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Information on EC 3.1.3.4 - phosphatidate phosphatase
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EC Tree
3.1.3.4 phosphatidate phosphataseIUBMB Comments
This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.
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Word Map
- 3.1.3.4
- phospholipid
- triacylglycerols
- phospholipase
-
lipins
- phosphatidylcholine
- triglyceride
- propranolol
- adipose
-
lysophosphatidic
- glycerolipids
- acyltransferase
- adipocyte
-
lipogenesis
-
lipogenic
- sphingosine
- pkc
- steatosis
- lipodystrophy
- rhabdomyolysis
- cytidylyltransferase
-
mg2+-independent
- sphingosine-1-phosphate
- phosphatidylethanol
-
diradylglycerol
-
bromoenol
-
transphosphatidylation
-
kennedy
- cdp-diacylglycerol
- sn-glycerol
-
argonaut
- 1,2-diacylglycerol
-
sphingoid
-
srebf1
-
dgats
-
pirnas
- glycerolphosphate
- pc-plc
-
plectonema
-
ctp:phosphocholine
-
plasticity-related
- acaca
-
prophenoloxidase
-
cholinephosphotransferase
-
phosphatidylcholine-specific
- sn-glycerol-3-phosphate
- medicine
- analysis
- drug development
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
phosphatidate phosphohydrolase, lipin-1, lpin1, pap-1, lipin1, phosphatidate phosphatase, lipin 1, prg-1, phosphatidic acid phosphohydrolase, pa phosphatase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acid phosphatidyl phosphatase
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ecto-PAPase
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ecto-phosphatidic acid phosphohydrolase
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Germ cell guidance factor
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PA phosphatase
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-
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PAP
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-
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phosphatidate phosphohydrolase
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-
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phosphatidic acid phosphatase
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-
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phosphatidic acid phosphohydrolase
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-
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Wunen protein
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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-, -, -, -, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
diacylglycerol-3-phosphate phosphohydrolase
This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.
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CAS REGISTRY NUMBER
COMMENTARY
9025-77-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
acylglycerol kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Adenocarcinoma of Lung
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Adenocarcinoma of Lung
Prognostic role of lipid phosphate phosphatases in non-smoker, lung adenocarcinoma patients.
Anaphylaxis
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
Anemia
A conserved serine residue is required for the phosphatidate phosphatase activity but not transcriptional coactivator functions of lipin-1 and lipin-2.
Asthma
Alleviating airway inflammation by inhibiting ERK-NF-?B signaling pathway by blocking Kv1.3 channels.
Atherosclerosis
Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Atherosclerosis
Correction to: Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Atherosclerosis
Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model.
Atherosclerosis
Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis.
Atherosclerosis
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Atherosclerosis
Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Atherosclerosis
Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
Autoimmune Diseases
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
Barth Syndrome
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Brain Diseases
Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway.
Breast Neoplasms
Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene.
Breast Neoplasms
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
Breast Neoplasms
Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Breast Neoplasms
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
Breast Neoplasms
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Breast Neoplasms
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Carcinogenesis
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Carcinogenesis
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
Carcinogenesis
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Carcinogenesis
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Carcinogenesis
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Carcinoma
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Carcinoma
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Carcinoma, Hepatocellular
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Carcinoma, Hepatocellular
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Cardiomegaly
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Cardiomyopathies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Cardiovascular Diseases
Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
Cardiovascular Diseases
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Cardiovascular Diseases
The potential role of the lipid phosphate phosphatase 3 (Plpp3) gene in cardiovascular disease.
choline kinase deficiency
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Colitis
PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway.
Colitis, Ulcerative
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Colonic Neoplasms
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Coronary Artery Disease
Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.
Coronary Artery Disease
Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis.
Coronary Artery Disease
Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Demyelinating Diseases
A hypomorphic mutation in lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
Dermatitis, Allergic Contact
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Diabetes Mellitus
Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils.
Diabetes Mellitus
Genetic variants of LPIN1 indicate an association with Type?2 diabetes mellitus in a Chinese population.
Diabetes Mellitus
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Diabetes Mellitus
PPAR? agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPAR? phosphatase.
