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Information on EC 3.1.3.16 - protein-serine/threonine phosphatase and Organism(s) Homo sapiens and UniProt Accession P53041

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.16 protein-serine/threonine phosphatase
IUBMB Comments
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
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Select one or more organisms in this record:
This record set is specific for:
Homo sapiens
UNIPROT: P53041
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
calcineurin, protein phosphatase, pac-1, serine/threonine phosphatase, phosphoprotein phosphatase, dusp1, pp2ac, dusp6, pp-2a, ppm1d, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-hydroxy 3-methylglutaryl CoenzymeA reductase phosphatase
-
-
-
-
Aspergillus awamori acid protein phosphatase
-
-
-
-
B56beta
247
regulatory subunit of protein phosphatase 2A
B56gamma-PP2A
247
-
B56gamma-specific protein phosphatase 2A
247
-
Balpha
247
-
BCKDH phosphatase
-
-
-
-
branched-chain alpha-keto acid dehydrogenase phosphatase
-
-
-
-
calcineurin
Calcineurin A1
-
-
-
-
Calcineurin A2
-
-
-
-
calcineurin B-like protein
278562
-
calcium-dependent protein phosphatase 2B
247
-
CALNA
247
-
CALNB
247
-
CaM kinase phosphatase
247
-
CaM-kinase phosphatase
-
-
-
-
CaMIIKPase
247
-
CaMKPase
-
-
-
-
casein phosphatase
-
-
-
-
CBLP
278562
-
class I cysteine-based dual-specificity phosphatase
CN phosphatase
247
-
CNA
247
calcineurin catalytic subunit
CNAa
247
-
CNAalpha
247
-
CNAbeta
247
-
CNAgamma
247
-
CNBII
278562
-
DRES10
-
-
-
-
DSP
282087, 282091, 286399, 286400, 286401, 286402, 286403, 286404, 286405
PTP domain class I DSPs differ from classical PTPs in that they can dephosphorylate phospho-Tyr, phospho-Ser and phospho-Thr residues, as well as nonproteinaceous substrates
DSP hVH5
247
-
dual specificity phosphatase
247
-
dual specificity protein phosphatase 1
286405
-
dual specificity protein phosphatase 10
282091
-
dual specificity protein phosphatase 26
286399
-
dual specificity protein phosphatase 6
282087
-
dual-specificity phosphatase 5
247
-
dual-specificity phosphatase hVH5
247
-
DUSP1
286405
-
DUSP10
282091
-
DUSP26
286399
-
DUSP5
247
-
DUSP6
282087
-
EPM2A
286403
-
Fcp1
247
-
Fibroblast growth factor inducible protein 13
-
-
-
-
FIN13
Flap wing protein
-
-
-
-
hFEM2
247
-
HMG-CoA reductase phosphatase
-
-
-
-
ILKAP
247
-
KAP
247
-
kinase associated phosphatase
247
-
laforin
286403
-
Magnesium-dependent calcium inhibitable phosphatase
-
-
-
-
MCPP
-
-
-
-
Microtubule star protein
-
-
-
-
MKP-1
286405
-
MKP-5
282091
-
MKP-8
286399
-
MMAC-1
286404
-
MTMR5
286402
-
myosin light chain phosphatase
247
a specific form of PP1
NERPP-2C
247
-
P10
247
-
P11
247
-
P5
247
-
P6
247
-
P7
247
-
P8
247
-
P9
247
-
Pac-1
286400
-
PDP1
247
-
PDP2
247
-
PGAM5
310518
-
phosphatase 2A
-
-
-
-
phosphatase 2B
-
-
-
-
phosphatase C-II
-
-
-
-
Phosphatase esp1
-
-
-
-
phosphatase H-II
-
-
-
-
phosphatase I
-
-
-
-
phosphatase IB
-
-
-
-
phosphatase II
-
-
-
-
phosphatase III
-
-
-
-
phosphatase IV
-
-
-
-
phosphatase of activated cells 1
286400
-
phosphatase of regenerating liver
286401
-
phosphatase PP4
247
-
phosphatase SP
-
-
-
-
phosphoglycerate mutase 5
310518
-
phosphoprotein phosphatase
-
-
-
-
phosphopyruvate dehydrogenase phosphatase
-
-
-
-
phosphorylase phosphatase
296291, 297004, 301853
-
phosphospectrin phosphatase
-
-
-
-
phosphothreonine/serine-specific PP
247
-
PK-Pase
-
-
-
-
polycation modulated (PCM-) phosphatase
-
-
-
-
POPX1
247
-
POPX2
247
-
PP-1A
-
-
-
-
PP-1B
-
-
-
-
PP-1G
-
-
-
-
PP-2A
247
-
PP-2B
247
-
PP-2C
247
-
PP1alpha
247
-
PP1beta
247
-
PP1c
247
protein phosphatase 1 catalytic subunit
PP1cgamma
247
-
PP1delta
247
-
PP1gamma
PP2
247
-
PP2A-alpha
-
-
-
-
PP2A-B56gamma
247
-
PP2A-beta
-
-
-
-
PP2Aalpha
247
-
PP2Abeta
247
-
PP2Ac
247
catalytic subunit of protein phosphatase 2A
PP2Acalpha
PP2Acbeta
247
-
PP2Balpha
247
-
PP2Bbeta
247
-
PP2Bgamma
247
-
PP2C epsilon
278561
-
PP2C phosphatase
247
-
PP2C-alpha
-
