan syndrome.
Leukemia, Myelomonocytic, Juvenile
Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Role of protein phosphatases in the cancer microenvironment.
Leukemia, Myelomonocytic, Juvenile
Serial investigation of PTPN11 mutation in nonhematopoietic tissues in a patient with juvenile myelomonocytic leukemia who was treated with unrelated cord blood transplantation.
Leukemia, Myelomonocytic, Juvenile
SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton.
Leukemia, Myelomonocytic, Juvenile
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
Leukemia, Myelomonocytic, Juvenile
Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Leukemia, Myelomonocytic, Juvenile
Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.
Leukemia, Myelomonocytic, Juvenile
The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia.
Leukemia, Myelomonocytic, Juvenile
The molecular basis of leukemia.
Leukemia, Myelomonocytic, Juvenile
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease.
Leukemia, Myelomonocytic, Juvenile
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Leukemia, Myelomonocytic, Juvenile
Transient juvenile myelomonocytic leukemia in the setting of PTPN11 mutation and Noonan syndrome with secondary development of monosomy 7.
Leukemia, Prolymphocytic
Alkaline phosphatase and tartrate resistant acid phosphatase activity in cells of prolymphocytic leukemia.
Leukemia, Prolymphocytic, T-Cell
Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies.
Leukemia, Promyelocytic, Acute
Inhibition of ATRA-induced myeloid differentiation in acute promyelocytic leukemia by a new protein tyrosine phosphatase inhibitor, 3,4-dephostatin.
Leukemia, Promyelocytic, Acute
Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines.
Leukemia, T-Cell
Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies.
Leukemia, T-Cell
Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.
Leukemia, T-Cell
Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate.
Leukemia, T-Cell
Protein Phosphatase 2A as a Potential Target for Treatment of Adult T Cell Leukemia.
Leukemia, T-Cell
Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways.
Leukemia-Lymphoma, Adult T-Cell
Comprehensive high-throughput meta-analysis of differentially expressed microRNAs in transcriptomic datasets reveals significant disruption of MAPK/JNK signal transduction pathway in Adult T-cell leukemia/lymphoma.
Leukemia-Lymphoma, Adult T-Cell
Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
Leukemia-Lymphoma, Adult T-Cell
KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma Cells.
Leukemia-Lymphoma, Adult T-Cell
Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.
Leukocytosis
Increased expression of tyrosine phosphatase SHP2 in experimental pneumococcal meningitis: correlation with tumor necrosis factor-alpha and cerebrospinal fluid pleocytosis.
Leukocytosis
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Leukocytosis
[Changes in the functional state of the lysosomal apparatus of the peripheral blood neutrophilic leukocytes in rabbits under the action of immobilization with thyroid hormone deficiency]
Leukocytosis
[Effect of beta receptor blockaders on the status of the lysosomal system of peripheral blood neutrophils in rabbits with immobilization stress]
Leukomalacia, Periventricular
Accelerated Axonal Loss Following Acute CNS Demyelination in Mice Lacking Protein Tyrosine Phosphatase Receptor Type Z.
Li-Fraumeni Syndrome
Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.
Lichen Planus, Oral
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients.
Lipoma
PP2A binds the LIM-domains of Lipoma Preferred Partner via its PR130/B" subunit to regulate cell adhesion and migration.
Liposarcoma
Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12.
Liver Abscess, Amebic
Characterization of the protein tyrosine phosphatase PRL from Entamoeba histolytica.
Liver Cirrhosis
Computational identification of microRNAs and their targets in liver cirrhosis.
Liver Cirrhosis
Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression.
Liver Cirrhosis
Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone.
Liver Cirrhosis
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis.
Liver Cirrhosis
p66Shc Contributes to Liver Fibrosis through the Regulation of Mitochondrial Reactive Oxygen Species.
Liver Cirrhosis
Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.
Liver Cirrhosis
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells.
Liver Cirrhosis
PTP1B promotes macrophage activation by regulating the NF-?B pathway in alcoholic liver injury.
Liver Cirrhosis
Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis.
Liver Cirrhosis
The metabolic behaviour of the lymphocytes from serous effusions in various benign internal diseases.
Liver Cirrhosis
[Methods of hemostasis and hepatectomy in injuries of the liver]
Liver Cirrhosis, Biliary
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Liver Cirrhosis, Biliary
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Liver Cirrhosis, Biliary
The PTPN22 1858T variant is not associated with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22.
Liver Diseases
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Liver Diseases
Dual-specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice through TAK1 Suppression.
Liver Diseases
Dual-specificity Phosphatase 9 protects against Cardiac Hypertrophy by targeting ASK1.
Liver Diseases
Dual-Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression.
Liver Diseases
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Liver Diseases
Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease.
Liver Diseases
Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol-induced liver dysfunction: Rescue effect of ginger extract.
Liver Diseases
Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease.
Liver Diseases
Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors.
Liver Diseases
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.
Liver Diseases
Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.
Liver Diseases
Polymorphism of Receptor-Type Tyrosine-Protein Phosphatase Delta gene in the development of non-alcoholic fatty liver disease.