Diabetes Mellitus
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Diabetes Mellitus, Type 2
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Diabetes Mellitus, Type 2
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Diabetes Mellitus, Type 2
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Diabetes Mellitus, Type 2
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
Diabetes Mellitus, Type 2
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.
Diabetes Mellitus, Type 2
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
Diabetes Mellitus, Type 2
The Associations of LPIN1 Gene Expression in Adipose Tissue With Metabolic Phenotypes in the Chinese Population.
Diabetes Mellitus, Type 2
The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPAR? on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
Drug-Related Side Effects and Adverse Reactions
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Dyslipidemias
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
Dyslipidemias
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Fatty Liver
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Fatty Liver
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Fatty Liver
Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats.
Fatty Liver
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism.
Fatty Liver
Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice.
Fatty Liver
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
Fatty Liver
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Fatty Liver
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
Fatty Liver
HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver.
Fatty Liver
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
Fatty Liver
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Fatty Liver
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Fatty Liver
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
Fatty Liver
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
Fatty Liver
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
Fatty Liver
Regulation of fatty acid oxidation and triglyceride and phospholipid metabolism by hypolipidemic sulfur-substituted fatty acid analogues.
Fatty Liver
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Fatty Liver, Alcoholic
Adipose-Specific Lipin-1 Overexpression Renders Hepatic Ferroptosis and Exacerbates Alcoholic Steatohepatitis in Mice.
Fatty Liver, Alcoholic
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
Fatty Liver, Alcoholic
Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling.
Fatty Liver, Alcoholic
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Fatty Liver, Alcoholic
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emerging Role of Lipin-1.
Fatty Liver, Alcoholic
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
Fatty Liver, Alcoholic
[Role of lipin-1 in the pathogenesis of alcoholic fatty liver disease].
Glioblastoma
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Glioma
Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine.
Heart Failure
Alterations of sarcolemmal phospholipase D and phosphatidate phosphohydrolase in congestive heart failure.
Hepatitis C
Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.
Hepatitis C
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.
Hepatitis, Alcoholic
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Hepatoblastoma
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.
Herpes Zoster
Lipocalins Are Required for Apical Extracellular Matrix Organization and Remodeling in Caenorhabditis elegans.
Hypercholesterolemia
Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Hyperglycemia
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
Hyperglycemia
Metformin counteracts glucose-dependent lipogenesis and impairs transdeamination in the liver of gilthead sea bream (Sparus aurata).
Hyperglycemia
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Hyperglycemia
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats.
Hyperinsulinism
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Hyperkinesis
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
Hyperlipidemias
Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-
?
B/MAPK Signaling Pathways.
Hyperlipidemias
Hepatic triacylglycerol synthesizing activity during progression of alcoholic liver injury in the baboon.
Hypersensitivity
Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
Hypertension
A central role for protein kinase C overactivity in diabetic glomerulosclerosis: implications for prevention with antioxidants, fish oil, and ACE inhibitors.
Hypertension
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Hypertension
Erratum to: K(+) Channels Expression in Hypertension After Arterial Injury, and Effect of Selective Kv1.3 Blockade with PAP-1 on Intimal Hyperplasia Formation.
Hypertension
K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation.
Hypertension
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Hyperthyroidism
Mechanisms for the effects of ethanol on hepatic phosphatidate phosphohydrolase.
Hyperthyroidism
Phosphatidate phosphohydrolase and palmitoyl-coenzyme A hydrolase in cardiac subcellular fractions of hyperthyroid rabbits and cardiomyopathic hamsters.
Hypertriglyceridemia
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Hypertriglyceridemia
Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats.
Hypertriglyceridemia
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Hypertriglyceridemia
The PPAR{beta}/{delta} Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation.
Infarction, Middle Cerebral Artery
Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
Infections
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation.
Infections
Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.
Infections
LPP-1 infection of the blue-green alga Plectonema boryanum. 3. Protein synthesis.
Infections
LPP-1 infection of the blue-green alga Plectonema boryanum. I. Electron microscopy.
Infections
LPP-1 infection of the blue-green alga Plectonema boryanum. II. Viral deoxyribonucleic acid synthesis and host deoxyribonucleic acid breakdown.