-
-
-
PP2C-beta
-
-
-
-
PP2C-delta
-
-
-
-
PP2C-epsilon
278561
-
PP2C-gamma
-
-
-
-
PP2Calpha
PP2Cbeta
PP2Cdelta
247
-
PP2CE
278561
-
PP2Cepsilon
247
isoform
PP2Ceta
247
isoform
PP2Cgamma
PP2Ckappa
282049
isozyme
PP2Cm
247
isoform
PP2CR
247
-
PP4c
247
catalytic subunit of protein phosphatase 4
PP6R1
247
regulatory subunit of protein phosphatase 6, PP6R1 acts as a scaffold with separate regions for binding to protein phosphatase 6 and to ankyrin repeat protein 28
PP7
247
-
PPEF
-
-
-
-
PPEF1
247
-
PPEF2
247
-
PPIalpha
247
-
PPM family phosphatase
247
-
PPM1D
247
-
PPM1D/Wip1
247
-
PPM1F
247
-
PPN
-
-
-
-
PPP phosphatase
247
-
PPP1
296291, 297004, 301853
-
PPP1CA
296291
isoform
Ppp1calpha
247
-
PPP1CB
301853
isoform
Ppp1cbeta
247
-
PPP1CC
297004
isoform
Ppp1cgamma
247
-
PPP2CA
247
protein phosphatase 2 catalytic subunit alpha
Ppp2calpha
247
-
Ppp2cbeta
247
-
PPP3CA
247
protein phosphatase 3 catalytic subunit alpha
Ppp3calpha
247
-
Ppp3cbeta
247
-
Ppp3cgamma
247
-
PPP3R-like protein
278562
-
PPP3RL
278562
-
PPP4
247
-
Ppp4c
247
-
Ppp5c
247
-
Ppp6c
247
-
Ppp7calpha
247
-
Ppp7cbeta
247
-
PR55gamma
247
protein phosphatase 2A subunit
PR65
247
structural core subunit of protein phosphatase 2A
PRL-1
286401
-
protein D phosphatase
-
-
-
-
protein phosphatase
-
-
-
-
protein phosphatase 1
protein phosphatase 1-like
278561
-
Protein phosphatase 1A
-
-
-
-
protein phosphatase 1alpha
247
-
Protein phosphatase 1B
-
-
-
-
Protein phosphatase 1C
-
-
-
-
protein phosphatase 1gamma
247
-
protein phosphatase 1L
278561
-
protein phosphatase 2
247
-
protein phosphatase 2A
protein phosphatase 2A regulatory subunit B56alpha
247
-
protein phosphatase 2B
247
-
protein phosphatase 2C
protein phosphatase 2Cdelta
247
-
protein phosphatase 2Ckappa
282049
-
protein phosphatase 3
protein phosphatase 4
247
-
protein phosphatase 5
protein phosphatase 6
247
-
Protein phosphatase magnesium-dependent 1 delta
-
-
-
-
Protein phosphatase magnesium-dependent 1 gamma
-
-
-
-
protein phosphatase type 2A
247
-
Protein phosphatase with EF calcium-binding domain
-
-
-
-
protein phosphatase-1
247
-
protein phosphatase-2A
247
-
protein serine/threonine phosphatase
protein serine/threonine phosphatase 2A
247
-
protein serine/threonine phosphatase 4
247
-
PSPase
-
-
-
-
PSTP
247
-
PTEN
286404
-
PTP
286400, 286401, 286402, 286403, 286404
-
PTP-1B
247
-
PTPCAAX1
286401
-
Retinal degeneration C protein
-
-
-
-
S/T phosphatase
247
-
SBF1
286402
-
Ser/Thr phosphatase
247
-
Ser/Thr protein phosphatase
247
-
Ser/Thr protein phosphatase 5
247
-
serine-threonine phosphatase
296291, 297004, 301853
-
serine-threonine protein phosphatase
247
-
serine/threonine (S/T) phosphatase
247
-
serine/threonine phosphatase
247
-
serine/threonine protein phosphatase
297004
-
serine/threonine protein phosphatase 1
serine/threonine protein phosphatase 4
247
-
serine/threonine protein phosphatase type 5
247
-
serine/threonine protein phosphatase-5
247
-
Set-binding factor 1
286402
-
STPP
296291, 297004, 301853
-
Suppressor protein SDS21
-
-
-
-
TEP1
286404
-
type 1 protein phosphatase
247
-
type 2A protein phosphatase
247
-
type 2C protein phosphatase
247
-
type-I phosphatase
247
-
type-II phosphatase
247
-
wild-type p53-induced phosphatase
247
-
wound-induced protein 1
247
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
protein-serine/threonine-phosphate phosphohydrolase
A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48 protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1, phosphoamidase).
CAS REGISTRY NUMBER
COMMENTARY hide
9025-75-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl methylphosphonate + H2O
4-nitrophenol + methylphosphonate
show the reaction diagram
-
-
-
-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
show the reaction diagram
-
-
-
-
?
a phosphoprotein + H2O
dephosphorylated protein + phosphate
show the reaction diagram
-
-
-
-
?
AAApTVA + H2O
AAATVA + phosphate
show the reaction diagram
-
-
-
?
AGPALpSPVPPV + H2O
AGPALSPVPPV + phosphate
show the reaction diagram
-
-
-
?
