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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
phosphoglycolate phosphatase, pgpase, 2-phosphoglycolate phosphatase, p-glycolate phosphatase, pglp1,
slr0458, pho15, pglp2, sfpgpase,
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2-Phosphoglycolate phosphatase
p-Glycolate phosphatase
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PGLP1
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respiratory enzyme
PGLP2
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non-respiratory enzyme
Phosphatase, phosphoglycolate
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Phosphoglycolate hydrolase
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Phosphoglycolate phosphatase
2-Phosphoglycolate phosphatase
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2-Phosphoglycolate phosphatase
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Pgp
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PGPase
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Pho15
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Phosphoglycolate phosphatase
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Phosphoglycolate phosphatase
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Phosphoglycolate phosphatase
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photorespiratory enzyme
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photorespiratory enzyme
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2-Phosphoglycolate + H2O = glycolate + phosphate
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hydrolysis of phosphoric ester
additional information
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hydrolysis of phosphoric ester
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hydrolysis of phosphoric ester
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2-phosphoglycolate phosphohydrolase
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1,3-dihydroxyacetone phosphate + H2O
1,3-dihydroxyacetone + phosphate
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about 20% of the activity with 2-phosphoglycolate
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?
2-Chloroethyl-phosphate + H2O
Chloroethanol + phosphate
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?
2-glycerol phosphate + H2O
glycerol + phosphate
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about 17% of the activity with 2-phosphoglycolate
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?
2-Hydroxyethyl-phosphate + H2O
Hydroxyethanol + phosphate
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?
2-phospho-L-lactate + H2O
L-lactate + phosphate
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?
2-Phosphoglycolate + H2O
Glycolate + phosphate
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
D-fructose-1,6-bisphosphate + H2O
D-fructose-1-phosphate + phosphate
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?
D-ribulose-5-phosphate + H2O
D-ribulose + phosphate
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?
diphosphate + H2O
2 phosphate
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?
Ethyl-phosphate + H2O
Ethanol + phosphate
glyceraldehyde-3-phosphate + H2O
glyceraldehyde + phosphate
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about 20% of the activity with 2-phosphoglycolate
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?
glycerol 1-phosphate + H2O
glycerol + phosphate
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glycerol 2-phosphate + H2O
glycerol + phosphate
i-Propyl-phosphate + H2O
i-Propanol + phosphate
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slowly
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L-Phospholactate + H2O
L-Lactate + phosphate
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Methyl-phosphate + H2O
Methanol + phosphate
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?
n-Propyl-phosphate + H2O
n-Propanol + phosphate
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weak
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p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
phosphoglycolate + H2O
glycolate + phosphate
additional information
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
a key enzyme of photorespiration in photosynthetic organisms
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
the enzyme is involved in a reaction relevant for DNA repair
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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first unique step of oxidative photosynthetic carbon cycle
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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first unique step of oxidative photosynthetic carbon cycle
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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Ethyl-phosphate + H2O
Ethanol + phosphate
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Ethyl-phosphate + H2O
Ethanol + phosphate
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Ethyl-phosphate + H2O
Ethanol + phosphate
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glycerol 2-phosphate + H2O
glycerol + phosphate
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glycerol 2-phosphate + H2O
glycerol + phosphate
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p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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additional information
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no substrates: phosphopeptides, 4-nitrophenylsulfate
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additional information
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no substrates: phosphopeptides, 4-nitrophenylsulfate
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additional information
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not: 3-phosphoglycerate, D-ribose-5-phosphate, phosphoenolpyruvate, O-phospho-1-serine, p-nitrophenylphosphate
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additional information
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not: 3-phosphoglycerate, D-ribose-5-phosphate, phosphoenolpyruvate, O-phospho-1-serine, p-nitrophenylphosphate
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additional information
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2-Phosphoglycolate + H2O
Glycolate + phosphate
glycerol 1-phosphate + H2O
glycerol + phosphate
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glycerol 2-phosphate + H2O
glycerol + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
2-Phosphoglycolate + H2O
Glycolate + phosphate
a key enzyme of photorespiration in photosynthetic organisms
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2-Phosphoglycolate + H2O
Glycolate + phosphate
the enzyme is involved in a reaction relevant for DNA repair
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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first unique step of oxidative photosynthetic carbon cycle
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2-Phosphoglycolate + H2O
Glycolate + phosphate
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first unique step of oxidative photosynthetic carbon cycle
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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phosphoglycolate + H2O
glycolate + phosphate
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?
