pleiotropic defective phenotype of disrupted TPS2, cell wall integrity and ability to form chlamydospores maintained, reduced growth and temperature sensitivity (42°C) of homozygous mutant, severe oxidative exposure (50 mM H2O2), null mutants reveal adaptive antioxidant response and cross-tolerance between temperature and oxidative stress, expression of TPS2 and TPS1 genes promoted in wild-type cells in response to acute (50 mM) but not gentle (5 mM) oxidative exposure
pleiotropic defective phenotype of disrupted TPS2, cell wall integrity and ability to form chlamydospores maintained, reduced growth and temperature sensitivity (42°C) of homozygous mutant, severe oxidative exposure (50 mM H2O2), null mutants reveal adaptive antioxidant response and cross-tolerance between temperature and oxidative stress, expression of TPS2 and TPS1 genes promoted in wild-type cells in response to acute (50 mM) but not gentle (5 mM) oxidative exposure
Immunization of Mastomys coucha with Brugia malayi Recombinant Trehalose-6-Phosphate Phosphatase Results in Significant Protection against Homologous Challenge Infection.
[Identification of trehalose-phosphate phosphatase associated with drug-resistance from culture supernatants of isoniazid-resistant Mycobacterium tuberculosis]
pleiotropic defective phenotype of disrupted TPS2, cell wall integrity and ability to form chlamydospores maintained, reduced growth and temperature sensitivity (42°C) of homozygous mutant, severe oxidative exposure (50 mM H2O2), null mutants reveal adaptive antioxidant response and cross-tolerance between temperature and oxidative stress, differential measurement of trehalose and trehalose 6-phosphate by HPLC, accumulation of trehalose 6-phosphate in null mutants but not in parental cells, accumulation of trehalose 6-phosphate enhanced after oxidative exposure, expression of TPS2 and TPS1 genes promoted in wild-type cells in response to acute (50 mM) but not gentle (5 mM) oxidative exposure, transcriptional response absent in mutants, co-culture of yeast cells with macrophages and fungicidal assays, role of trehalose biosynthetic pathway in the cellular response to oxidative stress
pleiotropic defective phenotype of disrupted TPS2, cell wall integrity and ability to form chlamydospores maintained, reduced growth and temperature sensitivity (42°C) of homozygous mutant, severe oxidative exposure (50 mM H2O2), null mutants reveal adaptive antioxidant response and cross-tolerance between temperature and oxidative stress, differential measurement of trehalose and trehalose 6-phosphate by HPLC, accumulation of trehalose 6-phosphate in null mutants but not in parental cells, accumulation of trehalose 6-phosphate enhanced after oxidative exposure, expression of TPS2 and TPS1 genes promoted in wild-type cells in response to acute (50 mM) but not gentle (5 mM) oxidative exposure, transcriptional response absent in mutants, co-culture of yeast cells with macrophages and fungicidal assays, role of trehalose biosynthetic pathway in the cellular response to oxidative stress