ALSAGpSNEYLR + H2O
ALSAGSNEYLR + phosphate
show the reaction diagram
-
-
-
?
ASQEPpSPAASA + H2O
ASQEPSPAASA + phosphate
show the reaction diagram
-
-
-
?
carrier protein-T3-phosphothreonine + H2O
carrier protein-T3-threonine + phosphate
show the reaction diagram
-
-
-
-
?
carrier protein-T4-phosphothreonine + H2O
carrier protein-T4-threonine + phosphate
show the reaction diagram
-
-
-
-
?
chicken acidic leucine-rich epidermal growth factor-like domain-containing brain protein/neuroglycan C + H2O
?
show the reaction diagram
-
the regulatory subunit of protein phosphatase 2A, B56beta, interacts with chicken acidic leucine-rich epidermal growth factor-like domain-containing brain protein/neuroglycan C (CALEB/NGC) and inhibits CALEB/NGC-mediated dendritic branching but not spine formation
-
-
?
DDApTVA + H2O
DDATVA + phosphate
show the reaction diagram
-
-
-
?
ENDpTINASL + H2O
ENDTINASL + phosphate
show the reaction diagram
-
-
-
?
ESEMEpTPSAIN + H2O
ESEMETPSAIN + phosphate
show the reaction diagram
-
-
-
?
FLRT(P)SCG + H2O
FLRTSCG + phosphate
show the reaction diagram
-
-
-
-
?
FLRTS(P)CG + H2O
FLRTSCG + phosphate
show the reaction diagram
-
-
-
-
?
FLRTT(P)CG + H2O
FLRTTCG + phosphate
show the reaction diagram
-
-
-
-
?
glycogen synthase + H2O
glycogen synthase + phosphate
show the reaction diagram
-
-
-
-
?
glycogen synthase b + H2O
glycogen synthase I + phosphate
show the reaction diagram
-
-
-
-
?
HSAPPpSPEEKD + H2O
HSAPPSPEEKD + phosphate
show the reaction diagram
-
-
-
?
myelin basic protein + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
myosin light chain phosphate + H2O
myosin light chain + phosphate
show the reaction diagram
-
myosin light chain phosphatase is a specific form of PP1
-
-
?
NFEDHpSAPPSP + H2O
NFEDHSAPPSP + phosphate
show the reaction diagram
-
-
-
?
NPCTEpTFTGTL + H2O
NPCTETFTGTL + phosphate
show the reaction diagram
-
-
-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
show the reaction diagram
p38 MAP kinase phosphoprotein
?
show the reaction diagram
-
-
-
-
?
peptide mGluR3 + H2O
?
show the reaction diagram
-
-
-
?
phosphatidylinositol-(3,4,5)-triphosphate + H2O
?
show the reaction diagram
the enzyme displays activity towards the D3 position of the phosphoinositide second messenger phosphatidylinositol (3,4,5)-triphosphate
-
-
?
phospho-Cdk2 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-Cdk6 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-MKK + H2O
MKK + phosphate
show the reaction diagram
-
-
-
-
?
phospho-TAK1 + H2O
TAK1 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-threonylpeptide + H2O
threonylpeptide + phosphate
show the reaction diagram
-
-
-
-
?
phosphocasein + H2O
casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphohistone + H2O
histone + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein + H2O
protein + phosphate
show the reaction diagram
phosphoprotein K15F + H2O
protein K15F + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein R20A + H2O
protein R20A + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein RII + H2O
protein RII + phosphate
show the reaction diagram
-
-
-
-
?
phosphoproteins + H2O
proteins + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylase a + H2O
?
show the reaction diagram
-
-
-
-
?
phosphorylase a + H2O
phosphorylase b + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated AD P-Tau + H2O
AD P-Tau + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Akt protein + H2O
Akt protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Akt protein
-
?
phosphorylated androgen receptor + H2O
androgen receptor + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of androgen receptor
-
?
phosphorylated AP-1/AP-2 + H2O
AP-1/AP-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of AP-1/AP-2
-
?
phosphorylated APC protein + H2O
APC protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of APC protein
-
?
phosphorylated apoptosis signal-regulating kinase 1 + H2O
apoptosis signal-regulating kinase 1 + phosphate
show the reaction diagram
apoptosis signal-regulating kinase 1 is transiently activated by autophosphorylation at Thr845
-
-
?
phosphorylated ASK1 + H2O
ASK1 + phosphate
show the reaction diagram
-
ASK1 is inactivated by the isoform PP2Ceta
-
-
?
phosphorylated ataxia telangiectasia and Rad3-related + H2O
ataxia telangiectasia and Rad3-related + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ataxia telangiectasia mutated kinase + H2O
ataxia telangiectasia mutated kinase + phosphate
show the reaction diagram
phosphorylated ATM and Rad 3 related kinase + H2O
ATM and Rad 3 related kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated ATM protein + H2O
ATM protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of ATM protein
-
?
phosphorylated aurora A + H2O
aurora A + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of aurora A
-
?
phosphorylated axin + H2O
axin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of axin
-
?
phosphorylated B-catenin + H2O
B-catenin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of B-catenin
-
?
phosphorylated BAD protein + H2O
BAD protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of BAD protein
-
?
phosphorylated BAX protein + H2O
BAX protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of BAX protein
-
?
