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Information on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Homo sapiens and UniProt Accession P35236

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     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.48 protein-tyrosine-phosphatase
IUBMB Comments
Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2, non-specific protein-tyrosine kinase.
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Homo sapiens
UNIPROT: P35236
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
ptp1b, protein tyrosine phosphatase, shp-1, shp-2, tyrosine phosphatase, protein phosphatase 2a, acid phosphatase activity, mkp-1, cdc25a, ptpn22, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70Z-SHP
-
-
-
-
alpha-PTP-PEST
247
-
BDP
286458
-
Brain-derived phosphatase
-
-
-
-
BVP
-
-
-
-
CD148
247
-
CD148 antigen
-
-
-
-
CD45 antigen
-
-
-
-
CD45 protein tyrosine phosphatase
247
-
Cdc25 phosphatase
247
-
Cdc25-like protein
-
-
-
-
Cdc25A
Cdc25B
Cdc25B phosphatase
Cdc25C
CDK2-associated dual specificity phosphatase
-
-
-
-
Ch-1PTPase
CPTP1
-
-
-
-
cysteine-dependent protein tyrosine phosphatase
247
-
DEP-1
DLAR
-
-
-
-
DSP18
247
-
dual specificity phosphatase
Dual specificity phosphatase Cdc25A
-
-
-
-
Dual specificity phosphatase Cdc25B
-
-
-
-
Dual specificity phosphatase Cdc25C
-
-
-
-
dual specificity protein phosphatase
282089
-
dual specificity protein phosphatase 23
312936
UniProt
dual specificity protein phosphatase 3
312885
UniProt
Dual specificity protein phosphatase hVH1
-
-
-
-
Dual specificity protein phosphatase hVH2
-
-
-
-
Dual specificity protein phosphatase hVH3
-
-
-
-
Dual specificity protein phosphatase PYST1
-
-
-
-
Dual specificity protein phosphatase PYST2
-
-
-
-
Dual specificity protein phosphatase VHR
-
-
-
-
dual-specificity (Thr/Tyr) MAPK protein phosphatase
247
-
dual-specificity phosphatase
282089
-
dual-specificity protein tyrosine phosphatase 18
247
-
Dual-specificity tyrosine phosphatase TS-DSP6
-
-
-
-
Dual-specificity tyrosine phosphatase YVH1
-
-
-
-
ED-Eya2
292106
-
ES cell phosphatase
-
-
-
-
FAP-1
247
-
Fap1
278604
-
GLEPP1
286476
-
HCP
-
-
-
-
HD-PTP
Hematopoietic cell protein-tyrosine phosphatase
-
-
-
-
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
-
-
-
-
Hematopoietic protein-tyrosine phosphatase
-
-
-
-
hematopoietic tyrosine phosphatase
282094
-
HEPTP
His domain protein tyrosine phosphatase
286462
-
histidine domain-protein tyrosine phosphatase
247
-
HPTP beta-like tyrosine phosphatase
-
-
-
-
HPTP eta
-
-
-
-
HPTPbeta
247
-
HPTPbeta-CD
286464
-
hPTPE1
-
-
-
-
IA-2
286475
-
IA-2A
286475
-
IA-2beta
286474
-
IAR
247
-
ICAAR
-
-
-
-
IF1
278604
-
IF2
278604
-
insulinoma associated protein tyrosine phosphatase 2
286475
-
islet cell antigen-related PTP
247
-
Islet cell autoantigen related protein
-
-
-
-
KIM-PTP
282094
-
kinase associated phosphatase
-
-
-
-
kinase interaction motif phosphatase
282094
-
L-CA
-
-
-
-
Late protein H1
-
-
-
-
LCA
-
-
-
-
LCA-related phosphatase
-
-
-
-
LDP-3
312936
UniProt
leucocyte common antigen-related protein tyrosine phosphatase
247
-
Leukocyte antigen related
-
-
-
-
leukocyte common antigen-related
247
-
LMW-PTP
low molecular mass dual specificity phosphatase 3
312936
UniProt
Low molecular weight cytosolic acid phosphatase
-
-
-
-
low molecular weight protein tyrosine phosphatase
278604
-
low molecular weight-PTP
247
-
LRP
-
-
-
-
Lymphoid phosphatase
-
-
-
-
lymphoid-specific tyrosine phosphatase
247
-
M1851
-
-
-
-
MAP kinase phosphatase
