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Information on EC 3.1.3.25 - inositol-phosphate phosphatase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9M8S8

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     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.25 inositol-phosphate phosphatase
IUBMB Comments
Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known .
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9M8S8
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The taxonomic range for the selected organisms is: Arabidopsis thaliana
Synonyms
AF2372, All2917, I-1-Pase, IMP, IMP-1 protein, IMPA1, IMPA2, IMPase, IMPase 1, IMPase I, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
I-1-Pase
-
-
-
-
IMPase
-
-
-
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inositol 1-phosphate phosphatase
-
-
-
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inositol monophosphatase
inositol monophosphate phosphatase
-
-
-
-
inositol phosphatase
-
-
-
-
inositol phosphohydrolase
-
-
-
-
inositol-1(or 4)-monophosphatase
-
-
-
-
inositol-1-phosphatase
-
-
-
-
L-myo-inositol-1-phosphate phosphatase
-
-
-
-
Lithium-sensitive myo-inositol monophosphatase A1
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-
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myo-inositol 1 (or 4) -monophosphatase
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-
-
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myo-inositol 1-phosphatase
-
-
-
-
myo-inositol monophosphatase
288485, 288486, 288487
-
Myo-inositol monophosphatase A2
-
-
-
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myo-inositol-1(or 4)-phosphate phosphohydrolase
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
myo-inositol-phosphate phosphohydrolase
Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate. Two isoforms are known [4].
CAS REGISTRY NUMBER
COMMENTARY hide
37184-63-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
show the reaction diagram
-
-
-
?
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
show the reaction diagram
Q6NPM8, Q94F00, Q9M8S8
-
-
-
?
myo-inositol 3-phosphate + H2O
myo-inositol + phosphate
show the reaction diagram
Q6NPM8, Q94F00, Q9M8S8
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the impl2 mutant has an embryo lethal phenotype, while the impl1 and vtc4 mutants do not
metabolism
myo-inositol monophosphatase catalyzes the dephosphorylation of myo-inositol 3-phosphate in the last step of myo-inositol biosynthesis. Expression of IMP genes is correlated with expression of the gene for myo-inositol polyphosphate 1-phosphatase, which is involved in the myo-inositol salvage pathway, suggesting a possible salvage pathway role in seed development. Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development
physiological function
myo-inositol monophosphatase catalyzes the dephosphorylation of myo-inositol 3-phosphate in the last step of myo-inositol biosynthesis. Myo-inositol monophosphatase is also important in phosphate metabolism and is required for the biosynthesis of cell wall polysaccharides, phytic acid, and phosphatidylinositol
malfunction
the impl2 mutant has an embryo lethal phenotype, while the impl1 and vtc4 mutants do not
metabolism
myo-inositol monophosphatase catalyzes the dephosphorylation of myo-inositol 3-phosphate in the last step of myo-inositol biosynthesis. Expression of IMP genes is correlated with expression of the gene for myo-inositol polyphosphate 1-phosphatase, which is involved in the myo-inositol salvage pathway, suggesting a possible salvage pathway role in seed development. Moreover, the partial rescue of the impl2 phenotype by histidine application implies that IMPL2 is also involved in histidine biosynthesis during embryo development
physiological function
myo-inositol monophosphatase catalyzes the dephosphorylation of myo-inositol 3-phosphate in the last step of myo-inositol biosynthesis. Myo-inositol monophosphatase is also important in phosphate metabolism and is required for the biosynthesis of cell wall polysaccharides, phytic acid, and phosphatidylinositol
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
VTC4_ARATH
271
0
29121
Swiss-Prot
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in Agrobacterium tumefaciens
expression in Agrobacterium tumefaciens
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Siddique, S.; Endres, S.; Atkins, J.M.; Szakasits, D.; Wieczorek, K.; Hofmann, J.; Blaukopf, C.; Urwin, P.E.; Tenhaken, R.; Grundler, F.M.; Kreil, D.P.; Bohlmann, H.
Myo-inositol oxygenase genes are involved in the development of syncytia induced by Heterodera schachtii in Arabidopsis roots
New Phytol.
184
457-472
2009
Arabidopsis thaliana (Q6NPM8), Arabidopsis thaliana (Q94F00), Arabidopsis thaliana (Q9M8S8)
Manually annotated by BRENDA team
Sato, Y.; Yazawa, K.; Yoshida, S.; Tamaoki, M.; Nakajima, N.; Iwai, H.; Ishii, T.; Satoh, S.
Expression and functions of myo-inositol monophosphatase family genes in seed development of Arabidopsis
J. Plant Res.
124
385-394
2011
Arabidopsis thaliana (Q6NPM8), Arabidopsis thaliana (Q94F00), Arabidopsis thaliana (Q9M8S8)
Manually annotated by BRENDA team
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