phosphorylated BCL-2 + H2O
BCL-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of BCL-2
-
?
phosphorylated Bcl2 + H2O
Bcl2 + phosphate
show the reaction diagram
-
PP2A-mediated dephosphorylation of Bcl2 promotes its direct interaction with p53 as well as a conformational change in Bcl2, PP2A directly interacts with the BH4 domain of Bcl2 as a docking site to potentially bridge PP2A to Bcl2's flexible loop domain containing the target serine 70 phosphorylation site
-
-
?
phosphorylated beta-catenin + H2O
beta-catenin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated c-Jun N-terminal kinase + H2O
c-Jun N-terminal kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated c-MET + H2O
c-MET + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of c-MET
-
?
phosphorylated c-Myc + H2O
c-Myc + phosphate
show the reaction diagram
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O
Ca2+/calmodulin-dependent protein kinase II + phosphate
show the reaction diagram
phosphorylated calpain + H2O
calpain + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of calpain
-
?
phosphorylated CAM kinase IV + H2O
CAM kinase IV + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CAM kinase IV
-
?
phosphorylated carboxypeptidase D + H2O
carboxypeptidase D + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of carboxypeptidase D
-
?
phosphorylated CAS protein + H2O
CAS protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CAS protein
-
?
phosphorylated casein + H2O
casein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Cav1.2 + H2O
Cav1.2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Cav1.2
-
?
phosphorylated Cdc25c + H2O
Cdc25c + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Cdc25c
-
?
phosphorylated Cdc6 protein + H2O
Cdc6 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Cdc6 protein
-
?
phosphorylated CFTRCXCR2 + H2O
CFTRCXCR2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of CFTRCXCR2
-
?
phosphorylated Chk1 + H2O
Chk1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Chk1 protein + H2O
Chk1 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Chk1 protein
-
?
phosphorylated Chk2 + H2O
Chk2 + phosphate
show the reaction diagram
phosphorylated cyclin G1 + H2O
cyclin G1 + phosphate
show the reaction diagram
-
the B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated
-
-
?
phosphorylated DARPP-32 + H2O
DARP-32 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of DARP-32
-
?
phosphorylated deoxycytidine kinase + H2O
deoxycytidine kinase + phosphate
show the reaction diagram
-
protein phosphatase 2A negatively regulates deoxycytidine kinase activity via Ser-74 dephosphorylation
-
-
?
phosphorylated DNA-dependent protein kinase + H2O
DNA-dependent protein kinase + phosphate
show the reaction diagram
phosphorylated E-cadherin + H2O
E-cadherin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of E-cadherin
-
?
phosphorylated ERK + H2O
ERK + phosphate
show the reaction diagram
phosphorylated ERK protein + H2O
ERK protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of ERK protein
-
?
phosphorylated ERK-2 + H2O
ERK-2 + phosphate
show the reaction diagram
phosphorylated ERK1 + H2O
ERK1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ERK2 + H2O
ERK2 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ERK5 + H2O
ERK5 + phosphate
show the reaction diagram
-
dephosphorylation at Thr218 and Tyr220 residues, dephosphorylation site sequences, overview
-
-
?
phosphorylated estrogen receptor A + H2O
estrogen receptor A + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of estrogen receptor A
-
?
phosphorylated glucocorticoid receptor-heat shock protein 90 + H2O
glucocorticoid receptor-heat shock protein 90 + phosphate
show the reaction diagram
-
-
-
?
phosphorylated glycogen phosphorylase a + H2O
glycogen phosphorylase a + phosphate
show the reaction diagram
phosphorylated Gp130 protein + H2O
Gp130 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Gp130 protein
-
?
phosphorylated GSK3beta + H2O
GSK3beta + phosphate
show the reaction diagram
laforin dephosphorylates the inhibitory Ser9 of GSK3beta
-
-
?
phosphorylated H2AX + H2O
H2AX + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of H2AX
-
?
phosphorylated HAND-1 + H2O
HAND-1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HAND-1
-
?
phosphorylated HAND-2 + H2O
HAND-2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HAND-2
-
?
phosphorylated HDAC4 + H2O
HDAC4 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of HDAC4
-
?
phosphorylated histone 2A member X + H2O
histone 2A member X + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated histone deacetylase 3 + H2O
histone deacetylase 3 + phosphate
show the reaction diagram
phosphorylated histone deacetylase 7 + H2O
histone deacetylase 7 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated IKKB + H2O
IKKB + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of IKKB
-
?
phosphorylated IKKB protein + H2O
IKKB protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of IKKB protein
-
?
phosphorylated ILK1 + H2O
ILK1 + phosphate
show the reaction diagram
phosphorylated INAD-protein + H2O
INAD-protein + phosphate
show the reaction diagram
-
INAD-protein is inactivation no afterpotential D-protein
-
-
?
phosphorylated JNK protein + H2O
JNK protein + phosphate
show the reaction diagram
phosphorylated JNK1 + H2O
JNK1 + phosphate
show the reaction diagram
-
dephosphorylation at Thr183 and Tyr185 residues, dephosphorylation site sequences, overview
-
-
?
phosphorylated keratin 8 + H2O
keratin 8 + phosphate
show the reaction diagram
-
dephosphorylates at phospho-Ser431
-
-
?
phosphorylated KSR protein + H2O
KSR protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of KSR protein
-
?