282087, 282091, 282092
-
MAP-kinase phosphatase CPG21
-
-
-
-
MAPK-specific tyrosine phosphatase
282088, 282093, 282094
-
MEG
-
-
-
-
mitogen-activated protein kinase phosphatase
282087, 282091, 282092
-
mitogen-activated protein kinase phosphatase-1
247
-
mitogen-activated protein kinase-specific tyrosine phosphatase
282088, 282093, 282094
-
Mitosis initiation protein
-
-
-
-
Mitosis initiation protein MIH1
-
-
-
-
Mitotic inducer homolog
-
-
-
-
MKP
247
-
MKP-1
247
trivial names CL100, erp, 3CH134, hVH1
MKP-1 like protein tyrosine phosphatase
-
-
-
-
MKP-2
247
trivial names Typ1, Sty8, hVH2
MKP-3
MKP-4
MKP-5
MKP-7
247
-
MKP-X
247
trivial names Pyst2, B59
MKP1
247
a dual-specificity phosphatase
MKP5-C
282087, 282091, 282092
catalytic domain of MKP5
MPTP
-
-
-
-
MPTP-PEST
-
-
-
-
N3PTP
286450
-
NC-PTPCOM1
Neural-specific protein-tyrosine phosphatase
-
-
-
-
non-receptor protein tyrosine phosphatase
247
-
ORF5
-
-
-
-
OST-PTP
osteoclastic protein-tyrosine phosphatase
286467
-
P19-PTP
-
-
-
-
p52shc
247
-
p66shc
247
-
P80
-
-
-
-
PC12-PTP1
-
-
-
-
PCPTP1
282088
UniProt
PEST
247
-
Phogrin
-
-
-
-
Phosphacan
-
-
-
-
phosphatase of regenerating liver-3
247
-
phosphatase, phosphoprotein (phosphotyrosine)
-
-
-
-
phosphatase, phosphotyrosine
-
-
-
-
phosphoprotein phosphatase (phosphotyrosine)
-
-
-
-
phosphotyrosine histone phosphatase
-
-
-
-
phosphotyrosine phosphatase
-
-
-
-
Phosphotyrosine phosphatase 13
-
-
-
-
phosphotyrosine phosphatase 1B
247
-
phosphotyrosine protein phosphatase
-
-
-
-
phosphotyrosine-specific PP
247
-
phosphotyrosylprotein phosphatase
-
-
-
-
PP2A
247
-
PRL-3
247
-
Protein phosphatase 1B
278604
-
protein phosphatase 2A
247
-
protein phosphotyrosine phosphatase
-
-
-
-
protein tyrosine phosphatase
protein tyrosine phosphatase 1B
protein tyrosine phosphatase beta
286464
-
protein tyrosine phosphatase epsilon
286467
-
protein tyrosine phosphatase N12
286455
-
protein tyrosine phosphatase N3
286450
-
Protein tyrosine phosphatase receptor-type T
247
-
protein tyrosine phosphatase SHP-1
247
-
protein tyrosine phosphatase, non-receptor type 1
278604
-
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
247
-
protein tyrosine phosphatase-1B
protein tyrosine phosphatase-2
247
-
protein tyrosine phosphatase-BL
247
-
Protein tyrosine phosphatase-NP
-
-
-
-
Protein-protein-tyrosine phosphatase HA2
-
-
-
-
protein-tyrosine phosphatase
Protein-tyrosine phosphatase 1B
Protein-tyrosine phosphatase 1C
-
-
-
-
Protein-tyrosine phosphatase 1E
-
-
-
-
Protein-tyrosine phosphatase 2C
-
-
-
-
Protein-tyrosine phosphatase 2E
-
-
-
-
Protein-tyrosine phosphatase 3CH134
-
-
-
-
Protein-tyrosine phosphatase CL100
-
-
-
-
Protein-tyrosine phosphatase D1
Protein-tyrosine phosphatase ERP
-
-
-
-
Protein-tyrosine phosphatase G1
-
-
-
-
Protein-tyrosine phosphatase H1
-
-
-
-
Protein-tyrosine phosphatase LC-PTP
-
-
-
-
Protein-tyrosine phosphatase MEG1
-
-
-
-
Protein-tyrosine phosphatase MEG2
-
-
-
-
Protein-tyrosine phosphatase P19
-
-
-
-
Protein-tyrosine phosphatase PCPTP1
-
-
-
-
Protein-tyrosine phosphatase pez
-
-
-
-
Protein-tyrosine phosphatase PTP-RL10
-
-
-
-
Protein-tyrosine phosphatase PTP36
-
-
-
-
Protein-tyrosine phosphatase PTPL1
-
-
-
-
Protein-tyrosine phosphatase striatum-enriched
-
-
-
-
Protein-tyrosine phosphatase SYP
-
-
-
-
Protein-tyrosine-phosphatase SL
-
-
-
-
Protein-tyrosine-phosphate phosphohydrolase
-
-
-
-
PTEN
247
-
PTEN phosphoprotein phosphatase
247
-
PTK
247
-
PTP 1B
278604
-
PTP IA-2beta
-
-
-
-
PTP-1B
PTP-1C
-
-
-
-
PTP-1D
