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Information on EC 3.1.3.3 - phosphoserine phosphatase and Organism(s) Rattus norvegicus and UniProt Accession Q5M819

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.3 phosphoserine phosphatase
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q5M819 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
psp, serine/threonine protein phosphatase, phosphoserine phosphatase, pspase, ctd phosphatase fcp1, serb653, serb2, l-phosphoserine phosphatase, 3-phosphoserine phosphatase, ipsp1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoserine phosphatase
-
3-phosphoserine phosphatase
-
-
-
-
CTD phosphatase fcp1
-
-
-
-
L-phosphoserine phosphatase
-
-
O-phosphoserine phosphohydrolase
-
-
-
-
phosphatase, phosphoserine
-
-
-
-
PSP
-
-
-
-
PSPase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
O-phosphoserine phosphohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9025-73-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-phosphoserine + H2O
D-Ser + phosphate
show the reaction diagram
L-phosphoserine + H2O
L-Ser + phosphate
show the reaction diagram
additional information
?
-
-
the enzyme may play a role in altered neuronal function in Alzheimer‘s disease via enhancing glutamate-induced neurotoxicity by D-serine and the IL-11 receptor system
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the enzyme may play a role in altered neuronal function in Alzheimer‘s disease via enhancing glutamate-induced neurotoxicity by D-serine and the IL-11 receptor system
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-2-amino-3-phosphonopropionic acid
-
-
DL-2-Amino-4-phosphonobutyric acid
-
-
Glycerophosphorylcholine
-
-
hexadecylphosphocholine
-
-
L-2-amino-3-phosphonopropionic acid
-
-
L-serine
N-ethylmaleimide
-
-
p-chloromercuriphenylsulfonate
-
-
phosphonoalanine
-
-
phosphorylcholine
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.8 - 1.2
D-phosphoserine
0.05 - 0.056
L-phosphoserine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SERB_RAT
225
0
24968
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000
x * 25000, Western blot analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 25000, Western blot analysis
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-9°C, stable for several months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) Gold pLysS and in HEK-293 cell
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vidal, Y.; Cassaigne, A.; Neuzil, E.
Interactions of aminophosphonates with rat liver phosphoserine phosphatase
Biochem. Soc. Trans.
13
788-789
1985
Rattus norvegicus
-
Manually annotated by BRENDA team
Knox, W.E.; Herzfeld, A.; Hudson, J.
Phosphoserine phosphatase distribution in normal and neoplastic rat tissues
Arch. Biochem. Biophys.
132
397-403
1969
Rattus norvegicus
Manually annotated by BRENDA team
Byrne, W.L.
Glucose 6-phosphatase and phosphoserine phosphatase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
73-78
1961
Gallus gallus, Rattus norvegicus
-
Manually annotated by BRENDA team
Kearney, P.; Holloway, B.W.
Regulation and routes of biosynthesis of serine and arginine in Methylophilus methylotrophus AS1
FEMS Microbiol. Lett.
42
109-112
1987
Methylophilus methylotrophus, Rattus norvegicus
-
Manually annotated by BRENDA team
Wood, P.L.; Hawkinson, J.E.; Goodenough, D.B.
Formation of D-serine from L-phosphoserine in brain synaptosomes
J. Neurochem.
67
1485-1490
1996
Rattus norvegicus
Manually annotated by BRENDA team
Hawkinson, J.E.; Acosta-Burruel, M.; Ta, N.D.; Wood, P.L.
Novel phosphoserine phosphatase inhibitors
Eur. J. Pharmacol.
337
315-324
1997
Rattus norvegicus
Manually annotated by BRENDA team
Heese, K.; Nagai, Y.; Sawada, T.
Induction of rat L-phosphoserine phosphatase by amyloid-beta (1-42) is inhibited by interleukin-11
Neurosci. Lett.
288
37-40
2000
Rattus norvegicus
Manually annotated by BRENDA team
Antflick, J.E.; Vetiska, S.; Baizer, J.S.; Yao, Y.; Baker, G.B.; Hampson, D.R.
L-Serine-O-phosphate in the central nervous system
Brain Res.
1300
1-13
2009
Rattus norvegicus (Q5M819)
Manually annotated by BRENDA team