Liver Diseases
Protein tyrosine Phosphatase (PTP1B): A promising Drug Target against life threatening ailments.
Liver Diseases
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases.
Liver Diseases
Protein Tyrosine Phosphatase Nonreceptor Type 2 Expression Does Not Correlate with Viral Load or Response to Direct-Acting Antiviral Therapy in Hepatitis C Virus Infections-Infected Patients.
Liver Diseases
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Liver Diseases
PTPROt aggravates inflammation by enhancing NF-?B activation in liver macrophages during nonalcoholic steatohepatitis.
Liver Diseases
Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-?B activation.
Liver Diseases
[Changes in tissue acid phosphatase activity in serveral liver disease]
Liver Diseases, Alcoholic
Activated protein phosphatase 2A disrupts nutrient sensing balance between mTORC1 and AMPK causing sarcopenia in alcoholic liver disease.
Liver Diseases, Alcoholic
Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice.
Liver Diseases, Alcoholic
Reduced methylation of PP2Ac promotes ethanol-induced lipid accumulation through FOXO1 phosphorylation in vitro and in vivo.
Liver Failure
Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.
Liver Failure
Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure.
Liver Failure
Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B.
Liver Failure, Acute
Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo.
Liver Failure, Acute
PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
Liver Neoplasms
Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies.
Liver Neoplasms
Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A.
Liver Neoplasms
Functions of Shp2 in cancer.
Liver Neoplasms
miR-186 Inhibits Liver Cancer Stem Cells Expansion via Targeting PTPN11.
Liver Neoplasms
New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.
Liver Neoplasms
Oncogenic potential of CK2? and its regulatory role in EGF-induced HDAC2 expression in human liver cancer.
Liver Neoplasms
SHP-1 Acts as a Tumor Suppressor in Hepatocarcinogenesis and HCC Progression.
Liver Neoplasms
Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic ?-Catenin, PIK3CA and MET.
Liver Neoplasms
Silencing CDC25A inhibits the proliferation of liver cancer cells by downregulating IL?6 in vitro and in vivo.
Liver Neoplasms
Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-?B activation.
Liver Neoplasms
[Inhibiting effects of RNA interference PRL-3 on the invasion of human hepatocellular cancer cells.]
Lung Diseases
Circulating levels of tartrate-resistant acid phosphatase in macrophage-activated lung disease.
Lung Diseases
Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations.
Lung Diseases
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Lung Diseases
Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells.
Lung Diseases
The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.
Lung Diseases
[Comparative data of a study of the alkaline and acid phosphatase activity of blood serum and of neutrophils in patients with nonspecific inflammatory lung diseases]
Lung Diseases
[Determination of alveolar macrophage function in nonspecific lung diseases by the simultaneous estimation of phagocytosis and acid phosphatase activity]
Lung Injury
Loss of myeloid-specific protein phosphatase 2A enhances lung injury and fibrosis and results in IL-10-dependent sensitization of epithelial cell apoptosis.
Lung Injury
Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury.
Lung Injury
Protection against reperfusion lung injury via aborgating multiple signaling cascades by trichostatin A.
Lung Injury
Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury.
Lung Injury
Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice.
Lung Injury
YAP expression in endothelial cells prevents ventilator-induced lung injury.
Lung Neoplasms
A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A.
Lung Neoplasms
A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.
Lung Neoplasms
A superoxide-mediated MKP-1 Degradation and JNK Activation Pathway for Luteolin-induced Lung Cancer Cytotoxicity.
Lung Neoplasms
Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis.
Lung Neoplasms
Altered expression of phosphatase of regenerating liver gene family in non-small cell lung cancer.
Lung Neoplasms
Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells.
Lung Neoplasms
Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells.
Lung Neoplasms
Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese.
Lung Neoplasms
Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers.
Lung Neoplasms
CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.
Lung Neoplasms
CDC25B: relationship with angiogenesis and prognosis in non-small cell lung carcinoma.
Lung Neoplasms
Cell cycle arrest biomarkers in human lung cancer cells after treatment with selenium in culture.
Lung Neoplasms
Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line.
Lung Neoplasms
Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells.
Lung Neoplasms
Copy number variations of chromosome 17p13.1 might be linked to high risk of lung cancer in heavy smokers.
Lung Neoplasms
DDIAS promotes STAT3 activation by preventing STAT3 recruitment to PTPRM in lung cancer cells.
Lung Neoplasms
Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.
Lung Neoplasms
Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer.
Lung Neoplasms
Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway.
Lung Neoplasms
Downregulating PRL-3 inhibit migration and invasion of lung cancer cell via RhoA and mDia1.
Lung Neoplasms
Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells.
Lung Neoplasms
Dual Specificity Phosphatase 6 (DUSP6) Polymorphism Predicts Prognosis of Inoperable Non-Small Cell Lung Cancer after Chemoradiotherapy.
Lung Neoplasms
Dysfunction of Poly (ADP-Ribose) Glycohydrolase Induces a Synthetic Lethal Effect in Dual Specificity Phosphatase 22-Deficient Lung Cancer Cells.