phosphorylated lamban + H2O
lamban + phosphate
show the reaction diagram
phosphorylated Mdm2 protein + H2O
Mdm2 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Mdm2 protein
-
?
phosphorylated MEK3 + H2O
MEK3 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of MEK3
-
?
phosphorylated MEKK3 + H2O
MEKK3 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of MEKK3
-
?
phosphorylated Mid1 + H2O
Mid1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated mitogen-activated protein kinase kinase 3 + H2O
mitogen-activated protein kinase kinase 3 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated MKK3b + H2O
MKK3b + phosphate
show the reaction diagram
-
MKK3b is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated MKK4 + H2O
MKK4 + phosphate
show the reaction diagram
phosphorylated MKK6b + H2O
MKK6b + phosphate
show the reaction diagram
-
MKK6b is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated MKK7 + H2O
MKK7 + phosphate
show the reaction diagram
-
MKK7 is inactivated by the isoforms PP2Calpha and PP2Cbeta
-
-
?
phosphorylated mouse double minute 2 homologue + H2O
mouse double minute 2 homologue + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated myelin basic protein + H2O
myelin basic protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated myosin light chain + H2O
myosin light chain + phosphate
show the reaction diagram
phosphorylated nemo protein + H2O
nemo protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of nemo protein
-
?
phosphorylated occludin + H2O
occludin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of occludin
-
?
phosphorylated P107 + H2O
P107 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of P107
-
?
phosphorylated p38 + H2O
p38 + phosphate
show the reaction diagram
phosphorylated p38alpha + H2O
p38alpha + phosphate
show the reaction diagram
phosphorylated p53 + H2O
p53 + phosphate
show the reaction diagram
phosphorylated p53 protein + H2O
p53 protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of p53 protein
-
?
phosphorylated p53-binding protein 1 + H2O
p53-binding protein 1 + phosphate
show the reaction diagram
-
p53-binding protein 1 is dephosphorylated at Ser25 and Ser1778
-
-
?
phosphorylated PACS-1 + H2O
PACS-1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PACS-1
-
?
phosphorylated paxillin + H2O
paxillin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of paxillin
-
?
phosphorylated peptide + H2O
peptide + phosphate
show the reaction diagram
-
PP2Cdelta prefers the dephosphorylation at diphosphorylated T(P)X(P)Y sequence compared to monophosphorylated T(P)XY sequence
-
-
?
phosphorylated period + H2O
period + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of period
-
?
phosphorylated phosphorylase a + H2O
phosphorylase a + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated phosphorylase kinase + H2O
phosphorylase kinase + phosphate
show the reaction diagram
phosphorylated PIM protein + H2O
PIM protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PIM protein
-
?
phosphorylated PKCbeta II + H2O
PKBbeta II + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PKCbeta II
-
?
phosphorylated PKCdelta + H2O
PKCdelta + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of PKCdelta
-
?
phosphorylated Polo-like kinase 1 + H2O
Polo-like kinase 1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated protein kinase CK2alpha + H2O
protein kinase CK2alpha + phosphate
show the reaction diagram
-
-
-
?
phosphorylated protein phosphatase inhibitor-1 + H2O
protein phosphatase inhibitor-1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Raf-1 kinase + H2O
Raf 1 kinase + phosphate
show the reaction diagram
phosphorylated Raf1 + H2O
Raf-1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Raf1 + H2O
Raf1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Raf1
-
?
phosphorylated RalA + H2O
RalA + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of RalA
-
?
phosphorylated RelA + H2O
RelA + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of RelA
-
?
phosphorylated retinoblastoma protein + H2O
retinoblastoma protein + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated rhodopsin + H2O
rhodopsin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated RNA polymerase II + H2O
RNA polymerase II + phosphate
show the reaction diagram
phosphorylated SCR protein + H2O
SCR protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of SCR protein
-
?
phosphorylated securin + H2O
securin + phosphate
show the reaction diagram
phosphorylated Ser/Thr protein kinase + H2O
DNA-dependent Ser/Thr protein kinase + phosphate
show the reaction diagram
-
-
-
?
phosphorylated seratonin + H2O
seratonin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of seratonin
-
?
phosphorylated serine-phosphorylated glycogen phosphorylase + H2O
glycogen phosphorylase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Shc protein + H2O
Shc protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Shc protein
-
?
phosphorylated Sp1 + H2O
Sp1 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of Sp1
-
?
phosphorylated spliceosome-associated protein 155 + H2O
spliceosome-associated protein 155 + phosphate
show the reaction diagram
phosphorylated sprouty + H2O
sprouty + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of sprouty
-
?
phosphorylated Src protein + H2O
Src protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of Src protein
-
?
phosphorylated stress-activated protein kinase + H2O
stress-activated protein kinase + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated Tau + H2O
Tau + phosphate
show the reaction diagram
-
the Balpha regulatory subunit of PP2A facilitates dephosphorylation of the phosphorylated Tau
-
-
?
phosphorylated tau protein + H2O
tau protein + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of tau protein
-
?
phosphorylated threonine-phosphorylated lipocortin I + H2O
lipocortin I + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated TRAF2 + H2O
TRAF2 + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to inhibition of TRAF2
-
?
phosphorylated transforming growth factor beta-activated kinase 1 + H2O
transforming growth factor beta-activated kinase 1 + phosphate
show the reaction diagram
-
dephosphorylates Thr-187 in the TAK1 activation loop
-
-
?
