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Information on EC 3.1.3.23 - sugar-phosphatase
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3.1.3.23 sugar-phosphataseIUBMB Comments
Has a wide specificity, acting on aldohexose 1-phosphates, ketohexose 1-phosphates, aldohexose 6-phosphates, ketohexose 6-phosphates, both phosphate ester bonds of fructose 1,6-bisphosphate, phosphoric esters of disaccharides, and on pentose and triose phosphates, but at a slower rate.
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Word Map
- 3.1.3.23
- phosphatases
-
phosphosugars
- meningitidis
- d-ribose-5-phosphate
-
c1-type
- methylerythritol
-
broad-range
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
sugar phosphatase, sugar phosphate phosphohydrolase, sugar-phosphatase, pflu2693, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
PFLU2693
phosphatase, sugar
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SPP
sugar phosphatase
sugar phosphate phosphohydrolase
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additional information
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the enzyme is a member of the ubiquitous haloalkanoate dehalogenase superfamily
sugar phosphatase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
sugar phosphate + H2O = sugar + phosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
sugar-phosphate phosphohydrolase
Has a wide specificity, acting on aldohexose 1-phosphates, ketohexose 1-phosphates, aldohexose 6-phosphates, ketohexose 6-phosphates, both phosphate ester bonds of fructose 1,6-bisphosphate, phosphoric esters of disaccharides, and on pentose and triose phosphates, but at a slower rate.
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CAS REGISTRY NUMBER
COMMENTARY
9023-07-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-ribose 5-phosphate + H2O
2-deoxy-D-ribose + phosphate
-
-
-
?
alpha-D-gentibiose-1-phosphate + H2O
alpha-D-gentibiose + phosphate
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66% of the activity with alpha-D-glucose 1-phosphate
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-
?
alpha-D-gentiobiose 1-phosphate + H2O
alpha-D-gentiobiose + phosphate
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-
-
-
?
alpha-D-glucosamine 1-phosphate + H2O
alpha-D-glucosamine + phosphate
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-
-
-
?
beta-D-methyl-thiogalactopyranoside 6-phosphate + H2O
beta-D-methyl-thiogalactopyranoside + phosphate
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-
-
-
?
D-glucose 2-phosphate + H2O
D-glucose + phosphate
second best substrate
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-
?
D-glyceraldehyde 3-phosphate + H2O
D-glyceraldehyde + phosphate
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24.5% of the activity with alpha-D-glucose 1-phosphate
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-
?
D-sorbose 1,6-diphosphate + H2O
?
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15% of the activity with alpha-D-glucose 1-phosphate
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?
D-sorbose 1-phosphate + H2O
D-sorbose + phosphate
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108% of the activity with alpha-D-glucose 1-phosphate
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?
deoxyxylulose 5-phosphate + H2O
deoxyxylulose + phosphate
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?
inositol phosphate + H2O
inositol + phosphate
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5% of the activity with alpha-D-glucose 1-phosphate
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-
?
methylerythritol phosphate + H2O
methylerythritol + phosphate
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-
-
?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
preferred substrate
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-
?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
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-
-
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?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
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?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
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103% of the activity with alpha-D-glucose 1-phosphate
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?
2-Deoxy-D-glucose 6-phosphate + H2O
2-Deoxy-D-glucose + phosphate
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?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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AraL is a phosphatase displaying activity towards the synthetic substrate 4-nitrophenyl phosphate, although there is no evidence that pNPPase activity is physiologically relevant
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?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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?
alpha-D-galactose 1-phosphate + H2O
alpha-D-galactose + phosphate
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-
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?
alpha-D-galactose 1-phosphate + H2O
alpha-D-galactose + phosphate
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115% of the activity with alpha-D-glucose 1-phosphate
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?
alpha-D-glucose 1-phosphate + H2O
alpha-D-glucose + phosphate
Escherichia acidilactici
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?
alpha-D-glucose 1-phosphate + H2O
alpha-D-glucose + phosphate
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?
alpha-D-glucose 1-phosphate + H2O
alpha-D-glucose + phosphate
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?
alpha-D-glucose 1-phosphate + H2O
alpha-D-glucose + phosphate
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
Escherichia acidilactici
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
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75.6% of the activity with alpha-D-glucose 1-phosphate
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?
alpha-D-glucuronic acid 1-phosphate + H2O
alpha-D-glucuronic acid + phosphate
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?
alpha-D-mannose 1-phosphate + H2O
alpha-D-mannose + phosphate
Escherichia acidilactici
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?
alpha-D-mannose 1-phosphate + H2O
alpha-D-mannose + phosphate
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?
alpha-D-mannose 1-phosphate + H2O
alpha-D-mannose + phosphate
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?
alpha-D-mannose 1-phosphate + H2O
alpha-D-mannose + phosphate
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103% of the activity with alpha-D-mannose 1-phosphate
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?
alpha-D-mannose 1-phosphate + H2O
alpha-D-mannose + phosphate
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?
alpha-lactose 1-phosphate + H2O
alpha-lactose + phosphate
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15% of the activity with alpha-D-glucose 1-phosphate
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?
D-fructose 1,6-diphosphate + H2O
?
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93% of the activity with alpha-D-glucose 1-phosphate
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?
D-fructose 1-phosphate + H2O
D-fructose + phosphate
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104% of the activity with alpha-D-glucose 1-phosphate
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?