Lung Neoplasms
Effect of protein-tyrosine phosphatase 4A3 by small interfering RNA on the proliferation of lung cancer.
Lung Neoplasms
Epithelial-specific methylation marker: a potential plasma biomarker in advanced non-small cell lung cancer.
Lung Neoplasms
Erratum to: The role of SHP-1 promoter 2 hypermethylation detection of lymph node micrometastasis in resectable stage I non-small cell lung cancer as a prognostic marker of disease recurrence.
Lung Neoplasms
Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
Lung Neoplasms
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
Lung Neoplasms
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Lung Neoplasms
Expression of the cdc25B gene as a prognosis marker in non-small cell lung cancer.
Lung Neoplasms
Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7.
Lung Neoplasms
Functions of Shp2 in cancer.
Lung Neoplasms
Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
Lung Neoplasms
Genome Wide Methylome Alterations in Lung Cancer.
Lung Neoplasms
Genomic data from NSCLC tumors reveals correlation between SHP-2 activity and PD-L1 expression and suggests synergy in combining SHP-2 and PD-1/PD-L1 inhibitors.
Lung Neoplasms
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers.
Lung Neoplasms
Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.
Lung Neoplasms
High expression of CIP2A protein is associated with tumor aggressiveness in stage I-III NSCLC and correlates with poor prognosis.
Lung Neoplasms
High Expression of PTPN3 Predicts Progression and Unfavorable Prognosis of Glioblastoma.
Lung Neoplasms
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines.
Lung Neoplasms
Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice.
Lung Neoplasms
IA-2, a transmembrane protein tyrosine phosphatase, is expressed in human lung cancer cell lines with neuroendocrine phenotype.
Lung Neoplasms
Implication of a protein-tyrosine-phosphatase in human lung cancer.
Lung Neoplasms
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Lung Neoplasms
Increased PTPRA expression leads to poor prognosis through c-Src activation and G1 phase progression in squamous cell lung cancer.
Lung Neoplasms
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy.
Lung Neoplasms
Inhibitors of Protein Tyrosine Phosphatase PTP1B With Anticancer Potential.
Lung Neoplasms
Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition.
Lung Neoplasms
Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer.
Lung Neoplasms
Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents.
Lung Neoplasms
Involvement of cdc25c in cell cycle alteration of a radioresistant lung cancer cell line established with fractionated ionizing radiation.
Lung Neoplasms
Involvement of MAPK phosphatase-1 in dexamethasone-induced chemoresistance in lung cancer.
Lung Neoplasms
Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4.
Lung Neoplasms
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP ?/? signaling by menin.
Lung Neoplasms
Methylation of gene encoding the growth suppressor protein tyrosine phosphatase receptor-type O (PTPRO) in human hepatocellular carcinoma and identification of VCP as its bona fide substrate.
Lung Neoplasms
Microcystin-LR induces a wide variety of biochemical changes in the A549 human non-small cell lung cancer cell line: Roles for protein phosphatase 2A and its substrates.
Lung Neoplasms
MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc.
Lung Neoplasms
MicroRNA-574-5p promotes metastasis of non-small cell lung cancer by targeting PTPRU.
Lung Neoplasms
MiR-1260b promotes the migration and invasion in non-small cell lung cancer via targeting PTPRK.
Lung Neoplasms
miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.
Lung Neoplasms
miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1).
Lung Neoplasms
MiR-365 enhances the radiosensitivity of non-small cell lung cancer cells through targeting CDC25A.
Lung Neoplasms
Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients.
Lung Neoplasms
Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance.
Lung Neoplasms
Molecular analysis of the protein tyrosine phosphatase gamma gene in human lung cancer cell lines.
Lung Neoplasms
Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer.
Lung Neoplasms
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Lung Neoplasms
Mutational analysis of PTPRT phosphatase domains in common human cancers.
Lung Neoplasms
N160 of Aiolos Determines its DNA-Binding Activity.
Lung Neoplasms
Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells.
Lung Neoplasms
Novel PROTACs for degradation of SHP2 protein.
Lung Neoplasms
NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma.
Lung Neoplasms
Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc.
Lung Neoplasms
p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells.
Lung Neoplasms
Phosphatase of regenerating liver-1 promotes cell migration and invasion and regulates filamentous actin dynamics.
Lung Neoplasms
Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition.
Lung Neoplasms
Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutants.
Lung Neoplasms
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
Lung Neoplasms
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells.
Lung Neoplasms
PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer.
Lung Neoplasms
Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer.
Lung Neoplasms
Prognostic value of dual-specificity phosphatase 6 expression in non-small cell lung cancer.
Lung Neoplasms
Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer.
Lung Neoplasms
Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer.
Lung Neoplasms
Protein tyrosine phosphatase L1 inhibits high-grade serous ovarian carcinoma progression by targeting I?B?.
Lung Neoplasms
Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation.
Lung Neoplasms
Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC.
Lung Neoplasms
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
Lung Neoplasms
Protein tyrosine phosphatase receptor-type O targeted by methylation in lung cancer.
Lung Neoplasms
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Lung Neoplasms
PTPL1 suppresses lung cancer cell migration via inhibiting TGF-?1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT.