phosphorylated transforming growth factor-beta-activated kinase 1 + H2O
transforming growth factor-beta-activated kinase 1 + phosphate
show the reaction diagram
-
transforming growth factor-beta-activated kinase 1 is inactivated by the isoforms PP2Cbeta and PP2Cepsilon
-
-
?
phosphorylated tumor suppressor protein p53 + H2O
tumor suppressor protein p53 + phosphate
show the reaction diagram
-
dephosphorylation at Thr55
-
-
?
phosphorylated UNG2 + H2O
UNG2 + phosphate
show the reaction diagram
-
dephosphorylation at Thr residues, identification of dephosphorylation site sequences, overview
-
-
?
phosphorylated vimentin + H2O
vimentin + phosphate
show the reaction diagram
-
-
the dephosphorylation leads to activation of vimentin
-
?
phosphospectrin + H2O
spectrin + phosphate
show the reaction diagram
-
-
-
-
?
phosphothreonine + H2O
threonine + phosphate
show the reaction diagram
-
-
-
?
PVARTpSPLQTP + H2O
PVARTSPLQTP + phosphate
show the reaction diagram
-
-
-
?
Raf proto-oncogene serine/threonine protein kinase + H2O
dephosporylated Raf proto-oncogene serine/threonine protein kinase + phosphate
show the reaction diagram
PP5 plays a role in the inactivation of Raf proto-oncogene serine/threonine protein kinase, PP5/Raf proto-oncogene serine/threonine protein kinase association occurs in response to growth factor stimulation and results in the selective dephosphorylation of Ser338, removing phosphate from this critical site that helps to maintain Raf proto-oncogene serine/threonine protein kinase activation
-
-
?
RAT(P)VA + H2O
RATVA + phosphate
show the reaction diagram
-
-
-
-
?
RGRGSpSVGGGS + H2O
RGRGSSVGGGS + phosphate
show the reaction diagram
-
-
-
?
RII peptide + H2O
? + phosphate
show the reaction diagram
-
-
-
-
?
RRApSVA + H2O
RRASVA + phosphate
show the reaction diagram
-
-
-
?
RRApTVA + H2O
RRATVA + phosphate
show the reaction diagram
RRAS(P)VA + H2O
RRASVA + phosphate
show the reaction diagram
-
synthetic substrate
-
-
?
RRAT(P)VA + H2O
RRATVA + phosphate
show the reaction diagram
-
synthetic substrate
-
-
?
SQLHIpTPGTAY + H2O
SQLHITPGTAY + phosphate
show the reaction diagram
-
-
-
?
tumor necrosis factor receptor-associated factor 6 + H2O
?
show the reaction diagram
-
PP4 negatively regulates lipopolysaccharide-induced and tumor necrosis factor receptor-associated factor 6-mediated nuclear factor-kappaB activation by inhibiting the ubiquitination of tumor necrosis factor receptor-associated factor 6, PP4 is a negative feedback regulator of lipopolysaccharide/toll-like receptor 4 pathway
-
-
?
tyrosine-phosphorylated sEGF-R + H2O
phosphorylated sEGF-R + phosphate
show the reaction diagram
-
-
-
-
?
VARKLpSAREQR + H2O
VARKLSAREQR + phosphate
show the reaction diagram
-
-
-
?
vasodilator associated phosphoprotein + H2O
vasodilator associated protein + phosphate
show the reaction diagram
-
-
-
-
?
WHLADpSPAVNG + H2O
WHLADSPAVNG + phosphate
show the reaction diagram
-
-
-
?
YLRSIpSLPVPV + H2O
YLRSISLPVPV + phosphate
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
myosin light chain phosphate + H2O
myosin light chain + phosphate
show the reaction diagram
-
myosin light chain phosphatase is a specific form of PP1
-
-
?
phospho-Cdk2 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-Cdk6 + H2O
Cdk6 + phosphate
show the reaction diagram
-
-
-
-
?
phospho-MKK + H2O
MKK + phosphate
show the reaction diagram
-
-
-
-
?
phospho-TAK1 + H2O
TAK1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphoprotein + H2O
protein + phosphate
show the reaction diagram
phosphorylated c-Myc + H2O
c-Myc + phosphate
show the reaction diagram
phosphorylated Ca2+/calmodulin-dependent protein kinase II + H2O
Ca2+/calmodulin-dependent protein kinase II + phosphate
show the reaction diagram
-
dephosphorylation of the autophosphorylated Thr286, PPM1F negatively regulates the multifunctional Ca2+/calmodulin-dependent protein kinase II, e.g. reducing the phosphorylation of vimentin
-
-
?
phosphorylated cyclin G1 + H2O
cyclin G1 + phosphate
show the reaction diagram
-
the B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated
-
-
?
phosphorylated DNA-dependent protein kinase + H2O
DNA-dependent protein kinase + phosphate
show the reaction diagram
-
activation of DNA-dependent protein kinase to repair DNA double strand breaks by the process of nonhomologous end joining
-
-
?
phosphorylated ERK1 + H2O
ERK1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated ERK2 + H2O
ERK2 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated glycogen phosphorylase a + H2O
glycogen phosphorylase a + phosphate
show the reaction diagram
-
inactivation of the substrate enzyme, overview
-
-
?