D-fructose 1-phosphate + H2O
D-fructose + phosphate
best substrate
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?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
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104% of the activity with alpha-D-glucose 1-phosphate
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?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
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?
D-fructose 6-phosphate + H2O
D-fructose + phosphate
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about 609% of the activity with D-fructose 1-phosphate
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?
D-galactose 6-phosphate + H2O
D-galactose + phosphate
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30.3% of the activity with alpha-D-glucose 1-phosphate
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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106% of the activity with alpha-D-glucose 1-phosphate
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?
D-glucose 6-phosphate + H2O
D-glucose + phosphate
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?
D-mannose 6-phosphate + H2O
D-mannose + phosphate
preferred substrate
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?
D-mannose 6-phosphate + H2O
D-mannose + phosphate
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28.5% of the activity with alpha-D-glucose 1-phosphate
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?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
preferred substrate
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?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
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24.8% of the activity with alpha-D-glucose 1-phosphate
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?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
preferred substrate
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?
D-ribose 5-phosphate + H2O
D-ribose + phosphate
preferred substrate
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?
D-xylose 1-phosphate + H2O
D-xylose + phosphate
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72% of the activity with alpha-D-glucose 1-phosphate
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?
dihydroxyacetone phosphate + H2O
dihydroxyacetone + phosphate
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12% of the activity with alpha-D-glucose 1-phosphate
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?
dihydroxyacetone phosphate + H2O
dihydroxyacetone + phosphate
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?
additional information
?
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AraL shows low specificity and catalytic activity towards several sugar phosphates, which are metabolic intermediates of the glycolytic and pentose phosphate pathways, substrate specificity, overview
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?
additional information
?
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sugar phosphate phosphatase II appears to play a role in inducer expulsion
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?
additional information
?
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at least one more site for alpha-aldohexose 1-phosphate other than the catalytic site for glucose 6-phosphate
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?
additional information
?
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low activity towards D-fructose 1,6-bisphosphate, D-galactose 1-phosphate, glycerol 2-phosphate, glucosamine 1-phosphate, D-mannose 1-phosphate, phosphoenolpyruvate, sedoheptulose 7-phosphate, sorbitol 6-phosphate, trehalose 6-phosphate, 2-phosphoglyceric acid, and 3-phosphoglyceric acid
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?
additional information
?
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low activity towards D-fructose 1,6-bisphosphate, D-galactose 1-phosphate, glycerol 2-phosphate, glucosamine 1-phosphate, D-mannose 1-phosphate, phosphoenolpyruvate, sedoheptulose 7-phosphate, sorbitol 6-phosphate, trehalose 6-phosphate, 2-phosphoglyceric acid, and 3-phosphoglyceric acid
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?
additional information
?
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the enzyme is most active against monophosphorylated three to six-carbon monosaccharides
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?
additional information
?
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the enzyme is most active against monophosphorylated three to six-carbon monosaccharides
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?
additional information
?
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no activity towards phosphoenolpyruvate
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?
additional information
?
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sugar phosphate phosphatase II appears to play a role in inducer expulsion
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?
additional information
?
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poor substrates: D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 1,6-bisphosphate
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?
additional information
?
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sugar phosphate phosphatase II appears to play a role in inducer expulsion
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-fructose 1-phosphate + H2O
D-fructose + phosphate
best substrate
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-
?
additional information
?
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AraL shows low specificity and catalytic activity towards several sugar phosphates, which are metabolic intermediates of the glycolytic and pentose phosphate pathways, substrate specificity, overview
-
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?
additional information
?
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sugar phosphate phosphatase II appears to play a role in inducer expulsion
-
-
?
additional information
?
-
-
sugar phosphate phosphatase II appears to play a role in inducer expulsion
-
-
?
additional information
?
-
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sugar phosphate phosphatase II appears to play a role in inducer expulsion
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
Mg2+
-
the enzyme is dependent on divalent cations, Mg2+ is most effective, half-maximal stimulation at 1 mM
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
F-
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10 mM, 98% inhibition of hydrolysis of glucose 6-phosphate, 70% inhibition of hydrolysis of glucose 1-phosphate
mannose 1-phosphate
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strong competitive inhibitor of hydrolysis of glucose 6-phosphate
Mn2+
addition of MN2+ decreaseds the reaction rate both without and in combination with Mg2x05
glucose 1-phosphate
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complete inhibition of hydrolysis of glucose 6-phosphate as long as glucose 1-phosphate to glucose 6-phosphate ratios are greater than 0.12
glucose 1-phosphate
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complete inhibition of hydrolysis of glucose 6-phosphate as long as glucose 1-phosphate to glucose 6-phosphate ratios are greater than 0.12
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
S46D HPr
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i.e. mutant phosphocarrier protein, 10fold activation of sugar phosphate phosphatase I
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S46D HPr
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i.e. mutant phosphocarrier protein, 10fold activation of sugar phosphate phosphatase I
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Malaria
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.
Malaria
Cap-domain closure enables diverse substrate recognition by the C2-type haloacid dehalogenase-like sugar phosphatase Plasmodium falciparum HAD1.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
4.6
2-deoxy-D-glucose 6-phosphate
wild type enzyme, in 20 mM Tris-HCl(pH 7.0), 5 mM MgCl2, at 32°C
5