Lung Neoplasms
PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor.
Lung Neoplasms
PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization.
Lung Neoplasms
PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma.
Lung Neoplasms
PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer.
Lung Neoplasms
PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies.
Lung Neoplasms
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Lung Neoplasms
Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2.
Lung Neoplasms
Regulation and deregulation of G2 checkpoint proteins with cisplatin.
Lung Neoplasms
Regulation of lung cancer cell growth and invasiveness by beta-TRCP.
Lung Neoplasms
SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A.
Lung Neoplasms
SHP-2 and PD-L1 Inhibition Combined with Radiotherapy Enhances Systemic Antitumor Effects in an Anti-PD-1-Resistant Model of Non-Small Cell Lung Cancer.
Lung Neoplasms
Shp2 confers cisplatin resistance in small cell lung cancer via an AKT-mediated increase in CA916798.
Lung Neoplasms
Shp2 regulates migratory behavior and response to EGFR-TKIs through ERK1/2 pathway activation in non-small cell lung cancer cells.
Lung Neoplasms
Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients.
Lung Neoplasms
Statistical completion of a partially identified graph with applications for the estimation of gene regulatory networks.
Lung Neoplasms
Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.
Lung Neoplasms
Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo.
Lung Neoplasms
The carcinogen (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces Cdc25B expression in human bronchial and lung cancer cells.
Lung Neoplasms
The clinicopathological and prognostic implications of tyrosine phosphatase SHP2 and ankyrin Hook1 gene expression in non- small cell lung cancer patients treated with gemcitabine plus platinum as first-line chemotherapy.
Lung Neoplasms
The increased expression and aberrant methylation of SHC1 in non-small cell lung cancer: Integrative analysis of clinical and bioinformatics databases.
Lung Neoplasms
The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase Kappa and Inhibits {beta}-Catenin Transcriptional Activity in Lung Cancer Cells.
Lung Neoplasms
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Lung Neoplasms
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells.
Lung Neoplasms
The red wine component ellagic acid induces autophagy and exhibits anti-lung cancer activity in vitro and in vivo.
Lung Neoplasms
The role of SHP-1 promoter 2 hypermethylation detection of lymph node micrometastasis in resectable stage I non-small cell lung cancer as a prognostic marker of disease recurrence.
Lung Neoplasms
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Lung Neoplasms
Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer.
Lung Neoplasms
Tripartite motif protein 11 (TRIM11), an oncogene for human lung cancer via the DUSP6-mediated ERK1/2 signaling pathway.
Lung Neoplasms
Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer.
Lung Neoplasms
Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer.
Lung Neoplasms
Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.
Lung Neoplasms
VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC.
Lung Neoplasms
Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells.
Lung Neoplasms
YBX1 regulates tumor growth via CDC25a pathway in human lung adenocarcinoma.
Lung Neoplasms
[Expression and clinical significance of SHP2 in the tumor tissues of smokers with lung cancer]
Lung Neoplasms
[Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer]
Lung Neoplasms
[Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene].
Lung Neoplasms
[Expression of protein-tyrosine-phosphatase 1B in non-small-cell lung cancer and its prognostic significance].
Lung Neoplasms
[Expressions and significances of PRL-3 and RhoC in A549 cell].
Lung Neoplasms
[The relationship between histological classification of lung cancer and protein tyrosine phosphatase.]
Lupus Erythematosus, Systemic
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Lupus Erythematosus, Systemic
A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
Lupus Erythematosus, Systemic
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population.
Lupus Erythematosus, Systemic
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.
Lupus Erythematosus, Systemic
Association between PPP2CA polymorphisms and clinical features in southwest Chinese systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Association of PTPN22 gene polymorphism and systemic lupus erythematosus in a cohort of Egyptian patients: impact on clinical and laboratory results.
Lupus Erythematosus, Systemic
Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.
Lupus Erythematosus, Systemic
Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Lupus Erythematosus, Systemic
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.
Lupus Erythematosus, Systemic
Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis.
Lupus Erythematosus, Systemic
Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-? receptor signaling.
Lupus Erythematosus, Systemic
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Lupus Erythematosus, Systemic
Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland.
Lupus Erythematosus, Systemic
CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.
Lupus Erythematosus, Systemic
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
Lupus Erythematosus, Systemic
Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
Lupus Erythematosus, Systemic
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Expression of the sialosyl-Tn epitope on CD45 derived from activated peripheral blood T cells.
Lupus Erythematosus, Systemic
Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening.
Lupus Erythematosus, Systemic
Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.
Lupus Erythematosus, Systemic
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Lupus Erythematosus, Systemic
High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility.
Lupus Erythematosus, Systemic
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Lupus Erythematosus, Systemic
JAK2 and PTPRC mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
Lupus Erythematosus, Systemic
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes.
Lupus Erythematosus, Systemic
Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue.
Lupus Erythematosus, Systemic
Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele.
Lupus Erythematosus, Systemic
No association of PTPN22 R620 W gene polymorphism with rheumatic heart disease and systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Pathogenesis and treatment of autoimmune rheumatic diseases.