Infertility
Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Infertility
Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs.
Influenza, Human
Pharmacokinetics, toxicity, and functional studies of the selective kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.
Insulin Resistance
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.
Insulin Resistance
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Insulin Resistance
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.
Insulin Resistance
Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.
Insulin Resistance
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Insulin Resistance
Complementary measures for promoting insulin sensitivity in skeletal muscle.
Insulin Resistance
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
Insulin Resistance
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.
Insulin Resistance
Effect of Combined Exercise Versus Aerobic-Only Training on Skeletal Muscle Lipid Metabolism in a Rodent Model of Type1 Diabetes.
Insulin Resistance
Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes.
Insulin Resistance
Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.
Insulin Resistance
Expression and significance of lipin1 and AMPK? in hepatic insulin resistance in diet-induced insulin resistance rats.
Insulin Resistance
Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Insulin Resistance
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Insulin Resistance
Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis.
Insulin Resistance
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Insulin Resistance
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Insulin Resistance
Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator-Activated Receptor {gamma} Activation.
Insulin Resistance
Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.
Insulin Resistance
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
Insulin Resistance
Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.
Insulin Resistance
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Insulin Resistance
Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
Insulin Resistance
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
Insulin Resistance
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Insulin Resistance
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Insulin Resistance
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Insulin Resistance
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Insulin Resistance
Transcriptomic Responses of Skeletal Muscle to Acute Exercise in Diabetic Goto-Kakizaki Rats.
Ischemic Stroke
Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke.
Leukemia, Lymphocytic, Chronic, B-Cell
Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia.
Lipodystrophy
A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome.
Lipodystrophy
A hypomorphic mutation in lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
Lipodystrophy
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Lipodystrophy
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Lipodystrophy
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism.
Lipodystrophy
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Lipodystrophy
Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.
Lipodystrophy
Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.
Lipodystrophy
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Lipodystrophy
Intermuscular and intramuscular adipose tissues: Bad vs. good adipose tissues.
Lipodystrophy
Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.
Lipodystrophy
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Lipodystrophy
Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro.
Lipodystrophy
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
Lipodystrophy
Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility.
Lipodystrophy
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
Lipodystrophy
miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir.
Lipodystrophy
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Lipodystrophy
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
Lipodystrophy
Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes.
Lipodystrophy
Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue.
Lipodystrophy
Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle.
Lipodystrophy
The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.
Lipodystrophy
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.
Lipodystrophy, Congenital Generalized
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
Liver Cirrhosis, Biliary
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
Liver Diseases
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
Liver Diseases
Lipin Is a Central Regulator of Adipose Tissue Development and Function in Drosophila melanogaster.
Liver Diseases
LPIN1 rs13412852 Polymorphism in Pediatric Non-Alcoholic Fatty Liver Disease.
Liver Diseases
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emerging Role of Lipin-1.
Liver Diseases
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Liver Diseases, Alcoholic
Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3.1.3.4) in alcoholic liver disease.
Liver Diseases, Alcoholic
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
Liver Diseases, Alcoholic
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis.
Liver Diseases, Alcoholic
The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings.
Lung Neoplasms
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Lymphoma
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Large-Cell, Anaplastic
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Melanoma
The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.
Metabolic Diseases
Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.
Metabolic Syndrome
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Metabolic Syndrome
Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina.
Metabolic Syndrome
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Metabolic Syndrome
Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans.
Metabolic Syndrome
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Metabolic Syndrome
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Metabolic Syndrome
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.
Muscular Diseases
Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Muscular Diseases
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Muscular Diseases
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
Muscular Diseases
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Muscular Diseases
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway.
Muscular Diseases
Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components.
Muscular Dystrophies
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Myalgia
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Myalgia
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Myoglobinuria
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Myoglobinuria
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Myoglobinuria
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
Myopia
Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.
Neoplasm Metastasis
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
Neoplasm Metastasis
LPPR4 promotes peritoneal metastasis via Sp1/integrin ?/FAK signaling in gastric cancer.
Neoplasms
Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma.
Neoplasms
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.
Neoplasms
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer.
Neoplasms
Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1.
