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Information on EC 3.1.3.15 - histidinol-phosphatase
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3.1.3.15 histidinol-phosphataseSpecify your search results
Word Map
- 3.1.3.15
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photosensitizer
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photodynamic
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trinuclear
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phosphoesterase
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polxs
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mthpc
- drug development
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mthpp, impl2, histidinol phosphatase, histidinol-phosphate phosphatase, holpase, histidinol phosphate phosphatase, sco5208, cg0910, ton_0887, cg0911, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
cg0910
Cg0911
Cgl0800
D-erythro-imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase
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HisB-N
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N-terminal domain of the bifunctional enzyme HisB with histidinol phosphate phosphatase activity
hisN
HisPPase
histidinol phosphatase
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histidinol phosphate phosphatase
histidinol-P-phosphatase
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histidinolphosphatase
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histinol-phosphate phosphatase
HOL-P phosphatase
HolPase
HP phosphatase
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HPP
HPpase
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imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase
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IMPase-like HolPase
inositol monophosphatase-like HolPase
L-histidinol phosphatase
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L-histidinol phosphate phosphatase
L-histidinol-phosphate phosphatase
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L-histidinol-phosphate phosphohydrolase
Mtb HolPase
Rv3137
SCO5208
histidinol phosphate phosphatase
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histinol-phosphate phosphatase
myoinositol monophosphatase-like2, IMPL2
HolPase
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HolPase
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member of the DDDD phosphohydrolase/phosphotransferase superfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-histidinol phosphate + H2O = L-histidinol + phosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
L-histidinol-phosphate phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9025-79-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-histidinol 1-phosphate + H2O
L-histidinol + phosphate
105% of the activity with D-myo-inositol1-phosphate
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-
?
L-histidinol phosphate + H2O
?
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-
-
-
?
L-histidinol phosphate + H2O
?
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-
-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
low activity
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
the enzyme encoded by the Rv3137 gene, belonging to the inositol monophosphatase (IMPase) family, functions as the Mtb HolPase and specifically dephosphorylates histidinol phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
the enzyme encoded by the Rv3137 gene, belonging to the inositol monophosphatase (IMPase) family, functions as the Mtb HolPase and specifically dephosphorylates histidinol phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
the enzyme encoded by the Rv3137 gene, belonging to the inositol monophosphatase (IMPase) family, functions as the Mtb HolPase and specifically dephosphorylates histidinol phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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the enzyme catalyses the eigthth step of histidine biosynthesis
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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the enzyme catalyses the eigthth step of histidine biosynthesis
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?
N-formyl-L-histidinol phosphate + H2O
N-formyl-L-histidinol + phosphate
the rate of hydrolysis of N-formyl-L-histidinol phosphate is less than 1% of the rate of hydrolysis of L-histidinol phosphate at pH 8.5
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?
N-formyl-L-histidinol phosphate + H2O
N-formyl-L-histidinol + phosphate
the rate of hydrolysis of N-formyl-L-histidinol phosphate is less than 1% of the rate of hydrolysis of L-histidinol phosphate at pH 8.5
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no substrate: 4-nitrophenyl phosphate
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?
additional information
?
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no activity with inositol monophosphate by wild-type or mutant Mtb HolPases. Phosphate detection with malachite green
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?
additional information
?
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no activity with inositol monophosphate by wild-type or mutant Mtb HolPases. Phosphate detection with malachite green
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?
additional information
?
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no activity with inositol monophosphate by wild-type or mutant Mtb HolPases. Phosphate detection with malachite green
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?
additional information
?
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no activity with inositol monophosphate by wild-type or mutant Mtb HolPases. Phosphate detection with malachite green
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?
additional information
?
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does not show any phosphatase activity with p-nitrophenyl phosphate
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-histidinol phosphate + H2O
?
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?
L-histidinol phosphate + H2O
?
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
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?
L-histidinol phosphate + H2O
L-histidinol + phosphate
-
the enzyme catalyses the eigthth step of histidine biosynthesis
-
?
L-histidinol phosphate + H2O
L-histidinol + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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the enzyme catalyses the eigthth step of histidine biosynthesis
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?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Fe2+
Mg2+
Mn2+
Ni2+
Zn2+
additional information
Co2+
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shifts optimal pH to 6.5, decreases Km at pH 6.5
Mg2+
assay in presence of 5 mM, Km value 0.65 mM, Hill coefficient 2.44
Mg2+
a divalent cation is required, saturation kinetics for Mtb HolPase with Mg2+ as a cofactor, the specificity constant (kcat/Km) with Zn2+ is 1.16fold higher compared to Mg2+, metal binding in the active site of Mtb HolPase, structure, overview
Mn2+
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shifts optimal pH to 6.5, decreases Km at pH 6.5
Zn2+
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the presence of a structural Zn2+ ion stabilizes the conformation of an extended loop
Zn2+
a divalent cation is required, saturation kinetics for Mtb HolPase with Zn2+ as a cofactor, the specificity constant (kcat/Km) with Zn2+ is 1.16fold higher compared to Mg2+, Michaelis-Menten kinetics, overview
Zn2+
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shifts optimal pH to 6.5, decreases Km at pH 6.5
additional information
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no activating effect by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
no activating effect by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
no activating effect by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
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no activating effect on activity by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
no activating effect on activity by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
no activating effect on activity by Zn2+, Cu2+, Ca2+, Mi2+, and Fe2+ at 5 mM
additional information
the enzyme does not show any significant increases in catalytic activity when Zn2+, Mn2+, Co2+ or Ni2+ are added
additional information
-
the enzyme does not show any significant increases in catalytic activity when Zn2+, Mn2+, Co2+ or Ni2+ are added
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
3-[(1-(R))-1-(2,6-dichloro-4-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
NSC756645
4-chloro-1-N,3-N-bis[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzene-1,3-dicarboxamide
NSC67436
5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium-9-ol
NSC311153, best tested inhibitor
5,5'-dithiobis(2-nitrobenzoic acid)
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inhibits more rapidly at pH 7 than at pH 8.5
[(1S,4aR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine benzoic acid
NSC65238
EDTA
10 mM, complete loss of activity; 10 mM, complete loss of activity