Lupus Erythematosus, Systemic
Promoter Hypomethylation Results in Increased Expression of Protein Phosphatase 2A in T Cells from Patients with Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts.
Lupus Erythematosus, Systemic
Protein tyrosine phosphatase PTPN22 in human autoimmunity.
Lupus Erythematosus, Systemic
PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results.
Lupus Erythematosus, Systemic
PTPN22 1858C?>?T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
Lupus Erythematosus, Systemic
PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes.
Lupus Erythematosus, Systemic
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Lupus Erythematosus, Systemic
PTPN22 gene polymorphism in Behçet's disease.
Lupus Erythematosus, Systemic
PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.
Lupus Erythematosus, Systemic
PTPN22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population.
Lupus Erythematosus, Systemic
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Lupus Erythematosus, Systemic
PTPN22 Variant R620W Is Associated With Reduced Toll-like Receptor 7-Induced Type I Interferon in Systemic Lupus Erythematosus.
Lupus Erythematosus, Systemic
PTPN22: its role in SLE and autoimmunity.
Lupus Erythematosus, Systemic
PTPN22: the archetypal non-HLA autoimmunity gene.
Lupus Erythematosus, Systemic
R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity.
Lupus Erythematosus, Systemic
Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE).
Lupus Erythematosus, Systemic
Regulation of autoimmune and anti-tumour T cell responses by PTPN22.
Lupus Erythematosus, Systemic
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.
Lupus Erythematosus, Systemic
Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity.
Lupus Erythematosus, Systemic
ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling.
Lupus Erythematosus, Systemic
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Lupus Erythematosus, Systemic
The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update.
Lupus Erythematosus, Systemic
The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.
Lupus Erythematosus, Systemic
The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus.
Lupus Erythematosus, Systemic
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
Lupus Erythematosus, Systemic
The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility.
Lupus Erythematosus, Systemic
The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
Lupus Erythematosus, Systemic
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
Lupus Erythematosus, Systemic
The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.
Lupus Erythematosus, Systemic
The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.
Lupus Erythematosus, Systemic
The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in caucasian case-control samples.
Lupus Erythematosus, Systemic
The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.
Lupus Erythematosus, Systemic
The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.
Lupus Erythematosus, Systemic
TRAF1/C5, eNOS, C1q, but not STAT4 and PTPN22 gene polymorphisms are associated with genetic susceptibility to systemic lupus erythematosus in Turkey.
Lupus Erythematosus, Systemic
Tumor necrosis factor receptor II and PTPN22 genes polymorphisms and the risk of systemic lupus erythematosus in Egyptian children.
Lupus Erythematosus, Systemic
[Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients.]
Lupus Erythematosus, Systemic
[Genetic polymorphisms of low molecular weight protein tyrosine phosphatase (LMW-PTP): relationship with erythrocyte enzymatic phenotype in patients with Systemic Lupus Erythematosus]
Lupus Nephritis
Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads.
Lupus Nephritis
IL-34-Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Faslpr Mice.
Lymphadenopathy
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
Lymphangioma, Cystic
How necessary is to analyze PTPN11 gene in fetuses with first trimester cystic hygroma and normal karyotype?
Lymphangioma, Cystic
Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings.
Lymphangioma, Cystic
Prenatal DNA diagnosis of Noonan syndrome in a fetus with massive hygroma colli, pleural effusion and ascites.
Lymphangioma, Cystic
PTPN11 analysis for the prenatal diagnosis of Noonan syndrome in fetuses with abnormal ultrasound findings.
Lymphatic Metastasis
Aberrant promoter 2 methylation?mediated downregulation of protein tyrosine phosphatase, non?receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Lymphatic Metastasis
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Lymphatic Metastasis
Association of Tyrosine PRL-3 Phosphatase Protein Expression with Peritoneal Metastasis of Gastric Carcinoma and Prognosis.
Lymphatic Metastasis
CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
Lymphatic Metastasis
Clinical importance of phosphatase of regenerating liver-3 expression in breast cancer.
Lymphatic Metastasis
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus.
Lymphatic Metastasis
Clinical significance of sCIP2A levels in breast cancer.
Lymphatic Metastasis
Clinicopathological significance of PTPN12 expression in human breast cancer.
Lymphatic Metastasis
Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer.
Lymphatic Metastasis
Combined expression of metastasis related markers Naa10p, SNCG and PRL-3 and its prognostic value in breast cancer patients.
Lymphatic Metastasis
Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation.
Lymphatic Metastasis
Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients.
Lymphatic Metastasis
Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.
Lymphatic Metastasis
Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference.
Lymphatic Metastasis
Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer.
Lymphatic Metastasis
Expression and Prognostic Value of PRL-3 in Human Intrahepatic Cholangiocarcinoma.
Lymphatic Metastasis
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Expression of phosphatase of regenerating liver-3 in squamous cell carcinoma of the cervix.
Lymphatic Metastasis
Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer.
Lymphatic Metastasis
Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis.
Lymphatic Metastasis
Expression of PRL-3 regulates proliferation and invasion of breast cancer cells in vitro.