Neoplasms
Expression and clinicopathological significance of lipin-1 in human breast cancer and its association with p53 tumor suppressor gene.
Neoplasms
IL-33-Induced Transcriptional Activation of LPIN1 Accelerates Breast Tumorigenesis.
Neoplasms
Increasing the low lipid phosphate phosphatase 1 activity in breast cancer cells decreases transcription by AP-1 and expressions of matrix metalloproteinases and cyclin D1/D3.
Neoplasms
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.
Neoplasms
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Neoplasms
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.
Neoplasms
Lipid phosphate phosphatase-3 regulates tumor growth via ?-catenin and CYCLIN-D1 signaling.
Neoplasms
Lipid profile of platelets and platelet-derived microparticles in ovarian cancer.
Neoplasms
Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses.
Neoplasms
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Neoplasms
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
Neoplasms
Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer.
Neoplasms
LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability.
Neoplasms
Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl-CoA synthetase on incubation of adipocytes with the tumour promoter 12-O-tetradecanoylphorbol 13-acetate.
Neoplasms
Regulation of Proliferation by a Mitochondrial Potassium Channel in Pancreatic Ductal Adenocarcinoma Cells.
Neoplasms
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Neoplasms
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Neoplasms
Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo.
Neoplasms
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Neoplasms
Translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in thioacetamide-induced liver tumours in rats.
Nervous System Diseases
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Neuroblastoma
Bimodal distribution of phosphatidic acid phosphohydrolase in NG108-15 cells. Modulation by the amphiphilic lipids oleic acid and sphingosine.
Neuroblastoma
Coamplification of DDX1 correlates with an improved survival probability in children with MYCN-amplified human neuroblastoma.
Neuroinflammatory Diseases
Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.
Neuroinflammatory Diseases
Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept.
Neuroinflammatory Diseases
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
Neuroinflammatory Diseases
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles.
Non-alcoholic Fatty Liver Disease
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents.
Non-alcoholic Fatty Liver Disease
HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver.
Non-alcoholic Fatty Liver Disease
LPIN1 rs13412852 Polymorphism in Pediatric Non-Alcoholic Fatty Liver Disease.
Non-alcoholic Fatty Liver Disease
Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats.
Non-alcoholic Fatty Liver Disease
Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.
Non-alcoholic Fatty Liver Disease
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Obesity
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.
Obesity
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Obesity
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Obesity
Expression and significance of lipin1 and AMPK? in hepatic insulin resistance in diet-induced insulin resistance rats.
Obesity
Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis.
Obesity
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.
Obesity
Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus--associated lipodystrophy syndrome.
Obesity
Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.
Obesity
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Obesity
Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
Obesity
Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility.
Obesity
Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes.
Obesity
Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats.
Obesity
Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast.
Obesity
Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue.
Obesity
Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue.
Obesity
Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes.
Obesity
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes.
Obesity
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Obesity, Abdominal
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.
Obesity, Abdominal
Association of PPARG and LPIN1 gene polymorphisms with metabolic syndrome and type 2 diabetes.
Optic Nerve Injuries
Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration.
Ovarian Neoplasms
Decreased Peritoneal Ovarian Cancer Growth in Mice Lacking Expression of Lipid Phosphate Phosphohydrolase 1.
Ovarian Neoplasms
MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1.
Ovarian Neoplasms
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.
Ovarian Neoplasms
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Ovarian Neoplasms
Translocation of lysophosphatidic acid phosphatase in response to gonadotropin-releasing hormone to the plasma membrane in ovarian cancer cell.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Paralysis
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Paraplegia
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Parvoviridae Infections
First presentation of LPIN1 acute rhabdomyolysis in adolescence and adulthood.
Peripheral Nervous System Diseases
Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.
Peripheral Nervous System Diseases
Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases.