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K+
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needed for optimal activation, can be replaced by Li+, Na+, Rb+, Cs+, NH4+
KCl
activates at chloride ion concentration up to 50 mM
ZnCl2
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slight activation up to 0.1 mM
Cl-
the activity is 11fold increased, cooperative effect of Cl- and Mg2+
Cl-
activates at low concentration, below 50
Co2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Co2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Co2+
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Anacystis: no activation, Chlamydomonas: activation
Co2+
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Chlamydomonas: most effective activator
Co2+
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Anacystis: no activation, Chlamydomonas: activation
Co2+
activates, KD = 0.036 +/- 0.004
Mg2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Mg2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Mg2+
cooperative effect of Cl- and Mg2+
Mg2+
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most effective activator
Mg2+
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preferred divalent cation
Mg2+
activates, KD = 0.13 +/- 0.01
Mg2+
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most effective activator
Mn2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Mn2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Mn2+
activates, KD = 0.02 +/- 0.004
Ni2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Ni2+
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cations tested, in decreasing order of efficiency: Mn2+, Co2+, Mg2+, Ni2+
Zn2+
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Anacystis: no activation, Chlamydomonas: activation
Zn2+
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Anacystis: no activation, Chlamydomonas: activation
Zn2+
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activates less than Mg2+
additional information
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divalent cation required, no cofactor: Cu2+
additional information
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divalent cation required, no cofactor: Cu2+
additional information
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divalent cation required
additional information
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univalent cation required for optimum activity
additional information
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divalent cation required
additional information
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divalent cation required
additional information
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divalent cation required
additional information
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divalent cation required
additional information
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divalent cation required
additional information
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divalent cation required
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5,5'-dithiobis(2-nitrobenzoate)
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6-phospho-gluconate
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isoenzyme I, french bean
alpha-alanine
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isoenzyme II, french bean
CaCl2
the enzyme binds to Ca2+, the inhibition is recovered by addition of EGTA and MgCl2
Cl-
inhibits at high concentration, above 50 mM, competitive inhibition; total inhibition at chloride ion concentration of 600 mM
diisopropylfluorophosphate
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formate
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isoenzyme I, french bean
fructose-6-phosphate
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isoenzyme I and II, french bean
glutamate
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isoenzyme II, french bean
glycine
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isoenzyme II, french bean
glyoxylate
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isoenzyme II, french bean
KCl
total inhibition at chloride ion concentration of 600 mM
NaCl
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1 M, shift in oligomeric state of the protein from dimer towards monomer
p-chloromercuribenzoate
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p-mercuribenzoic acid
the inhibition is recovered by addition of dithiothreitol
Phosphoglycolate * Mg2+ complex
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serine
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isoenzyme I, french bean
ZnCl2
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20% inhibition at 0.2 mM, 50% inhibition at 0.5 mM
additional information
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inactivated by lipase EC 3.1.1.3
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EDTA
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glycolate
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glycolate
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isoenzyme I and II, french bean
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tris(2-carboxyethyl)phosphine
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Cl-
the activity is 11fold increased, cooperative effect of Cl- and Mg2+
Cl-
activates at chloride ion concentration up to 50 mM
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Anemia
Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Anemia, Aplastic
Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Anemia, Hemolytic
Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Leprosy
Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae.
phosphoglycolate phosphatase deficiency
A Photorespiratory Mutant of Chlamydomonas reinhardtii.
Polycystic Kidney, Autosomal Dominant
A study of genetic linkage heterogeneity in adult polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Mapping of the familial Mediterranean fever gene to chromosome 16.
Polycystic Kidney, Autosomal Dominant
Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.
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3.3
2-Chloroethyl-phosphate
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14.48
2-glycerol phosphate
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pH 8.3, 42°C
0.54
2-Hydroxyethyl-phosphate
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4.77
2-phospho-L-lactate
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pH 7.4, 37°C
0.029 - 3.47
2-Phosphoglycolate
2.11
Glycerol 2-phosphate
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pH 7.4, 37°C
0.21
methyl-phosphate
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0.17 - 3.1
p-nitrophenyl phosphate
0.026 - 2
Phosphoglycolate
additional information
additional information
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0.029
2-Phosphoglycolate
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pH 7.5, 70°C
0.037
2-Phosphoglycolate
pH 7.5, 70°C
0.061
2-Phosphoglycolate
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pH 7.5, 70°C
0.14
2-Phosphoglycolate
pH 8.0
0.21
2-Phosphoglycolate
25°C
0.3
2-Phosphoglycolate
pH not specified in the publication, temperature not specified in the publication
2.5 - 3
2-Phosphoglycolate
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pH 7.4, 37°C
3.26
2-Phosphoglycolate
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pH 8.0, 37°C
3.47
2-Phosphoglycolate
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pH 8.3, 42°C
0.17
Co2+
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isoemzyme I
0.17
diphosphate
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3.1
diphosphate
pH 7.5, 70°C
0.015
Mg2+
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0.17
p-nitrophenyl phosphate
pH 7.5, 70°C
3.1
p-nitrophenyl phosphate
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0.026
Phosphoglycolate
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Spinacea oleracea
0.03
Phosphoglycolate
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Phaseolus vulgaris
0.04
Phosphoglycolate
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Pisum sativum
0.57
Phosphoglycolate
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Zea mays
1.5 - 2
Phosphoglycolate
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ethyl-phosphate, human
additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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additional information
additional information
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Km increases at higher pH, above 7.5
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67.34
2-phospho-L-lactate
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pH 7.4, 37°C
0.031 - 292
2-Phosphoglycolate
10.18
Glycerol 2-phosphate
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pH 7.4, 37°C
0.58 - 4.8
p-nitrophenyl phosphate
0.031 - 0.51
2-Phosphoglycolate
pH 7.5, 70°C
2.13
2-Phosphoglycolate
pH not specified in the publication, temperature not specified in the publication
8.26
2-Phosphoglycolate
pH 7.5, 70°C
19
2-Phosphoglycolate
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pH 7.5, 70°C
75.15
2-Phosphoglycolate
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pH 7.4, 37°C
94
2-Phosphoglycolate
25°C
292
2-Phosphoglycolate
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pH 7.5, 70°C
0.58
diphosphate
pH 7.5, 70°C
6.08
diphosphate
pH 7.5, 70°C
0.58
p-nitrophenyl phosphate
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4.8
p-nitrophenyl phosphate
pH 7.5, 70°C
3.1.3.18 phosphoglycolate phosphatase
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