Lymphatic Metastasis
Expressions of Src homology 2 domain-containing phosphatase and its clinical significance in laryngeal carcinoma.
Lymphatic Metastasis
Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.
Lymphatic Metastasis
High expression of PRL-3 can promote growth of gastric cancer and exhibits a poor prognostic impact on patients.
Lymphatic Metastasis
High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer.
Lymphatic Metastasis
High labeling indices of cdc25B is linked to progression of gastric cancers and associated with a poor prognosis.
Lymphatic Metastasis
High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study.
Lymphatic Metastasis
High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer.
Lymphatic Metastasis
Identification of Prognostic miRNA Signature and Lymph Node Metastasis-Related Key Genes in Cervical Cancer.
Lymphatic Metastasis
IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation.
Lymphatic Metastasis
Increased PTPRA expression leads to poor prognosis through c-Src activation and G1 phase progression in squamous cell lung cancer.
Lymphatic Metastasis
Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis.
Lymphatic Metastasis
Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9.
Lymphatic Metastasis
Loss of PTPN4 activates STAT3 to promote the tumor growth in rectal cancer.
Lymphatic Metastasis
Low Expression of Tyrosine-protein Phosphatase Nonreceptor Type 12 is Associated with Lymph Node Metastasis and Poor Prognosis in Operable Triple-negative Breast Cancer.
Lymphatic Metastasis
Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma.
Lymphatic Metastasis
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes.
Lymphatic Metastasis
Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis.
Lymphatic Metastasis
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration.
Lymphatic Metastasis
Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Phosphatase of regenerating liver-3 as a prognostic biomarker in histologically node-negative gastric cancer.
Lymphatic Metastasis
Phosphatase of Regenerating Liver-3 Induces Angiogenesis by Increasing Extracellular Signal-Regulated Kinase Phosphorylation in Endometrial Adenocarcinoma.
Lymphatic Metastasis
PRL-3 and E-cadherin show mutual interactions and participate in lymph node metastasis formation in gastric cancer.
Lymphatic Metastasis
PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer.
Lymphatic Metastasis
Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer.
Lymphatic Metastasis
Prognostic importance of RASSF2 expression in patients with gastric cancer who had undergone radical gastrectomy.
Lymphatic Metastasis
Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy.
Lymphatic Metastasis
Protein tyrosine phosphatase 1B expression contributes to the development of breast cancer.
Lymphatic Metastasis
PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.
Lymphatic Metastasis
PTP4A3 expression increases strongly in lymph node metastases from colorectal carcinoma.
Lymphatic Metastasis
Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma.
Lymphatic Metastasis
Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer.
Lymphatic Metastasis
The Expression of p66Shc Protein in Benign, Premalignant, and Malignant Gastrointestinal Lesions.
Lymphatic Metastasis
The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance.
Lymphatic Metastasis
Therapeutic Potential of PRL-3 Targeting and Clinical Significance of PRL-3 Genomic Amplification in Gastric Cancer.
Lymphatic Metastasis
Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway.
Lymphatic Metastasis
Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto's Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis.
Lymphatic Metastasis
[Expression and its relationship of PRL-3 and RhoC in non-small cell lung cancer]
Lymphatic Metastasis
[Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene].
Lymphatic Metastasis
[Expression of phosphatase of regenerating liver-3 in gastric cancer, its relationship with prognosis, and its role in gastric cancer cell proliferation]
Lymphatic Metastasis
[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]
Lymphatic Metastasis
[Methylation of PTPRG gene and its regulation in gastric cancer]
Lymphedema
Mutations in the VEGFR3 signaling pathway explain 36% of familial lymphedema.
Lymphedema
Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans.
Lymphocytic Choriomeningitis
CD8+ T cell responses to a viral escape mutant epitope: active suppression via altered SHP-1 activity.
Lymphocytic Choriomeningitis
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection.
Lymphocytic Choriomeningitis
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity.
Lymphocytic Choriomeningitis
PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.
Lymphocytic Choriomeningitis
PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Lymphohistiocytosis, Hemophagocytic
Reduced Tyk2/SHP-1 interaction and lack of SHP-1 mutation in a kindred of familial hemophagocytic lymphohistiocytosis.
Lymphoma
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.
Lymphoma
Acid phosphatase activity of the lymphocytes during polychemotherapy of lymphoproliferative diseases.
Lymphoma
Activating Mutations in PTPN11 and KRAS in Canine Histiocytic Sarcomas.
Lymphoma
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.
Lymphoma
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Lymphoma
Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma.
Lymphoma
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
Lymphoma
Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer.
Lymphoma
B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells.
Lymphoma
Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.
Lymphoma
c-Myc oncogene and Cdc25A cell activating phosphatase expression in non-Hodgkin's lymphoma.
Lymphoma
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma
cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkin's lymphomas.
Lymphoma
Cdc25A and cdc25B expression in malignant lymphoma of the thyroid: correlation with histological subtypes and cell proliferation.
Lymphoma
cdc25a and the splicing variant cdc25b2, but not cdc25B1, -B3 or -C, are over-expressed in aggressive human non-Hodgkin's lymphomas.