Peripheral Nervous System Diseases
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
Peripheral Nervous System Diseases
Lipin1 Alleviates Autophagy Disorder in Sciatic Nerve and Improves Diabetic Peripheral Neuropathy.
phosphatidate phosphatase deficiency
A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey.
phosphatidate phosphatase deficiency
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
phosphatidate phosphatase deficiency
Cardiac function and exercise adaptation in 8 children with LPIN1 mutations.
phosphatidate phosphatase deficiency
Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
phosphatidate phosphatase deficiency
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
phosphatidate phosphatase deficiency
Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development.
phosphatidate phosphatase deficiency
Fat oxidation is impaired during exercise in lipin-1 deficiency.
phosphatidate phosphatase deficiency
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.
phosphatidate phosphatase deficiency
Intermuscular and intramuscular adipose tissues: Bad vs. good adipose tissues.
phosphatidate phosphatase deficiency
Investigation of Lpin1 as a candidate gene for fat deposition in pigs.
phosphatidate phosphatase deficiency
Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.
phosphatidate phosphatase deficiency
Lipin 1 modulates mRNA splicing during fasting adaptation in liver.
phosphatidate phosphatase deficiency
Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
phosphatidate phosphatase deficiency
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
phosphatidate phosphatase deficiency
Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle.
phosphatidate phosphatase deficiency
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
phosphatidate phosphatase deficiency
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
phosphatidate phosphatase deficiency
Liver-specific loss of lipin 1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic triglyceride accumulation in mice.
phosphatidate phosphatase deficiency
Long-term outcomes in a 25-year-old female affected with lipin-1 deficiency.
phosphatidate phosphatase deficiency
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
phosphatidate phosphatase deficiency
Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
phosphatidate phosphatase deficiency
LPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation of creatine kinase levels due to chromosome 2 maternal isodisomy.
phosphatidate phosphatase deficiency
LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients.
phosphatidate phosphatase deficiency
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
phosphatidate phosphatase deficiency
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.
phosphatidate phosphatase deficiency
Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.
phosphatidate phosphatase deficiency
Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1.
phosphatidate phosphatase deficiency
Phenotypic Modulation of Skeletal Muscle Fibers in LPIN1-Deficient Lipodystrophic ( fld) Mice.
phosphatidate phosphatase deficiency
PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/?1-Integrin Signaling.
phosphatidate phosphatase deficiency
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.
phosphatidate phosphatase deficiency
Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice.
phosphatidate phosphatase deficiency
Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
phosphatidate phosphatase deficiency
Target-controlled infusion of Propofol and Remifentanil in a child with recurrent rhabdomyolysis secondary to LPIN1 deficiency.
phosphatidate phosphatase deficiency
The role of lipin 1 in adipogenesis and lipid metabolism.
Polycystic Ovary Syndrome
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.
Prostatic Neoplasms
Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.
Prostatic Neoplasms
Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment.
protein acetyllysine n-acetyltransferase deficiency
SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1?-LIPIN 1 pathway and increasing CD36 through Nrf2.
Psoriasis
Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat.
Psoriasis
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Retinitis Pigmentosa
Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex.
Retinitis Pigmentosa
CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing.
Retinitis Pigmentosa
PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor.
Rhabdomyolysis
A neglected cause of recurrent rhabdomyolysis, LPIN1 gene defect: a rare case from Turkey.
Rhabdomyolysis
A novel therapeutic approach for LPIN1 mutation-associated rhabdomyolysis--The Austrian experience.
Rhabdomyolysis
A rare case of pediatric recurrent rhabdomyolysis with compound heterogenous variants in the LPIN1.
Rhabdomyolysis
Acute recurrent rhabdomyolysis in a Chinese boy associated with a novel compound heterozygous LPIN1 variant: a case report.
Rhabdomyolysis
Cardiac function and exercise adaptation in 8 children with LPIN1 mutations.
Rhabdomyolysis
Case Report: The first probable Hong Kong Chinese case of LPIN1-related acute recurrent rhabdomyolysis in a boy with two novel variants.
Rhabdomyolysis
Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
Rhabdomyolysis
Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis.
Rhabdomyolysis
Detection of compound heterozygous variants in LPIN1 does not necessarily imply pathogenicity in a patient with rhabdomyolysis.
Rhabdomyolysis
First presentation of LPIN1 acute rhabdomyolysis in adolescence and adulthood.
Rhabdomyolysis
Lipin-1 Deficiency-Associated Recurrent Rhabdomyolysis and Exercise-Induced Myalgia Persisting into Adulthood: A Case Report and Review of Literature.