phosphorylated histone deacetylase 3 + H2O
histone deacetylase 3 + phosphate
show the reaction diagram
phosphorylated ILK1 + H2O
ILK1 + phosphate
show the reaction diagram
-
negative regulation of Wnt signaling
-
-
?
phosphorylated lamban + H2O
lamban + phosphate
show the reaction diagram
phosphorylated myosin light chain + H2O
myosin light chain + phosphate
show the reaction diagram
phosphorylated p38 + H2O
p38 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated p38alpha + H2O
p38alpha + phosphate
show the reaction diagram
-
mediation of a negative feedback loop of the p38 MAPK-p53 signaling pathway
-
-
?
phosphorylated p53 + H2O
p53 + phosphate
show the reaction diagram
-
dephosphorylation of Ser15 by PP1, no activity with PP2A, PP1 inhibition leads to hyperphosphorylation of p53, PP1 has regulatory function
-
-
?
phosphorylated phosphorylase kinase + H2O
phosphorylase kinase + phosphate
show the reaction diagram
-
isozyme PP1 preferentially dephosphorylates the beta-subunit of phosphorylase kinase, isozyme PP2 preferentially dephosphorylates the alpha-subunit of phosphorylase kinase
-
-
?
phosphorylated Raf-1 kinase + H2O
Raf 1 kinase + phosphate
show the reaction diagram
-
phosphatase 2A dephosphorylates Raf-1 Ser259 in response to mitogens
-
-
?
phosphorylated Raf1 + H2O
Raf-1 + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated rhodopsin + H2O
rhodopsin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated RNA polymerase II + H2O
RNA polymerase II + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated securin + H2O
securin + phosphate
show the reaction diagram
-
-
-
-
?
phosphorylated spliceosome-associated protein 155 + H2O
spliceosome-associated protein 155 + phosphate
show the reaction diagram
-
i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component. nuclear inhibitor of PP1, i.e. NIPP1, a major PP1 interactor in the vertebrate nucleus, recruits PP1 to Sap155
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3-bis(4-amino-2-methylquinolin-6-yl)urea
-
1-(3-bromophenyl)-6-undecyl-1,3,5-triazinane-2,4-diimine
-
2-amino-4-methyl-N-naphthalen-2-ylpentanamide
-
3-iodo-7-[(8-iodo-10-phenyl-5,10-dihydrophenazin-2-yl)amino]-5-phenylphenazin-5-ium
-
5,5',6,6',8,8'-hexahydroxy-2,2',3,3'-tetramethyl-2,2',3,3'-tetrahydro-4H,4'H-9,9'-bibenzo[g]chromene-4,4'-dione
-
6,6-dimethyl-1-[4-(4-phenylbutyl)phenyl]-1,3,5-triazinane-2,4-diimine
-
6-(3,4-dichloro-phenyl)-4-(N,N-dimethylaminoethylthio)-2-phenyl-pyrimidine
-
i.e. CN585, noncompetitively and reversibly inhibits calcineurin activity, without affecting other Ser/Thr protein phosphatases or peptidyl prolyl cis/trans isomerases. The compound shows potent immunosuppressive effects by inhibiting NFAT nuclear translocation and transactivation, cytokine production, and T cell proliferation
c(M-L-2-amino-4-phosphono-4,4-difluorobutanoate-IpYVA)
-
-
C-terminally truncated nuclear inhibitor of protein phosphatase-1
-
C-terminally truncated NIPP1 forms a hyperactive holoenzyme with PP1, rendering PP1 minimally phosphorylated on an inhibitory site
-
caffeic acid phenethyl ester
-
down-regulation of expression of PP2A catalytic subunit in cells treated with caffeic acid phenethyl ester at 48 h
calyculin
-
moderate inhibition at 0.00001 mM
calyculin A
calyculin-A
-
cantharidin
cantharidine
-
cantheridin
-
strong inhibition at 0.005 mM
Co2+
-
-
CPI-17
-
encoded by gene PPP1R14A, chromosome 19. Upon phosphorylation at Thr38, the 17 kDa PP1 inhibitor protein, CPI-17, selectively inhibits a specific form of PP1, myosin light chain phosphatase, which transduces multiple kinase signals into the phosphorylation of myosin II and other proteins. Phosphorylation of CPI-17 at Thr38 is necessary and sufficient to convert the protein into a potent MLCP inhibitor, mechanism, modeling, overview
-
creatine phosphate
-
60 mM
cyclic phosphopeptide c(M-L-2-amino-4-phosphono-4,4-difluorobutanoate-IpYVA)
-
inhibits only Wip1
cyclic phosphopeptide c(MpSIpY)
-
-
cyclic phosphopeptide c(MpSIpYV)
-
-
cyclic phosphopeptide c(MpSIpYVA)
-
inhibits only Wip1
cyclic phosphopeptide c(MpSIpYVAT)
-
-
cyclic phosphopeptide c(TDDEMpSIpYVAT)
-
-
cyclin-dependent kinase 2
-
-
-
cyclophilin
-
-
-
cyclosporin
cyclosporin A
DARPP-32
-
-
-
di-mu-chloro(bis[1-[(morpholin-4-yl-kappaN)methyl]naphthalen-2-olato-kappaO])dicopper
-
di-mu-chloro(bis[1-[(piperidin-1-yl-kappaN)methyl]naphthalen-2-olato kappaO])dicopper
-
dinophysistoxin-2
-
docetaxel
-
docetaxel induces the decrease in the activity of protein phosphatase 1
DSCR1
-
a calcineurin inhibitor, encoded by gene Dscr1 on chromosome 21, is elevated in Down syndrome individuals. Increased dosage of Dyrk1A, appears to act in concert with Dscr1 to suppress tumor angiogenesis by further attenuating VEGF-calcineurin-NFAT signalling in endothelial cells, mechanism, overview. DSCR1-dependent inhibition of the VEGF-calcineurin-NFAT pathway in endothelial cells as a key component of the reduced cancer incidence in Down syndrome individuals
-
EDTA
-