-
-
-
-
PTP-2C
-
-
-
-
PTP-BAS
PTP-BL
247
-
PTP-E1
-
-
-
-
PTP-eta
247
-
PTP-H1
-
-
-
-
PTP-HA2
-
-
-
-
PTP-MEG2
247
-
PTP-NP
-
-
-
-
PTP-oc
286467
-
PTP-PEST
PTP-phosphatase
247
-
PTP-SH2beta
-
-
-
-
PTP1
247
-
PTP1B
PTP1C
-
-
-
-
PTP1D
-
-
-
-
PTP1e
247
-
PTP1N13
286456
-
PTP1N21
286460
-
PTP2C
-
-
-
-
PTP36
286457
-
PTPalpha
PTPase YVH1
-
-
-
-
PTPase-MEG1
PTPase-MEG2
PTPB1
PTPBAS
286456
-
PTPbeta
PTPD1
PTPepsilon
286467
-
PTPG1
-
-
-
-
PTPgamma
247
-
PTPH1
PTPL1
247
-
PTPMEG
247
-
PTPN1
278604
-
PTPN11
PTPN12
286455
-
PTPN13
286456
-
PTPN14
PTPN20 variant 15
286459
-
PTPN21
286460
-
PTPN22
PTPN23
PTPN3
286450
-
PTPN4
286453
-
PTPN5
PTPN6
PTPN7
PTPN9
286452
-
PTPNE6
-
-
-
-
PTPP
247
-
PTPRA
286463
-
PTPRB
286464
-
PTPRC
286465
-
PTPRD
286466
-
PTPRdelta
286466
-
PTPRE
286467
-
PTPRF
286468
-
PTPRG
286469
-
PTPRH
286470
-
PTPRJ
PTPRK
286472
-
PTPRM
286473
-
PTPRN
286475
-
PTPRN2
286474
-
PTPRO
286476
-
PTPRomega
282088
-
PTPRQ
PTPRR
PTPRS
286478
-
PTPRT
PTPRU
286480
-
PTPRV
247
-
PTPRZ
286481
-
PTPRZ1
247
-
PTPS31
286477
-
PY protein phosphatase
-
-
-
-
R-PTP-alpha
-
-
-
-
R-PTP-beta
-
-
-
-
R-PTP-delta
-
-
-
-
R-PTP-epsilon
-
-
-
-
R-PTP-eta
-
-
-
-
R-PTP-gamma
-
-
-
-
R-PTP-kappa
-
-
-
-
R-PTP-mu
-
-
-
-
R-PTP-zeta
-
-
-
-
receptor protein tyrosine phosphatase isoform delta
286466
-
receptor protein tyrosine phosphatase isoform omega
282088
-
receptor protein tyrosine phosphatase T
247
-
receptor protein tyrosine phosphatase {kappa}
247
-
receptor PTPepsilon
286467
-
Receptor-linked protein-tyrosine phosphatase 10D
-
-
-
-
Receptor-linked protein-tyrosine phosphatase 99A
-
-
-
-
receptor-type protein tyrosine phosphatase J
247
-
Receptor-type protein-tyrosine phosphatase-kappa
247
-
receptor-type tyrosine-protein phosphatase R
282088
UniProt
RNA/RNP complex-intereracting phosphatase
-
-
-
-
ROL B protein
-
-
-
-
RPTPalpha
RPTPdelta
286466
-
RPTPepsilon
286467
-
RPTPgamma
286469
-
RPTPkappa
RPTPlambda
286480
-
RPTPmu
286473
-
RPTPrho
286479
-
RPTPsigma
286478
-
RPTPzeta
286481
-
SAP1
286470
-
Scr homology 2-containing tyrosine phosphatase
247
-
selective striatal enriched protein phosphatase
282093
-
SH-PTP1
-
-
-
-
SH-PTP2
-
-
-
-
SH-PTP3
-
-
-
-
SH2 domain-containing tyrosine phosphatase-1
247
-
SH2 domain-containing tyrosine phosphatase-2
247
-
SHP
-
-
-
-
SHP-1
SHP-2
Small tyrosine phosphatase
-
-
-
-
Small, acidic phosphotyrosine protein phosphatase
-
-
-
-
SPH-1
247
-
SPH-2
247
-
Src homology region 2 domain-containing phosphatase 1
247
-
Src homology-2 domain containing protein tyrosine phosphatase-1
247
-
Src homology-2 domain containing protein tyrosine phosphatase-2
247
-
striatal-enriched PTP
247
-
String protein
-
-
-
-
Syp
-
-
-
-
T cell protein tyrosine phosphatase
247
-
T-cell protein tyrosine phosphatase
247
-
T-cell protein-tyrosine phosphatase
-
-
-
-
T-cell PTP
T-DSP11
-
-
-
-
T200
-
-
-
-
TC PTP
247
-
TC48
286449
isoform
TCPTP
testis- and skeletal-muscle-specific DSP
247
-
testis- and skeletal-muscle-specific dual specificity protein phosphatase
247
-
Testis-and skeletal-muscle-specific DSP
-
-
-
-
TMDP
247
-
TypPT
286459
-
tyrosine O-phosphate phosphatase
-
-
-
-
tyrosine phosphatase
Tyrosine phosphatase CBPTP
-
-
-
-
tyrosine phosphatase IA-2
286475
-
tyrosine phosphatase-1B
278604
-
tyrosine-protein phosphatase non-receptor type 5
282093
UniProt
tyrosylprotein phosphatase
-
-
-
-
vaccinia H1-related PTP
282087, 282091, 282092
-
VE-PTP
286464
-
VHZ
312936
-
YopH
278604
-
[phosphotyrosine]protein phosphatase
-
-
-
-
additional information