Lymphoma
Comparative quantitative analysis of cluster of differentiation 45 antigen expression on lymphocyte subsets.
Lymphoma
Correction: The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration.
Lymphoma
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.
Lymphoma
Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.
Lymphoma
Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing.
Lymphoma
DNA methylation of membrane bound tyrosine phosphatase genes in acute lymphoblastic leukemia.
Lymphoma
Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes.
Lymphoma
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Lymphoma
Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes.
Lymphoma
Elevation of lymphocyte CD45 protein tyrosine phosphatase activity during mitosis.
Lymphoma
Enzyme polymorphism in the classification of human malignant lymphoma.
Lymphoma
Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.
Lymphoma
Expression of pleiotrophin and its receptors in human placenta suggests roles in trophoblast life cycle and angiogenesis.
Lymphoma
Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis.
Lymphoma
Expression patterns of microRNA-218 and its potential functions by targeting CIP2A and BMI1 genes in melanoma.
Lymphoma
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
Lymphoma
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development.
Lymphoma
Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice.
Lymphoma
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
Lymphoma
Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia.
Lymphoma
High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity.
Lymphoma
High-resolution genomic profiling reveals clonal evolution and competition in gastrointestinal marginal zone B-cell lymphoma and its large cell variant.
Lymphoma
Identification of pleiotrophin in conditioned medium secreted from neural stem cells by SELDI-TOF and SELDI-tandem mass spectrometry.
Lymphoma
Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.
Lymphoma
Inhibition of Receptor Protein Tyrosine Phosphatase ?/? reduces alcohol intake in rats.
Lymphoma
Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter.
Lymphoma
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
Lymphoma
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.
Lymphoma
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.
Lymphoma
MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway.
Lymphoma
Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells.
Lymphoma
Molecular Pathogenesis of Peripheral T Cell Lymphoma.
Lymphoma
Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin lymphoma and T-cell non-Hodgkin lymphoma.
Lymphoma
No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis.
Lymphoma
Oxidative stress induces B lymphocyte DNA damage and apoptosis by upregulating p66shc.
Lymphoma
Phenylarsine oxide (PAO) blocks antigen receptor-induced calcium response and tyrosine phosphorylation of a distinct group of proteins.
Lymphoma
Pleiotrophin increases neurite length and number of spiral ganglion neurons in vitro.
Lymphoma
Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP-43) mRNA through the ALK/GSK3beta/beta-catenin signaling in developing mouse neurons.
Lymphoma
Pleiotrophin receptor RPTP-zeta/beta expression is up-regulated by L-DOPA in striatal medium spiny neurons of parkinsonian rats.
Lymphoma
Potential biomarkers screening to predict side effects of dexamethasone in different cancers.
Lymphoma
PRL-2 increases Epo and IL-3 responses in hematopoietic cells.
Lymphoma
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL.
Lymphoma
Protein tyrosine phosphatase receptor type C (PTPRC or CD45).
Lymphoma
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.
Lymphoma
Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis.
Lymphoma
Proteomic Analysis of Malignant B-Cell Derived Microparticles Reveals CD148 as a Potentially Useful Antigenic Biomarker for Mantle Cell Lymphoma Diagnosis.
Lymphoma
PTN-PTPRZ signalling is involved in deer antler stem cell regulation during tissue regeneration.
Lymphoma
PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer.
Lymphoma
Pulmonary inflammatory myofibroblastic tumor harboring EML4-ALK fusion gene.
Lymphoma
Receptor-type tyrosine-protein phosphatase ? directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.
Lymphoma
Reciprocal Cdc25A and p27 expression in B-cell non-Hodgkin lymphomas.
Lymphoma
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.
Lymphoma
Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias : combination analysis with cDNA expression array and tissue microarray.
Lymphoma
Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities.
Lymphoma
SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts.
Lymphoma
SHP-1 promoter 2 methylation in normal epithelial tissues and demethylation in psoriasis.
Lymphoma
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases.
Lymphoma
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Lymphoma
Structure and function of midkine as the basis of its pharmacological effects.
Lymphoma
TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.
Lymphoma
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Lymphoma
The efficacy of cisplatin on nasopharyngeal carcinoma cells may be increased via the downregulation of fibroblast growth factor receptor 2.
Lymphoma
The function of the protein tyrosine phosphatase SHP-1 in cancer.
Lymphoma
The genetics of nodal marginal zone lymphoma.
Lymphoma
The heparin-binding growth factor midkine: the biological activities and candidate receptors.
Lymphoma
The improved anticancer effects of Bortezomib-loaded hollow mesoporous silica nanospheres on lymphoma development.
Lymphoma
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
Lymphoma
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration.
Lymphoma
The tyrosine343 residue of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions.
Lymphoma
Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells.
Lymphoma
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
Lymphoma
Tumor-associated macrophages increase the proportion of cancer stem cells in lymphoma by secreting pleiotrophin.
Lymphoma
Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor.
Lymphoma
Tyrosine phosphatase activity of lymphoma CD45 (GP180) is regulated by a direct interaction with the cytoskeleton.
Lymphoma
Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry.