isozyme PP1 has low activity after depletion of Mn2+ with EDTA
endothall
-
specific inhibitor of isozyme PP2A
FK506
fostriecin
glutamate
-
inhibitor of isozyme PP2A
human Inhibitor-3
-
possesses a putative protein phosphatase-1 binding motif, 39KKVEW43. A second interaction site, whose deletion leads to loss of inhibitory potency, is identified between residues 65-77
-
Inhibitor-1
-
inhibitor of isozyme PP1
-
Inhibitor-2
-
mesalazine
-
1 mg/ml efficiently inhibits PP2A
microcystin
-
microcystin-LR
microsystin-LR
-
N-methyl-N'-phenanthren-9-ylimidodicarbonimidic diamide
-
NaF
-
moderate inhibition; strong inhibition
neurabin-I
-
IC50 for the wild-type catalytic subunit PP1alpha is 1.75 nM
-
Ni2+
-
-
nodularin
ocadaic acid
-
-
okadaic acid
p-bromotetramisole
-
PTP-1B
paclitaxel
-
paclitaxel induces decrease in activity of protein phosphatase 2 subgroups
pervanadate
-
-
phosphate
-
-
phosphocholine
-
-
phosphonothioic acid
-
phosphopeptide TDDEMpS-cyclohexylalanine-pYVAT
-
40% inhibition at 0.1 mM
phosphopeptide TDDEMpS-D-pYVAT
-
32% inhibition at 0.1 mM
phosphopeptide TDDEMpS-I-pYVAT
-
54% inhibition at 0.1 mM
phosphopeptide TDDEMpS-P-pYVAT
-
26% inhibition at 0.1 mM
phosphopeptide TDDEMpS-V-pYVAT
-
51% inhibition at 0.1 mM
pimecrolimus
protein phosphatase inhibitor II
-
specific inhibitor of isozyme PP1
-
Protein phosphatase inhibitor-1
-
protein phosphatase inhibitor-2
-
protein phosphatase-1 inhibitor-1
-
plays a role in cardiac physiology and pathophysiology, overview
-
protein phosphatase-1 inhibitor-3
-
a potent inhibitor of protein phosphatase-1 that selectively associates with PP1gamma1 and PP1alpha, but not the PP1beta isoform. It is a physiological substrate of caspase-3 harboring a putative caspase-3 cleavage site, 46DTVD49, located between the two PP1 interaction sites, which consist of a RVXF motif and an adjacent inhibitory domain, both of which are required for inhibition of PP1. Inh-3 mutant D49A is caspase-3 resistant
-
RCAN proteins
-
RCAN inhibition of CN phosphatase activity is mediated by the extreme C-terminal region
-
sanguinarine
-
small t antigen
-
small t antigen of DNA tumor virus SV40 inhibits the phosphatase activity of the PP2A core enzyme
-
small t antigen of SV40 and polyomavirus
-
inhibits isozyme PP2A
-
small T antigen of SV40 virus
-
specifically inhibits PP2A holoenzymes with B55 or B56 regulatory subunits
-
Sodium fluoride
-
50 mM
Sodium vanadate
-
-
tacrolimus
Tartrate
-
moderate inhibition of P11 at 2 mM; strong inhibition
tautomycin
tetramisole
-
strong inhibition at 2 mM
Trifluorperazine
-
moderate inhibition; strong inhibition; strong inhibition at 0.1 mM
vanadate
-
at 1 mM inhibition to 60% of its activity
Zn2+
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additional information
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arachidonic acid
C2-ceramide
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potent PP2A activator
Calmodulin
chlorogenic acid
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PP2B but not PP1 is stimulated 4fold by 0.1 mM chlorogenic acid
docetaxel
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docetaxel induces increase in activity of protein phosphatase 2 subgroups
ERK-2
association with ERK-2 results in catalytic activation of Pac-1
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estrogen
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estrogen maintains the function of PP1, PP2A, and calcineurin
heparin
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causes dissociation to alpha1, beta1 and hence stimulation
HSP70
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heat shock protein, activation of Ppp5 by dissociation from Hsp70
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Hsp90
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linoleic acid
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increases PP2A expression rate
lipopolysaccharide
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lipopolysaccharide stimulation induces the expression of PP4
nocodazole
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causes loss of heat shock protein interaction and increases Ppp5 activity
nuclear inhibitor of protein phosphatase-1
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NIPP1 directs PP1 to dephosphorylate the U2 small nuclear ribonucleoprotein particle component, spliceosome-associated protein 155, Sap155
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paclitaxel
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paclitaxel induces the increase in the activity of protein phosphatase 1
PTPase activator
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PTPase activator acts like a chaperone directly affecting the activity of PP2Ac
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TFIIF
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a transcription factor that binds to the C-terminal domain
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additional information
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