Rhabdomyolysis
Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle.
Rhabdomyolysis
Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy.
Rhabdomyolysis
Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular Signal-regulated Kinase (ERK) Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal.
Rhabdomyolysis
Long-term outcomes in a 25-year-old female affected with lipin-1 deficiency.
Rhabdomyolysis
Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.
Rhabdomyolysis
Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
Rhabdomyolysis
LPIN1 deficiency with severe recurrent rhabdomyolysis and persistent elevation of creatine kinase levels due to chromosome 2 maternal isodisomy.
Rhabdomyolysis
LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood.
Rhabdomyolysis
Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
Rhabdomyolysis
Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.
Rhabdomyolysis
Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
Rhabdomyolysis
Target-controlled infusion of Propofol and Remifentanil in a child with recurrent rhabdomyolysis secondary to LPIN1 deficiency.
Rhabdomyolysis
The etiology of rhabdomyolysis: an interaction between genetic susceptibilities and external triggers.
Rhabdomyolysis
Volatile anesthesia for a child with LPIN1 gene mutation and recurrent rhabdomyolysis.
Seizures
Dynamic pattern of gene expression of ZnT-1, ZnT-3 and PRG-1 in rat brain following flurothyl-induced recurrent neonatal seizures.
Seizures
Dynamic Pattern of Gene Expression of ZnT-4, Caspase-3, LC3, and PRG-3 in Rat Cerebral Cortex Following Flurothyl-Induced Recurrent Neonatal Seizures.
Seizures
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
Seizures
Long-term Effects of Recurrent Neonatal Seizures on Neurobehavioral Function and Related Gene Expression and Its Intervention by Inhibitor of Cathepsin B.
Seizures
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Skin Diseases
Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
Spinal Cord Injuries
Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of lipid metabolism-related genes in head and neck squamous cell carcinoma.
Starvation
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Starvation
Effects of starvation, corticotropin injection and ethanol feeding on the activity and amount of phosphatidate phosphohydrolase in rat liver.
Starvation
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically.
Starvation
Glycerolipid biosynthesis in rat adipose tissue. 10. Changes during a starvation and re-feeding cycle.
Starvation
Reduced insulin/IGF-1 signaling restores germ cell immortality to caenorhabditis elegans Piwi mutants.
Starvation
Relationship between the inhibition of phosphatidic acid phosphohydrolase-1 by oleate and oleoyl-CoA ester and its apparent translocation.
Starvation
Some aspects of the physiological and pharmacological control of the synthesis of triacylglycerols and phospholipids.
Starvation
The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection.
Thrombosis
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo.
Triple Negative Breast Neoplasms
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.
Uterine Cervical Neoplasms
Targeting mTOR by CZ415 Suppresses Cell Proliferation and Promotes Apoptosis via Lipin-1 in Cervical Cancer In Vitro and In Vivo.
Uterine Cervical Neoplasms
[Less pap-2 results ('minor abnormalities') in the population screening for cervical cancer since the introduction of new guidelines in 1996]
Vascular System Injuries
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo.
Virus Diseases
Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
additional information
-
isozyme LPPdelta contains no plastidic transit peptide
-
brenda
additional information
isozyme LPPdelta contains no plastidic transit peptide
-
brenda
additional information
isozyme LPPdelta contains no plastidic transit peptide
-
brenda
additional information
isozyme LPPdelta contains no plastidic transit peptide
-
brenda
additional information
isozyme LPPdelta contains no plastidic transit peptide
-
brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakamura, Y.; Tsuchiya, M.; Ohta, H.
Plastidic phosphatidic acid phosphatases identified in a distinct subfamily of lipid phosphate phosphatases with prokaryotic origin
J. Biol. Chem.
282
29013-29021
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q0WUC2), Arabidopsis thaliana (Q6NLA5), Arabidopsis thaliana (Q6NQL6), Arabidopsis thaliana (Q9SUW4)
brenda
EXTERNAL LINKS (specific for EC-Number 3.1.3.4)
Transporter Classification Database (TCDB): 9.B.105.3.2
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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