Lymphoma
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Lymphoma
Variable expression of leucocyte-common (CD45) antigen in CD30 (Ki1)-positive anaplastic large-cell lymphoma: implications for the differential diagnosis between lymphoid and nonlymphoid malignancies.
Lymphoma
[As2O3 induces demethylation and up-regulates transcription of SHP-1 gene in human lymphoma cell line T2 cells]
Lymphoma
[Construction and expression of recombinant adenovirus carrying human SHP-1 gene]
Lymphoma
[Effect of As2O3 on demethylation of SHP-1 gene in human lymphoma cell line T2.]
Lymphoma
[Effect of Bortezomib on Proliferation, Apoptosis and SHP-2 Gene Expression of Lymphoma Cells].
Lymphoma
[Effects of sodium orthovanadate on proliferation and apoptosis in raji cells and its mechanism]
Lymphoma
[Evaluation of tartrate-resistant acid phosphatase activity in lymphoma cells of the bone marrow]
Lymphoma
[Expression and Significance of PTPL1 in Hematological Malignan-cies].
Lymphoma
[Methylation Status of PTPL1 Gene in Non-Hodgkin's Lymphoma Cells].
Lymphoma
[Polar acid phosphatase as T lymphoma marker (author's transl)]
Lymphoma
[Recent progress in the protein-tyrosine phosphatase SHP1 gene: the significant correlation of the SHP1 gene silencing with the onset of lymphomas/leukemias]
Lymphoma
[SHP-1 gene's methylation status of Daudi lymphoma cell and the demethylation effect of 5-aza-2'-deoxycytidine]
Lymphoma, B-Cell
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.
Lymphoma, B-Cell
Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma.
Lymphoma, B-Cell
BCL6 regulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt.
Lymphoma, B-Cell
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, B-Cell
DNA methylation of membrane bound tyrosine phosphatase genes in acute lymphoblastic leukemia.
Lymphoma, B-Cell
Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway.
Lymphoma, B-Cell
Effect of Jianpi Bushen prescription on the expression of SHP-1 and apoptosis-related genes in chemically damaged model mice.
Lymphoma, B-Cell
Epigenetic deregulation in pediatric acute lymphoblastic leukemia.
Lymphoma, B-Cell
Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy.
Lymphoma, B-Cell
Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.
Lymphoma, B-Cell
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.
Lymphoma, B-Cell
Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.
Lymphoma, B-Cell
In silico analyses reveal common cellular pathways affected by loss of heterozygosity (LOH) events in the lymphomagenesis of Non-Hodgkin's lymphoma (NHL).
Lymphoma, B-Cell
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
MiR-127 modulates macrophage polarization and promotes lung inflammation and injury by activating the JNK pathway.
Lymphoma, B-Cell
PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis.
Lymphoma, B-Cell
Protective effect of zinc on N-methyl-N-nitrosourea and testosterone-induced prostatic intraepithelial neoplasia in the dorsolateral prostate of Sprague Dawley rats.
Lymphoma, B-Cell
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Lymphoma, B-Cell
PTPN1 Is Recurrently Mutated in Lymphoid Cancers.
Lymphoma, B-Cell
PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.
Lymphoma, B-Cell
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.
Lymphoma, B-Cell
SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts.
Lymphoma, B-Cell
SHP-1 expression in primary central nervous system B-cell lymphomas in immunocompetent patients reflects maturation stage of normal B cell counterparts.
Lymphoma, B-Cell
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6.
Lymphoma, B-Cell
TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.
Lymphoma, B-Cell
The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.
Lymphoma, B-Cell, Marginal Zone
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, Follicular
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, Follicular
Histochemical and immunohistochemical study of diffuse large-cell lymphomas.
Lymphoma, Large B-Cell, Diffuse
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma.
Lymphoma, Large B-Cell, Diffuse
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, Large B-Cell, Diffuse
Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy.
Lymphoma, Large B-Cell, Diffuse
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.
Lymphoma, Large-Cell, Anaplastic
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma.
Lymphoma, Large-Cell, Anaplastic
Upregulation of the CDC25A phosphatase down-stream of the NPM/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation.
Lymphoma, Mantle-Cell
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, Mantle-Cell
Expression patterns of CD200 and CD148 in leukemic B-cell chronic lymphoproliferative disorders and their potential value in differential diagnosis.
Lymphoma, Mantle-Cell
Proteomic analysis of malignant B-cell derived microparticles reveals CD148 as a potentially useful antigenic biomarker for mantle cell lymphoma diagnosis.
Lymphoma, Mantle-Cell
Proteomic Analysis of Malignant B-Cell Derived Microparticles Reveals CD148 as a Potentially Useful Antigenic Biomarker for Mantle Cell Lymphoma Diagnosis.
Lymphoma, Mantle-Cell
SHP-1 expression by malignant small B-cell lymphomas reflects the maturation stage of their normal B-cell counterparts.
Lymphoma, Non-Hodgkin
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
c-Myc oncogene and Cdc25A cell activating phosphatase expression in non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells.
Lymphoma, Non-Hodgkin
High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to non-hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin lymphoma and T-cell non-Hodgkin lymphoma.
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