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Information on EC 3.1.3.12 - trehalose-phosphatase

for references in articles please use BRENDA:EC3.1.3.12
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.3 Phosphoric-monoester hydrolases
                3.1.3.12 trehalose-phosphatase
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UNIPROT: Q5AI14 not found.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
trehalose-6-phosphate phosphatase, attps1, ostpp1, gob-1, otsb2, trehalose 6-phosphate phosphatase, trehalose-6-phosphate synthase/phosphatase, trehalose phosphate phosphatase, trehalose-phosphate phosphatase, t6p phosphatase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TPP
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trehalose 6-phosphatase
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trehalose 6-phosphate phosphatase
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trehalose phosphate phosphatase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose-6-phosphate phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
9025-72-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trehalose 6-phosphate + H2O
trehalose + phosphate
show the reaction diagram
trehalose-6-phosphate + H2O
trehalose + phosphate
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
trehalose 6-phosphate + H2O
trehalose + phosphate
show the reaction diagram
pleiotropic defective phenotype of disrupted TPS2, cell wall integrity and ability to form chlamydospores maintained, reduced growth and temperature sensitivity (42°C) of homozygous mutant, severe oxidative exposure (50 mM H2O2), null mutants reveal adaptive antioxidant response and cross-tolerance between temperature and oxidative stress, expression of TPS2 and TPS1 genes promoted in wild-type cells in response to acute (50 mM) but not gentle (5 mM) oxidative exposure
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trehalose-6-phosphate + H2O
trehalose + phosphate
show the reaction diagram
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?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q5AI14_CANAL
Candida albicans (strain SC5314 / ATCC MYA-2876)
888
0
100407
TrEMBL
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
the disruption of gene leads to aggregation of the cells in stationary phase and greatly decreases infectivity of Candida albicans in mice
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zaragoza, O.; de Virgilio, C.; Ponton, J.; Gancedo, C.
Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity
Microbiology
148
1281-1290
2002
Candida albicans (Q5AI14), Candida albicans
Manually annotated by BRENDA team
Martinez-Esparza, M.; Martinez-Vicente, E.; Gonzalez-Parraga, P.; Ros, J.M.; Garcia-Penarrubia, P.; Argueelles, J.C.
Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans
Int. J. Med. Microbiol.
299
453-464
2009
Candida albicans (Q5AI14), Candida albicans
Manually annotated by BRENDA team